Assignee: Children's Hospital & Research Center at Oakland

Location: Oakland, CA
No. of patents: 28

Number	Title	Issue Date
8138158	Compositions and methods for therapy for diseases characterized by defective chloride transport Compositions and methods for therapy of cystic fibrosis, asthma, and other conditions characterized by defective chloride transport are provided. The compositions comprise one or more compounds such as flavones and/or isoflavones, ascorbate and/or derivatives thereo...	03/20/2012
8137977	Lipidomic approaches to determining drug response phenotypes in cardiovascular disease The present invention concerns the application of lipidomics to statin treatment for disorders such as cardiovascular disorders. Hence, the invention provides, among other things, a method of correlating a lipid profile with a positive or negative response to a stat...	03/20/2012
8124111	Immunomodulation by altering sphingosine 1-phosphate lyase (SPL) activity Compositions and methods for modulating immune function are provided based on the unexpected discovery that inhibition of sphingosine-1-phosphate lyase (SPL) activity confers useful immunosuppressive effects, for example to modulate immune function in treatment or p...	02/28/2012
7973143	Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicte...	07/05/2011
7964587	Tocopherol and tocotrienol aerosols Anti-inflammatory compositions include medicaments comprising predetermined amounts of a phytyl substituted chromanol and a prostaglandin E2 inhibitor, wherein: said medicament is in unit dosage form suitable for pharmaceutical administration; said phytyl...	06/21/2011
7964200	Methods and compositions for immunizing against infection The present invention relates, in part, to methods and compositions for immunizing against infection by Chlamydia trachomatis. The methods and compositions rely, in part, on administering an immunogenic composition comprising one or more peptides derived from...	06/21/2011
7935345	Monoclonal antibodies that specifically bind to and neutralize toxin, compositions, and methods of use The invention features compositions relating to antibodies that specifically bind to the protective antigen of Bacillus anthracis, fragments thereof, and nucleic acids encoding same. The invention further features methods of using such compositions. ...	05/03/2011
7919279	Methods and compositions for KIR genotyping The present invention provides methods for single nucleotide polymorphism (SNP)-based killer cell immunoglobulin-like receptor (KIR) gene cluster genotyping using the matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometer. In genera...	04/05/2011
7906499	Polycarboxylated porphyrins and use thereof in treatment of metal toxicities Metal binding polycarboxylated porphyrins, their precursors, or cofactors in the porphyrin biosynthetic pathway, are administered to individuals determined to be subject to or predisposed to a polycarboxylated porphyrin-binding metal toxicity to increase the level o...	03/15/2011
7893024	Enhancement of iron chelation therapy The present invention provides methods of enhancing the rate of iron release from ferritin. By increasing the amount of iron available for chelation, the invention also provides methods of treating conditions associated with iron overload. The invention also provide...	02/22/2011
7811765	Methods and compositions for determining predisposition to inflammation-mediated cardiovascular disease The present invention provides methods and compositions for detecting a predisposition to an inflammation-mediated cardiovascular disease in a human subject by detecting a level of leukotriene C4 synthase (LTC4S) gene product in a sample from a human subject indicat...	10/12/2010
7718694	Compositions and methods for therapy for diseases characterized by defective chloride transport Compositions and methods for therapy of cystic fibrosis, asthma, and other conditions characterized by defective chloride transport are provided. The compositions comprise one or more compounds such as flavones and/or isoflavones, ascorbate and/or derivatives thereo...	05/18/2010
7674580	Compositions and methods for the modulation of sphingolipid metabolism and/or signaling Compositions, methods and kits for diagnosing and treating cancer and muscular disorders are provided. Therapeutic compositions may comprise agents that modulate sphingolipid metabolism and/or signaling pathways. Such compositions may be administered to a mammal aff...	03/09/2010
7651846	Treatment and diagnosis of conditions associated with elevated arginase activity The invention features methods and compositions for diagnosis and treatment of conditions associated with decreased nitric oxide bioavailability, such as a condition associated with elevated arginase activity, using an arginine- and/or arginase-inhibitor based thera...	01/26/2010
7648840	Diagnosis of conditions associated with decreased arginine bioavailability The invention features methods and compositions for diagnosis, including prognosis, of conditions associated with decreased arginine bioavailability (which can result from dysregulated arginine metabolism, e.g., due to increased arginase activity) by assessing in a ...	01/19/2010
7527978	Flow cytometry based micronucleus assays and kits The invention is a method for analyzing immature reticulocytes for the presence of micronuclei. The method includes reticulocyte enrichment, fluorescent labeling, micronuclei staining, and analysis using single-laser flow cytometry. The invention also includes kits ...	05/05/2009
7449293	Methods and compositions for detecting species The invention provides methods and compositions for rapid, sensitive, and highly specific nucleic acid-based detection of B. anthracis in a sample. In general, the methods involve detecting within the sspE gene of B. anthracis the presence of a fragmen...	11/11/2008
7399784	Tocopherol and tocotrienol anti-obesity medicaments Anti-obesity compositions include medicaments comprising predetermined amounts of a phytyl substituted chromanol and an obesity-promoting drug, wherein: said medicament is in unit dosage form suitable for pharmaceutical administration; said phytyl substituted chroma...	07/15/2008
7335683	Compositions and methods for cystic fibrosis therapy Compositions and methods for therapy of cystic fibrosis and other conditions are provided. The compositions comprise one or more compounds such as flavones and/or isoflavones capable of stimulating chloride transport in epithelial tissues. Therapeutic methods involv...	02/26/2008
7285396	Aβ-heme peroxidase Aβ-heme peroxidase activity is selectively measured and inhibited, packaged as a pharmaceutical composition with heme biosynthetic cofactors or as an industrial enzyme, and used to oxidize target substrates. ...	10/23/2007
7262044	Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicte...	08/28/2007
7192779	Diagnosis of Smith-Lemli-Optiz syndrome The invention provides a non-invasive assay for the detection of a SLOS affected individual by determining the ratio of at least one of the specific SLOS steroid analytes, dehydro-estriol (8-DHE3) and a dehydro-pregnanetriol (7-DHPT) to their normal steroid counterp...	03/20/2007
7160855	Enhancement of iron chelation therapy The present invention provides methods of enhancing the rate of iron release from ferritin. By increasing the amount of iron available for chelation, the invention also provides methods of treating conditions associated with iron overload. The invention also provide...	01/09/2007
7105637	Dehydro-estriol (8-DHE3) and dehydro-pregnanetriol (7-DHPT), methods of their synthesis The invention provides isolated dehydro-estriol (8-DHE3) and dehydro-pregnanetriol (7-DHPT), and methods of their synthesis. These compounds are useful in diagnosis of Smith-Lemli-Optiz syndrome (SLOS). ...	09/12/2006
7041291	Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicte...	05/09/2006
6936261	Vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis The present invention generally provides methods and vaccines for the prevention of diseases caused by Neisseria meningitidis bacteria, particularly serogroup B strains. ...	08/30/2005
6830881	Sphingosine-1-phosphate lyase polypeptides, polynucleotides and modulating agents and methods of use therefor Compositions, methods and kits for diagnosing and treating cancer are provided. Therapeutic compositions may comprise agents that modulate the expression or activity of a sphingosine-1-phosphate lyase (SPL). Such compositions may be administered to a mammal afflicte...	12/14/2004
6808932	Diagnosis of Smith-Lemli-Optiz syndrome The invention provides a non-invasive assay for the detection of a SLOS affected individual by determining the ratio of at least one of the specific SLOS steroid analytes, dehydro-estriol (8-DHE3) and a dehydro-pregnanetriol (7-DHPT) to their normal steroid counterp...	10/26/2004

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Assignee: Children's Hospital & Research Center at Oakland