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Vehicular Impact Signaling Device
An apparatus for the deployment of a visible plume to alert other motorists that a proximate motor vehicle has been involved in a collision.
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| Number | Title | Issue Date |
| 8183364 | Substituted porphyrins To improve bioavailability of the catalytic metalloporphyrin-based SOD mimics Mn(III) 5,10,15,20-tetrakis[N-ethylpyridinium-2-yl]porphyrin (MnTE-2-PyP5+) and Mn(III) 5,10,15,20-tetrakis[N,N′-diethylimidazolium-2-yl]porphyrin (MnTDE-2-ImP5+), ... | 05/22/2012 |
| RE43372 | C16 unsaturated FP-selective prostaglandins analogs Compounds having the general structure: which are useful for the treatment of a variety of diseases and conditions, such as bone disorders. ... | 05/08/2012 |
| 8163514 | Methods of cleaving DNA with rationally-designed meganucleases Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number ... | 04/24/2012 |
| 8158344 | Methods and compositions for correlating genetic markers with multiple sclerosis The present invention provides, in certain aspects, a method of identifying a subject as having an increased risk of developing multiple sclerosis, comprising detecting in the subject the presence of a nucleotide variant in the interleukin 7 receptor alpha chain gen... | 04/17/2012 |
| 8149400 | Coded aperture snapshot spectral imager and method therefor The present invention enables snap-shot spectral imaging of a scene at high image generation rates. Light from the scene is processed through an optical system that comprises a coded-aperture. The optical system projects a plurality of images, each characterized by ... | 04/03/2012 |
| 8148605 | Biological systems input-output response system and plant sentinels A eukaryotic input circuit: computationally designed receptors, synthetic eukaryotic signal transduction pathways, and a synthetic signal sensitive promoter that allow highly specific transcriptional induction in response to an externally provided ligand is disclose... | 04/03/2012 |
| 8148098 | Methods of cleaving DNA with rationally-designed meganucleases Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number ... | 04/03/2012 |
| 8147668 | Apparatus for manipulating droplets Apparatuses for mixing droplets, such as a binary mixing apparatus, are provided. The binary mixing apparatus includes an array of electrodes and a conducting element positioned in relation to at least one of the electrodes to enable a droplet placed in electrical c... | 04/03/2012 |
| 8143233 | RNA aptamers and methods for identifying the same RNA aptamers and methods for identifying the same are disclosed. The RNA aptamers selectively bind coagulation factors, E2F family members, Ang1 or Ang2, and therapeutic and other uses for the RNA aptamers are also disclosed. ... | 03/27/2012 |
| 8143016 | Methods of cleaving DNA with rationally-designed meganucleases Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number ... | 03/27/2012 |
| 8143015 | Methods of cleaving DNA with rationally-designed meganucleases Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number ... | 03/27/2012 |
| 8137977 | Lipidomic approaches to determining drug response phenotypes in cardiovascular disease The present invention concerns the application of lipidomics to statin treatment for disorders such as cardiovascular disorders. Hence, the invention provides, among other things, a method of correlating a lipid profile with a positive or negative response to a stat... | 03/20/2012 |
| 8137910 | Method of regulating gene expression The present invention relates, in general, to gene expression and, in particular, to a method of inhibiting the expression of a target gene and to constructs suitable for use in such a method. ... | 03/20/2012 |
| 8133697 | Methods of cleaving DNA with rationally-designed meganucleases Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number ... | 03/13/2012 |
| 8130031 | Tunable metamaterial Examples of the present invention include a metamaterial comprising a plurality of resonators disposed on a substrate, the substrate comprising a dielectric support layer and a relatively thin semiconductor layer, having a Schottky junction between at least one cond... | 03/06/2012 |
| 8129344 | Method of reducing cell death by administering a Sfrp polypeptide A purified paracrine factor of a mesenchymal stem cell, such as a Secreted frizzled related protein (Sfrp) is useful to reduce cell death an/or tissue injury associated with ischemic condtions. ... | 03/06/2012 |
| 8129134 | Methods of cleaving DNA with rationally-designed meganucleases Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number ... | 03/06/2012 |
| 8124831 | Transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase Recombinant or transgenic non-human mammals are described having a mutant tryptophan hydroxylase 2 (Tph2) gene resulting in altered synthesis of 5-hydroxytryptophan and serotonin in the brain. In some embodiments the mutant tryptophan hydroxylase 2 gene contains mou... | 02/28/2012 |
| 8124369 | Method of cleaving DNA with rationally-designed meganucleases Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number ... | 02/28/2012 |
| 8119381 | Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number ... | 02/21/2012 |
| 8119361 | Methods of cleaving DNA with rationally-designed meganucleases Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number ... | 02/21/2012 |
| 8119140 | Immunogenic compositions comprising human immunodeficiency virus (HIV) mosaic Nef proteins The present invention relates to mosaic clade M HIV-1 Nef polypeptides and to compositions comprising same. The polypeptides of the invention are suitable for use in inducing an immune response to HIV-1 in a human. ... | 02/21/2012 |
| 8118744 | Methods, systems and computer program products for ultrasound shear wave velocity estimation and shear modulus reconstruction Methods for determining a mechanical parameter of a sample include detecting shear waves that have been generated in the sample by an applied shear wave source. A time of peak displacement of the shear waves for a plurality of sample positions is determined. At leas... | 02/21/2012 |
| 8105781 | Predictors of long-term mortality following coronary artery bypass graft surgery The present invention relates, in general, to perioperative depression and, in particular, to methods of identifying individuals at risk of perioperative depression. ... | 01/31/2012 |
| 8097415 | Methods for identifying an individual at increased risk of developing coronary artery disease The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or... | 01/17/2012 |
| 8088587 | Genetic variants increase the risk of age-related macular degeneration Age-related macular degeneration (AMD) is a leading cause of visual impairment and blindness in the elderly whose etiology remains largely unknown. Previous studies identified chromosome 1q32 as harboring a susceptibility locus for AMD, but it was not identified. We... | 01/03/2012 |
| 8086297 | Dark blood delayed enhancement magnetic resonance viability imaging techniques for assessing subendocardial infarcts The technology herein provides a dark blood delayed enhancement technique that improves the visualization of subendocardial infarcts that may otherwise be disguised by the bright blood pool. The timed combination of a slice-selective and a non-selective preparation ... | 12/27/2011 |
| 8081364 | High-speed multi-dimensional beam scanning system with angle amplification A beam-steering system having high positional resolution and fast switching speed is disclosed. Embodiments of the beam-steering system comprise a diffraction limited optical system that includes a reflective imager and two controllably rotatable MEMS elements. The ... | 12/20/2011 |
| 8077325 | Methods, systems and computer program products for characterizing structures based on interferometric phase data Structure profiles from optical interferometric data can be identified by obtaining a plurality of broadband interferometric optical profiles of a structure as a function of structure depth in an axial direction. Each of the plurality of interferometric optical prof... | 12/13/2011 |
| 8076059 | Adjuvant capable of specifically activating the adaptive immune response A composition for eliciting an immune response to an immunogen comprises an immunogen in combination with a mast cell membrane activator such as compound 48/80. Any suitable immunogen may be employed, such as an antibody-inducing determinant, a lipid, a peptide (e.g... | 12/13/2011 |
| 8075922 | Method of co-infusing a deoxygenated hemoglobin containing blood substitute and inorganic nitrite Contrary to current opinion that nitrite in general oxidizes hemoglobin with elimination of active nitric oxide, deoxygenated hemoglobin reacts with low concentration inorganic nitrite to produce very stable iron nitrosyl hemoglobin which on delivery into the body i... | 12/13/2011 |
| 8074661 | Method and apparatus for laser tissue ablation A method and apparatus for ablating material. The material is preferably a heterogenous or composite material, such as animal tissue. A table top laser system can be employed in the invention. Alternatively, a larger laser, such as a free electron laser can be emplo... | 12/13/2011 |
| 8071107 | Nucleic acids encoding modified human immunodeficiency virus type 1 (HIV-1) group M consensus envelope glycoproteins The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates t... | 12/06/2011 |
| 8067553 | PEG-urate oxidase conjugates and use thereof A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average... | 11/29/2011 |
| 8048628 | Methods for nucleic acid amplification on a printed circuit board Methods for amplifying nucleic acid, such as DNA or RNA, on a printed circuit board (PCB) substrate are disclosed. The amplification can be achieved through a variety of methods such as thermocycling or isothermally. The printed circuit board substrate can comprise ... | 11/01/2011 |
| 8048431 | Modified HIV-1 clade C envelope glycoprotein immunogens comprising deletions in the gp120/gp41 cleavage site and gp41 fusion domain The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralize a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to... | 11/01/2011 |
| 8048415 | Compositions and methods for promoting or inhibiting angiogenesis Compounds, compositions and methods for promoting or inhibiting angiogenesis, and screening methods for identifying compounds are disclosed. The compounds bind to F1 ATP synthase, particularly to the alpha and/or beta subunits of F1 ATP synthase. When bound to these... | 11/01/2011 |
| 8041463 | Modular droplet actuator drive A droplet actuator drive including a detection apparatus for sensing a property of a droplet on a droplet actuator; circuitry for controlling the detection apparatus electronically coupled to the detection apparatus; a droplet actuator cartridge connector arranged s... | 10/18/2011 |
| 8039593 | Antibodies and immunotoxins that target human glycoprotein NMB The invention provides high affinity antibodies suitable for forming immunotoxins that inhibit the growth of cells expressing human glycoprotein NMB, including glioblastoma multiform cells, anaplastic astrocytoma cells, anaplastic oligodendroglioma cells, oligodendr... | 10/18/2011 |
| 8039217 | Proteomic interaction and genomic action determinations in the presence of associated redox state conditions Genomic actions and/or proteomic interactions for pathophysiological processes and for physiological processes are determined at associated redox state conditions. Protein interactions are correlated with oxygen tensions. Identification of markers for disease includ... | 10/18/2011 |
