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...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.

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Assignee: CuraGen Corporation


Location: New Haven, CT
No. of patents: 30

NumberTitleIssue Date
8067544Antibodies against T cell immunoglobulin domain and mucin domain 1 (TIM-1) antigen and uses thereof
The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies. In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amin...
11/29/2011
7566536WNT-regulated cytokine-like polypeptide and nucleic acids encoding same
The present invention provides novel polypeptides, termed FCTRX polypeptides, as well as polynucleotides encoding FCTRX polypeptides and antibodies that immunospecifically bind to an FCTRX or a derivative, variant, mutant, or fragment of an FCTRX polypeptide, polynu...
07/28/2009
7291483FGF-CX polynucleotide sequences and methods of producing same
The present invention provides FGF-CX, a novel isolated polypeptide, as well as a polynucleotide encoding FGF-CX and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibo...
11/06/2007
7259144Methods for diagnosing and treatment of hyperphosphatemic conditions using FGF20 polypeptides
The present invention describes novel methods for diagnosis and treatment of conditions that alter phosphate transport in mammals. The fibroblast growth factor proteins and nucleotides that may be useful as a therapeutic or in the diagnosis of such conditions are al...
08/21/2007
7122345Nucleic acid encoding a NOVX13 polypeptide
Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragm...
10/17/2006
7108972Proteins, polynucleotides encoding them and methods of using the same
Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragm...
09/19/2006
7060444Zone 3 necrosis associated markers and method of use thereof
Disclosed are methods of identifying toxic agents, e.g., hepatotoxic agents, using differential gene expression. ...
06/13/2006
7045509Proteins and nucleic acids encoding same
Disclosed are polypeptides and nucleic acids encoding same. Also disclosed are vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same. ...
05/16/2006
7033790Proteins and nucleic acids encoding same
The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment o...
04/25/2006
7005499Wnt-regulated cytokine-like polypeptide and nucleic acids encoding same
The present invention provides novel polypeptides, termed FCTRX polypeptides, as well as polynucleotides encoding FCTRX polypeptides and antibodies that immunospecifically bind to an FCTRX or a derivative, variant, mutant, or fragment of an FCTRX polypeptide, polynu...
02/28/2006
7001766Nucleic acid sequences encoding human angiopoietin-like polypeptides
This application is drawn to novel nucleic acid sequences encoding mammalian polypeptides that have sequence similarity to human angiopoietin-related proteins. The nucleic acid sequence is 1855 nucleotides long and contains an open reading frame from nucleotides 154...
02/21/2006
6992170Polypeptides and polynucleotides homologous to thymosin, ephrin a receptors, and fibromodulin
Disclosed herein are novel human nucleic acid sequences that have homology to thymosin, ephrin A receptors, proteoglycans and fibromodulin. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the p...
01/31/2006
6991901Proteins and nucleic acids encoding same
Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragm...
01/31/2006
6989232Proteins and nucleic acids encoding same
Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragm...
01/24/2006
6987212Amino polyol amine oxidase polynucleotides and related polypeptides and methods of use
The present invention provides transformed plants comprising a polynucleotide enconding amino polyol amine oxidase (APAO ) from Exophiala spinifera and a method of expressing APAO transgenic plants and seeds. In this way, transgenic plant can be produced havi...
01/17/2006
6982250Methods of prevention and treatment of inflammatory bowel disease
The present invention is based upon methods of treating inflammatory conditions in the intestinal tract of mammals using growth factor related polypeptides. The invention includes methods of reducing the morality rate or delaying mortality in a subject suffering fro...
01/03/2006
6974684Therapeutic polypeptides, nucleic acids encoding same, and methods of use
Disclosed herein are nucleic acid sequences that encode G-coupled protein-receptor related polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives...
12/13/2005
6964849Proteins and nucleic acids encoding same
Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragm...
11/15/2005
6942992Nucleic acid sequences encoding human slit-, megf-, and roundabout-like polypeptides
This application is drawn to novel nucleic acid sequences encoding mammalian polypeptides that have sequence similarity to slit-, MEGF- or multiple epidermal growth factor, and roundabout-proteins. The nucleic acid sequence is 2341 nucleotides long and contains an o...
09/13/2005
6916907Nucleic acids encoding osteoprotegern-like proteins and methods of using same
Disclosed are osteoprotegerin-like polypeptides, nucleic acids encoding osteoprotegerin-like polypeptides, and methods of using these molecules. The osteoprotegerin-like polypeptides sequence homology to osteoprotegerin and tumor necrosis factor receptor molecules.
07/12/2005
6903201Proteins and nucleic acids encoding same
Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragm...
06/07/2005
6875570Proteins and nucleic acids encoding same
Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies, which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragm...
04/05/2005
6875567Method of detecting cardiac hypertrophy through probe hybridization and gene expression analysis
The present invention is based upon the identification of genes which are differentially expressed in hypertrophic cardiac tissue as compared to normal cardiac tissue. Accordingly, the present invention provides nucleotide sequences of genes selected from the group ...
04/05/2005
6872704Acidic mammalian proteins and polynucleotides encoding the same
Genes are disclosed that are differentially-regulated during feeding and fasting cycles. These genes, and their encoded polypeptides are useful to combat obesity and other metabolic disorders. ...
03/29/2005
6863889Polynucleotides and proteins encoded thereby
The present invention provides novel isolated SECX polynucleotides and the membrane-associated or selected polypeptides encoded by the SECX polynucleotides. Also provided are the antibodies that immunospecifically bind to a SECX polypeptide or any derivative, varian...
03/08/2005
6855806Thymosin beta 10-like proteins and nucleic acids encoding same
Disclosed herein are novel human nucleic acid sequences. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies which immunospecifically-bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the aforemen...
02/15/2005
6852845Method of identifying toxic agents using NSAID-induced differential gene expression in liver
The invention provides methods of identifying toxic agents, e.g., hepatotoxic agents, using differential gene expression. Also provided are methods of predicting the risk level and or injury type of NSAIDs. Also disclosed are novel nucleic acid sequences whose expre...
02/08/2005
6822140Compositions and methods for fumonisin detoxification
Compositions and methods for the complete detoxification of fumonisin and fumonisin degradation products are provided. Particularly, nucleotide sequences corresponding to the detoxification enzymes are provided. The sequences find use in preparing expression cassett...
11/23/2004
6753314Protein-protein complexes and methods of using same
The invention provides complexes of at least two polypeptides, and methods of using the same. Purified complexes of two polypeptides are provided, including chimeric complexes, and chimeric polypeptides and complexes thereof are also provided, as are nucleic acids e...
06/22/2004
6750012Method of identifying a psychotropic agent using differential gene expression
Disclosed are methods of identifying psychotropic agents that do not induce motor side effects using differential gene expression. Also disclosed are novel nucleic acid sequences whose expression is differentially regulated by psychotropic agents. ...
06/15/2004
 
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