Did You Know...
...that Charles Goodyear performed some of his experiments on rubber while in debtor's prison? He was there so often he referred to it as his "hotel". Chronically in debt because of poor business sense and ill health, Goodyear depended on the generosity of friends and family. Even after he unlocked the secret to vulcanizing rubber, he was unable to improve his financial situation. When he died, his estate was $200,000 in debt.
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| Number | Title | Issue Date |
| 7709621 | Vectors with modified protease-dependent tropism The present invention provides cell fusogenic vectors having replicative ability, whose protease-dependent tropism has been modified. M gene-deficient viral vectors encoding modified F proteins, in which the cleavage site of the F protein of paramyxovirus is modifie... | 05/04/2010 |
| 7521043 | Gene therapy for tumors using minus-strand RNA viral vectors encoding immunostimulatory cytokines The present invention provides methods for treating tumors, which comprise the step of administering into tumor sites a minus-strand RNA viral vector encoding an immunostimulatory cytokine or cells introduced with the vector. The present invention also provides comp... | 04/21/2009 |
| 7510706 | Pseudotype retroviral vectors containing membrane proteins having hemagglutinin activity The present invention provides a retroviral vector containing a membrane protein having a hemagglutinin activity. The present inventors constructed a retroviral vector pseudotyped by the membrane protein having a hemagglutinin activity. This viral vector showed gene... | 03/31/2009 |
| 7402427 | Vectors with modified protease-dependent tropism The present invention provides cell fusogenic vectors having replicative ability, whose protease-dependent tropism has been modified. M gene-deficient viral vectors encoding modified F proteins, in which the cleavage site of the F protein of paramyxovirus is ... | 07/22/2008 |
| 7323337 | Gene transfer into primate embryonic stem cells using VSV-G pseudotyped simian immunodeficiency virus vectors Highly efficient gene transfer into primate-derived embryonic stem (ES) cells has successfully been achieved by using a simian immunodeficiency virus vector (SIV) pseudotyped with VSV-G protein, which is a surface glycoprotein of vesicular stomatitis virus (VSV) The... | 01/29/2008 |
| 7101685 | Recombinant Sendai virus A method for generating Sendai virus particles by transfecting the Sendai virus genome to a host expressing all genes for the initial viral replication has been developed, enabling the genetic manipulation of Sendai virus and effective utilization of said virus as t... | 09/05/2006 |
| 6905860 | Artificial chromosome An artificial mammalian chromosome, more specifically, a clone containing a mammalian centromere sequence and a DNA replication origin with mammalian telomere sequences added to both ends of the clone, is provided by preparing a CEPH artificial yeast chromosome libr... | 06/14/2005 |
| 6828138 | Recombinant sendai virus vector including a gene encoding a chemokine A recombinant Sendai virus vector expressing chemokine is provided. This vector enables large quantity production of clinically useful chemokines. It is also useful for treatment of diseases that can be treated by chemokines. ... | 12/07/2004 |
| 6589528 | Method for induction of differentiation of osteoclasts The present invention provides a simple method of producing osteoclasts from monocytes, a agent comprising monoclonal antibody to be used for the method, and a method for screening a ligand that induces differentiation of monocytes to osteoclasts. Differe... | 07/08/2003 |
| 6576813 | Knockout animals Transgenic mice are constructed by binding the "hHB-EGF/DTR" gene to the downstream of an albumin enhancer/promoter that is expressed specifically in hepatic parenchymal cells and introducing this unit into mice. After the "hHB-EGF/DTR" gene has been conf... | 06/10/2003 |
| 6300120 | Phage with nuclear localization signal A λ phage with a nuclear localization signal has been obtained by constructing a vector capable of expressing a fused protein between a gpD protein constituting the head of a λ phage and a nuclear localization signal sequence, transforming Escherichia c... | 10/09/2001 |
