Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 8173371 | Serial coupling of nucleic acid metabolism and extension for nucleic acid amplification A novel method of pyrophosphorolysis activated polymerization (PAP) has been developed. In PAP, pyrophosphorolysis and polymerization by DNA polymerase are coupled serially for each amplification by using an activatable oligonucleotide P* that has a non-extendible 3... | 05/08/2012 |
| 8163783 | Ribonucleotide reductase inhibitors and methods of use Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme. These inhibitors may be used to inhibit RR activity and to treat various conditions associated with RRM2 ... | 04/24/2012 |
| 8148065 | Ligation amplification of nucleic acid sequences A method is described for the identification of point mutations by a template-dependent ligation procedure. Also described is a template-dependent ligase chain reaction procedure for the amplification and detection of nucleic acid sequences. ... | 04/03/2012 |
| 8138327 | Inducible systems and methods for controlling siRNA expression An inducible system and methods for controlling expression of siRNA are provided. An inducible system for producing siRNA only in the presence of HIV TAT, and methods for inhibiting HIV-1 gene expression in cells comprising such inducible system also are provided. | 03/20/2012 |
| 8124655 | Use of LR-90 and LR-102 to overcome insulin resistance The present invention provides methods for ameliorating, overcoming, or inhibiting insulin resistance in a subject, comprising administering to the subject an effective amount of a compound selected from the group consisting of LR-90 and LR-102, or a pharmaceuticall... | 02/28/2012 |
| 8119695 | Compounds and methods for treating breast cancer and other diseases Disclosed are novel compositions and novel methods for the creation of both the novel compounds and known compounds. Also disclosed are methods for use of the novel compounds for treating a variety of diseases relating to decreasing or preventing activation of estro... | 02/21/2012 |
| 8110193 | Methods for conditioning a subject for hematopoietic cell transplantation Allogeneic hematopoietic cell transplantation (HCT) is an effective therapy for treatment of hematological malignancies and various autoimmune conditions. However, HCT traditionally requires conditioning by total body irradiation and/or chemotherapy, both of which a... | 02/07/2012 |
| 8106181 | Methods for producing interfering RNA molecules in mammalian cells and therapeutic uses for such molecules Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided. ... | 01/31/2012 |
| 8088908 | Humanized anti-prostate stem cell antigen monoclonal antibody Prostate stem cell antigen (PSCA) is expressed in the majority of prostate cancer patients, making it an ideal target for cancer immunotherapy. Murine monoclonal antibody 1G8 binds to PSCA with nanomolar affinity, but its efficacy as a therapeutic agent is limited b... | 01/03/2012 |
| 8084599 | Methods and compositions for the specific inhibition of gene expression by double-stranded RNA The invention is directed to compositions and methods for selectively reducing the expression of a gene product from a desired target gene in a cell, as well as for treating diseases caused by the expression of the gene. More particularly, the invention is directed ... | 12/27/2011 |
| 8076071 | Methods for producing interfering RNA molecules in mammalian cells and therapeutic uses for such molecules Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided. ... | 12/13/2011 |
| 8071752 | Multi-targeting short interfering RNAs The present invention relates to novel short interfering RNA (siRNA) molecules that are multi-targeted. More specifically, the present invention relates to siRNA molecules that target two or more sequences. In one embodiment, multi-targeting siRNA molecules are desi... | 12/06/2011 |
| RE43000 | Artificial riboswitch for controlling pre-mRNA splicing The present invention relates to riboswitches that have been engineered to regulate pre-mRNA splicing. In particular, the insertion of a high affinity theophylline binding aptamer into the 3′ splice site region, 5′ splice site region, or branchpoint sequence (BP... | 12/06/2011 |
| 8067192 | Methods for detection of botulinum neurotoxin Provided herein is a large immuno-sorbent surface area assay (ALISSA) for rapid and sensitive detection of toxin or enzyme activity. This assay is designed to capture a low number of toxin or enzyme molecules and to measure their intrinsic protease activity via conv... | 11/29/2011 |
| 8044241 | Ligands for estrogen related receptors and methods for synthesis of said ligands Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described. ... | 10/25/2011 |
| 8030290 | Cell-type specific aptamer-siRNA delivery system for HIV-1 Therapy The present invention relates to compositions and methods for delivery of siRNA to specific cells or tissue. More particularly, the present invention relates to compositions and methods for cell type-specific delivery of anti-HIV siRNAs via fusion to an anti-gp120 a... | 10/04/2011 |
| 8017759 | Adenoviral VA1 Pol III promoter system for RNAi expression An adenoviral VA1 Pol III expression system for RNAi expression is provided. ... | 09/13/2011 |
| 7976779 | Integrated LC-ESI on a chip A microfluidic system with on-chip pumping which can be used for liquid chromatography and also electrospray ionization mass spectrometry and which provides improved efficiency, better integration with sensors, improved portability, reduced power consumption, and re... | 07/12/2011 |
| 7956076 | Ribonucleotide reductase inhibitors and methods of use Provided herein are novel compounds that inhibit ribonucleotide reductase (RR) by binding to RRM2 and interfering with the activity of the RRM1/RRM2 holoenzyme. These inhibitors may be used to inhibit RR activity and to treat various conditions associated with RRM2 ... | 06/07/2011 |
| 7927790 | Suppression of HIV-1 replication via inhibition of human flap endonuclease-1-mediated HIV-1 central DNA flap processing FEN-1 is involved in processing HIV central DNA flap (CDF) and is a target for intervention of HIV-1 replication. Inhibition of HIV-1 CDF removal by expression of D181A FEN-1 mutant suppresses viral DNA replication, further demonstrating that FEN-1 is a target. Meth... | 04/19/2011 |
| 7923221 | Methods of making antibody heavy and light chains having specificity for a desired antigen The invention relates to processes for producing an immunoglobulin or an immunologically functional immunoglobulin fragment containing at least the variable domains of the immunoglobulin heavy and light chains. The processes can use one or more vectors which produce... | 04/12/2011 |
| 7919253 | Serial coupling of nucleic acid metabolism and extension for nucleic acid amplification A novel method of pyrophosphorolysis activated polymerization (PAP) has been developed. In PAP, pyrophosphorolysis and polymerization by DNA polymerase are coupled serially for each amplification by using an activatable oligonucleotide P* that has a non-extendible 3... | 04/05/2011 |
| 7914995 | Reaction mixture for pyrophosphorolysis activated polymerization (PAP) A novel method of pyrophosphorolysis activated polymerization (PAP) has been developed. In PAP, pyrophosphorolysis and polymerization by DNA polymerase are coupled serially for each amplification by using an activatable oligonucleotide P* that has a non-extendible 3... | 03/29/2011 |
| 7871820 | High frequency of neurexin 1β signal peptide structural variants in patients with autism The three β-neurexins have similar roles in synaptogenesis and interact with the neuroligins. Mutations located within the gene encoding neurexin 1 have been identified as molecular markers associated with autism and autism-related disorders. The estimated attribut... | 01/18/2011 |
| 7820632 | Methods for producing interfering RNA molecules in mammalian cells and therapeutic uses for such molecules Methods for producing interfering RNA molecules in mammalian cells are provided. Therapeutic uses for the expressed molecules, including inhibiting expression of HIV, are also provided. ... | 10/26/2010 |
| 7812034 | Method of using protease inhibitors for the treatment of liposarcomas Liposarcomas are treated using HIV protease inhibitors, particularly nelfinavir. The protease inhibitors may be used alone or in combination with traditional cancer treatments, such as chemotherapy, radiotherapy, or surgery. ... | 10/12/2010 |
| 7776330 | Humanized anti-CEA T84.66 antibody and uses thereof Embodiments of the present invention utilize a more efficient CDR grafting technique to generate humanized versions of the T84.66 antibody. The technique used to generate these antibodies utilizes crystallographic structural data to select an immunoglobulin framewor... | 08/17/2010 |
| 7727525 | Engineered anti-CD20 antibody fragments for in vivo targeting and therapeutics The present invention provides anti-CD20 antibody fragments for use as in vivo imaging probes and as therapeutic moieties for the diagnosis and treatment of NHL. ... | 06/01/2010 |
| 7692141 | Polymer based electrospray nozzle for mass spectrometry A MEMS device with an overhanging ‘polymer’ capillary provides vital and significant improvements in interfacing a MEMS electrospray nozzle to an MS inlet or other macroscopic instrumentation. The fabrication methodology associated therewith is easily expanded t... | 04/06/2010 |
| 7662912 | Polyomavirus diagnostic reagents The present invention relates to HLA-A*02-restricted cellular epitopes within the VP1 polypeptide of human polyomaviruses, which are useful as diagnostic reagents for virus infection. Preferred peptides correspond to amino acids residues 107-116, 108-116 and 44-52 o... | 02/16/2010 |
| 7652037 | Methods of lowering lipid levels in a mammal This invention relates to methods for lowering lipid levels in mammals using compounds that inhibit advanced glycation endproducts (AGEs), LR-9, LR-74 and LR-90. These compounds, which inhibit non-enzymatic protein glycation, also inhibit the formation of advanced l... | 01/26/2010 |
| 7615638 | Synthesis of grossularines-1 and analogs thereof and method of use In one embodiment of the present invention, a synthesis of grossularine-1 and N,N-didesmethylgrossularine-1 2 and analogs thereof based on a novel oxidative dimerization-electrocyclization sequence of 2-amino-4-(3-indolyl)imidazoles derived from oxotryptamine... | 11/10/2009 |
| 7608040 | Device to aid in placing tracheal tubes A laryngoscope includes a blade assembly with a base that is coupled to a handle. Attached to the blade assembly are two hollow guide tubes that generally follow along the longitudinal axis of the blade assembly. The two tubes are oriented at different angles of att... | 10/27/2009 |
| 7563601 | Artificial riboswitch for controlling pre-mRNA splicing The present invention relates to riboswitches that have been engineered to regulate pre-mRNA splicing. In particular, the insertion of a high affinity theophylline binding aptamer into the 3′ splice site region, 5′ splice site region, or branchpoint sequence (BP... | 07/21/2009 |
| 7563448 | Modified vaccinia ankara expressing P53 in cancer immunotherapy Mutations to the tumor suppressor protein p53 have been observed in 40-60% of all human cancers. These mutations are often associated with high nuclear and cytoplasmic concentrations of p53. Since many tumors exhibit highly elevated p53 levels, the protein is an att... | 07/21/2009 |
| 7544838 | Ligands for estrogen related receptors and methods for synthesis of said ligands Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described. ... | 06/09/2009 |
| 7531647 | Lentiviral vectors for site-specific gene insertion Murine leukemia virus (MLV) and lentivirus vectors have been used previously to deliver genes to hematopoietic stem cells (HSCs) in human gene therapy trials. However, these vectors integrate randomly into the host genome, leading to disruption or inactivation of vi... | 05/12/2009 |
| 7531578 | Compounds and methods for treating breast cancer and other diseases Disclosed are novel compositions and novel methods for the creation of both the novel compounds and known compounds. Also disclosed are methods for use of the novel compounds for treating a variety of diseases relating to decreasing or preventing activation of estro... | 05/12/2009 |
| 7514537 | Chimeric immunoreceptor useful in treating human gliomas The present invention relates to chimeric transmembrane immunoreceptors, named “zetakines,” comprised of an extracellular domain comprising a soluble receptor ligand linked to a support region capable of tethering the extracellular domain to a cell surface, a tr... | 04/07/2009 |
| 7504221 | Pyrophosphorolysis activated polymerization (PAP) A novel method of pyrophosphorolysis activated polymerization (PAP) has been developed. In PAP, pyrophosphorolysis and polymerization by DNA polymerase are coupled serially for each amplification by using an activatable oligonucleotide P* that has a non-extendible 3... | 03/17/2009 |
