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| Number | Title | Issue Date |
| 5646013 | Method of producing foreign gene products A method of producing foreign gene products which comprises (1) transforming animal cells either (a) by using two plasmids, namely a plasmid containing the MMTV LTR and a foreign gene encoding a physiologically active substance inserted therein downstream... | 07/08/1997 |
| 5476950 | Intermediates for pyridonecarboxylic acid derivatives This invention provides novel pyridonecarboxylic acid derivatives having a quite high antimicrobial activity. The derivatives have the following formula: ##STR1## wherein R1, R2 and R3 represent each a hydrogen or ... | 12/19/1995 |
| 5416222 | 3-pyrrolidine methanamines wherein the alpha-carbon is substituted by 1 or 2 lower alkyl groups which are intermediates for pyridone-carboxylic acid derivatives This invention provides novel pyridonecarboxylic acid derivatives having a quite high antimicrobial activity. The derivatives have the following formula: ##STR1## wherein R1, R2 and R3 represent each a hydrogen or C | 05/16/1995 |
| 5380874 | Intermediates for pyridonecarboxylic acid derivatives This invention provides novel pyridonecarboxylic acid derivatives having a quite high antimicrobial activity. The derivatives have the following formula: ##STR1## wherein R1, R2 and R3 represent each a hydrogen or C | 01/10/1995 |
| 5312999 | Propoxybenzene derivatives and process for preparing the same Propoxybenzene derivatives represented by the following formula ##STR1## wherein Ra represents a nitro group, an amino group which may have a protecting group or an --NHCH.dbd.C(COO--C1-6 -Alkyl)2 group, Rb represents a hydrogen... | 05/17/1994 |
| 5110729 | Method of producing peptides using baculovirus vectors in cultured cells Recombinant Bombyx mori nuclear polyhedrosis viruses having, in the polyhedral protein-encoding structural gene portion of the Bombyx mori nuclear polyhedrosis virus DNA (BmNPV DNA), a structural gene for a desired protein as joined to the whole of or a p... | 05/05/1992 |
| 5098912 | Pyridonecarboxylic acid derivatives This invention provides novel pyridonecarboxylic acid derivatives having a quite high antimicrobial activity. The derivatives have the following formula: ##STR1## wherein R1, R2 and R3 represent each a hydrogen or C | 03/24/1992 |
| 5096891 | Cyclic amp derivative ointments An ointment comprising an adenosine 3',5'-cyclic phosphate derivative as an active ingrediment, an ointment base having water-absorbing and drying properties, a saccharide and/or inorganic high polymer is disclosed. The ointment exhibits improved stabilit... | 03/17/1992 |
| 5037804 | Agent for preventing and treating thrombocytopenia The present invention relates to an agent for preventing and treating thrombocytopenia which comprises, an an active ingredient, a muramyldipeptide derivative of the formula: ##STR1## wherein X represents an amino acid residue selected from L-alanine... | 08/06/1991 |
| 5019499 | Method of producing peptides by transforming myeloma cells with a recombinant plasmid A method of producing desired peptides by transforming mammalian cells and cultivating the transformed cells can be improved by using myeloma cells as the mammalian cells and/or using a vector having the SV40 early promoter sequence on both the 5' upstrea... | 05/28/1991 |
| 5006647 | Phosphorus containing disaccharide derivatives A disaccharide compound represented by formula (I): ##STR1## wherein R, R1, R2, R3, R4, and R5 are as defined in the specification and a salt thereof are disclosed. The compound exhibits excellen... | 04/09/1991 |
| 4985557 | Optically active pyridobenzoxazine derivatives and intermediates thereof An optically action pyridobenzoxazine derivative, a process for preparing the same and a novel intermediate useful for preparing the optically active pyridobenzoxazine derivative are disclosed. The optically active pyridobenzoxazine derivative possesses i... | 01/15/1991 |
| 4983725 | Mannobiose derivatives Novel mannobiose derivative represented by the general formula [I]: ##STR1## wherein groups of R1 to R5 each represents --OH, --OR6, --NHR6, (R6 represents an acyl group) or a group represented by ... | 01/08/1991 |
| 4962202 | Mercapto-bicycloheterocyclics useful as intermediates for penem derivatives New derivatives of penem and pharmaceutically acceptable salt thereof are herein disclosed; these compounds being useful as an antibacterial agent which has an extremely wide antibacterial spectrum, exhibits a high sensitivity to bacteria resistant to con... | 10/09/1990 |
| 4960595 | Lipid membrane structures Lipid membrane structures containing a lactose monofatty acid ester or amide are disclosed. The lipid membrane structures are delivered preferentially to the liver parenchymal cells and are useful as carriers of drugs.... | 10/02/1990 |
| 4942171 | The compound, 6-(1-imidazolyl methyl)-5,6,7,8-tetrahydronaphthalene-2-carboxylic acid and salts thereof having antidiabetic activity An antidiabetic agent is disclosed, which comprises a compound represented by formula (I): ##STR1## wherein R represents an imidazolyl group, a thiazolyl group or a pyridyl group; n represents 1 or 2; and m represents an integer of from 1 to 4, or ... | 07/17/1990 |
| 4937266 | Inhibitory agent of hepatic fibrosis An inhibitory agent of hepatic fibrosis containing pantethine as an active ingredient.... | 06/26/1990 |
| 4935368 | Process for producing tissue plasminogen activator This invention discloses a process for producing tissue plasminogen activator. The process comprises cultivating Escherichia coli, yeast, or mammalian cells into which the vector having the gene for human tissue plasminogen activator (tPA) has been introd... | 06/19/1990 |
| 4933349 | Treating agent for heart failure A preventing and treating agent for heart failure is disclosed, which comprises a compound represented by formula (I): ##STR1## wherein R represents an imidazolyl group, a thiazolyl group or a pyridyl group; n represents 1 or 2; and m represents an i... | 06/12/1990 |
| 4923862 | Topical preparation containing ofloxacin A topical preparation containing, as an active ingredient, 9-fluoro-3-methyl-10-(4-methyl-1-piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido[ 1,2,3][1,4]-benzoxazine-6-carboxylic acid or a salt thereof.... | 05/08/1990 |
| 4900815 | Sulfated polysaccharide DS4152 A sulfated polysaccharide DS4152 useful as an angiogenesis inhibitor or antitumor agent is provided selectively. As the sodium salt, it has the following physicochemical characteristics. Molecular weight by the gel filtration method: 29,000&#b1;3,000. Ele... | 02/13/1990 |
| 4898943 | Tricyclic triazolopyrimidine derivatives Novel tricyclic triazolopyrimidine compounds represented by formula (I) shown in the specification and physiologically acceptable salts thereof are disclosed. These compounds have an excellent anti-allergic activity and are useful for treatment and prophy... | 02/06/1990 |
| 4880926 | Optical resolution of benzoxazines The invention relates to a process for producing a (&#b1;)-3-alkyl-3,4-dihydro-2H-[1,4]benzoxazine derivate of formula (II) by stepwise racemization procedure. ##STR1## The invention further provides a process for optical resolution through the ... | 11/14/1989 |
| 4874772 | Antiasthmatic agent An agent for treatment and prevention of asthma comprising 2-[2-phenyl-2-(2-pyridyl)]ethyl-2-imidazoline or a salt thereof as an active ingredient is disclosed.... | 10/17/1989 |
| 4873227 | 3',5'-Camp derivatives for treatment of certain types of skin ulcers A novel therapeutic agent for skin ulcers comprising as its active component adenosine-3',5'-cyclic phosphate or a derivative thereof, and a method for the treatment of skin ulcers by using the agent. The therapeutic agent is prepared into various forms such a... | 10/10/1989 |
| 4871852 | Quinoline-carboxylic acid derivatives Novel 4-oxoguinoline-3-carboxylic acid derivatives having the formula ##STR1## wherein X1 represents a halogen or hydrogen atom, X2 represents a halogen or hydrogen atom, X3 represents a halogen atom, and R1 | 10/03/1989 |
| 4833242 | Cephalosporin derivatives and salts thereof Novel cephalosporin derivatives and salts thereof are disclosed. These compounds exhibit excellent antimicrobial activity against a wide variety of Gram-negative and Gram-positive bacteria and also have other excellent characteristics as a medicine such a... | 05/23/1989 |
| 4778891 | Certain pyrano (3,4-f)-indolizine derivatives A pyranoindolizine derivative represented by the following general formula (I): ##STR1## wherein R means a hydrogen atom or hydroxyl group and Q denotes >C.dbd.O or ##STR2## with a proviso that Q is other than >C.dbd.O when R is a hydrogen ... | 10/18/1988 |
| 4777257 | Certain tetrahydronaphthyl or indanylcarboxylates and derivatives thereof which inhibit the synthesis of thromboxane Benzocycloalkane derivatives of the formula (I) ##STR1## wherein: Z represents a methylene group or an ethylene group, either one of R1 and R2 represents --(CH2)m --COOR3 and the other represents... | 10/11/1988 |
| 4766126 | Process for treatment of nephritis with imidazoquinazolines An agent for treatment and prevention of nephritis comprising at least one imidazoquinazoline compound represented by formula ##STR1## wherein R1 represents a dialkylamino group having 1 to 6 carbon atoms in each alkyl moiety, or an unsubs... | 08/23/1988 |
| 4746668 | Method for treating retinopathy A method for treating and preventing retinopathy which comprises administering a therapeutically effective amount of 2-(2-phenyl-2-(2-pyridyl))ethyl-2-imidazoline or a pharmaceutically acceptable salt thereof to a patient having retinopathy is disclosed.... | 05/24/1988 |
| 4687661 | Method for producing liposomes A method for producing liposomes which comprises mixing liposome membrane components with a water-soluble non-volatile solvent and, then, dispersing the mixture in an aqueous medium. The pharmaceutically acceptable liposome preparation as a drug delivery ... | 08/18/1987 |
| 4665188 | Certain [(1-imidazolyl)-lower-alkylene]-tetrahydronaphthalenecarboxylic acids or corresponding idan-carboxylic acids which are thromboxane A2 Benzocycloalkane derivatives of the formula (I) ##STR1## wherein: Z represents a methylene group or an ethylene group, either one of R1 and R2 represents --(CH2)m --COOR3 and the other represents... | 05/12/1987 |
| 4652646 | Thiazolo[3,2-a][1,2,3]triazolo[4,5-d]pyrimidine and [1,3,4]thiadiazolo[3,2-a][1,2,3]triazolo[4,5-d]pyrimidine derivatives Novel triazolopyrimidine compounds represented by the formula (I) and physiologically acceptable salts thereof are disclosed. These compounds have an excellent anti-allergic activity in oral administration and are useful for treatment and prophylaxis of a... | 03/24/1987 |
| 4610987 | Imidazoquinazolin-2-one compounds Imidazoquinazolin-2-one compounds having platelet aggregation inhibitory activity is disclosed. These compounds have high water-solubility and reduced influences on the circulatory system and are useful for treatment and prophylaxis of intravascular throm... | 09/09/1986 |
| 4606857 | Muramyldipeptide derivatives Muramyldipeptide derivatives represented by the formula: ##STR1## wherein Ala represents alanine; Acyl represents an acyl group; R1 and R2 each represents a hydrogen atom or, when taken together, may form an alkylidene group; R | 08/19/1986 |
| 4603197 | Mannoglucan derivatives Mannoglucan derivatives wherein from about 2 to 51 per 100 of side chain -D-mannopyranosyl residues of mannoglucan have been cleaved and reduced to polyhydroxy residues possess antitumor activity with reduced pyrogenecity.... | 07/29/1986 |
| 4603198 | Cephalosporin derivatives Novel cephalosporin derivatives and physiologically acceptable salts thereof which are useful as antibacterial agents against gram-negative and gram-positive bacteria, and a process for preparing these compounds are disclosed.... | 07/29/1986 |
| 4596806 | 7-piperidino-1,2,3,5-tetrahydroimidazo[2,1-b]-quinazolin-2-one having platelet aggregation inhibitory activity 7-Piperidino-1,2,3,5-tetrahydroimidazo[2,1-b]-quinazolin-2-one having platelet aggregation inhibitory activity is disclosed. The compound has high water-solubility and reduced influences on the circulatory system.... | 06/24/1986 |
| 4539401 | Pyridobenzoxazine derivatives useful as antibacterial agents Pyridobenzoxazine derivatives of formula (I) ##STR1## wherein: X1 represents a hydrogen atom or a halogen atom, R1 represents a cyclic amino group which may contain additional hetero atom(s) of N,S and O and may be substituted with o... | 09/03/1985 |
