Assignee: Dana-Farber Cancer Institute, Inc.

Location: Boston, MA
No. of patents: 47

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Number	Title	Issue Date
8178317	Compositions and methods for identifying transforming and tumor suppressor genes Provided herein are nucleic acids, proteins, vectors, cells, kits, devices and methods useful for identifying regulatable proteins that are able to complement components of cellular signaling pathways. Also provided are compositions and methods using these complemen...	05/15/2012
8168602	Compositions, kits and methods for identification, assessment, prevention and therapy of cancer The invention relates to compositions, kits, and methods for detecting, characterizing, preventing, and treating human cancer. A variety of chromosomal regions (MCRs) and markers corresponding thereto, are provided, wherein alterations in the copy number of one or m...	05/01/2012
8148084	Diagnosis of autoimmune disease Methods and compositions for diagnosing and treating autoimmune disease, e.g., acute disseminated encephalomyelitis (ADEM), are described. ...	04/03/2012
8129506	Modulation of the interaction of MUC1 with MUC1 ligands The present invention provides for chimeric proteins comprising a MUC1 extracellular (MUC1-EC) polypeptide and a carrier polypeptide that function as traps for MUC1 ligands. ...	03/06/2012
8129345	MUC1-IκB kinase complexes and their activities The disclosure provides methods of identifying and making compounds and pharmaceutical compositions containing the compounds that inhibit the interaction between MUC1 and an IKK. The disclosure also provides in vivo and in vitro methods of inhibiting such an interac...	03/06/2012
8119684	Thiophene derivatives for up-regulating HLA-DM activity Compounds of formula (I), compositions, methods and kits are provided. The compounds and compositions may be particularly useful for modulating immunological responses. Formula (I) wherein, R1 is alkyl, aryl, or heterocyclyl; R2 is H, alkyl, ar...	02/21/2012
8110370	IBC-1 (Invasive Breast Cancer-1), a putative oncogene amplified in breast cancer This invention encompasses antibodies specific for IBC-1 (Invasive Breast Cancer-1), methods for diagnosis and prognosis of metastatic breast cancer and degenerative neural conditions, methods of identifying and manufacturing therapeutic compounds, and methods of tr...	02/07/2012
8105774	PGC-1β, PGC-1 homologue and uses therefor The invention provides isolated nucleic acid molecules, designated PGC-1β nucleic acid molecules, which encode novel PGC-1 related coactivator molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PGC-1β...	01/31/2012
8105769	Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensit...	01/31/2012
8101176	Compositions and methods related to TIM-3, a TH1-specific cell surface molecule The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is r...	01/24/2012
8034561	HIN-1, a tumor suppressor gene The invention encompasses isolated DNAs encoding HIN-1 polypeptides, vectors containing such DNAs, cells containing the vectors, and isolated HIN-1 polypeptides. The invention also features methods of making and using HIN-1 polypeptides. ...	10/11/2011
8026230	Methods and compositions for treating cancer using proteasome inhibitors The present invention relates to therapeutic compositions for treating cancer or preventing the growth of cancer cells, e.g., tumor growth, in a subject. The present invention also relates to methods for treating cancer, e.g., inhibiting tumor growth, in a subject w...	09/27/2011
8026224	Tumor cells with increased immunogenicity and uses therfor Tumor cells modified to express a T cell costimulatory molecule are disclosed. In one embodiment, the costimulatory molecule is a CD28/CTLA4 ligand, preferably a B lymphocyte antigen B7. The tumor cells of the invention can be modified by transfection with nucleic a...	09/27/2011
8012695	Methods and compositions relating to promoter regulation by MUC1 and KLF proteins This invention relates to regulation of cell signaling, cell growth, and more particularly to the regulation of cancer or inflammatory cell growth and/or activation. The invention provides methods of, and compositions useful for, inhibiting interactions between MUC1...	09/06/2011
7981609	Methods for identifying and using SNP panels Described are methods for identifying single nucleotide polymorphism (SNPs) that are useful for analyzing genetic samples, and for using said SNPs to determine genetic identity of samples. ...	07/19/2011
7972870	Methods and compositions relating to the regulation of MUC1 by HSF1 and STAT3 This invention relates to regulation of cell signaling, cell growth, and more particularly to the regulation of cancer or inflammatory cell growth and/or activation. The invention provides methods of inhibiting interactions between MUC1 and a heat shock factor, meth...	07/05/2011
7964700	Inhibitors of Taspase1 protease activity A novel protease, Taspase1, is described. Taspase1 is involved in the cleavage of the myeloid/lymphoid or mixed-lineage leukemia (i.e., MLL) protein, which is required for proper HOX gene regulation. Diagnostic methods utilizing Taspase1 are provided, as well as inh...	06/21/2011
7964349	Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments The present invention is directed to a method for determining the responsiveness of cancer to an epidermal growth factor receptor (EGFR) treatment. In a preferred embodiment, the presence of at least one variance in the kinase domain of the erbB1 gene confers sensit...	06/21/2011
7947652	Compositions and methods for modulating PGC-1α to treat huntington's disease The present invention provides methods for modulating mitochondrial function, modulating lesion formation in the brain, modulating neurite growth, modulating neuronal degeneration, and treating and preventing neurological diseases or disorders comprising modulating ...	05/24/2011
7919274	Light-emitting fusion proteins and diagnostic and therapeutic methods therefor Light-generating fusion proteins having a ligand binding site and a light-generating polypeptide moiety and their use as diagnostics, in drug screening and discovery, and as therapeutics, are disclosed. The light-generating fusion protein has a feature where the bio...	04/05/2011
7910325	Method for determination and quantification of radiation or genotoxin exposure The present invention discloses methods for detecting exposure of a living subject to genotoxic agents, testing sensitivity to a genotoxic agent, and determining DNA damage caused by exposure to an agent, comprising detecting the presence of FANCD2-containing foci f...	03/22/2011
7892767	Phosphospecific chemokine receptor antibodies The present invention provides chemokine receptor antibodies that selectively bind to an activated form of the receptor but not to a non activated form of the receptor. In particular, the current invention provides phosphospecific chemokine receptor antibodies. The ...	02/22/2011
7847240	Mass spectroscopy system and method including an excitation gate An ion extraction method and system includes: i) confining ions within an ion trap extending along a longitudinal axis; ii) exciting a subset of the ions to cause them to oscillate along at least one transverse coordinate; iii) after the transverse excitation, apply...	12/07/2010
7871784	Methods and compositions relating to the regulation of apoptosis by MUC1 and BH3-containing proapoptotic proteins This invention relates to regulation of cell signaling, cell growth, and more particularly to the regulation of cancer or immune cell growth. The invention provides methods of inhibiting interactions between MUC1 and BH3-containing proapoptotic proteins, methods of ...	01/18/2011
7786269	Antibody to latent membrane proteins and uses thereof The present invention provides antibodies and antibody fragments directed against extracellular domains of the EBV LMP proteins, including LMP1, LMP2A and LMP2B. The invention also provides methods of treating EBV-associated malignancies using these LMP specific ant...	08/31/2010
7781393	Methods for inhibiting tumor cell growth The invention methods using a insulin-like growth factor receptor inhibitor to inhibit tumor cell growth in a subject in need thereof. ...	08/24/2010
7776520	Use of microphthalmia for diagnosis, prognosis and/or treatment of melanoma Microphthalmia (Mi) while present in melanocytes, a cells and osteoclast, is not normally present in other cells. We have found that Mi is present in the nucleus of melanoma cells. Melanoma can be diagnosed by contacting a malignant cell with a probe for Mi. If the ...	08/17/2010
7741024	Immunogenic proteoliposomes, and uses thereof An immunogenic proteoliposome containing a transmembrane protein or oligomeric complexes containing such proteins, including viral envelope glycoproteins, in a lipid membrane around an elliptoid or spherical shape. The shape preferably also contains an attractant su...	06/22/2010
7723469	Stabilized alpha helical peptides and uses thereof Novel polypeptides and methods of making and using the same are described herein. The polypeptides include cross-linking (“hydrocarbon stapling”) moieties to provide a tether between two amino acid moieties, which constrains the secondary structure of the polype...	05/25/2010
7722868	Agents that modulate the interaction of B7-1 polypeptide with PD-L1 and methods of use thereof Disclosed are methods for modulating an immune response including a method for inhibiting the interaction between a B7 polypeptide and a PD-1 ligand, the method comprising contacting an immune cell bearing a PD-1 ligand, or an immune cell bearing a B7 polypeptide, w...	05/25/2010
7709214	Methods for upregulating an immune response with agents that inhibit the intereaction between PD-L2 and PD-1 The invention provides isolated nucleic acids molecules, designated PD-L2 nucleic acid molecules, which encode novel B7-related molecules which are ligands for PD-1. The invention also provides antisense nucleic acid molecules, recombinant expression vectors contain...	05/04/2010
7691578	Methods and compositions for treating obesity The present invention relates to therapeutic compositions for treating or preventing obesity and obesity-related disorders in a subject. The present invention also relates to the use of PGC-1 expression levels to determine the safe dosage range for known or putative...	04/06/2010
7666997	Methods of treatment using NBS-1, antibodies and proteins thereto, and uses of the antibodies Antibodies that will specifically bind to NBS-1 are described. It is also shown that NBS-1 will interact with p53 responsive elements in a p53 promoter. Thus, NBS-1 can be used in subjects having a p53-dependent tumor to inhibit growth of that tumor. ...	02/23/2010
7659382	Methods and compositions for the treatment and prevention of HIV infection using TRIM5α The invention provides novel TRIM polypeptides, proteins, and nucleic acid molecules. In addition to isolated, full-length TRIM proteins, the invention further provides isolated TRIM fusion proteins, antigenic peptides and anti-TRIM antibodies. The invention also pr...	02/09/2010
7645589	Use of microphthalmia for diagnosis, prognosis and/or treatment of melanoma Microphthalmia (Mi) while present in melanocytes, a cells and osteoclast, is not normally present in other cells. We have found that Mi is present in the nucleus of melanoma cells. Melanoma can be diagnosed by contacting a malignant cell with a probe for Mi. If the ...	01/12/2010
7638492	Methods of upmodulating an immune response with non-activating forms of B7-4 The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in...	12/29/2009
7635757	B7-4 Antibodies and uses therefor The invention provides isolated nucleic acids molecules, designated B7-4 nucleic acid molecules, which encode novel B7-4 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing B7-4 nucleic acid molecules...	12/22/2009
7632660	Lymphoma associated molecules and uses therefor The invention provides isolated nucleic acids molecules, designated BBAP nucleic acid molecules, which encode proteins that interact with or bind to BAL molecules, which are differentially expressed in non-Hodgkin's lymphoma. The invention also provides antisense nu...	12/15/2009
7625715	HIN-1, a tumor suppressor gene The invention encompasses isolated DNAs encoding HIN-1 polypeptides, vectors containing such DNAs, cells containing the vectors, and isolated HIN-1 polypeptides. The invention also features methods of making and using HIN-1 polypeptides. ...	12/01/2009
7619078	Nucleic acid molecules encoding B7-1 Novel structural forms of T cell costimulatory molecules are described. These structural forms comprise a novel structural domain or have a structural domain deleted or added. The structural forms correspond to naturally-occurring alternatively spliced forms of T ce...	11/17/2009

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Assignee: Dana-Farber Cancer Institute, Inc.