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Felix Hoffmann, a German chemist, was searching for something to relieve his father's arthritis. In doing so, he "rediscovered" acetylsalicylic acid and in 1900, patented a stable process for developing it. Hence, we have aspirin.
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| Number | Title | Issue Date |
| 8153141 | Immunostimulatory G, U-containing oligoribonucleotides Compositions and methods relating to immunostimulatory RNA oligomers are provided. The immunostimulatory RNA molecules are believed to represent natural ligands of one or more Toll-like receptors, including Toll-like receptor 7 (TLR7) and Toll-like rec... | 04/10/2012 |
| 8128944 | RNA sequence motifs in the context of defined internucleotide linkages inducing specific immune modulatory profiles Immunostimulatory polymers that contain certain sequence-dependent immunostimulatory RNA motifs and methods for the use of such immunostimulatory polymers and compositions containing such polymers are provided according to the invention. The sequence-dependent immun... | 03/06/2012 |
| 7956043 | 5′ CpG nucleic acids and methods of use The invention relates to a class of CpG immunostimulatory oligonucleotides containing a 5′TCG motif or a CG at or near the 5′ end that are useful for stimulating an immune response. ... | 06/07/2011 |
| 7820379 | Process for high throughput screening of CpG-based immuno-agonist/antagonist The invention pertains to murine TLR9 and related TLR9s which include murine-specific amino acids, as well as nucleic acids which encode those polypeptides. The present invention also includes fragments and biologically functional variants of the murine TLR9. The in... | 10/26/2010 |
| 7795235 | Semi-soft c-class immunostimulatory oligonucleotides The invention relates to specific C-Class semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response. In particular the oligonucleotides are useful for treating allergy, such as allergic rhinitis and asthma, cancer and infect... | 09/14/2010 |
| 7776344 | Methods related to immunostimulatory nucleic acid-induced interferon Methods and compositions are provided for extending the clinical utility of IFN-α in the treatment of a variety of viral and proliferative disorders. Among other aspects, the invention provides methods which increase the efficacy of IFN-α treatment and reduce IFN-... | 08/17/2010 |
| 7615539 | Nucleic acid-lipophilic conjugates The invention relates to a nucleic acid-lipophilic conjugates and methods for modulating an immune response using the conjugates. The lipophilic moiety associated with an immunostimulatory nucleic acid. ... | 11/10/2009 |
| 7566703 | Semi-soft C-class immunostimulatory oligonucleotides The invention relates to specific C-Class semi-soft CpG immunostimulatory oligonucleotides that are useful for stimulating an immune response. In particular the oligonucleotides are useful for treating allergy, such as allergic rhinitis and asthma, cancer and infect... | 07/28/2009 |
| 7534772 | Methods for enhancing antibody-induced cell lysis and treating cancer The invention relates to methods and products for treating cancer. In particular the invention relates to combinations of nucleic acids and antibodies for the treatment and prevention of cancer. The invention also relates to diagnostic methods for screening cancer c... | 05/19/2009 |
| 7271156 | Immunostimulatory nucleic acids The invention relates to immunostimulatory nucleic acid compositions and methods of using the compositions. The T-rich nucleic acids contain poly T sequences and/or have greater than 25% T nucleotide residues. The TG nucleic acids have TG dinucleotides. The C-rich n... | 09/18/2007 |
