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Assignee: Cobe Laboratories, Inc.


Location: Lakewood, CO
No. of patents: 133

1        
NumberTitleIssue Date
6153113Method for using ligands in particle separation
A system and method are disclosed for separating particles having different sedimentation velocities. The system includes a container containing a binding substance including first particles and ligands attached to the first particles. When the binding su...
11/28/2000
6129656Extracorporeal blood processing methods and apparatus
An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which direc...
10/10/2000
6071422Particle separation method and apparatus
An apparatus and method are disclosed for filtering or separating particles. The apparatus has a centrifuge rotor rotatable about an axis of rotation. A fluid chamber rotates with the rotor. A substance is supplied to the inlet of the chamber. A saturated...
06/06/2000
6053856Tubing set apparatus and method for separation of fluid components
An apparatus and method are provided for separating components of a fluid or particles. A separation vessel having a barrier dam is provided to initially separate an intermediate density components of a fluid, and a fluid chamber is provided to further se...
04/25/2000
5970423Blood component collection system with optimizer
A blood component collection system with optimization capabilities. In one embodiment, process parameters are derived from an input/configured predetermined blood component yield and which is based upon the maximization of at least one process parameter. ...
10/19/1999
5954626Method of minimizing coriolis effects in a centrifugal separation channel
A centrifuge separation device is disclosed and includes a rotor configured to be connected to a centrifuge motor for rotation about an axis of rotation. A retainer is associated with the rotor and defines a passageway for a separation channel. A protrusi...
09/21/1999
5951877Particle filter method
An apparatus and method are disclosed for filtering or separating particles. The apparatus has a motor coupled to a centrifuge rotor rotatable about an axis of rotation. A fluid chamber rotates with the rotor. A substance is supplied to the inlet of the c...
09/14/1999
5939319Particle separation method and apparatus
An apparatus and method are disclosed for filtering or separating particles. The apparatus has a centrifuge rotor rotatable about an axis of rotation. A fluid chamber rotates with the rotor. A substance is supplied to the inlet of the chamber. A saturated...
08/17/1999
5913768Particle filter apparatus
An apparatus and method are disclosed for filtering or separating particles. The apparatus has a motor coupled to a centrifuge rotor rotatable about an axis of rotation. A fluid chamber rotates with the rotor. A substance is supplied to the inlet of the c...
06/22/1999
5906570Particle filter apparatus
An apparatus and method are disclosed for filtering or separating particles. The apparatus has a motor coupled to a centrifuge rotor rotatable about an axis of rotation. A fluid chamber rotates with the rotor. A substance is supplied to the inlet of the c...
05/25/1999
5900270Technique for testing and coating a microporous membrane
The integrity of a microporous membrane within a mass transfer device such as an oxygenator is tested simultaneously with applying a biocompatible surfactant to at least the blood-contact surface of the membrane. The membrane integrity test contacts both ...
05/04/1999
5891080Biological fluid cassette and tubing set
An apparatus for managing and controlling fluid flow through a plurality of fluid conduits includes a chassis, a plurality of conduit occluders mounted in the chassis, each occluder for association with at least one of the plurality of fluid conduits and ...
04/06/1999
5876321Control system for the spillover collection of sparse components such as mononuclear cells in a centrifuge apparatus
A centrifuge apparatus is used for collecting white blood cells (WBC), primarily mononuclear cells, from whole blood stratified into layers. A thin mononuclear (MNC) layer is formed at the interface of red blood cells and plasma. A barrier is positioned i...
03/02/1999
5795317Extracorporeal blood processing methods and apparatus
An extracorporeal blood processing system is disclosed which includes a variety of novel components and which may be operated in accordance with a variety of novel methodologies. For instance, the system includes a graphical operator interface which direc...
08/18/1998
5792038Centrifugal separation device for providing a substantially coriolis-free pathway
A centrifuge separation device is disclosed and includes a rotor configured to be connected to a centrifuge motor for rotation about an axis of rotation. A retainer is associated with the rotor and defines a passageway for a separation channel. A protrusi...
08/11/1998
5750025Disposable for an apheresis system with a contoured support
An extracorporeal blood processing system is disclosed which includes a disposable for an apheresis system. The disposable can include a blood processing vessel and a contoured support. The blood processing vessel includes sidewalls to define the vessel a...
05/12/1998
5734464Red blood cell spillover detection technique
An apparatus and a method are provided to monitor a generally transparent blood tube at a location that is downstream from a blood separator in order to detect the presence of red blood cells in a tube that is intended to carry a different blood component...
03/31/1998
5720741Venous reservoir bag assembly
A venous reservoir bag subassembly is provided which is adapted to cooperate with a mounting assembly having a bracket frame and a front plate reproducibly relatively movable to enable constant accurate blood volume readout, cooperating means between the ...
02/24/1998
5704888Intermittent collection of mononuclear cells in a centrifuge apparatus
A centrifuge apparatus is used for collecting white blood cells, primarily mononuclear cells, from whole blood stratified into layers. A thin mononuclear (MNC) layer is formed at the interface of red blood cells and plasma. A barrier is positioned in the ...
01/06/1998
5704889Spillover collection of sparse components such as mononuclear cells in a centrifuge apparatus
A centrifuge apparatus is used for collecting white blood cells (WBC), primarily mononuclear cells, from whole blood stratified into layers. A thin mononuclear (MNC) layer is formed at the interface of red blood cells and plasma. A barrier is positioned i...
01/06/1998
5685835Technique for using a dialysis machine to disinfect a blood tubing set
A method of disinfecting a blood tubing set on a dialysis machine after the blood tubing set has been used in a dialysis treatment. One end of the blood tubing set is connected to a disinfection port on the dialysis machine and an opposite end of the bloo...
11/11/1997
5685875Fluid sampling device for closed collection systems
A method and device for sampling biological fluids during collection without opening the functionally closed collection system, thereby compromising the sterility of the collected fluid. A sample bag connected to a fluid line or collection reservoir is fi...
11/11/1997
5679245Retention device for extracorporeal treatment apparatus
Blood from a patient is treated extracorporeally by any selected one of a plurality of predetermined treatments. Each of the treatments involves the flow of blood from the patient into a primary chamber of a filtration unit, past a semipermeable membrane ...
10/21/1997
5674452Hollow fiber exchangers
An exchanger includes an outer casing having an inlet port and an outlet port for a first fluid, and an inlet port and an outlet port for a second fluid, and a bundle of hollow fibers located within the outer casing and being in flow communication with th...
10/07/1997
5674173Apparatus for separating particles
A fluid chamber and method are disclosed for filtering or separating particles. The fluid chamber includes a wall extending between an inlet and outlet to form a fluid chamber interior. The interior converges from a position of maximum cross-sectional are...
10/07/1997
5665061Biological/pharmaceutical method and apparatus for collecting and mixing fluids
A blood circulation apparatus includes a suction wand for receiving blood from a patient, a reservoir for collecting received blood, a flow path between the suction wand and the reservoir, and an anticoagulant pump and line for introducing anticoagulant i...
09/09/1997
5656027Surgical fluid suction accumulator and volume measurement device
An apparatus for minimizing trauma to a medical fluid while transporting the medical fluid from a surgical wound by reducing the air to fluid interface during transport. The apparatus includes a suction wand for collecting medical fluid and tubing for tra...
08/12/1997
5648206Lyophilization of cells
A process and medium are disclosed for the lyophilization of cells which comprises the use of solutions including monosaccharide hexoses and pentoses, and/or biocompatible amphipathic polymers to permit the reconstitution of viable cells....
07/15/1997
5648070Biocompatible anion exchange materials
Biocompatible anion exchange materials are provided comprising a support having a quaternary amine moiety and a polyethylene oxide (PEO) moiety having between about 10 and about 200 repeating units covalently bonded thereto, such that said quaternary amin...
07/15/1997
5644240Differential conductivity hemodynamic monitor
A flow rate of a fluid flowing in a tube is quantitatively determined by altering the electrical conductivity of the fluid by injection of a bolus of saline. The electrical conductivity of the altered conductivity is measured over the time it takes the al...
07/01/1997
5643681Biocompatible coated article
The biocompatibility of polymeric and metallic articles used in contact with blood can be substantially improved by coating the articles as described. The coating materials are triblock copolymers of the polylactone-polysiloxane-polylactone type. Optimum ...
07/01/1997
5641637Method of preparing lyophilized and frozen cell standards
A method is disclosed for preparing lyophilized and frozen cells as cytometry standards....
06/24/1997
5629871Wear trend analysis technique for components of a dialysis machine
The wear on components in a dialysis machine is analyzed for the purpose of making repair and maintenance decisions. The actual performance of components is used to establish a test value. The test value is compared to a threshold value which represents t...
05/13/1997
5624572Power management system and method for maximizing heat delivered to dialysate in a dialysis machine
The amount of electrical power delivered to a dialysate heater in the dialysis machine is maximized without substantially exceeding a predetermined maximum allowed power consumption for the dialysis machine. The instantaneous power consumed by the machine...
04/29/1997
5605842Method for producing blood component products
A method for producing blood component products. In one embodiment, a plurality of a predetermined type of blood component is harvested from a source of whole blood. At least two on-line yield determination techniques are utilized to determine the yield o...
02/25/1997
5520218Medical tubing set for the use with an improved radio frequency tubing sealer
A tubing set includes at least one fluid conveying tube. The fluid conveying tube has a predetermined outside diameter, and is formed of a material adapted to be dielectrically heated at a sealing location. The insulating sleeve has an inside dimension at...
05/28/1996
5510717Differential conductivity recirculation monitor
A differential conductivity recirculation monitor quantitatively determines the degree of recirculation in a fistula by comparing the conductivity of blood entering the fistula to the conductivity of blood being withdrawn from the fistula. A discrete quan...
04/23/1996
5505685Automation of plasma sequestration
A plasma sequestration system having a volume control system is provided. When a calculated volume of whole blood has been processed, the system switches from a fill to an empty cycle. The termination point is calculated in advance, based on the desired c...
04/09/1996
5489413Hollow fiber blood oxygenator
An exchanger includes an outer casing having an inlet port and an outlet-port for a first fluid, and an inlet port and an outlet port for a second fluid, and a bundle of hollow fibers located within the outer casing and being in flow communication with th...
02/06/1996
5470531Exchanger and method for manufacturing the same
An exchanger for oxygenating blood includes a casing having walls and a cavity, sheet material with first and second ends covering distal edges of the walls, and a cover extending over the cavity to sandwich the first and second ends of the sheet material...
11/28/1995
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