Assignee: Choay S.A.

Location: Paris, FR
No. of patents: 42

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Number	Title	Issue Date
5599801	Purified heparin fractions, method for obtaining them and pharmaceutical compositions containing them Heparin fractions obtained by nitrous depolymerization, containing at most 150 ppb of total N-nitroso compounds, prepared by subjecting heparins of natural origin which have been depolymerized with a nitrite to the action of UV radiation....	02/04/1997
5019649	Method for obtaining biologically active mucopolysaccharides of high purity, by controlled depolymerization of heparin Method for obtaining biologically active mucopolysaccharides by controlled depolymerization of heparin, wherein the quantity of products generating nitrous acid is selected so that those products are totally consumed when the desired depolymerization degr...	05/28/1991
4987223	Derivatives of the uronic acid The invention relates to derivatives with a uronic acid structure having substituents selected among a reactive group, a functionalisable group and --OH functions blocked by protective groups. These derivatives are useful for preparing glycosides, particu...	01/22/1991
4826827	Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs Short chained ligosaccharides of high structural homogeneity constituted essentially by hexasaccharides of the formula: ##STR1## in which R represents a hydrogen atom or the --SO331 group. These hexasaccharides have a highly se...	05/02/1989
4804652	Mucopolysaccharides having biological properties, preparation and application thereof as drugs Mucopolysaccharides biologically active and more specific than heparin, particularly with respect to the blood factor Xa. These mucopolysaccharides may be obtained by partial depolymerization, under controlled conditions, of heparin, by the action of a ch...	02/14/1989
4801583	Oligosaccharides and their biological applications The oligosaccharides of the invention contain or are constituted by a tetrasaccharide enchainment of the formula: ##STR1## in which R1 represents an organic anion, R2 is identical to R1 or represents a hydrogen atom, ...	01/31/1989
4788307	Oligosaccharidic fractions devoid or practically devoid of antithrombotic activity The oligosaccharidic fractions of the invention are soluble in an hydro-alcoholic mixture 50/50 (v/v) in which is added 0.5% NaCl, at pH 3.8, are constituted by chains the majority of which have 2 to 14 sugar units, are terminated by end units with a 2,5-...	11/29/1988
4777161	Medicaments favoring the properties of blood flow and their use in therapeutics The medicaments of the invention contain in their active principle, oligosaccharides of low molecular weight corresponding to or including heparin fragments....	10/11/1988
4774231	Disaccharides formed by patterns having a glucosamine and uronic acid structure, preparation thereof and biological applications 1,4댝isaccharides of formula: ##STR1## with Z representing a nitrogenous functional group, M hydrogen or a sulphate or acetyl group, R an alkyl radical of 1 to 4 carbon atoms and A functional group such as an acid group, or a derivative....	09/27/1988
4740594	Dextran derivatives endowed, particularly with anti-coagulant properties and anti-complementary properties, their preparation and their biological uses The dextran derivatives have a molecular weight higher than about 5000 daltons and comprise statistically at least about 35% of units substituted by radicals having a COO- function and at least 3% of units comprising a group of structure #...	04/26/1988
4714700	N-substituted 2,4-dialkoxy benzenesulfonamides and pharmaceutical compositions The invention relates to new N-substituted benzenesulfonamides, the process for their preparation and their use. The compounds according to the invention correspond to the general formula (I): ##STR1## in which: n and m have values from 0 to 4; R	12/22/1987
4687765	Method and composition for thrombolytic treatment The invention relates to a method and composition for thrombolytic treatment. It comprises administering to thrombosis-afflicted patients a low molecular weight heparin in an amount effective to cause lysis of thrombi in vivo....	08/18/1987
4652555	Heparin compositions freed of mineral salts, particularly oxalates, and process for obtaining same This invention relates to oxalate-free preparations of heparin, particularly in the form of calcium salts of heparin, which can be used for the preparation of injectable solutions of heparin which have long storage life. The invention is also directed to ...	03/24/1987
4618459	Substituted 2,4-dialkoxy benzene sulfonyl chlorides The invention relates to trisubstituted sulfohalides, the process for their preparation and their use as intermediate products for the manufacture of novel compounds. The trisubstituted sulfohalides according to the invention correspond to the following g...	10/21/1986
4613618	Method for treating disorders of lipid metabolism using benzene sulfonamides The invention relates to new medicaments having lipid regulating properties and processes for their preparation. The medicaments according to the invention contain as active principle at least one compound, (or its corresponding optical isomer) of the ary...	09/23/1986
4607025	Disaccharides having a glucosamine and uronic acid structure, and biological applications thereof 1,4 ଱ disaccharides of formula: ##STR1## with Z representing a nitrogenous functional group, M hydrogen or a sulphate or acetyl group, R an alkyl radical of 1 to 4 carbon atoms and A a functional group such as an acid group, or a derivative....	08/19/1986
4563445	3-Fucosyl-N-acetyl lactosamine derivatives, and their biological applications The invention relates to substitution derivatives of trisaccharide 3-fucosyl-N-acetyl lactosamine and to the immunological applications of these derivatives and of the trisaccharide itself particularly as diagnostic reagent and in therapy....	01/07/1986
4500519	Mucopolysaccharides having biological properties, preparation and method of use Mucopolysaccharides biologically active and more specific than heparin, particularly with respect to the blood factor Xa. These mucopolysaccharides may be obtained by partial depolymerisation, under controlled conditions, of heparin, by the action of a ch...	02/19/1985
4474770	Oligosaccharides having anti-Xa activity, pharmaceutical compositions containing them and method of use Oligosaccharides obtainable from heparin including heparinic constituents of molecular weights ranging from 2000 to 50,000. Said fractions have a Yin-Wessler titer and a U.S.P. titer in a ratio of at least 30. They consist of chains constituted by no more than...	10/02/1984
4474761	Oligopeptides with specific inhibiting properties of collagen induced aggregation, process for preparing the same and pharmaceutical compositions containing them Oligopeptides having no more than 10 amino acids containing the sequence having the capacity of interacting with blood platelets and an ability to inhibit the aggregation of platelets induced by a collogen containing substance....	10/02/1984
4457875	Substituted 2,4 dialkoxy benzene sulfonyl chlorides The invention relates to trisubstituted sulfohalides, the process for their preparation and their use as intermediate products for the manufacture of novel compounds. The trisubstituted sulfohalides according to the invention correspond to the following g...	07/03/1984
4401758	Process for making oligosaccharides having anti-Xa activity and the resulting oligosaccharides Oligosaccharides obtainable from heparin including heparinic constituents of molecular weights ranging from 2000 to 50,000. Said fractions have a Yin-Wessler titer and a USP titer in a ratio of at least 30. They consist of chains substituted by no more than 8 ...	08/30/1983
4226885	Guanylhydrazones and medicaments containing them New guanylhydrazones of phenoxyacetic acid. These guanylhydrazones, also their physiologically acceptable salts, are characterized by the following general formula I in which R1, R2, R3, R4, R5, R and...	10/07/1980
4225611	Novel n-substituted benzenesulfonamide, process for its preparation and medicaments containing it Amino-4 chloro-5 methoxy-2 N-(N-ethyl methyl-2 pyrrolidino) benzenesulfonamide is a novel compound corresponding to the formula ##STR1## and is prepared by reacting sulfonyl chloride of the formula ##STR2## with the amine of the formula ##S...	09/30/1980
4211776	N-Substituted 2-methoxybenzenesulphonamides, process for preparing them and medicaments containing them The invention relates to new N-substituted benzenesulphonamides of general formula ##STR1## in which n is 2 or 3, R1 and R2 are hydrogen atoms, methyl, ethyl groups, or jointly form with the nitrogen a nitrogenized heterocyclic ...	07/08/1980
4177262	Plasminogen compositions containing preactivated plasminogens with or without native plasminogens, process for making same, pharmaceutical compositions and control of blood clots The invention pertains to water soluble compositions having plasminogen activity capable of activation to plasmin formed of a mixture of different plasminogen compounds, among which native plasminogen and lysyl-plasminogen. It further concerns such compos...	12/04/1979
4168377	Process of preparing mixed heparin salts Mixed or simple heparin salt having a reduced amount of a selected metal ion alone or with another metal ion in a mixed heparin. A heparin salt having a reduced sodium content being essentially sodium free and having a selectively high calcium or other se...	09/18/1979
4148877	Fraction capable of inducing in vivo a resistance to bacterial infections, process for obtaining said fraction from bacteria and drugs containing said fraction A biologically active fraction of reduced toxicity or substantially free of it formed of components having molecular weights not exceeding 10,000-12,000, capable of stimulating in vivo the resistance to bacterial infections, is obtained from bacteria, mor...	04/10/1979
4125606	Octapeptide useful for the treatment of diabetes The invention relates to the compound consisting of the peptide chain: leucyl - seryl - arginyl -leucyl - phenylalanyl -aspartyl - asparaginyl - alanine (I). This compound forms the active substances of drugs useful for the treatment of diabetes....	11/14/1978
4118575	Derivatives of para-guanidino-L-phenylalanine and methods of preparing them The invention relates to novel derivatives of L-phenylalanine and particularly to tosyl-paraguanidino-L-phenylalanine methyl ester, to ter-butyloxycarbonyl derivative of para-guanidino-L-phenylalanine and to para-guanidino-L-phenylalanine. The tosyl-parag...	10/03/1978
4115551	Compounds of the plasminogen type and method for obtaining such compounds from placental pulps The placental pulps notably of human origin are separated from the placental blood, which is removed, and the pulps are macerated in a solution at a pH comprised between 5 and 10, e.g. isotonic NaCl solution, preferably at neutral pH, in the presence of a...	09/19/1978
4113816	Process for the manufacture of layered tablets incorporating controlled-release microcapsules The present invention relates to the manufacture of new tablets for administration of medicaments, which tablets contain in their mass, controlled-release microcapsules, that is to say elemental particles coated with a protective covering which contains a...	09/12/1978
4107158	Process for making an octapeptide useful for the treatment of diabetes Process for the preparation of the compound consisting of the peptide chain: leucyl -- seryl -- arginyl -- leucyl -- phenylalanyl -- aspartyl -- asparaginyl -- alanine (I), characterized in that the synthesis is carried out from constituent amino-acids of...	08/15/1978
4106992	Purification of urokinase An initial solution of crude urokinase especially of human origin, is subjected to exclusion chromatography by contact with a DEAE cellulose resin, following adjustment of the pH of the solution to a value of from 4 to 6, and of its conductivity to a valu...	08/15/1978
4055648	Papaverine thienyl-carboxylates and medicaments containing them Novel salts of papaverine are constituted by the thienyl-carboxylates of papaverine notably papaverine thienyl-2-carboxylate. A papaverine thienyl-carboxylate is prepared by reacting papaverine base with the corresponding thiophene carboxylic acid. The me...	10/25/1977
4039382	Immobilized ribonuclease and alkaline phosphatase An insoluble, solid matrix carrying simultaneously several different enzymatic functions, is constituted by the conjoint association by irreversible binding on a previously activated matrix support, of a nuclease selected from the group of ribonucleases A...	08/02/1977
4029767	Pharmaceutical compositions of stable urokinase-heparin complexes and methods for use thereof The present invention relates to pharmaceutical compositions of stable urokinase-heparin complexes, wherein the urokinase is purified, and methods for use thereof....	06/14/1977
4017361	Process for obtaining continuous lines of tumoral cells in vitro Process for obtaining cultures of tumoral cells in vitro, of specifically human origin. The cultures of tumoral cells in vitro are prepared, particularly from human tumoral cells obtained from surgical samples of malignant tumors, by introducing, into the...	04/12/1977
4007266	Pharmaceutical composition containing vitamin B₁₂, process of making the same and method of treatment A pharmaceutical composition for the treatment of disorders in the formation or regeneration of the cutaneous connective tissue including disorders due to aging of the skin, which composition comprises a homogeneous mixture of vitamin B12 in an...	02/08/1977
3996231	1-Quinolinyl-pyrazolidine derivatives The derivatives have the general formula ##STR1## in which X is a hydrogen atom or a methyl, phenyl or benzyl group; Y is a carbon chain comprising 2 to 6 carbon atoms, saturated or unsaturated, unsubstituted or substituted by alkyl, alkoxyl or halog...	12/07/1976

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Assignee: Choay S.A.