Assignee: Chiron Diagnostics Corporation

Location: E.Walpole, MA
No. of patents: 61

Browse patents
Browse applications

Number	Title	Issue Date
6063340	Reagent container for automated analyzer An analyzer for performing automated assay testing. The analyzer includes a storage and conveyor system for conveying cuvettes to an incubation or processing conveyor, a storage and selection system for test sample containers, a storage and selection syst...	05/16/2000
6058934	Planar hematocrit sensor incorporating a seven-electrode conductivity measurement cell A conductivity sensor for measuring hematocrit and a sensor housing for a blood analysis instrument using the conductivity sensor are described. The conductivity sensor includes a seven-electrode conductivity measurement cell in which three symmetric pair...	05/09/2000
5959095	Amplification of midivariant DNA templates New methods are provided for the amplification of a midivariant DNA containing an inserted target specific nucleic acid sequence(s) to enable detection of the presence of a target nucleic acid sequence in a test sample. One method employs midivariant DNA ...	09/28/1999
5911862	Material for establishing solid state contact for ion selective electrodes A polymeric material which to form a stable, reproducible interface between the ionic and electronic domains of an ion selective sensor, or an ion selective field effect transistor, or the like is provided. When employed in an ion selective sensor, the po...	06/15/1999
5897758	Solid contact system for potentiometric sensors An improvement to the coated wire electrode has been accomplished via inclusion of a fortiophore into a sensor device. Sensor devices of the present invention include: an internal reference element; a membrane; and a fortiophore. Fortiophores are neutral ...	04/27/1999
5891730	Method to prepare dye-based reference material Provided is a method of preparing dye-based reference materials useful for calibrating or qualifying instrument systems that are diagnostic spectroscopically for hemoglobin and CO-ox fractions. The dye-based reference materials are non-proteinaceous and m...	04/06/1999
5888835	Method and apparatus for wash, resuspension, recollection and localization of magnetizable particles in assays using magnetic separation technology Method and apparatus for enabling resuspension wash and magnetic localization of sample components bound to particles with magnetic properties in reaction vessels during separation and wash for enhanced chemiluminescent signal generation in biomedical ass...	03/30/1999
5885212	Non-invasive measurement of blood PH Methods and apparatus are provided for non-invasively determining blood pH by a multivariate analysis technique, such as classical least squares (CLS), partial least squares (PLS), or principal components regression (PCR). The technique employs at least o...	03/23/1999
5879894	Long emission wavelength chemiluminescent compounds and their use in test assays An assay method incorporating at least two different chemiluminescent compounds for detection and/or quantitation of at least two substances in a test sample is described. The synthesis of chemiluminescent reagents or conjugates for use in such methods as...	03/09/1999
5863972	Randomly segmented thermoplastic polyurethanes as matrix for electrochemical analysis of Ca⁺⁺ ions Composition, comprising in homogeneous distribution A) at least one salt containing a lipophilic anion, B) a plasticiser-free thermoplastic randomly segmented polyurethane which is soluble in organic solvents, a polyurea or a polyurethane urea, which comp...	01/26/1999
5863460	Oxygen sensing membranes and methods of making same A polymeric sensing membrane having a Stern-Volmer constant within a pre-determined range of Stern-Volmer constants. The membrane includes a polymeric material having a fluorescent dye molecule dispersed therein. The dye molecule is capable of having its ...	01/26/1999
5863742	Inhibition of protease activity of human whole blood cell lysates A method of inhibiting proteolytic degradation of a thermally-stable intracellular protein is described. The method involves adding 1 or more denaturing agents to a sample which contains the protease and the protein of interest and heating the resulting s...	01/26/1999
5841523	Method for performing spectroscopic analysis of inhomogeneous test samples A method is provided for more accurately calculating the concentration of analytes or components in test samples. The method includes the use of an algorithm for analysis, and selection of sets of signal measurements from a spectrophotometer. Sets of sign...	11/24/1998
5837195	Luminometer A luminometer for determining the composition of a specimen sample includes an annular guide path for sample containing cuvettes within a light tight housing. A rotor moves spaced segments through the guide path with the cuvettes positioned between the se...	11/17/1998
5827478	Incubation chamber Method and apparatus for transportation and processing of multiple protocol assays within an automated immunoassay analyzer instrument. The apparatus includes a cuvette ring movably coupled to a magnet ring. In one embodiment, the magnet ring and cuvette ...	10/27/1998
5828445	Method for measuring and reporting co-oximeter quality control results The present invention comprises methods of determining the performance of an absorbance spectrometer, and, in particular, of CO-oximeters. The methods comprise measuring the absorbance spectrum of a quality control sample and comparing it to a standard sp...	10/27/1998
5817527	Conjugation of ligand to immobilized protein in organic solvent A new method for immobilization of small molecules on solid supports via a macromolecular spacer has been developed. A protein or another macromolecule is first immobilized in an aqueous medium, and the solid support is than washed with an organic solvent...	10/06/1998
5817525	Stable protein solutions for diagnostics and method of making and using the same The present invention features stable bulking agents and blocking agents for solid phase materials containing proteins. The proteins have thiol groups which are blocked or chemically inert, preventing the formation of aggregates. Chemical solutions wherei...	10/06/1998
5804049	Material for establishing solid state contact for ion selective electrodes A polymeric material which to form a stable, reproducible interface between the ionic and electronic domains of an ion selective sensor, or an ion selective field effect transistor, or the like is provided. When employed in an ion selective sensor, the po...	09/08/1998
5800994	Hybridization-ligation assays for the detection of specific nucleic acid sequences A new method has been developed for conducting a gene probe assay. The preferred technique involves (1) using a gene amplification technique (e.g., PCR) to multiply the gene sequence of interest and (2) using a hybridization--ligation detection methodolog...	09/01/1998
5788928	Reagent handling system and reagent pack for use therein A reagent pack for keeping fluids with or without suspensions mixed or suspended upon rocking. The reagent pack has at least one chamber divided into separate sub-chambers with a throat region between them defined by baffles for agitation of suspended rea...	08/04/1998
5785830	Electrochemical planar metal/metal oxide electrodes An improved active electrode for use in planar sensors has been discovered, the electrode prepared by a process comprising combining a base component with a metal paste and heating the paste in the presence of air for a time sufficient to oxidize a portio...	07/28/1998
5786153	Prevention of probe coating on automated analyzers using a non-denaturing surfactant A method for substantially preventing coating of hydrophobic material on a probe of an automated analyzer during an assay is described. An automated analyzer having a probe is provided. A composition comprising a non-denaturing surfactant and a reagent fo...	07/28/1998
5783453	Non-separation specific binding chemiluminescent assay The assay described herein is predicated on an observation that when acridinium ester labeled tracers are bound to their corresponding binding conjugate immobilized on a metal oxide solid phase, the measurable chemiluminescent light emission of the labele...	07/21/1998
5780302	Method of packaging oxygen reference solution using flexile package with inside valve A novel flexible package for an oxygen reference solution has been developed. This package is made from a laminated film including preferably polypropylene as the inner layer, aluminum foil as the middle layer, and polyester as the outer layer. The seams ...	07/14/1998
5777221	Volume detection apparatus and method A failsafe apparatus for verifying a volume of aspirated reagent before it is provided to dilute a sample in an automated assay instrument. A pump draws reagent through a tube having a reagent probe disposed at one end. An optical flow detector includes a...	07/07/1998
5776360	Highly disperse magnetic metal oxide particles, processes for their preparation and their use This invention relates to magnetic particles comprising mixed oxides of divalent metals and iron (III), having a diameter of 1-10 nm and a surface area of 120-350 m2 /g, with silanes bound to the surface of said particle. It also relates to (1)...	07/07/1998
5773270	Three-layered membrane for use in an electrochemical sensor system A system for electrochemical measurement of glucose concentration in an undiluted test sample, e.g. blood is provided containing a sensor including a three-layered contiguous membrane. The membrane has a thickness of 50 to 130 microns, and is composed of ...	06/30/1998
5770028	Glucose and lactate sensors A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered t...	06/23/1998
5770176	Assays for functional nuclear receptors Methods and test kits for detecting, or detecting and quantitating functional nuclear receptors in cell or tissue samples are disclosed. Such methods provide highly sensitive assays requiring small sample sizes and short turnaround times. The methods are ...	06/23/1998
5763186	Use of antisense oligomers in a process for controlling contamination in nucleic acid amplification reactions A novel process for the use of antisense oligonucleotides and analogs thereof has been developed. Namely, this technique is useful for the elimination of contamination in the nucleic acid amplification area. Elimination of unwanted contamination has made ...	06/09/1998
5763169	Nucleic acid probes for the detection and identification of fungi Nucleic acid probes and primers are described for detecting fungi that cause disease in humans and animals, as well as spoilage of food and beverages. These probes can detect rRNA, rDNA or polymerase chain reaction products from a majority of fungi in cli...	06/09/1998
5750881	Method and apparatus for aspirating and dispensing sample fluids A method and apparatus for aspirating and dispensing a sample fluid. The apparatus includes an air source having an output port coupled to a first port of a flow through pressure transducer. A second port of the flow through pressure transducer is coupled...	05/12/1998
5750906	Multifunction valve The invention features a sample probe and reagent selector valve that enables selection among multiple functions of withdrawing a biological sample from a syringe or capillary into a fluid parameter sensor module, providing calibration and quality control...	05/12/1998
5741708	Automated analyzer having magnetic isolation device and method using the same An analyzer for performing automated assay testing. The analyzer includes a storage and conveyor system for conveying cuvettes to an incubation or processing conveyor, a storage and selection system for test sample containers, a storage and selection syst...	04/21/1998
5735387	Specimen rack handling system A magnetic conveyor system for transporting test samples in tubes disposed in a sample rack having a magnetic or magnetically attractive region is described. The magnetic conveyor system includes a drive system, a magnet coupled to the drive system and mo...	04/07/1998
5731150	IS6110 based molecular detection of mycobacterium tuberculosis The detection of the IS6110 insertion element in a clinical specimen is a rapid way of diagnosing infection by Mycobacterium tuberculosis. A reliable diagnostic test for tuberculosis based on the IS6110 DNA is described in this disclosure. A "Universal" s...	03/24/1998
5724268	Apparatus and methods for the analytical determination of sample component concentrations that account for experimental error The present invention provides apparatus and methods for determining the concentration of sample components of a sample by an analytical technique that yields a spectrum that can be written as Y(ω)=P(ω).multidot.C. The apparatus and methods of the ...	03/03/1998
5720377	Magnetic conveyor system A magnetic conveyor system for transporting test samples in tubes disposed in a sample rack having a magnetic or magnetically attractive region is described. The magnetic conveyor system includes a drive system, a magnet coupled to the drive system and mo...	02/24/1998
5711868	Electrochemical sensors membrane A solid state, multi-use electrochemical sensor having an electrically nonconductive substrate, a working electrode, and a semi-permeable membrane covering the working electrode. The working electrode includes an electrically conductive material adhered t...	01/27/1998

«First «Previous1 2 Next»Last»

PatentStorm

Quotables

PatentStorm News

Assignee: Chiron Diagnostics Corporation