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| Number | Title | Issue Date |
| 6001395 | Polymeric lamellar substrate particles for drug delivery The invention provides a composition for delivery of an active agent comprising a plurality of lamellar particles of a biodegradable polymer which is at least in part crystalline, and an active agent adsorbed to at least most of the particles. Preferably ... | 12/14/1999 |
| 5935604 | Nasal drug delivery composition containing nicotine The present invention provides a nasal drug delivery composition comprising nicotine or a pharmacologically-acceptable salt or derivative thereof wherein the composition is adapted to delivery a pulse of nicotine for rapid absorption and a controlled rele... | 08/10/1999 |
| 5928669 | Lymphatic delivery methods A composition for delivering an active agent to the lymphatic system comprises a plurality of colloidal particles and an active agent associated with each particle, wherein the surface of each particle has a hudrophobicity ratio as defined of less than 10... | 07/27/1999 |
| 5869103 | Polymer microparticles for drug delivery Provided are biodegradable microparticles, which exhibit a linear release profile of active agent, and methods for making the microparticles. The microparticles include a mixture of a biodegradable polymer, a water soluble polymer, and an active agent. Pr... | 02/09/1999 |
| 5863554 | Enhanced uptake drug delivery system A drug delivery system including a plurality of microsphere particles containing an active drug and including a material associated with each particle which material has the property of increasing the bioavailability of the active drug.... | 01/26/1999 |
| 5840341 | Drug delivery composition containing chitosan or derivative thereof having a defined z. potential A drug delivery composition for administration to mucosa is provided. The composition includes a pharmacologically active compound and particles, preferably powder or microspheres, of chitosan or a chitosan derivative or salt wherein the particles are eit... | 11/24/1998 |
| 5804212 | Small particle compositions for intranasal drug delivery A drug delivery composition for intranasal delivery comprises a plurality of bioadhesive microspheres and active drug associated with each microsphere, at least 90 wt % of the microspheres having a diameter in the range 0.1 μm to 10 μm. The microspheres... | 09/08/1998 |
| 5792475 | Lymphatic delivery composition A composition for delivering an active agent to the lymphatic system comprises a plurality of colloidal particles and an active agent associated with each particle, wherein the surface of each particle has a hydrophobicity ratio of less than 10 as defined... | 08/11/1998 |
| 5744166 | Drug delivery compositions Compositions for delivery of pharmacologically active agents and methods for their administration are provided. In one embodiment, the compositions include a complex of a polycationic polymer and a pharmacologically active agent in a pharmaceutically acce... | 04/28/1998 |
| 5725871 | Drug delivery compositions comprising lysophosphoglycerolipid Compositions for trans-mucosal delivery, e.g. intranasal, include a lysophosphatidyl-glycerol compound as the adsorption enhancer. The preferred compounds for delivery are insulin and calcitonin.... | 03/10/1998 |
| 5707644 | Small particle compositions for intranasal drug delivery A drug delivery composition for intranasal delivery comprises a plurality of bioadhesive microspheres and active drug associated with each microsphere, at least 90 wt % of the microspheres having a diameter in the range 0.1 μm to 10 μm. The microspheres... | 01/13/1998 |
| 5690954 | Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material A drug delivery system including a plurality of microsphere particles containing an active drug and including a material associated with each particle which material has the property of increasing the bioavailability of the active drug.... | 11/25/1997 |
| 5648095 | Preparation of microparticles Hollow microcapsules or solid microspheres for use in diagnostic procedures, as well as methods for making the microcapsules, are provided, which are formed by combining a volatile oil with an aqueous phase including a water soluble material such as a sta... | 07/15/1997 |
| 5629011 | Composition for nasal administration A composition for nasal administration of polar metabolites of opioid analgesics comprises a polar metabolite of an opioid analgesic and an absorption promoting agent. Preferred metabolites morphine-6-glucuronide and morphine-6-sulphate. A preferred absor... | 05/13/1997 |
| 5554388 | Systemic drug delivery compositions comprising a polycationi substance A composition for administration to the mucosa comprises a pharmacologically active compound and a polycationic substance. The polycationic substance is preferably DEAE-dextran or chitosan and the pharmacologically active compound is preferably insulin or... | 09/10/1996 |
| 5204108 | Transmucosal formulations of low molecular weight peptide drugs A drug delivery composition comprising a plurality of microspheres and active drug associated with each microsphere, the drug being for systemic delivery and having a maximum molecular weight of 6000, and the composition being substantially free of an enh... | 04/20/1993 |
| 4904479 | Drug delivery system Particles of a drug are directed away from the reticuloendothelial system by the use of surface coating and surface grafting techniques which substantially prevent the take up of the composite particles by the liver.... | 02/27/1990 |
