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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 7807358 | High-throughput methods for detecting DNA methylation The present invention provides a method of hybridization, differential methylation hybridization (DMH) for high throughput methylation analysis of multiple CpG island loci. DMH utilizes nucleic acid probes prepared from a cell sample to screen numerous CpG dinucleot... | 10/05/2010 |
| 7537452 | Photoinitiator systems with anthracene-based electron donors for curing cationically polymerizable resins The invention features a photopolymerizable composition that comprises a cationically polymerizable resin, and a photoinitiator system comprising an iodonium salt, a visible light sensitizer, and one or more anthracene-based compounds as electron donors. Electron do... | 05/26/2009 |
| 7399772 | Substituted benzimidazole dosage forms and method of using same The present invention relates to pharmaceutical preparations comprising substituted benzimidazole proton pump inhibitors. There is provided a liquid or solid pharmaceutical composition consisting of a proton pump inhibitor and at least one buffering agent. Also prov... | 07/15/2008 |
| 7317937 | Method and apparatus for monitoring cerebral physiology A method and apparatus for predicting the outcome of head injury trauma by monitoring cerebrospinal fluid (CSF) characteristics, preferably by monitoring the pH of CSF. The apparatus includes a catheter with a wall section adapted to permit CSF to flow therein, and ... | 01/08/2008 |
| 7262228 | Photoinitiator systems with anthracene-based electron donors for curing cationically polymerizable resins The invention features a photopolymerizable composition that comprises a cationically polymerizable resin, and a photoinitiator system comprising an iodonium salt, a visible light sensitizer, and one or more anthracene-based compounds as electron donors. Electron do... | 08/28/2007 |
| 7232852 | Photopolymerizable compositions that include alicyclic/aromatic dioxiranes and novel dioxiranyl tetraoxaspiro [5.5] undecanes A visible light cationically photopolymerizable composition is provided. This composition includes an expanding monomer and a dioxirane. More specifically, the expanding monomer used in this composition is one or more dioxiranyl tetraoxaspiro[5.5]undecanes. The comp... | 06/19/2007 |
| 7147838 | Gastrin receptor-avid peptide conjugates A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a n... | 12/12/2006 |
| 7090891 | Method for fabricating nanostructured solid oxide fuel cells and cell components A method of fabricating a nanostructured solid oxide fuel cell includes dispersing ceria and doped ceria nanoparticles in a first colloidal solution, atomizing the first colloidal solution into a spray, depositing the spray onto a substrate to form a thin film elect... | 08/15/2006 |
| 7090938 | Method of preparing a solid oxide fuel cell A solid oxide fuel cell having a multichannel electrode architecture and method for preparing the same, the method including forming a first carbon laden composition, including a first thermoplastic binder, into a rod, applying a first zirconia laden composition, in... | 08/15/2006 |
| 7020505 | Method and apparatus for monitoring cerebral physiology A method and apparatus for predicting the outcome of head injury trauma by monitoring cerebrospinal fluid (CSF) characteristics, preferably my monitoring the pH of CSF. The apparatus includes a catheter with a wall section adapted to permit CSF to flow therein, and ... | 03/28/2006 |
| 7014868 | Hexameric complexes and their preparation A composition comprising a guest/host assembly having a spheroidal host assembly comprised of a hexamer of a methylene-bridged trihydroxybenzene tetramer and a guest component encapsulated within the spheroidal host assembly to provide a highly stable guest/host ass... | 03/21/2006 |
| 7008533 | Macrocyclic antibiotics as separation agents Macrocyclic antibiotics having ring structures with at least 10 members act as separation agents in crystallization, precipitation, filtration, electrophoresis, and chromatography. The macrocyclic antibiotics include ansamacrolides, macrolides, macrocyclic peptides,... | 03/07/2006 |
| 6921526 | Gastrin receptor-avid peptide conjugates A compound for use as a therapeutic or diagnostic radiopharmaceutical includes a group capable of complexing a medically useful metal attached to a moiety which is capable of binding to a gastrin releasing peptide receptor. A method for treating a subject having a n... | 07/26/2005 |
| 6825364 | Dioxiranyl tetraoxaspiro [5.5] undecanes A visible light cationically photopolymerizable composition is provided. This composition includes an expanding monomer and a dioxirane. More specifically, the expanding monomer used in this composition is one or more dioxiranyl tetraoxaspiro[5.5]undecanes. The comp... | 11/30/2004 |
| 6780397 | Biomolecule conjugation strategy using novel water-soluble phosphine-based chelating agents This invention describes a novel strategy to produce phosphine-functionalized biomolecules (e.g. peptides or proteins) for potential use in the design and development of site-specific radiopharmaceuticals for diagnosis or therapy of specific cancers. Hydrophilic alk... | 08/24/2004 |
| 6669842 | Macrocyclic antibiotics as separation agents Macrocyclic antibiotics having ring structures with at least 10 members act as separation agents in crystallization, precipitation, filtration, electrophoresis, and chromatography. The macrocyclic antibiotics include ansamacrolides, macrolides, macrocycli... | 12/30/2003 |
| 6653486 | Spiroorthocarbonates containing epoxy groups Photopolymerizable compositions are provided which are the reaction products of a vinyl ether, a photoinitiator system comprising an iodonium salt, a visible light sensitizer, and an electron donor compound. These monomeric/oligomeric compositions may als... | 11/25/2003 |
| 6645988 | Substituted benzimidazole dosage forms and method of using same The present invention relates to pharmaceutical preparations comprising substituted benzimidazole proton pump inhibitors. There is provided a liquid or solid pharmaceutical dosage form that is not enteric coated or delayed released containing a proton pum... | 11/11/2003 |
| 6610759 | Cationically polymerizable adhesive composition containing an acidic component and methods and materials employing same An adhesive composition that includes a mixture of a cationically polymerizable component, an acidic component, and an initiator is provided. Preferably, the initiator comprises an iodonium salt, a visible light sensitizer, and an electron donor compound,... | 08/26/2003 |
| 6605432 | High-throughput methods for detecting DNA methylation The present invention provides a method of hybridization, differential methylation hybridization (DMH) for high throughput methylation analysis of multiple CpG island loci. DMH utilizes nucleic acid probes prepared from a cell sample to screen numerous Cp... | 08/12/2003 |
| 6599725 | Polypeptide compositions for controlling cell death and disease resistance in plants The present invention is drawn to methods and compositions for suppressing cell death in plants. Specifically, novel proteins and genes are provided for use in plant transformation. The proteins and genes are useful for activating disease resistance, enha... | 07/29/2003 |
| 6458865 | Photopolymerizable vinyl ether based monomeric formulations and polymerizable compositions which may include certain novel spiroorthocarbonates Photopolymerizable compositions are provided which are the reaction products of a vinyl ether, a photoinitiator system comprising an iodonium salt, a visible light sensitizer, and an electron donor compound. These monomeric/oligomeric compositions may als... | 10/01/2002 |
| 6245755 | Use of aldosterone antagonists to inhibit myocardial fibrosis This invention discloses a method of inhibiting aldosterone-mediated myocardial, perivascular and interstitial fibrosis using epoxymexrenone and other aldosterone antagonists.... | 06/12/2001 |
| 6211437 | Nucleic acids from maize encoding proteins which suppress plant cell death The present invention is drawn to genes from maize encoding proteins which suppress plant cell death and methods of plant transformation therewith.... | 04/03/2001 |
| 5964996 | Macrocyclic antibiotics as separation agents Macrocyclic antibiotics having ring structures with at least 10 members act as separation agents in crystallization, precipitation, filtration, electrophoresis and chromatography. The macrocyclic antibiotics include ansamacrolides, macrolides, macrocyclic... | 10/12/1999 |
| 5843673 | Method of screening for endometriosis A glycoprotein having a molecular weight of 28,000 to 32,000 and an isoelectric point of 7.0 to 9.0, both as determined by two-dimensional SDS polyacrylamide gel electrophoresis, is synthesized and secreted specifically by stromal cells of endometriotic o... | 12/01/1998 |
| 5831035 | Antibody against human endometrial stromal cell glycoprotein An antibody to the purified and isolated glycoprotein and functional analogs thereof characterized by being progesterone induced and estradiol inhibited secretory glycoprotein specifically from stromal cells of endometrial origin. The protein has the mole... | 11/03/1998 |
| 5637466 | Method of detecting bone acidic glycoprotein-75 and its 50,000 MW fragment and antibodies therefor A method of detecting bone acidic glycoprotein-75 (BAG-75) antigen includes the steps incubating a serum or synovial fluid sample with anti-BAG antibody, reacting the incubated sample with a signal generating antibody to the anti-BAG-75 antibody, and dete... | 06/10/1997 |
| 5610063 | cDNA for -N-acetyl-galactosaminidase from Gallus domesticus A purified and isolated cDNA clone, as set forth in SEQ ID No:1, encoding the mature chicken -N-acetylgalactosaminidase enzyme is disclosed.... | 03/11/1997 |
| 5601800 | New multifunctional ligands for potential use in the design therapeutic or diagnostic radiopharmaceutical imaging agents A class of diagnostic and therapeutic compounds derived from phosphinimines that include ligands containing either a single phosphinimine functionality or both a phosphinimine group and a phosphine or arsine group, or an aminato group, or a second phosphi... | 02/11/1997 |
| 5558636 | Method of effecting embryo transplant This invention is directed to a method of effecting the non-surgical transplant of embryos into the uterus of an animal. The method involves the use of a long tubular gripping instrument having an open forward end and an external gripping formation genera... | 09/24/1996 |
| 5529992 | Method for inhibiting myocardial fibrosis by administering an aldosterone antagonist which suppresses aldoster one receptors This invention discloses a method of using an aldosterone antagonist such as spironolactone, at a dosage which does not disrupt a patient's normal electrolyte and water-retention balance, to inhibit myocardial fibrosis, including left ventricular hypertro... | 06/25/1996 |
| 5516940 | Multifunctional ligand for use as a diagnostic or therapeutic pharmaceutical A compound and method of making a compound for use as a diagnostic or therapeutic pharmaceutical comprises either a phosphorous or germanium core and at least two hydrazine groups forming a ligand for bonding to a metal extending from the phosphorous or g... | 05/14/1996 |
| 5478474 | Method for treating liquid wastes The method of treating liquid waste in a media is accomplished by exposing the media to phosphinimines and sequestering 99 Tc from the media by the phosphinimine (PN) functionalities. The system for treating the liquid waste in the media includ... | 12/26/1995 |
| 5401819 | Trans-beta-isocyanatoacrylate esters, their preparation, and polymers made therefrom Novel trans-beta-isocyanatoacrylate esters, their preparation and use in forming novel polymeric compositions, including polymers useful as adhesives, are disclosed. The trans-beta-isocyanatoacrylate esters have the formula: ##STR1## wherein R i... | 03/28/1995 |
| 5347044 | Trans-beta-isocyanatoacrylate esters, their preparation, and polymers made therefrom Novel trans-beta-isocyanatoacrylate esters, their preparation and use in forming novel polymeric compositions, including polymers useful as adhesives, are disclosed. The trans-beta-isocyanatoacrylate esters have the formula: ##STR1## wherein R i... | 09/13/1994 |
| 5258370 | Artificial redox enzymes Artificial redox enzymes are disclosed wherein one or more redox coenzymes or cofactors are linked to the 2-O, 3-O or 6-O positions of a D-glucopyranose ring of -, ଲ-, or γ-cyclodextrins. Also disclosed are facile synthetic methods for produ... | 11/02/1993 |
| 5196646 | Dual purpose fuze A dual purpose fuze for a projectile which can activate a quantity of material selected from a group including high explosive, low explosive, propellant and pyrotechnic compounds. The fuze includes a charge holder having a socket therein facing the quanti... | 03/23/1993 |
| 5145636 | Soluble irradiation targets and methods for the production of radiorhenium Water soluble irradiation targets are disclosed for the production of 186 Re and 188 Re. The irradiation targets are selected for both water solubility and absence of elements which would produce contaminating isotopes for medical th... | 09/08/1992 |
| 5087752 | Synthesis of nitroxides using dioxiranes The subject invention relates to a method of synthesizing nitroxides from secondary amines. This method uses a suitable dioxirane compound such as dimethyldioxirane (DMD), which is relatively stable and simple to synthesize, as the oxidizing agent. A quan... | 02/11/1992 |
