Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
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| Number | Title | Issue Date |
| 5922717 | Piperazine derivatives, medicaments comprising these compounds, their use and processes for their preparation The present invention relates to piperazine derivatives of the general formula ##STR1## in which Ra, Y1 to Y3 and E are defined herein, tautomers thereof, stereoisomers thereof, including their mixtures, and salts ... | 07/13/1999 |
| 5922763 | Biphenyl derivatives, pharmaceutical compositions containing these compounds and processes for preparing them The invention relates to biphenyl derivatives of general formula ##STR1## wherein A to E and X are defined as in claim 1, the stereoisomers thereof, including their mixtures and the salts thereof, particularly the physiologically acceptable salts the... | 07/13/1999 |
| 5880284 | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them The invention relates to cyclic urea derivatives of general formula I ##STR1## wherein Ra, Rb, X and Y are defined as in claim 1, the tautomers, stereoisomers and salts thereof, particularly the physiologically acceptable salts ... | 03/09/1999 |
| 5837485 | DNA encoding and biosynthetic process for the preparation of chemical compounds, lantibiotics A bacterial host is described which is transformed by a plasmid coding for a polypeptide precursor wherein the host comprises a multi-enzyme complex capable of reacting with the expressed polypeptide precursor to produce a polypeptide comprising at least ... | 11/17/1998 |
| 5707989 | Pyrimido5,4-D!pyrimidines, medicaments comprising these compounds, their use and processes for their preparation The present invention relates to pyrimido5,4-d!pyrimidines of the general formula ##STR1## in which Ra to Rc are as defined herein, their tautomers, their stereoisomers and their salts, in particular their physiologically ... | 01/13/1998 |
| 5681961 | Arylsulphonamides, pharmaceutical compositions containing these compounds and processes for preparing them The invention relates to new arylsulphonamides of the formula ##STR1## (wherein A, B and R1 to R6 are as defined in claim 1, the enantiomers, the cis- and trans-isomers thereof where R4 and R5 together repr... | 10/28/1997 |
| 5677466 | Labelled fibrinogen receptor antagonists, the use thereof and processes for preparing them The invention relates to new labelled fibrinogen receptor antagonists which have an affinity for the receptor which is comparable to or greater than that of 125 I-fibrinogen and whose binding is not disrupted by foreign proteins.... | 10/14/1997 |
| 5650424 | Cyclic urea derivatives, pharmaceutical compositions containing these compounds and processes for preparing them The invention relates to cyclic urea derivatives of general formula ##STR1## wherein Ra, Rb, X and Y are as defined herein, pharmaceutical compositions containing the derivatives and processes for preparing them.... | 07/22/1997 |
| 5641772 | Condensed diazepinones, processes for preparing them and agents containing these compounds for treating diseases of the central nervous system and for promoting cerebral blood circulation New condensed diazepinones of general formula I ##STR1## wherein B represents one of the divalent groups ##STR2## and X, l, m, n and R1 to R7 are as defined herein, as well as the salts thereof with inorganic or organic aci... | 06/24/1997 |
| 5624690 | Controlled release of metered quantities of finely divided solids with a venturi nozzle and regulated control The invention relates to a process and apparatus for the controlled release of metered quantities of finely divided solids with one or more regulated venturi nozzles for the purpose of applying lubricant or separating compound to the stressed surfaces of ... | 04/29/1997 |
| 5618814 | Trisubstituted pyrimido [5,4-d] pyrimidines for modulating multi-drug resistance and pharmaceutical compositions containing these compounds The invention relates to trisubstituted pyrimido [5,4-d]-pyrimidines of general formula ##STR1## (wherein Ra, Rb and Rc are defined as in claim 1) and the salts thereof, more particularly for pharmaceutical use the ... | 04/08/1997 |
| 5610155 | Condensed diazepinones, processes for preparing them and agents containing these compounds for treating diseases of the central nervous system and for promoting cerebral blood circulation New condensed diazepinones of general formula I ##STR1## wherein B represents one of the divalent groups ##STR2## and X, l, m, n and R1 to R7 are as defined herein, as well as the salts thereof with inorganic or organic aci... | 03/11/1997 |
| 5604225 | Substituted thiazoles and oxazoles and 2-hydroxy-morpholines Substituted thiazoles, oxazoles and 2-hydroxy morpholine compounds useful in the treatment of diabetes mellitus and obesity are described.... | 02/18/1997 |
| 5597825 | Biphenyl derivatives, pharmaceutical compositions containing these compounds and processes for preparing them The invention relates to biphenyl derivatives of general formula ##STR1## wherein A to E and X are defined as in claim 1, the stereoisomers thereof, including their mixtures and the salts thereof, particularly the physiologically acceptable salts the... | 01/28/1997 |
| 5594003 | Tetrahydroimidazo[1,2-a]pyridin-2-yl-(benzimidazol-1-yl)-methyl-biph enyls useful as angiotensin-II antagonists Angiotensin-II antagonists of the formula ##STR1## wherein R1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R2 is, inter alia, optionally substituted benzimidazol-2-yl, 5,6,7,8-tetrahydro-imidazo[1... | 01/14/1997 |
| 5591762 | Benzimidazoles useful as angiotensin-11 antagonists Disclosed herein are angiotensin-II antagonists of the formula ##STR1## wherein R1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R2 is, inter alia, optionally substituted benzimidazol-2-yl, 5,6,7,8... | 01/07/1997 |
| 5587393 | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them The invention relates to benzimidazoles of general formula ##STR1## wherein R1 to R4 are as defined herein, the 1-, 3-isomer mixtures thereof and the addition salts thereof. The new compounds are useful, in particular, as angiot... | 12/24/1996 |
| 5576444 | Cyclic imino derivatives, processes for preparing them and pharmaceutical compositions containing these compounds Cyclic imino derivatives of the formula B--X2 --X1 --A--Y--E (I) wherein A, B, E, X1, X2 and Y are as defined herein, the stereoisomers, tautomers, mixtures and addition salts thereof, pha... | 11/19/1996 |
| 5565469 | Benzimidazoles and pharmaceutical compositions containing them Angiotensin-II inhibiting benzimidazoles, useful for the treatment of hypertension. Exemplary compounds are: (a) 4'-[(2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)-benzimidazol-1-yl)- methyl]-2-(1,3-thiazolidin-2,4-dione-5-methylidinyl)-biphenyl, (b) ... | 10/15/1996 |
| 5563268 | Heterobiaryl derivatives Heterobiaryl derivatives of the formula R1 NH--X1 --X2 --X3 --Y1 --Y2 --Y3 --Y4 --E (I) wherein R1, X1 to X | 10/08/1996 |
| 5560122 | One-pot mixer/granulator/dryer The invention relates to a one-pot mixer/granulator/dryer constituting a single step or one-pot production apparatus for successively mixing, moist-granulating and drying solid pharmaceutical products, for example in the manufacture of powdered products, ... | 10/01/1996 |
| 5552161 | Low viscosity, highly concentrated surfactant suspension Low viscosity, highly concentrated surfactant suspensions for replacement therapy In diseases of the respiratory tract are described. The suspensions are characterised in that they contain calcium and/or magnesium ions bound to the surfactant and unbound ... | 09/03/1996 |
| 5541229 | Benzimidazoles and medicaments containing these compounds The invention relates to benzimidazoles of the formula ##STR1## in which R1 to R2 are as defined in claim 1, 1 and 3 isomer mixtures thereof and addition salts thereof which have valuable properties. In particular, the novel compound... | 07/30/1996 |
| 5521177 | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them The invention relates to benzimidazoles of general formula ##STR1## Exemplary compounds are: (a) 4'-[[2-Ethyl-4-methyl-6-[(2-dimethylamino-3,4-dioxo-1-cyclobuten-1-yl)amin o]-1H-benzimidazol-1-yl]-methyl]-2-(1H-tetrazol-5-yl)-biphenyl, (b) 4'-[[2... | 05/28/1996 |
| 5519138 | Phenylalkyl derivatives, with pharmaceutical activity A phenylalkyl derivative of the formula ##STR1## wherein Ra to Rf, A and B are substituents and n is the number 0 or 1. These phenylalkyl derivatives possess angiotensin antagonist activity.... | 05/21/1996 |
| 5516773 | Agent for treating high blood pressure and cardiac insufficiency The use of a compound of formula ##STR1## wherein the substituents are defined herein and the physiologically acceptable acid addition salts thereof for treating high blood pressure and cardiac insufficiency.... | 05/14/1996 |
| 5482948 | Pyridyl derivatives and pharmaceutical compositions comprising these compounds This invention relates to pyridyl derivatives of the formula ##STR1## wherein X, Y, A, n and R3 to R8 are defined hereinbelow, the enantiomers thereof, the cis- and trans-isomers thereof, which have antithrombotic pharmaceutical... | 01/09/1996 |
| 5468766 | 1,5,6,7-tetrahydro-4H-indazol-4-ones Pharmaceutical compositions are described which contain 1,5,6,7-tetrahydro-4H-indazol-4-ones of the formula ##STR1## some of these substances themselves being new. The pharmaceutical compositions may be used as analgesics, antipyretics and antiphlogi... | 11/21/1995 |
| 5466687 | Arylidene-1-azacycloalkanes and arylalkyl-1-azacyclo-alkanes, their salts, medicaments containing these compounds and their use, and processes for their preparation The invention relates to arylidene-1-azacycloalkanes and arylalkyl-1-azacycloalkanes of the general formula ##STR1## (wherein n, m, p, A, W1, W2, X, Y, and R1 to R11 are as defined in claim 1) and the isome... | 11/14/1995 |
| 5463071 | 5-membered heterocyclic compounds, processes for preparing them and pharmaceutical compositions containing these compounds Compounds of the formula ##STR1## wherein X1 to X5 are as defined herein, the tautomers, the stereoisomers including the mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inor... | 10/31/1995 |
| 5459147 | Substituted benzimidazolyl derivatives and pharmaceutical compositions containing these compounds The invention relates to substituted benzimidazolyl derivatives of the general formula ##STR1## wherein A and Ra to Rc are defined as in claim 1, the mixtures of position isomers thereof and the salts thereof which have valuable... | 10/17/1995 |
| 5457205 | Substituted thiazoles useful for treatment of diabetes Compounds of formula ##STR1## where the substituents are as defined herein, are disclosed, which compounds are useful in the treatment of diabetes and obesity, among other uses.... | 10/10/1995 |
| 5442064 | Carboxylic acid derivatives, pharmaceutical compositions containing these compounds and processes for preparing them The invention relates to carboxylic acid derivatives of general formula A--B--C--D--E--F--G (I) wherein A to G are defined as in claim 1, the tautomers thereof, the stereoisomers thereof including the mixtures thereof and the ... | 08/15/1995 |
| 5434150 | Condensed 5-membered heterocyclic compounds, processes for preparing them and pharmaceutical preparations containing these compounds The invention relates to cyclic imino derivatives of general formula ##STR1## wherein A to G, R1, Z1 to Z6, X and Y are defined as in claim 1, the tautomers, stereoisomers and mixtures thereof and the salts thereof, p... | 07/18/1995 |
| 5426119 | Arylsulphonamides, pharmaceutical compositions containing these compounds The invention relates to new arylsulphonamides of the formula ##STR1## (wherein A, B and R1 to R6 are as defined in claim 1, the enantiomers, the cis- and trans-isomers thereof where R4 and R5 together repr... | 06/20/1995 |
| 5385925 | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them The invention relates to benzimidazoles of general formula ##STR1## wherein R1 to R4 are as defined herein, the 1-, 3-isomer mixtures thereof and the addition salts thereof. The new compounds are useful, in particular, as angiot... | 01/31/1995 |
| 5364646 | Oral pharmaceutical forms of pimobendan Pharmaceutical forms of pimobendan for oral administration comprising citric acid, whereby a constant, satisfactory resorption is ensured even when there are major pH fluctuations in the gastrointestinal tract.... | 11/15/1994 |
| 5356577 | Controlled release of metered quantities of finely divided solids with a venturi nozzle and regulated control The invention relates to a process and apparatus for the controlled release of metered quantities of finely divided solids with one or more regulated venturi nozzles for the purpose of applying lubricant or separating compound to the stressed surfaces of ... | 10/18/1994 |
| 5312924 | Phenylacetic acid benzylamides The present application relates to the uses of phenylacetic acid benzylamides and new (S)(+)-2-ethoxy-4-[N-[1-2-piperidino-phenyl)-3-methyl-1-butyl]-aminocarbon ylmethyl]benzoic acid and the salts thereof, which have valuable pharmacological propertie... | 05/17/1994 |
| 5294626 | Arylsulphonamides pharmaceutical compositions containing these compounds The invention relates to new arylsulphonamides of the formula ##STR1## (wherein A, B and R1 to R6 are as defined in claim 1, the enantiomers, the cis- and trans-isomers thereof where R4 and R5 together repr... | 03/15/1994 |
