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| Number | Title | Issue Date |
| 8173797 | Therapeutic compounds derived from spider venom and their method of use The present invention is directed to new therapeutic compounds isolated from spider venom and methods of using these new compounds. The compounds are sulfated nucleoside derivatives including ribonucleoside mono- and disulfates derived from guanine, adenosine, and c... | 05/08/2012 |
| 8168749 | Stimulating neurite outgrowth using Tctex-1-related polypeptides A method of stimulating neurite outgrowth in a subject may include administering to the subject a formulation that includes a tctex-1-related polypeptide that stimulates neurite outgrowth in vitro. ... | 05/01/2012 |
| 8168207 | Immunogenic proteins of The invention provides novel immunogenic proteins LigA and LigB from Leptospira for use in the development of effective vaccines and antibodies, as well as improved diagnostic methods and kits. ... | 05/01/2012 |
| 8165385 | System and method for three-dimensional image rendering and analysis The present invention relates to methods and systems for conducting three-dimensional image analysis and diagnosis and possible treatment relating thereto. The invention includes methods of handling signals containing information (data) relating to three-dimensional... | 04/24/2012 |
| 8163461 | Photoacid generator compounds and compositions The invention provides various photoacid generator compounds and ionic components thereof. Photoresist compositions that include the ions and non-ionic photoacid generator compounds are also provided. The invention further provides methods of making and using the ph... | 04/24/2012 |
| 8150523 | Feedback method for deep brain stimulation with detection of generalized efference copy signals Disclosed is a method for improving cognitive function or for improving coordination of function across a patient's cortical regions. The method includes applying electrical stimulation to at least a portion of the patient's subcortical structures involved in the ge... | 04/03/2012 |
| 8148398 | Intermediate duration neuromuscular blocking agents and antagonists thereof The invention provides novel neuromuscular blocking agents, methods of using the neuromuscular blocking agents as well as reagents, methods and kits for reversing the effects of the neuromuscular blocking agents. ... | 04/03/2012 |
| 8143254 | Methods for modulating ion channels In one embodiment, the invention provides an ion having the formula: (I) In another embodiment, the invention provides a method for modulating potassium, sodium, and cyclic nucleotide-modulated ion channels in a mammal in need thereof. In a further embodiment, the i... | 03/27/2012 |
| 8124110 | Proteins with repetitive bacterial-Ig-like (Big) domains present in species The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. Acc... | 02/28/2012 |
| 8103068 | Methods and systems for reconstruction of objects Methods and systems for reconstructing an object from observations of interaction of the object with a physical system. ... | 01/24/2012 |
| 8095480 | System and method to enable training a machine learning network in the presence of weak or absent training exemplars Described is a system and method for training a machine learning network. The method comprises initializing at least one of nodes in a machine learning network and connections between the nodes to a predetermined strength value, wherein the nodes represent factors d... | 01/10/2012 |
| 8094351 | Fibrous micro-composite material Fibrous micro-composite materials are formed from micro fibers. The fibrous micro-composite materials are utilized as the basis for a new class of MEMS. In addition to simple fiber composites and microlaminates, fibrous hollow and/or solid braids, can be used in str... | 01/10/2012 |
| 8088382 | Methods of inhibiting transendothelial migration of neutrophils and monocytes with anti-CD99L2 antibodies The present invention provides methods and compositions for modulating transendothelial migration (TEM) of leukocytes. In particular, inhibition of TEM can provide a potent therapeutic approach to treating inflammatory conditions. The invention specifically relates ... | 01/03/2012 |
| 8084254 | Human blood brain barrier model The present invention relates to an immortalized human brain endothelial cell line that is useful as an in vitro model of the blood brain barrier. ... | 12/27/2011 |
| 8084001 | Photoluminescent silica-based sensors and methods of use Sensor particles comprise a silica-based core and at least one photoluminescent dye. The silica-based core may comprise a plurality of pores and the at least one photoluminescent dye may comprise a reference dye, insensitive to its environment and analytes and a sen... | 12/27/2011 |
| 8072117 | Thermal-mechanical signal processing A source signal is converted into a time-variant temperature field with transduction into mechanical motion. In one embodiment, the conversion of a source signal into the time-variant temperature field is provided by utilizing a micro-fabricated fast response, bolom... | 12/06/2011 |
| 8063556 | Cascaded light emitting devices based on mixed conductor electroluminescence A cascaded light emitting device. The cascaded light emitting device includes: a base electrode formed of a base electrode material and electrically coupled to a base voltage lead; a top electrode layer formed of a top electrode material and electrically coupled to ... | 11/22/2011 |
| 8062919 | Monolithic silicon-based photonic receiver An integrated circuit, and method for manufacturing the integrated circuit, where the integrated circuit can include a phototransistor comprising a base having a SiGe base layer of a predetermined germanium composition and a thickness of more than 65 nm and less tha... | 11/22/2011 |
| 8053585 | Protecting group for carboxylic acids that can be photolyzed by visible light The present invention relates to a photolabile compound including a coumarin family caging group covalently bound to an organic moiety containing a carboxyl group, an amino group, a sulfhydryl group, and/or a hydroxyl group. The photolabile compound, upon absorbing ... | 11/08/2011 |
| 8050481 | Method and apparatus for small pulmonary nodule computer aided diagnosis from computed tomography scans The present invention is a multi-stage detection algorithm using a successive nodule candidate refinement approach. The detection algorithm involves four major steps. First, a lung region is segmented from a whole lung CT scan. This is followed by a hypothesis gener... | 11/01/2011 |
| 8049580 | MEMS controlled oscillator An array of micromechanical oscillators have different resonant frequencies based on their geometries. In one embodiment, a micromechanical oscillator has a resonant frequency defined by an effective spring constant that is modified by application of heat. In one em... | 11/01/2011 |
| 8045770 | System and method for three-dimensional image rendering and analysis The present invention relates to methods and systems for conducting three-dimensional image analysis and diagnosis and possible treatment relating thereto. The invention includes methods of handling signals containing information (data) relating to three-dimensional... | 10/25/2011 |
| 8043803 | Slitrks as markers for stem and progenitor cells and methods of use thereof The present invention relates to slitrk proteins as markers of stem and progenitor cells, including embryonic stem cells and hematopoietic stem and progenitor cells, and also as a marker of leukemia and lymphoma cells, and of endothelial cells. The invention provide... | 10/25/2011 |
| 8039655 | Production of isotactic and regiorandom polypropylene based polymer and block copolymers One step ortho-alkylation of anilines with styrenes to give chiral anilines is obtained using a strong acid catalyst, e.g. CF3SO3H. Condensation of the product to give ligand and metallation gives complex which catalyzes polymerization of propy... | 10/18/2011 |
| 8034347 | Method for inhibiting apoptosis through the p75 neurotrophin receptor The present invention provides an isolated protein comprising a pro-domain of a proneurotrophin, methods for producing the protein, and pharmaceutical compositions containing the isolated protein. The invention also provides a nucleic acid molecule which encodes the... | 10/11/2011 |
| 8030449 | Pressure cryocooling protein crystals Preparation of cryocooled protein crystal is provided by use of helium pressurizing and cryocooling to obtain cryocooled protein crystal allowing collection of high resolution data and by heavier noble gas (krypton or xenon) binding followed by helium pressurizing a... | 10/04/2011 |
| 8030061 | Devices and methods for pharmacokinetic-based cell culture system Devices, in vitro cell cultures, systems, and methods are provided for microscale cell culture analogous (CCA) device. ... | 10/04/2011 |
| 8026512 | Mobility engineered electroluminescent devices An electroluminescent (EL) device, including a semiconductor structure, a first electrode, and a second electrode. The semiconductor structure includes: a first higher mobility semiconductor layer having a first mobility; a second higher mobility semiconductor layer... | 09/27/2011 |
| 8026317 | Isotactic specific catalyst for direct production of highly isotactic poly (propylene oxide) or highly isotactic poly (butylene oxide) (Salph or methoxy salph) Co (initiating ligand) catalyze homopolymerizing rac-PO to produce pure highly isotactic PPO and rac-1-butylene oxide to produce pure isotactic poly(butylene oxide). A product is unfractionated isotactic PPO of m-dyad content >81%, normally ... | 09/27/2011 |
| 8021673 | Proteins with repetitive Bacterial-Ig-like (Big) domains present in species The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. Acc... | 09/20/2011 |
| 7993938 | Highly doped III-nitride semiconductors A method of forming a highly doped layer of AlGaN, is practiced by first removing contaminants from a MBE machine. Wafers are then outgassed in the machine at very low pressures. A nitride is then formed on the wafer and an AlN layer is grown. The highly doped GaAlN... | 08/09/2011 |
| 7989586 | Multiblock copolymers having improved mechanical properties Replacement of the amorphous peptide domain of a structural biopolymer, such as silk from silkworms or spiders, with a nonpeptide segment while maintaining the β-sheet forming crystalline segments provides synthetic multiblock copolymers having solid-state structur... | 08/02/2011 |
| 7977366 | Treating an inflammatory disorder or inhibiting respiratory burst in adherent neutrophils with chemical inhibitors of neutrophil activation The present invention relates to a method of treating an inflammatory disorder in a subject with an effective amount of compound having the general formula (I) as described in the present application, under conditions effective to treat the inflammatory disorder. Th... | 07/12/2011 |
| 7960776 | Transistor with floating gate and electret A sensor includes a field effect transistor having a source, drain, a control gate and floating gate, wherein the floating gate has an extended portion extending away from the control gate. A sensing gate is capacitively coupled to the extended portion of the floati... | 06/14/2011 |
| 7959929 | Materials and methods for respiratory disease control in canines The subject invention pertains to isolated influenza virus that is capable of infecting canids and causing respiratory disease in the canid. The subject invention also pertains to compositions and methods for inducing an immune response against an influenza virus of... | 06/14/2011 |
| 7958790 | Biaxial load cell with highly anisotropic force resolutions A load cell for measuring extremely low level, anisotropic biaxial loads is disclosed. The system includes at least one load cell of a specific geometry and dimension which, when mounted, provides a rotationless system accurately transmitting both normal and shearin... | 06/14/2011 |
| 7947774 | Ethylene-vinyl acetate copolymer of increased mechanical properties Solution blending of masterbatch of cationically functionalized polyvinyl acetate copolymer/silicate nanocomposite where the silicate is substantially exfoliated, and ethylene-vinyl acetate copolymer (EVA), produces product of increased tensile strength and Young's ... | 05/24/2011 |
| 7947453 | Methods for drug discovery, disease treatment, and diagnosis using metabolomics The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for pred... | 05/24/2011 |
| 7947439 | Detection of bovine viral diarrhea virus in tissue samples The present invention relates to a method of detecting whether a target animal is Bovine Viral Diarrhea Virus (BVDV) positive or negative by determining whether a gp48 protein-specific reagent binds to a gp48 Bovine Viral Diarrhea Virus protein or protein fragment, ... | 05/24/2011 |
| 7947438 | Detection of bovine viral diarrhea virus in hair samples The present invention relates to a method of detecting whether a target animal is Bovine Viral Diarrhea Virus (BVDV) positive or negative by determining whether a gp48 protein-specific reagent binds to a gp48 Bovine Viral Diarrhea Virus protein or protein fragment, ... | 05/24/2011 |
