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...When G.G. Hubbard learned of his future son-in-law's invention, he called it "only a toy." His daughter was engaged to a young man named Alexander Graham Bell.
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| Number | Title | Issue Date |
| 6020182 | Subunit respiratory syncytial virus vaccine preparation The fusion (F) protein, attachment (G) protein and matrix (M) protein of respiratory syncytial virus (RSV) are isolated and purified from respiratory syncytial virus by mild detergent extraction of the proteins from concentrated virus, loading the protein... | 02/01/2000 |
| 6019980 | Nucleic acid respiratory syncytial virus vaccines Vectors containing a nucleotide sequence coding for an F protein of respiratory syncytial virus (RSV) and a promoter for such sequence, preferably a cytomegalovirus promoter, are described. Such vectors also may contain a further nucleotide sequence locat... | 02/01/2000 |
| 6018019 | Synthetic Haemophilus influenzae conjugate vaccine The present invention provides immunogenic synthetic peptides which are useful alone or in PRP-conjugates in vaccines against Hemophilus influenza infection. Modifications are possible within the scope of the invention.... | 01/25/2000 |
| 5939297 | Analog of haemophilus HIN47 with reduced protease activity An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. ... | 08/17/1999 |
| 5876731 | Tandem synthetic HIV-1 Peptides Novel synthetic peptides are provided which are candidate vaccines against HIV-1 and which are useful in diagnostic application. The peptides comprise an amino acid sequence of a T-cell epitope of the gag protein of HIV-1, specifically p24E linked directl... | 03/02/1999 |
| 5869302 | Analog of haemophilus hin47 with reduced protease activity An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. ... | 02/09/1999 |
| 5800822 | Tandem synthetic HIV-1 peptides Novel synthetic peptides are provided which are candidate vaccines against HIV-1 and which are useful in diagnostic application. The peptides comprise an amino acid sequence of a T-cell epitope of the gag protein of HIV-1, specifically p24E linked directl... | 09/01/1998 |
| 5780606 | Neisseria meningitidis capsular polysaccharide conjugates Capsular polysaccharides containing multiple sialic acid residues, particularly the Group B polysaccharide of Neisseria meningitidis, are modified by chemical reaction to randomly introduce pendant reactive residues of heterobifunctional linker molecules ... | 07/14/1998 |
| 5679352 | Synthetic Haemophilus influenzae conjugate vaccine Synthetic peptides have an amino acid sequence corresponding to at least one antigenic determinant of at least one protein, usually a structural protein, particularly the P1, P2 and P6 protein, of Haemophilus influenzae (Hi), particularly type b, and are ... | 10/21/1997 |
| 5665353 | Composition containing an analog of haemophilus Hin47 with reduced protease activity An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. ... | 09/09/1997 |
| 5571712 | Non-infectious, replication defective, immunogenic HIV retrovirus-like particles produced from a recombinant HIV genome devoid of long terminal repeats This invention is directed towards nucleic acid molecules capable of producing human immunodeficiency virus (HIV) retrovirus-like particles, which are non-infectious, replication defective, and immunogenic. Recombinant HIV genomes were generated that are ... | 11/05/1996 |
| 5506139 | Analog of haemophilus Hin47 with reduced protease activity An isolated and purified analog of Haemophilus influenzae Hin47 protein has a decreased protease activity which is less than about 10% of that of natural Hin47 protein and preferably substantially the same immunogenic properties as natural Hin47 protein. ... | 04/09/1996 |
| 5444159 | Purification of a pertussis outer membrane protein Pertactin (formerly 69 kDa protein) is recovered in stable biologically pure form having no detectable adenylate cyclase activity from fermentation broth from the fermentation of Bordetella pertussis as well as from the cells. The broth is processed to se... | 08/22/1995 |
| 5439810 | Manipulation of gene copy number in bordetella Protein expression levels from Bordetella strains, particularly Bordetella pertussis, are altered by genetic modification to a natural Bordetella strain whereby one or more of the natural genes, particularly including the TOX, FHA, CYA and PRN genes, is d... | 08/08/1995 |
| 5439809 | Non-infectious HIV particles lacking long terminal repeats An immunogenic HIV retrovirus-like particle which is non-infectious and non-replicating and which is useful as a candidate vaccine component against HIV infection, is produced by genetic engineering. A DNA molecule comprising the HIV genome devoid of long... | 08/08/1995 |
| 5433945 | Immunoprotective genetically-detoxified mutants of pertussis toxin A new method is described for the preparation of a safe, immunogenic and efficacious vaccine for protection against the disease pertussis. In development of this vaccine, specific functional sites of pertussis toxin have been identified, and using this in... | 07/18/1995 |
| 5358868 | Genetic detoxification of pertussis toxin A new method is described for the preparation of a safe, immunogenic and efficacious vaccine for protection against the disease pertussis. In development of this vaccine, specific functional sites of pertussis toxin have been identified, and using this in... | 10/25/1994 |
| 5332583 | Vaccine containing genetically-detoxified pertussis holotoxin A new method is described for the preparation of a safe, immunogenic and efficacious vaccine for protection against the disease pertussis. In development of this vaccine, specific functional sites of pertussis toxin have been identified, and using this in... | 07/26/1994 |
| 5244657 | Genetic detoxification of pertussis toxin A new method is described for the preparation of a safe, immunogenic and efficacious vaccine for protection against the disease pertussis. In development of this vaccine, specific functional sites of pertussis toxin have been identified, and using this in... | 09/14/1993 |
| 5221618 | Genetic detoxification of pertussis toxin A new method is described for the preparation of a safe, immunogenic and efficacious vaccine for protection against the disease pertussis. In development of this vaccine, specific functional sites of pertussis toxin have been identified, and using this in... | 06/22/1993 |
| 5194254 | Enhancement of antigen immunogenicity A new method is described for eliciting IgG antibody response to proteins or synthetic peptides, particularly those that are weakly immunogenic, without the requirement for the use of adjuvants, thereby making it easier and safer to confer protection agai... | 03/16/1993 |
| 5061619 | Immunoassay using antibody-antigen conjugates A novel immunoassay techniques is provided which is useful in the detection and determination of antibodies to antigens. Antibodies of all classes to a given antigen or the specific subclass of immunoglobulin to a specified antigen can be detected. A conj... | 10/29/1991 |
| 4997915 | Purification of pertussis toxins Lymphocytosis promoting factor (LPF) and filamentous hemaglutinin (FHA) are isolated from the growth medium of the Bordatella pertussis organism and purified by selecting adsorbing the LPF and FHA on a selective adsorbing medium, such as filter aids or ge... | 03/05/1991 |
| 4956128 | Droplet generation Perfectly spherical, smooth and uniform microcapsules, which may contain living cells, are produced having a diameter less than 700 μm by employing an electrostatic droplet generator. A droplet is suspended from a pointed source, such as a needle, and is... | 09/11/1990 |
| 4950480 | Enhancement of antigen immunogenicity A new method is described for eliciting IgG antibody response to proteins or synthetic peptides without the requirement for the use of adjuvants, thereby making it easier and safer to confer protection against pathogenic organisms. The antigen is coupled ... | 08/21/1990 |
| 4849508 | Pasteurization of immunoglobulin solutions Pasteurization of immunoglobulin solutions to inactivate viruses without significantly altering the IgG molecules or their physiological activities is obtained with minimal aggregation in the absence of any stabilizer by heating this solution to mildly-el... | 07/18/1989 |
| 4806355 | Microencapsulation of living tissue and cells Living tissue or cells, for example, islets of Langerhans, are microencapsulated for implantation in the body for long term treatment of diabetes or other disease requiring organ transplantation. The microcapsules take the form of a biocompatible semi-per... | 02/21/1989 |
| 4789550 | Microcapsule composition suitable for cardiovascular injection Perfectly spherical, smooth and uniform microcapsules, which may contain living cells, are produced having a diameter less than 700 μm, e.g. 150 to about 500 microns, by employing an electrostatic droplet generator. A droplet is suspended from a pointed ... | 12/06/1988 |
| 4689293 | Microencapsulation of living tissue and cells Living tissue or cells, for example, islets of Langerhans, are microencapsulated for implantation in the body for long term treatment of diabetes or other disease requiring organ transplantation. The microcapsules take the form of a biocompatible semi-per... | 08/25/1987 |
| 4673566 | Microencapsulation of living tissue and cells Living tissue or cells, for example, islets of Langerhans, are microencapsulated for implantation in the body for long term treatment of diabetes or other disease requiring organ transplantation. The microcapsules take the form of a biocompatible semi-per... | 06/16/1987 |
| 4650673 | Oral immunization of mammals A composition and method for immunizing carnivores and other mammals, especially foxes, against rabies and other pathogenic diseases, by setting out and orally administering a dose of a vaccine, are described. The vaccine is enclosed in a bite-permeable s... | 03/17/1987 |
| 4492684 | Slow release injectable insulin composition A slow release injectable insulin composition is provided which is able to control blood sugar levels over extended periods of time. The albumin is partially cross-linked using a concentration of glutaraldehyde which is less than 3.75% v/w of the albumin ... | 01/08/1985 |
| 4477567 | Continuous bovine beta cell line A new cell line which is morphologically very similar to the beta cell of the Islets of Langerhans is obtained by transformation of pancreatic bovine cells. The transformed cells contain the diploid number of chromosomes for the bovine species and produce... | 10/16/1984 |
| 4464474 | Non-A, non-B hepatitis assay and vaccine A newly discovered particle in the urine and serum of non-A, non-B hepatitis patients has been associated with non-A, non-B hepatitis. The particle resembles a togavirus and is 50-60 nm in diameter with a discrete core of about 40 nm in diameter. The viru... | 08/07/1984 |
| 4323457 | Artificial endocrine pancreas The artificial endocrine pancreas device comprises a container in which are provided one, or more, hollow fibres; in the container and on the outside of the fibres are placed pancreatic islet cells; each fibre has a porosity allowing substances of molecul... | 04/06/1982 |
| 4286637 | Apparatus for dispensing liquids into tubes An apparatus useful in the addition of reagents in small quantities to micro reaction systems is described. The apparatus enables liquids to be dispensed within a narrow desired area of a receiving tube or other receptacle from a needle while avoiding und... | 09/01/1981 |
| 4258029 | Synthetic adjuvants for stimulation of antigenic responses Long chain alcohol esters of amino acids are used as adjuvants in vaccines to provide an improved antigenic capability when compared with conventional adjuvants.... | 03/24/1981 |
