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...that one person who claimed to be the inventor of the television is Russian emigre Vladimir Zworykin? In 1929 David Sarnoff, founder of RCA, asked Zworykin what it would take to develop TV for commercial use. He said: a year and a half and $100,000. In reality, it took 20 years and $50 million! Before his death in 1982 at the age of 92, Zworykin said of his invention: "The technique is wonderful. It is beyond my expectations. But the programs! I would never let my children even come close to this thing."

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Assignee: Children's Hospital of Philadelphia


Location: Philadelphia, PA
No. of patents: 17

NumberTitleIssue Date
7759625Systems and methods for multimodal imaging using a volumetric representation of an object
The invention relates to imaging systems that include a coded aperture detection system and an optical detection system. The coded aperture detection system is configured to detect radiation emitted by a radionuclide present within an object and to provide a first d...
07/20/2010
6531156Aqueous solven encapsulation method, apparatus and microcapsules
The present invention relates to microcapsules comprising a wall and an aqueous core comprising various active agents, and prepared by the interfacial reaction in aqueous medium of Lewis acid and base wall-forming reactants....
03/11/2003
6290968Rotavirus reassortant vaccine
The present invention provides novel rotavirus reassortants, vaccines employing the novel reassortants and methods for their preparation and administration. One such reassortant contains the gene encoding the v.p.7 neutralization antigen of a human rotavi...
09/18/2001
6093392Methods and compositions for use in gene therapy for treatment of hemophilia
The invention includes a composition comprising a recombinant adeno-associated viral vector comprising at least two adeno-associated virus inverted terminal repeats, a promoter/regulatory sequence, isolated DNA encoding Factor IX and accompanying 5' and 3...
07/25/2000
6077083Doll for instruction of sickle cell disease clinical observations
A medical teaching doll is provided with devices for simulating the differences between normal organs, and organs which are physically altered by sickle cell or other disease. The devices simulate the normal and diseased conditions so that the differences...
06/20/2000
5985547Detection of a mutation in the HLA-DMଲ gene in an immunocompromised patient
The identification of a mutation in the HLA-DMB locus in antigen presenting cells defective in presenting antigen is described. Methods of diagnosis and treatment of immunocompromised individuals and compositions and methods of treatment for patients suff...
11/16/1999
5948681Non-viral vehicles for use in gene transfer
The invention relates to a compositions and methods for transfection of cells, particularly airway epithelial cells, with DNA complexed to polylysine substituted with glycosyl residues. The invention also relates to methods of treating humans having respi...
09/07/1999
5935783Genes mapping in the digeorge and velocardiofacial syndrome minimal critical region
Transcription units encoded in the minimal DGS/VCFS critical region, primer pairs effective for amplifying said transcripts in a genomic DNA sample for the preparation of probes for detecting genetic deletions/mutations in the minimal DGS/VCFS critical re...
08/10/1999
5756105Opacity associated proteins, DNA encoding the same, and methods of use thereof
Opacity associated proteins and DNA encoding the same are provided by the present invention. Opacity associated proteins are membrane proteins of H. influenzae which are useful as immunogens in vaccines against infection by H. influenzae. Recombinant cell...
05/26/1998
5714666Measurement of intracellular calcium using bioluminescent apoaequorin expressed in mammalian cells
Mammalian cells which express apoaequorin and a receptor involved in the modulation of intracellular calcium are provided by the present invention. Transgenic mice in which neuronal cells express aequorin are also provided. Methods of use are provided....
02/03/1998
5676945Human leucine-zipper protein kinase and methods of use
A novel protein kinase, leucine-zipper protein kinase, 668 amino acids in length is provided by the present invention. This protein kinase is localized to the human brain. Nucleic acid sequences encoding the protein kinase are also provided....
10/14/1997
5650278Compositions and diagnostic kits for identifying alveolar rhabdomyosarcoma
Methods of determining whether a tumor is an alveolar rhabdomyosarcoma tumor by detecting the presence of a DNA sequence of a chimeric gene that is generated by translocation of a portion of human chromosome 2 and a portion of human chromosome 13 are disc...
07/22/1997
5601820Compositions and methods of making and using human full length TRK-B
The amino acid sequence of the full length version of the human neurotrophic factor receptor TRK B and a nucleotide sequence encoding it are disclosed. Transformed host cells and transgenic animals containing nucleic acid molecules encoding full length hu...
02/11/1997
5554523Nucleic acid sequences encoding human leucine-zipper protein-kinase
A novel protein kinase, leucine-zipper protein kinase, 668 amino acids in length is provided by the present invention. This protein kinase is localized to the human brain. Nucleic acid sequences encoding the protein kinase are also provided....
09/10/1996
5472944Suppression of megakaryocytopoiesis by neutrophil activating peptide-2
Neutrophil activating peptide-2 or analog thereof is administered to a mammal to achieve therapeutic reduction of the number of circulating platelets. The peptide is useful in treating essential thrombocythemia and reactive thrombocytosis....
12/05/1995
5449609Methods for screening for neurotoxicity using a clonal human teratocarcinoma cell line
Methods for screening for excitotoxic effects of an agent on neurons of the central nervous system are provided by the present invention....
09/12/1995
5304496Biological regulation of mineralization
An aspartic acid rich protein isolated from human urine, as well as proteins having substantial homology thereto and active portions of the foregoing are effective modulators of mineralization in mammals. These proteins and peptides are useful as therapeu...
04/19/1994
 
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