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| Number | Title | Issue Date |
| 6399627 | Inhibitors of factor Xa Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.... | 06/04/2002 |
| 6372475 | Cloning and characterization of a human adenylyl cyclase A DNA sequence encoding a human adenylyl cyclase is described. The amino acid sequence of the adenylyl cyclase is also described.... | 04/16/2002 |
| 6369063 | Selective factor Xa inhibitors Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.... | 04/09/2002 |
| 6297026 | Nucleic acids encoding the C140 receptor Nucleic acid molecules encoding the C140 cell surface receptor have been cloned and sequenced. The availability of C140 receptor DNA permits the recombinant production of the C140 receptor which can be produced on the surface of a cell, including an oocyt... | 10/02/2001 |
| 6228854 | Selective factor Xa inhibitors Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.... | 05/08/2001 |
| 6194557 | Nucleic acid molecules encoding Bap-1 proteins The present invention provides the amino acid and nucleotide sequence of a protein that binds to 댣 integrins, IIb and Src kinase and is involved in integrin mediated signaling. Based on this disclosure, the present invention provides methods... | 02/27/2001 |
| 6194435 | Lactams as selective factor Xa inhibitors Novel lactams, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds of Formula I below: ##STR1## are useful in vitro or in vivo for preventing or treating coagulation disorders.... | 02/27/2001 |
| 6133256 | Selective factor Xa inhibitors Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.... | 10/17/2000 |
| 6083688 | Platelet glycoprotein V gene and uses This invention relates to the glycoprotein v gene. Specifically, this invention discloses the sequence and structure of the glycoprotein v gene and the amino acid sequence of the glycoprotein v polypeptide. In addition, the evolutionary relationship of th... | 07/04/2000 |
| 6005089 | Platelet glycoprotein V gene and uses This invention relates to the glycoprotein v gene. Specifically, this invention discloses the sequence and structure of the glycoprotein v gene and the amino acid sequence of the glycoprotein v polypeptide. In addition, the evolutionary relationship of th... | 12/21/1999 |
| 5843897 | Platelet aggregation inhibitors An assay for screening snake venom for the presence or absence of platelet aggregation inhibitors (PAIs) based on specific receptor binding is described. Using this assay, the identification and characterization of PAIs in a wide range of snake venom samp... | 12/01/1998 |
| 5795910 | Method and compositions for inhibiting protein kinases A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a molecule of the formula ##STR1## wherein R1 is H, lower alkyl, or lower alkanoyl; R2 is H, lower ... | 08/18/1998 |
| 5728726 | Method and compositions for inhibiting protein kinases A method for selectively inhibiting a kinase is disclosed, which comprises contacting a composition containing a kinase with a molecule of the formula ##STR1## wherein R1 is H, lower alkyl, or lower alkanoyl; R2 is H, lower ... | 03/17/1998 |
| 5686572 | Domains of extracellular region of human platelet derived growth factor receptor polypeptides Defined constructs of modified human platelet-derived growth factor receptor polypeptides are provided. Extracellular region domain structures are identified and modifications and combinatorial rearrangements of the receptor segments are provided. Both ce... | 11/11/1997 |
| 5342830 | Antithrombosis agents Platelet antiadhesives (PAA) which are useful as antithrombotics are obtainable from snake venoms which have been identified using an assay which measures the ability of the venom to inhibit ristocetin- or botrocetin-induced agglutination of platelets in ... | 08/30/1994 |
| 5278144 | Antithrombosis agents Analogs of Factor Xa (Factor Xai) which are inactive as proteases in the prothrombinase reaction are useful in treatment of diseases characterized by thrombosis. These antithrombotic agents can be conveniently prepared using recombinant techniques.... | 01/11/1994 |