Assignee: Consejo Superior de Investigaciones Cientificas

Location: Madrid, ES
No. of patents: 123

Number	Title	Issue Date
8182816	Methods of treating cancer Disclosed are methods of treating subjects having cancers including administering an effective amount of an early activation molecule agonist, antagonist or depletor, to the subject. Human monoclonal antibodies specific to the early activation molecules, and methods...	05/22/2012
8168856	Method of production of recombinant sucrose synthase, use thereof in the manufacture of kits for determination of sucrose, production of adpglucose and production of transgenic plants whose leaves and storage organs accumulate high contents of adpglucose and starch An isolated sucrose synthase peptide. Also, a method of preparing ADPglucose by incubating the isolated sucrose synthase peptide with ADP in suitable conditions and then isolating and purifying the ADPG produced. Also, an assay kit for the spectrophotometric, fluori...	05/01/2012
8154063	Ultrafast and ultrasensitive novel photodetectors A photodetector is provided that includes a FET structure with a channel structure having one or more nanowire structures. Noble metal nanoparticles are positioned on the channel structure so as to produce a functionalized channel structure. The functionalized chann...	04/10/2012
8129336	Inhibitor of the uracil-DNA glycosylase enzyme and uses thereof The present invention relates to a protein which has the capacity to bind to and inhibit the viral uracil DNA glycosylase (UDG) enzyme and its use as a therapeutic agent; in particular, as an antiviral agent. ...	03/06/2012
8115001	Zeolite ITQ-30 The invention relates to a laminar microporous crystalline zeolite material known as ITQ-30 which, as when synthesized, has a chemical composition in the anhydrous state with the following molar relations: x (M1/n XO2):y YO2:SiO...	02/14/2012
8110019	Modified induction furnace and process for removing zinc-containing metallurgical waste, with recovery of the metals therefrom The present invention is based on a novel electric induction furnace design that enables the removal of zinc-containing filter dust (FD) originating from the production of steel (alloy or non-alloy) and the production of cast iron with galvanized steel scrap, using ...	02/07/2012
8097209	Method and apparatus for detecting substances or analytes from the analysis of one or more samples The invention relates to a method and apparatus for detecting substances or analytes form the analysis of one or several samples. The method comprises mixing the sample with a suitable liquid buffer, homogenizing said sample, adding reagents thereto, filtering it, i...	01/17/2012
8007765	Microporous crystalline material, zeolite ITQ-37, preparation method and use The present invention relates to a microporous crystalline material characterized in that it has the following chemical composition in the calcined from: xX2O3:nYO2:mGeO2 in which ...	08/30/2011
7978344	System and method for the inspection of micro and nanomechanical structures The system for surface inspection is arranged to detect relative displacement and/or vibration features of a plurality of points of a plurality of elements (51) forming part of a mechanical structure (5), such as a micro- or nanomechanical structure. A...	07/12/2011
7960025	Magnetic nanoparticles comprising a core formed from noble metals The invention relates to nanoparticles of noble metals, having a controlled microstructure which leads to the appearance of ferromagnetic behaviour in said nanoparticles, thereby enabling the use of very small magnets (	06/14/2011
7958563	Method for using an atomic force microscope The present invention relates to a method of using an atomic force microscope comprising exciting natural lower and higher vibration modes of a microlever (M) placed on a sample, and analyzing the variation of one variable of a first output signal (Ai cos...	06/07/2011
7932266	Isoquinoline derivatives as calpain inhibitors The invention relates to derivative compounds of partially-reduced isoquinoline with substitution of a sec-butyl group at position 3 with calpain inhibitor activity. The inventive compound comprises an ester or amide derived from (3-sec-butyl-1-oxo-2,3-dihydro-1H-is...	04/26/2011
7932048	Method for the in vitro diagnosis of alzheimer's disease using a monoclonal antibody The invention relates to a method for the in vitro diagnosis of Alzheimer's disease using a monoclonal antibody. Said antibody can bind at least to amino acids 12-16 of the β-amyloid peptide, specifically detecting the neuritic plaques which are characteristic of A...	04/26/2011
7921466	Method of using an atomic force microscope and microscope The invention relates to a method of using an atomic force microscope and to a microscope. The inventive method comprises the following steps consisting in at least performing bimodal excitation of a microlever (M) which is disposed on a sample and analysing at leas...	04/05/2011
7895891	Gas/liquid separator comprising a capacitive level sensor The invention relates to a gas/liquid separator comprising a capacitive level sensor, which is particularly suitable for systems that employ reduced volumes of fluids at high pressures. The inventive separator includes a metal part comprising a borehole which is clo...	03/01/2011
7883880	DNA polymerase lambda and uses thereof The present invention relates to the identification and isolation of a DNA polymerase and uses of this polymerase. In particular, the present invention describes the nucleotide sequence of the human gene for DNA polymerase lambda (Pol λ), the amino acid sequence of...	02/08/2011
7867475	Immune regulation based on the depletion of CD69+ cells Disclosed are methods of treating subjects having disorders or conditions characterized by an unwanted immune response including administering an effective amount of an early activation molecule agonist, antagonist or depletor, to the subject. Human monoclonal antib...	01/11/2011
7857981	Bimetallic catalyst for the treatment of water containing nitrates A catalyst which, by means of a reduction reaction at ambient temperature, permits the elimination of nitrates and nitrites in waters. The catalyst comprises a combination of a noble metal and a non-noble metal supported on or incorporated into the structure of a su...	12/28/2010
7794930	Snail, a new marker for tumour invasion and target protein of new antitumoral compounds The Snail transcription factor has been identified as a repressor of the expression of E-cadherin. The expression of Snail induces invasive and metastatic capacity in tumour cells. This invention presents: a new target protein, Snail, for the identification of new a...	09/14/2010
7781463	Enzyme inhibitors Compounds of general formula (I): where A, E, G, X, Y and the bond - - - take various meanings are of use in the preparation of a pharmaceutical formulation, for example in the treatment of a disease in which GSK-3 is invol...	08/24/2010
7781458	Derivatives of pyridine and quinoline The invention provides compounds of formula I blocking phosphorylcholine biosynthesis by means of the selective blocking of the choline kinase enzyme in tumor cells or in cells affected by parasitic infection and therefore being applicable in the treatment of tumors...	08/24/2010
7776519	Use of the slug gene, or of the transcription or expression products thereof in the detection and/or treatment of cancerous cells Method for the detection of cancerous cells, in particular, mesenchymal tumoral cells, in a biological sample suspected of containing said malignant cells. The methods are based on the aberrant expression of the Slug gene or transcription or expression products ther...	08/17/2010
7765634	Surface-cleaning machine Machine for cleaning mainly vertical surfaces comprising a body attached to the cable of the crane, brushes with an actuator attached to the body with the possibility of rotation, three or more wheels attached to the body with the possibility of rotation, and the at...	08/03/2010
7709408	Catalyst based on a solid microporous crystalline material and method of improving diesel fraction quality using said catalyst The invention relates to a catalyst consisting of at least: one matrix comprising at least one oxide which is selected from an amorphous oxide, an oxide with low crystallinity and a mixture of both; at least one solid microporous crystalline material which, in the c...	05/04/2010
7666885	Enzyme inhibitors Compounds of general formula (I): where A, E, G, X, Y and the bond - - - take various meanings are of use in the preparation of a pharmaceutical formulation, for example in the treatment of a disease in which GSK-3 is invol...	02/23/2010
7646494	System and method for detecting the displacement of a plurality of micro- and nanomechanical elements, such as micro-cantilevers The invention relates to a system and method for detecting the displacement, such as the deflection, of a plurality of elements (1), such as microcantilevers, forming part of an array (2), by emitting a light beam (4) towards the array (2...	01/12/2010
7626074	Method of screening candidate drugs for the treatment of leukemia Transgenic non-human mammals that reproduce human pathologies of stem cell origins, such as chromosomal anomalies associated with chronic myeloid leukemia, B-cell acute lymphoblastic leukemia, T-cell acute or lymphoblastic leukemia, or with the migration of hematopo...	12/01/2009
7619724	Device and method for detecting changes in the refractive index of a dielectric medium The device for detecting changes in the refractive index of a dielectric medium comprises: at least one metallic layer (300) ready to be placed in contact with the dielectric medium (200); at least one light source (20) configured to direct tran...	11/17/2009
7611623	Separation method using an ITQ-29 zeolite material The invention relates to a method of separating the components of a mixture. The inventive method is characterised in that it comprises the following steps: (a) the bringing into contact of the components of a mixture selected from (i) at least two hydrocarbons, (ii...	11/03/2009
7573734	Magnetoelectric device and method for writing non-volatile information into said magnetoelectric device This invention relates to a device comprising at least a first ferromagnetic layer (202) and an element (204) exchange-bias coupled to this layer in at least one place through an interface (208), for controlling the magnetic state of the ferroma...	08/11/2009
7553477	Zeolitic microporous crystalline material with an LTA structure (ITQ-29), preparation method thereof and uses of same in organic compound separation and transformation processes The invention relates to a material which, once calcined and in the anhydrous state has general formula x (M1/n XO2):z ZO2:y GeO2:(1−y) SiO2, wherein x has a value of less than 0.2, preferably less than 0.15 a...	06/30/2009
7544823	Sunflower seeds with high delta-tocopherol content The present invention relates to sunflower seeds which have been genetically modified through two artificial induction cycles of mutations followed in each case by processes for the identification of mutant individuals which have the desired character. The disclosed...	06/09/2009
7537918	Process of producing polyunsaturated fatty acids with yeasts through the incorporation of olefinic or acetylenic substrates The invention relates to a process of producing polyunsaturated fatty acids through the incorporation of olefinic or acetylenic fatty acids with a chain length of 13-18 carbon atoms as substrates with a haploid or diploid wild strain of Saccharomyces cerevisiae	05/26/2009
7537909	Enzymatic method of producing 4-O-β-D-galactopyranosyl-D-xylose, 4-O-β-D-galactopyranosyl-D-xylose obtained using said method, compositions contain same and the use thereof in evaluating intestinal lactase An enzymatic process to obtain 4-O-β-D-galactopyranosyl-D-xylose useful in compositions or solutions in the in vivo evaluation of intestinal lactose activity in humans, that comprises the steps of preparing a reaction mixture of D-xylose, a β-D-galactopyranoside a...	05/26/2009
7482159	Snail, a new marker for tumour invasion and target protein of new antitumoral compounds The Snail transcription factor has been identified as a repressor of the expression of E-cadherin. The expression of Snail induces invasive and metastatic capacity in tumor cells. This invention presents: a new target protein, Snail, for the identification of new an...	01/27/2009
7476754	Biphenyl derived thiamides as calpain inhibitors The present invention relates to compounds derived from biphenyl with activity as calpain inhibitors. One compound of the present invention is a 2,2′-disubstituted biphenyl, where the substituents in the 2 and 2′ positions of the biphenyl skeleton are chains con...	01/13/2009
7449169	Microporous crystalline zeolite material (zeolite ITQ-22), synthesis method thereof and use of same as a catalyst The present invention refers to a microporous crystalline material of zeolitic nature (ITQ-22) which, in the calcined state, has the empirical formula x(M1/nX02):yYO2:zR:wH20 wherein M is H+ or at least one inorganic...	11/11/2008
7445928	Bacterial artificial chromosome construct encoding recombinant coronavirus The present invention relates to methods of preparing a DNA comprising steps, wherein (a) a DNA comprising a full length copy of the genomic RNA (gRNA) or an RNA virus; or (b) a DNA comprising one or several fragments of a gRNA of an RNA virus, which fragments code ...	11/04/2008
7439411	Zeolite catalyst for the alkylation of aromatic compounds with olefins, alcohols or polyalkylated aromatic compounds The invention relates to a method of preparing an alkylated aromatic compound. The inventive method is characterized in that it comprises an alkylation reaction of an aromatic compound with an alkylating agent which is selected from an olefin, an alcohol and a polya...	10/21/2008
7414172	Method for improving plant tolerance to environmental stress Provided are DNA sequences encoding a novel type of AP2 domain-containing transcription factor as well as methods for obtaining similar sequences. Also described are methods for obtaining plants with improved growth and enhanced stress tolerance, particularly tolera...	08/19/2008

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Assignee: Consejo Superior de Investigaciones Cientificas