Assignee: Dyax Corp.

Location: Cambridge, MA
No. of patents: 71

Number	Title	Issue Date
8147836	Compositions and methods for treating osteolytic disorders comprising MMP-14 binding proteins Provided are methods and compositions for using MMP-14 or MMP-9 binding proteins alone or in combination with other therapeutic agents to treat osteolytic disorders such as osteotropic cancer and osteoporosis. ...	04/03/2012
8124586	Prevention and reduction of blood loss Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting...	02/28/2012
8114968	Metalloproteinase-12 specific monoclonal antibody Proteins that bind to matrix metalloproteinase 12 and methods of using such proteins are described. ...	02/14/2012
8106168	Metalloproteinase binding proteins Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described. ...	01/31/2012
8058017	Methods and compositions for purifying human factor VIII, factor VIII-like proteins or fragments thereof Provided herein are methods and compositions for purifying human factor VIII, human factor VIII-like peptide or fragments thereof. The methods comprise immobilizing a binding molecule for human factor VIII, human factor VIII-like protein or fragments thereof to a so...	11/15/2011
8044175	Peptides that specifically bind HGF receptor (CMET) and uses thereof A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed. ...	10/25/2011
8034775	Kallikrein-inhibitor therapies Methods are described for preventing or reducing ischemia, e.g., cerebral ischemia, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia, in a patient. ...	10/11/2011
8013125	Metalloproteinase 9 and metalloproteinase 2 binding proteins Proteins that bind to matrix metalloproteinase 9 and to matrix metalloproteinase 2 and methods of using such proteins are described. ...	09/06/2011
8008445	Metalloproteinase 9 binding proteins Proteins that bind to matrix metalloproteinase 9 and methods of using such proteins are described. ...	08/30/2011
7993646	HK1-binding proteins The invention features hK1 binding polypeptides as well as compositions comprising such polypeptides and methods of making and using such polypeptides. ...	08/09/2011
7919462	Inhibitors of human plasmin derived from the Kunitz domains This invention features novel proteins that are homologous to the first Kunitz domain (K1) of lipoprotein-associated coagulation inhibitor (LACI), and are capable of inhibiting plasmin and nucleic acids encoding these proteins. The invention also features the use of...	04/05/2011
7910088	Multivalent constructs for therapeutic and diagnostic applications The invention provides compositions and methods for therapeutic and diagnostic applications. ...	03/22/2011
7893007	Directed evolution of novel binding proteins In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen...	02/22/2011
7871610	Antibodies to Tie1 ectodomain Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial c...	01/18/2011
7851442	Prevention and reduction of blood loss Kits containing a dry lyophilized kallikrein inhibitor are described. ...	12/14/2010
7811991	Prevention and reduction of blood loss Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting...	10/12/2010
7745587	Antibodies that bind MMP-14 Proteins that bind to matrix metalloproteinase 14 and methods of using such proteins are described. ...	06/29/2010
7736867	Nucleic acids encoding polypeptide inhibitors of human plasmin derived from the Kunitz domains This invention features novel proteins that are homologous to the first Kunitz domain (K1) of lipoprotein-associated coagulation inhibitor (LACI), and are capable of inhibiting plasmin and nucleic acids encoding these proteins. The invention also features the use of...	06/15/2010
7718617	Methods for preserving organs and tissues The invention relates to a method for preserving an organ or tissue comprising contacting the organ or tissue with an effective amount of a kallikrein inhibitor and solutions useful for such a method. Also provided is a method for reducing reperfusion injury of an o...	05/18/2010
7704949	Kallikrein-inhibitor therapies Methods are described for preventing or reducing ischemia, e.g., cerebral ischemia, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia, in a patient. ...	04/27/2010
7691565	Binding molecules for human factor VIII and factor VIII-like proteins It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptid...	04/06/2010
7628983	Kallikrein-binding “Kunitz domain” proteins and analogues thereof This invention provides: novel protein homologous of a Kunitz domain, which are capable of binding kallikrein; polynucleotides that encode such novel proteins; and vectors and transformed host cells containing these polynucleotides. ...	12/08/2009
7550427	Poly-pegylated protease inhibitors Disclosed are compounds that comprise: (i) a Kunitz domain polypeptide that comprises a Kunitz domain that binds to and inhibits a protease; and (ii) a plurality of polyethylene glycol moieties attached to the Kunitz domain polypeptide. Each accessible primary amine...	06/23/2009
7514534	Metalloproteinase-binding proteins Disclosed are antibodies that interact with a matrix metalloproteases such as MMP-26. Exemplary antibodies inhibit MMP-26 activity. These antibodies can be used, e.g., to treat or prevent metastatic disorders, hyperproliferative disorders, disorders which are charac...	04/07/2009
7485297	Method of inhibition of vascular development using an antibody Tie1 and Tie2 are receptor tyrosine kinase proteins that include a transmembrane domain. Tie1 and Tie2 are present on endothelial cells. This disclosure describes agents, such as antibodies, that bind to Tie1, Tie2, and Ang, including ones that inhibit endothelial c...	02/03/2009
7438890	Binding peptides for carcinoembryonic antigen (CEA) The present invention provides binding moieties for CEA, which have a variety of uses wherever detecting, isolating or localizing CEA, and particularly CEA as opposed to cross-reactive antigens such as NCA, is advantageous. Particularly disclosed are synthetic, isol...	10/21/2008
7413537	Directed evolution of disulfide-bonded micro-proteins The invention relates, in part, to a library of chimeric proteins, each chimeric protein including a mini-protein between about eight and about forty amino acids long, wherein the mini-protein has a single disulfide bond formed by a pair of invariant cysteines and h...	08/19/2008
7348001	Tie1-binding ligands Tie1 is a receptor tyrosine kinase protein that includes a transmembrane domain. Tie1 is present on endothelial cells. This disclosure described antibodies that bind to Tie1, including ones that inhibit endothelial cell activity. ...	03/25/2008
7329737	Antibodies that bind hK-1 The invention features hK1 binding polypeptides as well as compositions comprising such polypeptides and methods of making and using such polypeptides. ...	02/12/2008
7276480	Prevention and reduction of blood loss Methods are described for preventing or reducing ischemia and/or systemic inflammatory response in a patient such as perioperative blood loss and/or systemic inflammatory response in a patient subjected to cardiothoracic surgery, e.g. coronary artery bypass grafting...	10/02/2007
7273610	Endotheliase-2 ligands Proteins that bind to ET2, such as immunoglobulins that inhibit ET2 with high affinity and selectivity, are provided. The ET2 binding proteins can be used to treat a variety of disorders, including angiogenesis-associated disorders. ...	09/25/2007
7261876	Multivalent constructs for therapeutic and diagnostic applications The invention provides compositions and methods for therapeutic and diagnostic applications. ...	08/28/2007
7244592	Ligand screening and discovery Disclosed is a method that includes: (i) providing a plurality of initial nucleic acid cassettes that include: a) a first coding region encoding a first immunoglobulin variable domain, b) a second coding region encoding a second immunoglobulin variable domain, and c...	07/17/2007
7211395	Serum albumin binding moieties Compositions comprising non-naturally occurring serum albumin binding moieties are described, together with methods of use thereof, e.g., for detecting or isolating serum albumin molecules in a solution, for blood circulation imaging, and for linking therapeutics or...	05/01/2007
7211240	Multivalent constructs for therapeutic and diagnostic applications The invention provides compositions and methods for therapeutic and diagnostic applications. ...	05/01/2007
7208293	Directed evolution of novel binding proteins In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen...	04/24/2007
7166576	Methods for preserving organs and tissues The invention relates to a method for preserving an organ or tissue comprising contacting the organ or tissue with an effective amount of a kallikrein inhibitor and solutions useful for such a method. Also provided is a method for reducing reperfusion injury of an o...	01/23/2007
7153829	Kallikrein-inhibitor therapies Methods are described for preventing or reducing ischemia, e.g., cerebral ischemia, and/or reperfusion injury, e.g., reperfusion injury associated with cerebral ischemia, in a patient. ...	12/26/2006
7118872	Binding polypeptides for B lymphocyte stimulator protein (BLyS) Binding polypeptides comprising specific amino acid sequences are disclosed that bind B Lymphocyte Stimulator (BLyS) protein or BLyS-like polypeptides. The binding polypeptides can be used in methods of the invention for detecting or isolating BLyS protein or BLyS-l...	10/10/2006
7118879	Method of recovering a nucleic acid encoding a proteinaceous binding domain which binds a target material In order to obtain a novel binding protein against a chosen target, DNA molecules, each encoding a protein comprising one of a family of similar potential binding domains and a structural signal calling for the display of the protein on the outer surface of a chosen...	10/10/2006

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Assignee: Dyax Corp.