Today In History
Robert Mushet received a patent for methods of manufacturing steel.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 5755269 | Fluid delivery system A fluid delivery system for aspirating liquid from a bottle and conveying the liquid to an analytical instrument while allowing ambient air or gas to enter the bottle to replace the aspirated liquid. The bottle opening is sealed by a valve. A tube extends... | 05/26/1998 |
| 5622825 | Efficient gene probe conjugations by an unconventional mixed anhydride method A novel method for conjugating haptens, ligands or luminescent labels to polynucleotides has been developed. This method involves the formation of a mixed anhydride, followed by reaction of the mixed anhydride intermediate with a nucleophilic group-contai... | 04/22/1997 |
| 5609822 | Reagent handling system and reagent pack for use therein A reagent pack for keeping fluids with or without suspensions mixed or suspended upon rocking. The reagent pack has at least one chamber divided into separate sub-chambers with a throat region between them defined by baffles for agitation of suspended rea... | 03/11/1997 |
| 5601694 | Electrochemical sensors A solid shale, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered t... | 02/11/1997 |
| 5599501 | Incubation chamber Method and apparatus for transportation and processing of multiple protocol assays within an automated immunoassay analyzer instrument. The apparatus includes a cuvette ring movably coupled to a magnet ring. In one embodiment, the magnet ring and cuvette ... | 02/04/1997 |
| 5595875 | Method for detection of an analyte using acridinium ester and liposomes A method for the detection of an analyte in a fluid sample using liposomes encapsulating acridinium esters (lumisomes). Hydrophilic polysubstituted aryl acridinium esters are useful as chemiluminescent markers and can be encapsulated within liposome vesic... | 01/21/1997 |
| 5586673 | Cap assembly for fluid delivery system A cap assembly for receiving a stopper and for application to the threaded neck of a bottle. The cap assembly includes a cap and a thrust washer. The cap has an end wall which has a central aperture and a circular side wall which has internal threads. The... | 12/24/1996 |
| 5586590 | Coupler for fluid delivery system A fluid delivery system for aspirating liquid from a bottle and conveying the liquid to an analytical instrument while allowing ambient air or gas to enter the bottle to replace the aspirated liquid. The bottle opening is sealed by a valve. A tube extends... | 12/24/1996 |
| 5582796 | Feed and orientation mechanism in automated analyzer An analyzer for performing automated assay testing. The analyzer includes a storage and conveyor system for conveying cuvettes to an incubation or processing conveyor, a storage and selection system for test sample containers, a storage and selection syst... | 12/10/1996 |
| 5573046 | Value housing for a fluid delivery system A valve assembly for a fluid delivery system for aspirating liquid from a bottle. The valve assembly includes a valve housing for insertion into the neck of the bottle, an elastomeric valve and an elongated tube. The valve housing has a primary bore and a... | 11/12/1996 |
| 5573647 | Electrical contact A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered t... | 11/12/1996 |
| 5554272 | Planar bicarbonate sensor A planar bicarbonate sensor has been discovered that has a dried residue internal electrolyte layer comprising a bicarbonate source and a halide salt of potassium, lithium, or sodium. The flow-through sensor is capable of providing bicarbonate level of a ... | 09/10/1996 |
| 5538901 | Nucleophilic polysubstituted aryl acridinium ester conjugates uses thereof This invention is directed to the novel assay methods utilizing nucleophilic polysubstituted aryl acridinium ester conjugates as the tracers. Conjugates prepared by covalent coupling of novel nucleophilic polysubstituted aryl acridinium esters with biolog... | 07/23/1996 |
| 5529676 | Sample chamber A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered t... | 06/25/1996 |
| 5525466 | Multiple output referencing system for evanescent wave sensor An evanescent wave system and method including an optical sensor for use in assaying a reference material and at least one molecular species or analyte in a test medium or test sample for diagnostic and other applicable purposes. The sensor includes a wav... | 06/11/1996 |
| 5518601 | Extended use planar sensors A planar, solid-state electrochemical oxygen sensor having a substrate, conductive strips deposited on the substrate, and a dielectric layer insulating portions of the conductive strips except those portions which define a working electrode and at least o... | 05/21/1996 |
| 5506148 | Method for activation of polyanionic fluorescent dyes in low dielectric media with quaternary onium compounds The invention pertains to a method for generating the fluorescence of polyanionic fluorophores in low dielectric media with fluorescence activation produced by specific quaternary onium compounds. The method may be used for measuring an analyte and may be... | 04/09/1996 |
| 5503036 | Obstruction detection circuit for sample probe An obstruction detection circuit for detecting an obstruction of a sample probe of an automated sample aspiration/dispensation device and a method for detecting such an obstruction. In one embodiment the obstruction detection circuit includes a pressure s... | 04/02/1996 |
| 5503719 | Extended use planar sensors A planar, solid-state electrochemical oxygen sensor having a substrate, conductive strips deposited on the substrate, and a dielectric layer insulating portions of the conductive strips except those portions which define a working electrode and at least o... | 04/02/1996 |
| 5494562 | Electrochemical sensors A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered t... | 02/27/1996 |
| 5464850 | Synergistic preservative systems for chemistry reagents A family of solutions that can be used to calibrate one or more electrochemical sensors has been developed. These systems can be used to determine analytes in biological fluids, such as whole blood, serum, plasma and urine. Since these reagents require pr... | 11/07/1995 |
| 5449556 | Method for detection of an analyte using acridinium esters and liposomes A method for the detection of an analyte in a fluid sample using liposomes encapsulating acridinium esters (lumisomes). Hydrophilic polysubstituted aryl acridinium esters are useful as chemiluminescent markers and can be encapsulated within liposome vesic... | 09/12/1995 |
| 5445936 | Method for non-competitive binding assays A novel non-competitive immunoassay technique has been developed which not only improves sensitivity, but also is convenient and less susceptible to interfering factors. It is compatible with existing instruments and is an assay that can be run in one tes... | 08/29/1995 |
| 5437838 | Clinical laboratory work-flow system A multi-tasking clinical laboratory work-flow system for test sample and reagent transfer to semi-automate various laboratory assays. The system includes a controller having a menu of protocols which provide format instructions to a robotic sample transfe... | 08/01/1995 |
| 5421189 | Electrical connection system for electrochemical sensors An electrochemical/gas analyzer providing a rugged contact system for removable sensors capable of withstanding inexpert sensor insertion or removal, providing protection for high impedance input electronics against electrostatic discharge (ESD) damage, a... | 06/06/1995 |
| 5407798 | Amplification of midivariant DNA templates New methods are provided for the amplification of a midivariant DNA containing an inserted target specific nucleic acid sequence(s) to enable detection of the presence of a target nucleic acid sequence in a test sample. One method employs midivariant DNA ... | 04/18/1995 |
| 5401376 | Electrochemical sensors An electrochemical sensor having a substrate, conductive strips deposited on the substrate, and a layer insulating portions of the conductive strips except those portions which define a working electrode and at least one second electrode. A solid electrol... | 03/28/1995 |
| 5395752 | Long emission wavelength chemiluminescent compounds and their use in test assays An assay method incorporating at least two different chemiluminescent compounds for detection and/or quantitation of at least two substances in a test sample is described. The synthesis of chemiluminescent reagents or conjugates for use in such methods as... | 03/07/1995 |
| 5394047 | Ultrasonic transducer control system A control system for providing a drive signal to an ultrasonic transducer and for controlling the tip motion of the ultrasonic transducer wherein the transducer tip is disposed in a hemolyzing chamber. The control system includes a sensor for sensing the ... | 02/28/1995 |
| 5391499 | Automated sampling method for medical diagnostic instrument A novel fluid sampling device has been developed. This device provides for sample entry to be handled automatically by the instrument, thus allowing the operator to be involved in other activities while the sampling process is underway. It also assures re... | 02/21/1995 |
| 5387676 | MN gene and protein A new gene--MN--and proteins/polypeptides encoded therefrom are disclosed. Recombinant nucleic acid molecules for expressing MN proteins/polypeptides and fusion proteins are provided. Expression of the MN gene is disclosed as being associated with tumorig... | 02/07/1995 |
| 5387329 | Extended use planar sensors A planar, solid-state electrochemical oxygen sensor having a substrate, conductive strips deposited on the substrate, and a dielectric layer insulating portions of the conductive strips except those portions which define a working electrode and at least o... | 02/07/1995 |
| 5387525 | Method for activation of polyanionic fluorescent dyes in low dielectric media with quaternary onium compounds The invention pertains to a method for generating the fluorescence of polyanionic fluorophores in low dielectric media with fluorescence activation produced by specific quaternary onium compounds. The method may be used for measuring an analyte and may be... | 02/07/1995 |
| 5378637 | Method for measuring hyaluronic acid A method for measuring hyaluronic acid in a biological sample which comprises (a) coating a solid support with hyaluronic acid; (b) incubating the sample with cartilage proteoglycan; (c) exposing the incubated sample to the coated solid support; (d) then ... | 01/03/1995 |
| 5372782 | Automated sampling device for medical diagnostic instrument A novel fluid sampling device has been developed. This device provides for sample entry to be handled automatically by the instrument, thus allowing the operator to be involved in other activities while the sampling process is underway. It also assures re... | 12/13/1994 |
| 5346832 | Homogeneous amperometric immunoassay A method is described for measuring the amount of analyte present in a sample containing the analyte using a homogeneous amperometric immunoassay. The analyte is chemically bonded to a suitable carrier molecule, which is also chemically bonded to an elect... | 09/13/1994 |
| 5344760 | Method of cancer detection Diagnostic/prognostic methods are provided for detecting and/or quantitating in the body fluids, preferably serum, of mammals carrying a malignant tumor burden, elevated levels of a portion of the epidermal growth factor receptor (EGFr) which comprises su... | 09/06/1994 |
| 5340715 | Multiple surface evanescent wave sensor with a reference An evanescent wave sensor and method for use in analyzing one or more media, the sensor including a waveguide having first and second wave propagating surfaces. The waveguide propagates an input signal along the waveguide between the first and second surf... | 08/23/1994 |
| 5324822 | Method of isolating a CA 195-like immunoreactive antigen from human amniotic fluid A method of isolation of a material with similar immunological properties to CA-195 from human amniotic fluid has been disclosed. This material can be substituted for CA-195 in many processes, for example in the preparation of analytical control materials... | 06/28/1994 |
| 5312730 | Immune complex transfer with lypophilic bridge This invention relates to methods that have been found useful in reducing non-specific binding in immunochemical assays, via methods that can be implemented much faster than those used by Ishikawa. The techniques include the use of a lipophilic bridge, su... | 05/17/1994 |
