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| Number | Title | Issue Date |
| 8182464 | Method for intravesical drug delivery Implant devices for intravesical administration and local drug delivery. The device has a body which includes a hollow tube formed of a biocompatible material; at least one reservoir in the tube which contains a drug; and one or more apertures through which the drug... | 05/22/2012 |
| 8168428 | Method to modulate hematopoietic stem cell growth The present invention provides for compositions and methods for modulating hematopoietic stem cell populations by using HCS modulators, which are agents that either increase HSC numbers or decrease HSC numbers as desired by a particular indication. For example, HSC ... | 05/01/2012 |
| 8153585 | Peptide antagonists of vascular endothelial growth factor and methods of use thereof The present invention provides isolated polypeptides having VEGF antagonist activity, pharmaceutical compositions and methods of treatment of subjects having a disease or disorder associated with VEGF activity or subjects having tumors expressing a VEGF receptor. Th... | 04/10/2012 |
| 8142782 | EGFR inhibitors promote axon regeneration Compositions and methods for promoting neural regeneration in a patient determined to have a lesion in a mature CNS neuron are disclosed. The method comprises the step of contacting the neuron with an EGFR inhibitor sufficient to promote regeneration of the neuron. | 03/27/2012 |
| 8137918 | Sperm-specific cation channel, CatSper4, and uses therefor Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper4) are disclosed. The CatSper4 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and an... | 03/20/2012 |
| 8133974 | Ferroportin1 nucleic acids, proteins, antibodies and methods Positional cloning has been carried out to identify the gene responsible for the hypochromic anemia of the zebrafish mutant weissherbst. The gene, ferroportin1, encodes a novel multiple-transmembrane domain protein, expressed in the yolk sac. Zebrafish ferroportin1 ... | 03/13/2012 |
| 8128707 | Bladder reconstruction The invention is directed to methods and devices for the reconstruction, repair, augmentation or replacement of laminarily organized luminal organs or tissue structures in a patient in need of such treatment. The device comprises a biocompatible synthetic or natural... | 03/06/2012 |
| 8110668 | Sperm-specific cation channel, catsper-3 and uses therefor Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper3) are disclosed. The CatSper3 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and an... | 02/07/2012 |
| 8110213 | Method of forming a tissue structure by introducing cells into an implanted matrix Polymeric materials are used to make a pliable, non-toxic, injectable porous template for vascular ingrowth. The pore size, usually between approximately 100 and 300 microns, allows vascular and connective tissue ingrowth throughout approximately 10 to 90% of the ma... | 02/07/2012 |
| 8101412 | Method of enhancing proliferation and/or hematopoietic differentiation of stem cells The present invention provides a method for enhancing the proliferation and/or hematopoietic differentiation and/or maintenance of mammalian stem cells. The method is useful for generating expanded populations of hematopoietic stem cells (HSCs) and thus mature blood... | 01/24/2012 |
| 8092524 | Transcatheter delivery of a replacement heart valve A replacement heart valve apparatus. The heart valve apparatus includes a stent and a valve frame having a substantially cylindrical body defining a lumen. The valve frame includes a plurality of curved wire pairs attached to the substantially cylindrical body. Each... | 01/10/2012 |
| 8088585 | Methods for purifying hematopoietic stem cells Described herein are methods for purifying hematopoietic stem cells. Also described herein are methods for purifying EPCR+ cells. The invention also provides substantially pure isolated hematopoietic stems cells, including EPCR+ hematopoietic stem cells. ... | 01/03/2012 |
| 8080394 | Method for determining predisposition to pulmonary infection Provided herein are methods and materials for diagnosing a subject's predisposition for pulmonary infection in a CF subject by detecting a pulmonary infection genetic marker. Pulmonary infection markers have been identified in the IL-1 gene cluster and may be useful... | 12/20/2011 |
| 8078261 | Light-guided transluminal catheter Generally, the present invention is directed to a light-guided catheter for direct visualization of placement through the skin. An embodiment of the invention includes a method for transcutaneous viewing and guiding of intracorporeal catheters into a body that compr... | 12/13/2011 |
| 8070800 | Transcatheter heart valve prostheses The present teachings relate to a heart valve prosthesis. The heart valve prosthesis includes a docking station (77) having a wire frame defining a lumen and a valve frame (91) for positioning within its lumen. The docking station includes a diaphragm ... | 12/06/2011 |
| 8039488 | Methods and compositions for inhibition of angiogenesis The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as thalidomide precursors, analogs, metabolites and hydrolysis products have been shown to inhibit angiogene... | 10/18/2011 |
| 8021876 | Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof The present invention is directed to pluripotent fetal stem cells derived from chorionic villus, amniotic fluid, and placenta and the methods for isolating, expanding and differentiating these cells, and their therapeutic uses such as manipulating the fetal stem cel... | 09/20/2011 |
| 8012996 | Methods and composition for inhibition of angiogenesis The present invention comprises a group of compounds that effectively inhibit angiogenesis. More specifically, thalidomide and various related compounds such as EM-12 and its derivatives have been shown to inhibit angiogenesis and to treat disease states resulting f... | 09/06/2011 |
| 8003326 | Method for diagnosing autism spectrum disorder The present invention provides methods of diagnosing and/or predicting autism spectrum disorder comprising determining the presence of microdeletions and microduplications on chromosomes 15 and 16. ... | 08/23/2011 |
| 7993905 | Device containing cytophilic islands that adhere cells separated by cytophobic regions The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells... | 08/09/2011 |
| 7993863 | Methods for diagnosis and prognosis of cancer We have discovered a protein in humans, herein referred to as collagen like gene (CLG) product (SEQ ID NOS: 12 and 13), that is expressed in human prostate cancer and breast cancer cell lines but not in normal adult, placenta, lung, liver, skeletal muscle, kidney or... | 08/09/2011 |
| RE42575 | Engineering of strong, pliable tissues It has been discovered that improved yields of engineered tissue following implantation, and engineered tissue having enhanced mechanical strength and flexibility or pliability, can be obtained by implantation, preferably subcutaneously, of a fibrous polymeric matri... | 07/26/2011 |
| 7968336 | Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof The present invention is directed to pluripotent fetal stem cells derived from chorionic villus, amniotic fluid, and placenta and the methods for isolating, expanding and differentiating these cells, and their therapeutic uses such as manipulating the fetal stem cel... | 06/28/2011 |
| RE42479 | Engineering of strong, pliable tissues It has been discovered that improved yields of engineered tissue following implantation, and engineered tissue having enhanced mechanical strength and flexibility or pliability, can be obtained by implantation, preferably subcutaneously, of a fibrous polymeric matri... | 06/21/2011 |
| 7959901 | EGFR inhibitors promote axon regeneration Compositions and methods for promoting neural regeneration in a patient determined to have a lesion in a mature CNS neuron are disclosed. The method comprises the step of contacting the neuron with an EGFR inhibitor sufficient to promote regeneration of the neuron. | 06/14/2011 |
| 7959292 | Vision screener Generally, the present invention relates to medical devices and a method of vision screening, and more particularly to a pediatric vision screening system and method thereof that identifies a risk factor for amblyopia or diagnoses amblyopia by measurement of microst... | 06/14/2011 |
| 7935680 | Methods for modulating the axonal growth of central nervous system neurons Methods for modulating the axonal outgrowth of central nervous system neurons are provided. Methods for stimulating the axonal outgrowth of central nervous system neurons following an injury (e.g., stroke, Traumatic Brain Injury, cerebral aneurism, spinal cord injur... | 05/03/2011 |
| 7914579 | Tissue engineered tendons and ligaments Connective tissue, including neo-tendons and ligaments, has been constructed using biodegradable synthetic scaffolds seeded with tenocytes. The scaffolds are preferably formed from biodegradable fibers formed of a polymer such as polyglycolic acid-polylactic acid co... | 03/29/2011 |
| 7897591 | Method of treating fatty liver disease The present invention relates to a method for treating a fatty liver disease or disorder in a patient in need thereof. The method comprises administering at least one matrix metalloproteinase (“MMP”) inhibitor to the patient. Fatty liver disease or disorders inc... | 03/01/2011 |
| 7846746 | Methods of analysis and labeling of protein-protein interactions We have discovered a new method to analyze and characterize complex cell signaling networks. The method is based on specific binding of protein-protein interaction modules to a single type of protein or a mixture of proteins. The method utilizes a number of differen... | 12/07/2010 |
| 7863295 | Treatments for neuropathy Small fiber neuropathy is treated by topically administering to a subject in need thereof topically active quinoline compounds or pharmaceutically acceptable salts thereof under conditions effective to treat neuropathy in the subject. Glial cell-derived neurotrophic... | 01/04/2011 |
| 7858324 | Cyr61 as a biomarker for diagnosis and prognosis of cancers of epithelial origin Urinary Cyr61 protein levels are up regulated in patients that have cancers of epithelial origin, i.e. breast cancer and ovarian cancer. Accordingly, the present invention is directed to methods for prognostic evaluation, and diagnosis of cancers of epithelial origi... | 12/28/2010 |
| 7838630 | Biologic replacement for fibrin clot The invention provides composition and methods for repairing a ruptured anterior cruciate ligament. ... | 11/23/2010 |
| 7838503 | Methods for extending the replicative lifespan of cells The present invention is directed to methods for enhancing the replicative capacity of cells, by culturing the cells in the presence of an active agent or compound which inhibits SIRT1. One method provides expanding stem cells by culturing the cells in the presence ... | 11/23/2010 |
| 7834884 | Method and apparatus for displaying information A method for displaying large amounts of information. The method includes the steps of forming a spatial layout of tiles each corresponding to a representative reference element; mapping observed elements onto the spatial layout of tiles of representative reference ... | 11/16/2010 |
| 7829281 | Compositions and methods for obesity screening using polymorphisms in NPY2R Methods and constructs are provided that are predictive of a subject's susceptibility to developing a metabolic disorder, such as obesity. The disclosed naturally-occurring SNPs located upstream of the NPY2R gene can be used as targets for the design of diagnostic r... | 11/09/2010 |
| 7811332 | Reconstruction method for urological structures utilizing polymeric matrices A method for repairing defects and reconstructing urological structures in vivo has been developed using a fibrous, open, synthetic, biodegradable polymeric matrix which is configured to provide the desired corrective structure. The matrix is shaped to correct the d... | 10/12/2010 |
| 7807150 | Injectable composition containing crosslinkable material and cells for forming animal tissue Slowly polymerizing polysaccharide hydrogels have been demonstrated to be useful as a means of delivering large numbers of isolated cells via injection. The gels promote engraftment and provide three dimensional templates for new cell growth. The resulting tissue is... | 10/05/2010 |
| 7806937 | Tissue engineered female reproductive organs The invention is directed to compositions and methods for reconstructing artificial female reproductive organs. The constructs and methods of the invention can be used for ameliorating congenital malformations and disorders of female reproductive tract using tissue ... | 10/05/2010 |
| 7790845 | Bacterial ion channel The present invention relates to a functionally expressed bacterial voltage-sensitive ion-selective channel. The novel channel can be used in conjunction with mammalian ion channel pore-containing regions in assays for screening for compounds that modulate activity ... | 09/07/2010 |
