Did You Know...
...that it was melting ice cream that inspired the invention of the outboard motor? It was a lovely August day and Ole Evinrude was rowing his boat to his favorite island picnic spot. As he rowed, he watched his ice cream melt and wished he had a faster way to get to the island. At that moment the idea for the outboard motor was born!
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| Number | Title | Issue Date |
| 8168651 | Protein kinase modulators The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. Molecules of the invention can modulate Pim ki... | 05/01/2012 |
| 8124649 | Oxindole compounds The invention provides compounds that inhibit PIM kinases and Flt3 kinase, and compositions containing such compounds. These compounds and compositions are useful for treating proliferative disorders such as cancer, as well as other kinase-associated conditions incl... | 02/28/2012 |
| 7956064 | Fused tricyclic compounds as serine-threonine protein kinase and PARP modulators The invention relates in part to fused tricyclic compounds having certain biological activities that include, but are not limited to, inhibiting cell proliferation, modulating protein kinase activity and modulating polymerase activity. The fused tricyclic compounds ... | 06/07/2011 |
| 7928100 | Quinolone analogs and methods related thereto The present invention provides novel quinolone compounds and pharmaceutical composition thereof which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing such compounds and compositions, and methods o... | 04/19/2011 |
| 7910600 | Therapeutic kinase modulators The invention relates in part to molecules having certain biological activities that include, but are not limited to, inhibiting cell proliferation, and modulating protein kinase activity. Molecules of the invention can modulate casein kinase (CK) activity. The inve... | 03/22/2011 |
| 7834180 | Methods of preparing quinolone analogs Compounds having formula 1: are produced by contacting a compound having formula (6A) with a compound having formula (7), or tautomers thereof, in the presence of a non-nucleophilic base, | 11/16/2010 |
| 7816524 | Methods of preparing quinolone analogs Compounds having formula 1 are produced by contacting a compound having formula(6A) with a compound having formula (7), or tautomers thereof, in the presence of a non-nucleophilic base, | 10/19/2010 |
| 7816406 | Quinolone analogs The present invention provides quinolone analogs which may inhibit cell proliferation and/or induce cell apoptosis. The present invention also provides methods of preparing quinolone analogs, and methods of using the same. ... | 10/19/2010 |
| 7652134 | Methods for converting quinolone esters into quinolone amides The present invention relates to methods of preparing compounds having formula (1), (2), (5), and ((6A)-(6D)) comprising contacting the corresponding ester, an amine with f... | 01/26/2010 |
| 7612063 | Substituted quinobenzoxazine analogs The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, V, W, X and Z are substituents. The ... | 11/03/2009 |
| 7507727 | Substituted quinobenzoxazine analogs and methods of using thereof The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein V, A, X, Z, W, U a... | 03/24/2009 |
| 7402579 | Quinobenzoxazine analogs and compositions The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, W, X, Z, B, ... | 07/22/2008 |
| 7381720 | Substituted quinobenzoxazine analogs The present invention relates to methods for ameliorating a cell proliferative disorder using quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and ... | 06/03/2008 |
| 7326702 | Substituted quinobenzoxazine analogs The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, V, W, X and Z are substituents. | 02/05/2008 |
| 7244760 | Methods for preparation and use of psorospermin analogs Psorospermin is a cytotoxic dihydroflranoxanthone that has found to exhibit significant activity against various tumor cell lines. Unfortunately, psorospermin is no longer readily available from its natural plant source. The present invention is directed to a method... | 07/17/2007 |
| 7163948 | Heterocyclic substituted 1,4-dihydri-4ox9-1,8-naphthyridine analogs The present invention relates to 1,4-dihydro-4-oxo-1,8-napthpyridine analogs of the formula and pharmaceutically acceptable salts, esters, and prodrugs thereof, wherein A, X, W and Y are ... | 01/16/2007 |
| 7141565 | Substituted quinobenzoxazine analogs The present invention relates to quinobenzoxazines analogs having the general formula: and pharmaceutically acceptable salts, esters and prodrugs thereof; wherein A, U, V, W, X and Z are substituents. | 11/28/2006 |
| 7001588 | Expanded porphyrin compositions for tumor inhibition Expanded porphyrin comprising substitutions for at least two NH groups by S, Se or Te are non-photoactive and are selective for binding G-quadruplexes characteristic of the c-MYC control region. Accordingly, these expanded porphyrins are useful to modulate the expre... | 02/21/2006 |
| 6933396 | Process to prepare psorospermin Psorospermin and analogs thereof are made using an enantiomerically selective process ... | 08/23/2005 |
