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| Number | Title | Issue Date |
| 7915432 | Method for improving the shelf-life of hematoxylin staining solutions A method is provided for improving the shelf-life of a nuclear staining solution. In particular, the present invention provides a method of adding an antioxidant to a hematoxylin staining solution which maintains the performance of the stain over its shelf-life.... | 03/29/2011 |
| 7914738 | Cell block cassette and filter assembly A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a c... | 03/29/2011 |
| 7914462 | Methods for processing cell block A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a c... | 03/29/2011 |
| 7906337 | Method of generating and using biological qualification slides to qualify biological screening devices Kits and methods for qualifying automated biological screening system. At least one biological specimen having a plurality of marked target zones (MTZs) exhibiting an attribute is provided. The biological specimen(s) is processed through the automated biological scr... | 03/15/2011 |
| 7901946 | Cell block cassette device A tissue cassette assembly includes a housing having a recess formed therein, and a compressible reservoir disposed partially or wholly inside of, or otherwise attached in fluid communication with, the housing recess, the compressible reservoir containing a tissue e... | 03/08/2011 |
| 7887758 | Sample vial for use in preparing cytological specimen A sample vial is disclosed for use in conjunction with an automated cytological specimen preparation system. ... | 02/15/2011 |
| 7881532 | Imaging device with improved image segmentation An improved image segmentation algorithm is provided that identifies each object in an image. Pixels of the image are sorted based on a range of attribute values of the image. These pixels are then added to a labeling image one by one starting with an extreme point ... | 02/01/2011 |
| 7848019 | Microscope calibration apparatus and method and stage including calibration apparatus A stage for supporting a specimen slide and for calibrating a microscope includes a base and a calibration component integral with the base. The calibration component includes at least one calibration element for positional calibration and at least one calibration e... | 12/07/2010 |
| 7846160 | Method and apparatus for sterilization A medical device and procedure is described for sterilizing a female. A two-part procedure includes an immediate sterilization part and a permanent sterilization part. The immediate sterilization part provides immediate sterility that endures at least until the perm... | 12/07/2010 |
| 7870284 | Scalable architecture for maximizing slide throughput Method and system for imaging and analyzing a biological specimen on a specimen carrier, such as a slide. One or more imagers acquire images of a biological specimen on a slide and generate electronic image data. One or more analysis computers, such as a cluster of ... | 01/11/2011 |
| 7866209 | Fluid level regulator A biological specimen collection and transfer system, including a biological sample container configured for storing a biological fluid sample, a vacuum source, a specimen filter having an interior chamber and an opening in communication with the chamber, and a flui... | 01/11/2011 |
| 7859667 | Slide misload detection system and method A system and method for determining whether one or more slides are loaded properly within a cassette. Each slide includes one or more transparent regions and one or more non-transparent regions. The slides are between a light source and a sensor. The light source ge... | 12/28/2010 |
| 7842035 | Method and apparatus for tubal occlusion Methods and devices for occlusion of the fallopian tubes of a woman. The method involves thermally damaging the lining of the utero-tubal junction with relatively low power, followed by placement of a reticulated foam plug. In one embodiment, vascularized tissue gro... | 11/30/2010 |
| 7829021 | Cell block processing station A system for making cell blocks includes a cell block cassette and processing station, the cassette including a main body having a having a collection aperture formed therein and a filter assembly removably attached to the main body, the filter assembly defining a c... | 11/09/2010 |
| 7826652 | Method for forming an optimally exposed image of cytological specimen First and second images of respective portions of a cytological specimen are acquired at different brightness levels. Sections of the respective first image are selected and combined with selected sections of the second image of each portion to form a composite imag... | 11/02/2010 |
| 7824859 | Methods for detection of a target nucleic acid by forming a cleavage structure using an RNA polymerase The invention relates to compositions and methods for generating a signal indicative of the presence of a target nucleic acid in a sample, where the compositions and methods include an RNA polymerase, a FEN nuclease, and a probe. ... | 11/02/2010 |
| 7803624 | Automated cytological sample classification An automated method for classifying a cytological sample is provided. The method comprises interrogating the sample with one or more wavelengths of light to obtain a result, and then attaching one or more designators to the sample based on whether the result meets a... | 09/28/2010 |
| 7803530 | Detection and typing of human papillomavirus using PNA probes The invention provides methods for detection and typing of HPV infection using PNA probes. More specifically, methods are provided for detecting high-risk types of HPV infection with minimal numbers of PNA probes or using PNA probes to selectively amplify only high-... | 09/28/2010 |
| 7769219 | Method for assessing image focus quality A method for determining the quality of focus of a digital image of a biological specimen includes obtaining a digital image of a specimen using a specimen imaging apparatus. A measure of image texture is calculated at two different scales, and the measurements are ... | 08/03/2010 |
| 7753457 | Apparatus for removably retaining a slide within a cassette Apparatus and slide cassette for removably retaining or securing a slide. The cassette includes trays for holding a slide. Each tray has a retaining lip at an end thereof. A first edge of a slide contacts a support member within the cassette when the slide that is p... | 07/13/2010 |
| 7744559 | Systems and methods for drug infusion with feedback control A system and method for infusing a drug under continuous positive pressure (such as convection enhanced deliver) to a target tissue to be treated is particularly useful for post-resection anticancer drug therapy. The system comprises a drug infusion catheter having ... | 06/29/2010 |
| 7731712 | Method and system for transcervical tubal occlusion A medical device and procedure is described for occluding a fallopian tube. A tubal occlusion device is inserted into a uterine cavity. The device includes an RF applicator head including an electrode carrier with one or more bipolar electrodes thereon. During inser... | 06/08/2010 |
| 7689038 | Method for improved image segmentation An improved image segmentation algorithm is provided that identifies each object in an image. Pixels of the image are sorted based on a range of attribute values of the image. These pixels are then added to a labeling image one by one starting with an extreme point ... | 03/30/2010 |
| 7687032 | Filter assembly for molecular testing A cytological material sample collection device comprises a cylinder having a longitudinal bore extending there through. The sample collection device further comprises a filter membrane configured for collecting a layer of cytological material when the bore is subje... | 03/30/2010 |
| 7686771 | Method and apparatus for obtaining aliquot from liquid-based cytological sample Sample vials and methods of processing the sample vials are provided. The sample vial comprises a vial container, a sample collection chamber within the vial container, a vial cap configured to be mated with the vial container to enclose the collection chamber, an a... | 03/30/2010 |
| 7674434 | Vials and apparatus for obtaining an aliquot of a sample Vials used for obtaining an aliquot of a biological sample are provided. Also provided are method of using the vials and instruments to obtain an aliquot of a biological sample. ... | 03/09/2010 |
| 7674260 | Emergency hemostasis device utilizing energy A method and system for achieving hemostasis (the stoppage of bleeding) is described. RF (radio frequency) energy is used to ablate the surface of tissue to stop bleeding. The depth of destruction of the tissue can be controlled so as to desiccate and coagulate the ... | 03/09/2010 |
| 7667890 | Cytological imaging systems and methods The present invention relates to the analysis of specimens. Specifically, the invention relates to methods and apparatus for reviewing specimen slides, including apparatus for holding the slides. The invention also relates to an automatic focusing method for an imag... | 02/23/2010 |
| 7666671 | Methods for fixing cytological samples A method of fixing a biological sample on a slide for cytological analysis, includes transferring a sample to a slide, applying a material having a slide-fixing amount of an inactivated, fixative to the slide, and activating the fixative. By way of example, the mate... | 02/23/2010 |
| 7666358 | Cell block cassette device A tissue cassette assembly includes a housing having a recess formed therein, and a compressible reservoir disposed partially or wholly inside of, or otherwise attached in fluid communication with, the housing recess, the compressible reservoir containing a tissue e... | 02/23/2010 |
| 7636465 | Cross-frame object reconstruction for image-based cytology applications Methods, computer software, and systems for analyzing a biological specimen (e.g., a cytological specimen) on a slide is provided. Magnified image data frames of the biological specimen are taken at different locations on the slide. An object that is not entirely co... | 12/22/2009 |
| 7628765 | Increasing retrievable cells from a breast duct The invention provides methods that increase retrievable cells from ductal fluid of a patient. Ductal fluid typically contains ductal epithelial cells and other markers that can aid in identifying a breast condition, including breast cancer and precancer. ... | 12/08/2009 |
| 7604633 | Moisture transport system for contact electrocoagulation An apparatus and method for use in performing ablation or coagulation of organs and other tissue includes a metallized fabric electrode array which is substantially absorbent and/or permeable to moisture and gases such as steam and conformable to the body cavity. Th... | 10/20/2009 |
| 7590492 | Method and system for organizing multiple objects of interest in field of interest Methods, systems, and computer software for screening and assisting in screening biological specimens. Images of a biological specimen are obtained, and image data is generated from the images. Objects of interest (OOI) are identified from the image data. The OOIs a... | 09/15/2009 |
| 7587078 | Automated image analysis One automated imaging process, as described herein, includes: a) obtaining digital images of objects in a biological sample; b) selecting a plurality of objects of interest from the digital images; c) obtaining multiple images of the selected objects of interest at ... | 09/08/2009 |
| 7582085 | Catheter placement detection system and operator interface A system for facilitating the placement of a catheter within the human body, in a lumen or vessel such as the fallopian tubes, and controlling the catheter after placement. The system coordinates the operation of treatment electrodes on the catheter with informative... | 09/01/2009 |
| 7579190 | Method and apparatus for preparing cytological specimens An automated system for preparing a plurality of cytological specimens from a plurality of fluid samples in vials includes an apparatus for collecting a monolayer of cells from each sample and transferring the cells to a microscope slide for fixing, staining, and in... | 08/25/2009 |
| 7561329 | Illumination source for stained biological samples A microscope illumination system includes a light source having at least four LED light sources, each LED source emitting light within a different portion of the visible spectrum. Each of the at least four LED light sources may be independently controllable. The res... | 07/14/2009 |
| 7556777 | Specimen vial cap handler and slide labeler A composite modular system for handling biological sample vials and slides comprises a vial scanner configured to read indicia on the sample vials, a slide labeler configured to mark the slides, a cap manipulator configured to uncap and cap the vials, and a controll... | 07/07/2009 |
| 7553451 | Platform apparatus with horizontal slide translation and method An apparatus and method for maintaining a slide in a substantially horizontal orientation while moving the slide between different elevations. A dual-hinge arrangement is utilized to maintain the slide in a horizontal orientation. A distal end of a second linking me... | 06/30/2009 |
