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Assignee: DSM IP Assets B.V.


Location: Te Heerlen, NL
No. of patents: 92

1      
NumberTitleIssue Date
8129143Method for production of a compound in a eukaryotic cell
The present invention relates to a eukaryotic cell containing peroxisomes that are capable to fuse with a membrane-structure of the cell involved in the secretory pathway of the cell. In this way, the eukaryotic cell is able to release the peroxisomal content outsid...
03/06/2012
8067157Expression cloning in filamentous fungi
Methods are provided for isolation of DNA sequences encoding proteins with properties of interest by means of expression cloning in filamentous fungal host cells. The isolated DNA sequences are useful in processes for producing the proteins of interest. ...
11/29/2011
8034580Determining presence of antibiotic in a fluid
The pressure of an antibiotic in a fluid is determined by contacting a sample of the fluid suspected of containing an antibiotic with a test medium containing a microorganism, a substance that provides a solid state and an indicator, such as Bromothymol Blue, incuba...
10/11/2011
8003686Aryl derivatives of curcumin, demethoxycurcumin, bisdemethoxycurcumin or curcuminisoxazolide and their use as animal feed additives
The present invention relates to the use of acyl derivatives of curcumin, desmethoxy curcumin and bisdesmethoxy curcumin and of curcuminisoxazolide as components of animal feed or feed additives for the improvement of animal performance and the new acyl derivatives ...
08/23/2011
7989189Mutant GTP cyclohydrolase II enzymes
The present invention relates to modified GTP cyclohydrolase II enzymes that display increased specific activity, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors....
08/02/2011
RE42593Photo-curable resin composition used for photo-fabrication of three-dimensional object
A photocurable resin composition suitable for photo-fabrication. The resin composition capable of being promptly cured by photo-irradiation, thereby reducing fabricating time and providing cured products having excellent mechanical strength and minimized shrinkage d...
08/02/2011
7968705Production of 5'-ribonucleotides
The present invention describes a composition comprising at least 55% w/w (on sodium chloride free dry matter weight) of 5′-ribonucleotides and a process for the production of this composition comprising the steps of: (i) treating microbial cells to release the ce...
06/28/2011
7968312Production of polypeptides by improved secretion
The present invention relates to polypeptides that have an activity corresponding to at least one activity of the SEC61 polypeptide, polynucleotides encoding these polypeptides and the use thereof in the preparation of host cells suitable for production of a polypep...
06/28/2011
7956140Polymerization catalyst comprising amidine ligand
The invention relates to a process for the preparation of a polymer comprising at least one aliphatic or aromatic hydrocarbyl C2-20 olefin in the presence of an ionic catalyst, comprising an organometallic compound and an activator, and optionally a scave...
06/07/2011
7906566Curable liquid resin composition
The invention relates to a curable liquid resin composition comprising: (A) a urethane(meth)acrylate having a structure originating from a polyol and a number average molecular weight of 800 g/mol or more, but less than 6,000 g/mol, and (B) a urethane(meth)acrylate ...
03/15/2011
7901903Determining presence of antibiotic in a fluid
The pressure of an antibiotic in a fluid is determined by contacting a sample of the fluid suspected of containing an antibiotic with a test medium containing a microorganism, a substance that provides a solid state and an indicator, such as Bromothymol Blue, incuba...
03/08/2011
7897779Ionic UV-A sunscreens and compositions containing them
The present invention relates to novel 1,4-dihydropyridine derivatives, to novel cosmetic or dermatological sunscreen compositions containing these derivatives and the use of these derivatives for photoprotecting human skin and/or hair against UV radiation, in parti...
03/01/2011
7879804Blood pressure lowering peptides in a single enzymatic step
A process to produce IPP and VPP from a protein source that comprises the -I-P-P- and -V-P-P- sequence in its protein sequence and whereby at least 40% of -I-P-P- sequence present in the protein source is converted into the peptide IPP and at least 40% of the -V-P-P...
02/01/2011
7865055Coated optical fibers
The invention relates to coated optical fibers comprising soft primary coatings and to such primary coatings for protecting glass optical fibers having a sufficient high resistance against cavitation. In particular, the primary coatings have a cavitation strength at...
01/04/2011
7854954Compositions with a chicken flavour, use and production thereof
The present invention provides with a method for producing compositions with a chicken flavor. The compositions of the invention can be obtained by applying the following method: (a) preparing a mixture comprising at least one reducing carbohydrate and at least one ...
12/21/2010
7829645Process for the production of a polymer comprising monomeric units of ethylene, an α-oplefin and a vinyl norbornene
The invention relates to a process for the preparation of a polymer comprising monomeric units of ethylene, an α-olefin and a vinyl norbornene applying as a catalyst system: a. a bridged or an group 4 metal containing an unbridged catalyst having a single cyclopent...
11/09/2010
7820848Process for the preparation of stilbene derivatives
A novel process for the preparation of resveratrol and piceatannol and esters thereof involving a Heck type reaction is disclosed. Also disclosed are novel intermediates in that process. ...
10/26/2010
7816548Method of preparing a hydrocarbylated metal-organic compound
The invention relates to a process for the preparation of a hydrocarbylated metal organic compound, comprising a hydrocarbyl group, a spectator ligand and optionally a ligand, by contacting a metal-organic reagent with a spectator ligand in the presence of at least ...
10/19/2010
7816332Stable aqueous solution of natamycin fungicide
The present invention provides an aqueous composition comprising—water; —a water miscible solvent; —and a polyene fungicide which is dissolved in the water and water miscible solvent. The present invention further provides a method for the production of the co...
10/19/2010
7794974Fungal transcriptional activators useful in methods for producing a polypeptide
The present invention relates to functional cDNA and genomic sequences encoding PrtT proteins, which have transcriptional activity on a protease promoter, to PrtT proteins and to their use. The invention further relates to two distinct types of filamentous fungal ce...
09/14/2010
7763273Method for reducing methane production emanating from the digestive activities of an animal
The present invention generally relates to a method for reducing the production of methane emanating from the digestion of animal by using one or more essential oil compounds selected from the group consisting of limonene, eugenol, a silicylate, quinoline, vanilla, ...
07/27/2010
7727966Stable needle-shaped crystals of natamycin
The present invention describes natamycin comprising needle shaped crystals. ...
06/01/2010
7695949Process for producing a target fermentation product
The present invention provides a process for producing a target fermentation product. This process includes providing a fermentation medium containing a recombinantly-produced microorganism that over-produces a fermentation product and contains a mutation which caus...
04/13/2010
7691420Compositions for the treatment and prevention of diabetes mellitus
Compositions comprising a catechin as found in green tea, e.g., epigallocatechin gallate, and ligand which activates the peroxisome proliferatoractivated receptor gamma (PPAR-gamma are useful for the treatment and prevention of diabetes mellitus). ...
04/06/2010
7670800Process for the purification of riboflavin
The invention relates to a process for the purification of riboflavin comprising the steps of (a) precipitating a first crystalline form of riboflavin, (b) isolating the first crystalline form of riboflavin, (c) transforming the first crystalline form of riboflavin ...
03/02/2010
7638658Ethynylation process
A process for the manufacture of an acetylenically unsaturated alcohol comprising reacting formaldehyde, an aldehyde or a ketone (a carbonyl compound) with acetylene in the presence of ammonia and an alkali metal hydroxide, the molar ratio of the alkali metal hydrox...
12/29/2009
763251825-hydroxy vitamin Dcompositions
An oil composition containing 25-hydroxy Vitamin D3 and an oil is provided. In addition an emulsion, a microencapsulated oil composition, and a feed premix composition each containing 25-hydroxy Vitamin D3 are provided. Methods of making an oil...
12/15/2009
7626046Manufacture of α-tocopherol
A process for the manufacture of (all-rac)-α-tocopherol comprises submitting isolated, purified phytyltrimethylhydroquinone to acid catalysis, thereby promoting ring closure to (all-rac)-α-t-tocopherol. The process can be conducted in the absence or presence of an...
12/01/2009
7611696Sunscreen compositions as well as dihydropyridines and dihydropyranes
1,4-dihydropyridine and 1,4-dihydropyrane derivatives and novel cosmetic or dematological sunscreen compositions containing novel and/or known 1,4-dihydropyridine or 1,4-dihydropyrane derivatives which are useful for photoprotecting human skin and/or hair against UV...
11/03/2009
7592166Enone reductase gene and microbial production of levodione
Disclosed is an isolated DNA comprising a nucleotide sequence coding for an enzyme having enone reductase activity wherein the enzyme is characterized by the following physico-chemical properties: (a) molecular mass: 61,300±5,000 Da (estimated using gel filtration,...
09/22/2009
7582674Nutraceutical compositions and use thereof
Compositions including, as the active ingredients, resveratrol, a derivative, metabolite or analogue thereof, and at least one additional component selected from epigallocatechin gallate (EGCG), genestein, vitamin E, polyunsaturated fatty acids, gamma-linolenic acid...
09/01/2009
7544494Vitamin C from sorbosone
The present invention relates to a process for the production of vitamin C from L sorbosone using an aldehyde dehydrogenase which is isolated from Gluconobacter oxydans DSM 4025 (FERM BP-3812), said enzyme having the following physicochemical properties: (a) ...
06/09/2009
7465563Enzymatic process for the manufacture of L-ascorbic acid and D-erythorbic acid
A process for producing L-ascorbic acid from 2-keto-L-gulonic acid or D-erythorbic acid from 2-keto-D-gluconic acid by contacting 2-keto-L-gulonic acid or 2-keto-D-gluconic acid, respectively, with an enzym having α-amylase activity in solution. The solvent for thi...
12/16/2008
7435836Process for the manufacture of tocopheryl acylates
The present invention relates to a process for the manufacture of a tocopheryl acylate which comprises reacting a tocopherol with an acylating agent in the presence of a solid basic catalyst comprising, an alkali metal and/or alkaline earth metal preferably on a sol...
10/14/2008
7432089DNA encoding favin-adenine-dinucleotide-dependent-D-erythronate-4-phosphate-de-hydrogenase, pdxR, and microbial production of vitamin B
The present invention relates to a DNA encoding a novel flavin adenine dinucleotide (FAD)-dependent D-erythronate 4-phosphate (EN4P) dehydrogenase originated from Sinorhizobium meliloti, which is involved in vitamin B6 biosynthesis, and a recombinant microorg...
10/07/2008
7432076Astaxanthin production using fed-batch fermentation process by Phaffia rhodozyma
Disclosed is a fermentation method of astaxanthin using Phaffia rhodozyma comprising the steps of: (a) in the growing phase, feeding of a nutrient medium containing glucose or sucrose based on the specific growth rate (μ) of Phaffia rhodozyma cells, and (b) in the ...
10/07/2008
7423162Process for the preparation of (4-hydroxy-6-oxo-tetrahydropyran-2-yl) acetonitrile and derivatives
The invention relates to a process for the preparation of (4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-acetonitrile from 6-X-substituted-methyl-4-hydroxy-tetrahydro-pyran-2-one, wherein X stands for a leaving group, by reacting 6-X-substituted-methyl-4-hydroxy-tetrahydro...
09/09/2008
7414138Benzoxazole and benzodiazole UV-A sunscreens
The present invention relates to 1,3-benzoxazole or benzodiazole UV-A sunscreens and to compositions, in particular topical compositions, containing the above UV-A sunscreens. ...
08/19/2008
7404977Rennets
The present invention describes an aspartic protease produced by a fungus from the class Eurotiomycetes, comprising the amino acid sequence of FDTGSSD or FDTGSSE. The present invention further provides a process for identifying new milk clotting enzymes comprising s...
07/29/2008
7402383Process for preparing variant polynucleotides
The present invention discloses a process for the preparation of variant polynucleotides using a combination of mutagenesis of a starting population of polynucleotides and recombination of the mutated polynucleotides. The process comprises the steps of subjecting a ...
07/22/2008
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