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| Number | Title | Issue Date |
| 8158957 | System and method for structured illumination and collection for improved optical confocality of raman fiber array spectral translator imaging and interactive raman probing The disclosure relates generally to methods and apparatus for using telescope optics and a fiber array spectral translator-based (“FAST”) spectroscopic system for improved imaging, spectral analysis, and interactive probing of a sample. In an embodiment, the con... | 04/17/2012 |
| 8098373 | Spatially and spectrally parallelized fiber array spectral translator system and method of use System and method for spatially and spectrally parallelized FAST. A sample is illuminated to thereby produce interacted photons. The photons are passed through a filter and received at a two-dimensional end of a FAST device wherein said FAST device comprises a two-d... | 01/17/2012 |
| 8094294 | Multipoint method for identifying hazardous agents The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multipoint spectral analysis of the sample. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and... | 01/10/2012 |
| 8078268 | System and method of chemical imaging using pulsed laser excitation and time-gated detection to determine tissue margins during surgery System and method for differentiating tissue margins in a biological sample using pulsed laser excitation and time-gated detection. A region containing a biological tissue is irradiated with substantially monochromatic pulsed laser light to thereby produce Raman sca... | 12/13/2011 |
| 8068222 | Method and apparatus for microlens array/fiber optic imaging A novel approach for chemical imaging is disclosed. In one embodiment, the disclosure relates to a system for producing a spatially accurate wavelength-resolved image of a sample from photons scattered from the sample, comprising an optical lens; a first optical fib... | 11/29/2011 |
| 8054454 | Time and space resolved standoff hyperspectral IED explosives LIDAR detector A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system direc... | 11/08/2011 |
| 8013991 | Raman difference spectra based disease classification A method to diagnosis a disease state of an unknown sample. A test Raman data set for an unknown sample is generated. A reference Raman database is provided where the database contains a plurality of reference Raman data sets and a plurality of reference Raman diffe... | 09/06/2011 |
| 7999928 | Method and system for combined Raman and LIBS detection In one embodiment, the disclosure relates to a method for interrogating a sample by: illuminating a first region of the sample with a first illumination pattern to obtain a plurality of first sample photons; illuminating a second region of the sample with a second i... | 08/16/2011 |
| 7990533 | System and method for analyzing biological samples using Raman molecular imaging A system and method for determining at least one of: a disease state, a metabolic state, a clinical outcome, and a disease progression of a test renal or prostate sample. A test Raman data set is obtained from the sample wherein said test Raman data set may comprise... | 08/02/2011 |
| 7990532 | Method and apparatus for multimodal detection System and method for assessing the occurrence of an unknown substance in a sample that comprises multiple entities. A reference library is provided comprising a plurality of reference data sets representative of at least one known substance. A first feature of the ... | 08/02/2011 |
| 7956996 | Distinguishing between invasive ductal carcinoma and invasive lobular carcinoma using raman molecular imaging A system and method to provide a diagnosis of the breast disease state of a test breast sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known breast sample and an associated kno... | 06/07/2011 |
| 7956991 | Method and apparatus for interactive hyperspectral image subtraction A method and apparatus of obtaining a spectral image of a plurality of predetermined chemical species. A sample is illuminated to produce photons. These photons are collected to produce a plurality of images for each predetermined chemical species, wherein each imag... | 06/07/2011 |
| 7945393 | Detection of pathogenic microorganisms using fused sensor data A system and method to search spectral databases to identify unknown materials, specifically pathogenic microorganisms. A library is provided, having sublibraries containing reference data sets of known materials and test data sets, both generated by at least one sp... | 05/17/2011 |
| 7933430 | Method and apparatus for spectral mixture resolution The spectral method for determining the concentrations of a substance in a mixture of any number of substances is defined by a chemical image having a plurality of pixels (520). The method includes steps of providing a spectrum for each of the n number of sub... | 04/26/2011 |
| 7848000 | Birefringent spectral filter with wide field of view and associated communications method and apparatus A spectral filter is adapted for use in a receiver, for example in a short range submarine laser signal path, wherein the relative orientations of the receiver is such that the signal may appear diffusely or at an unknown point in a wide external field of view aroun... | 12/07/2010 |
| 7815117 | Method and apparatus for counterfeiting protection The disclosure relates generally to methods and apparatus for protecting against counterfeit products and for methods and apparatus for providing counterfeiting protection for an object. In one embodiment, the method includes the steps of: (a) accessing an object in... | 10/19/2010 |
| 7808634 | Method and apparatus for automated spectral calibration A method and apparatus for automated spectral calibration of a spectroscopy device. In one embodiment, the disclosure relates to a method for simultaneous calibration and spectral imaging of a sample by: simultaneously illuminating the sample and a calibrant with a ... | 10/05/2010 |
| 7808633 | Spectroscopic system and method for predicting outcome of disease A system and method to predict the progression of disease of a test sample. A group of known biological samples is provided. Each known biological sample has an associated known outcome including a non-diseased sample or a diseased sample. A Raman data set is obtain... | 10/05/2010 |
| 7764371 | System and method for super resolution of a sample in a fiber array spectral translator system The disclosure relates generally to methods and apparatus for obtaining a super resolution image of a sample using a fiber array spectral translator system. In one embodiment includes collecting photons from a sample at a first end of a fiber array spectral translat... | 07/27/2010 |
| 7760353 | Spectral imaging of biofilms A spectroscopic method and system to identify a biofilm of a microorganism. A sample containing a sample microorganism is irradiated with substantially monochromatic radiation. A Raman data set is obtained based on radiation scattered from the irradiated sample. A d... | 07/20/2010 |
| 7757952 | Method and apparatus for counterfeiting protection The disclosure relates generally to methods and apparatus for protecting against counterfeit products and for methods and apparatus for providing counterfeiting protection for an object. In one embodiment, the method includes the steps of: (a) accessing an object in... | 07/20/2010 |
| 7755757 | Distinguishing between renal oncocytoma and chromophobe renal cell carcinoma using raman molecular imaging A system and method to provide a diagnosis of the renal disease state of a test renal sample. A database containing a plurality of reference Raman data sets is provided where each reference Raman data set has an associated known renal sample and an associated known ... | 07/13/2010 |
| 7755756 | Raman spectral analysis of pathogens A method of assessing occurrence of a plant pathogen in a sample. The method comprises irradiating the sample and assessing radiation scattered from the sample for radiation that exhibits a Raman scattering characteristic of the pathogen. Detection of scattered radi... | 07/13/2010 |
| 7738095 | Method and apparatus for compact spectrometer for detecting hazardous agents The disclosure relates to a portable system for obtaining a spatially accurate wavelength-resolved image of a sample having a first and a second spatial dimension that can be used for the detection of hazardous agents by irradiating a sample with light, forming an i... | 06/15/2010 |
| 7705981 | Method and apparatus for super montage large area spectroscopic imaging The disclosure relates to Method and Apparatus for Super Montage Large area Spectroscopic Imaging. In one embodiment of the disclosure, a method for producing a spectroscopic image of an object includes the steps of (a) irradiating the object with light to thereby p... | 04/27/2010 |
| 7701573 | Method for correlating spectroscopic measurements with digital images of contrast enhanced tissue A system and method of correlating Raman measurements with digital images of a sample so as to classify the sample's disease state. A spectroscopic data set is obtained for the sample positioned in the field of view of a spectroscopic device. With the sample removed... | 04/20/2010 |
| 7701572 | System and method for chemical imaging of microarrays The disclosure relates to systems and method for chemical imaging of microarrays. In one embodiment, the disclosure relates to a system for simultaneous spectral imaging of a plurality of samples arranged on an array. The system includes an illumination source for p... | 04/20/2010 |
| 7692775 | Time and space resolved standoff hyperspectral IED explosives LIDAR detection A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system direc... | 04/06/2010 |
| 7679740 | Method and apparatus for multimodal detection Methods for detecting and classifying an unknown substance in a sample include the steps of (a) providing a spectrum for each of a predetermined number of reference substances; (b) detecting an area of interest that contains the unknown substance; (c) targeting the ... | 03/16/2010 |
| 7659978 | Photobleaching by high power pulses A pulse photobleaching methodology wherein a monochromatic illumination (e.g., laser illumination) having a higher power intensity (photobleaching power) just below the photodamage threshold of a luminescent sample is initially used to significantly attenuate sample... | 02/09/2010 |
| 7649618 | System and method to perform raman imaging without luminescence A system and method for collecting Raman data sets without the “contaminating” effect of luminescence emitted photons. Using a frame transfer CCD for time resolved data collection, Raman imaging may be performed without photobleaching the sample. The system may ... | 01/19/2010 |
| 7629591 | System and method for structured illumination and collection for improved optical confocality of raman fiber array spectral translator imaging and interactive raman probing The disclosure relates generally to methods and apparatus for using a fiber array spectral translator-based (“FAST”) spectroscopic system for improved imaging, spectral analysis, and interactive probing of a sample. In an embodiment, the confocality of a fiber a... | 12/08/2009 |
| 7626696 | Method and apparatus for reconfigurable field of view in a FAST-based imaging system A system and method to obtain a variable field of view (FOV) of a sample without requiring an increase in an imaging CCD array size. In a fiber array spectral translator (FAST) based chemical imaging system, the fibers in the fiber bundle may be organized in differe... | 12/01/2009 |
| 7623232 | Raman spectral analysis of pathogens A method of ablating a viable biological pathogen in a sample. A viable biological pathogen in a portion of the sample is identified by irradiating the sample; assessing radiation scattered from the sample for radiation that exhibits a Raman shift characteristic of ... | 11/24/2009 |
| 7609370 | Single detector based dual excitation wavelength spectra display A single detector based spectroscopy system using FAST (fiber array spectral translator) fibers and two excitation sources in conjunction with a holographic spectrum analyzer (HSA) to obtain simultaneous and selective display of spectroscopic regions of interest. A ... | 10/27/2009 |
| 7596404 | Method of chemical imaging to determine tissue margins during surgery A method and system to differentiate a tissue margins during various medical procedures. A region containing a biological tissue is irradiated, with a substantially monochromatic light. Raman spectroscopic data is obtained from the irradiated region. A boundary betw... | 09/29/2009 |
| 7595878 | Spectroscopic methods for component particle analysis The invention relates to methods of assessing one or more geometric properties of a particle of a substance using an infrared spectroscopic property of the substance. The method is useful, for example, for assessing particle sizes and size distributions in mixtures ... | 09/29/2009 |
| 7570356 | System and method for classifying cells and the pharmaceutical treatment of such cells using Raman spectroscopy A system and method to distinguish normal cells from apoptotic cells. A pre-determined vector space is selected where the vector space mathematically describes a first plurality of reference Raman data sets for normal cells and a second plurality of reference Raman ... | 08/04/2009 |
| 7564546 | Dynamic imaging of biological cells and other subjects The invention relates to methods of dynamic chemical imaging, including methods of cellular imaging. The method comprises illuminating at least a portion of a cell with substantially monochromatic light and assessing Raman-shifted light scattered from the illuminate... | 07/21/2009 |
| 7561264 | System and method for the coincident deposition, detection and identification of threat agents A system and method for depositing a sample of a threat agent is deposited onto a substrate. The threat agent is identified substantially coincident in time with the depositing of the sample of the threat agent onto the substrate. ... | 07/14/2009 |
