Assignee: Cerus Corporation

Location: Concord, CA
No. of patents: 56

Number	Title	Issue Date
7655392	Quenching methods for red blood cell inactivation process Methods are provided for improved quenching of undesired side reactions upon treating a red blood cell composition with a pathogen inactivating compound comprising a nucleic acid binding ligand and a functional group which is, or which is capable of forming, an elec...	02/02/2010
7611831	Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly po...	11/03/2009
7459695	Apparatus, and systems for processing and treating a biological fluid with light Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid tre...	12/02/2008
7445756	Fluid processing sets and organizers for the same Apparatus, systems and methods are disclosed for treating a biological fluid with light. A disposable fluid processing set including integrally connected containers and tubing and a holder or organizer for receiving at least some of the containers and tubing are dis...	11/04/2008
7433030	Apparatus, systems and methods for processing and treating a biological fluid with light Apparatus (10), systems and methods are disclosed for treating a biological fluid with light. A container (206) of biological fluid is introduced into a fluid treatment chamber (40) where it is contacted with light provided by one or more light ...	10/07/2008
7425304	Processing set and methods for processing and treating a biological fluid Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid tre...	09/16/2008
7293985	Methods for quenching pathogen inactivators in biological materials Methods are provided for quenching undesired side reactions of pathogen inactivating compounds in biological materials comprising red blood cells. In a particular embodiment, methods are provided for quenching undesired side reactions of a pathogen inactivating comp...	11/13/2007
7105093	Processing set and methods for processing and treating a biological fluid Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid tre...	09/12/2006
7068361	Apparatus, systems and methods for processing and treating a biological fluid with light Apparatus (10), systems and methods are disclosed for treating a biological fluid with light. A container (206) of biological fluid is introduced into a fluid treatment chamber (40) where it is contacted with light provided by one or more light ...	06/27/2006
7037642	Removing compounds from blood products with porous particles immobilized in a matrix Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition containing cells while substantially maintaining a desired biological activity of the biological composition. The device comprises highly po...	05/02/2006
7025877	Processing set for processing and treating a biological fluid Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to the fluid tre...	04/11/2006
6951713	Absorbing pathogen-inactivating compounds with porous particles immobilized in a matrix Methods and devices are provided for reducing the concentration of low molecular weight compounds in a biological composition, while substantially maintaining a desired biological activity of the biological composition. The device comprises highly porous adsorbent p...	10/04/2005
6949753	Device and method for photoactivation Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Contaminants in blood cell preparations are inactivated prior to long term storage and transfusion. Inact...	09/27/2005
6866992	Synthetic platelet storage media formulation Synthetic platelet storage media is disclosed for use with blood preparations intended for in vivo use. The synthetic platelet storage media is prepared by providing sodium chloride, sodium citrate, sodium acetate and sodium phosphate, and formulating in water 45-12...	03/15/2005
6709810	Methods for quenching pathogen inactivators in biological materials Methods are provided for quenching undesired side reactions of pathogen inactivating compounds in biological materials. In a particular embodiment, methods are provided for quenching undesired side reactions of a pathogen inactivating compound that includes a functi...	03/23/2004
6686480	Compounds for the photodecontamination of pathogens in blood Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in ...	02/03/2004
6680025	Device and method for photoactivation A device containing a light source, a sample support and a temperature control compartment. The sample support is positioned to support multiple sample vessels for irradiation by the light source. The temperature control compartment maintains the temperat...	01/20/2004
6586749	Device and method for photoactivation Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Contaminants in blood cell preparations are inactivated prior to long term storage and transfu...	07/01/2003
6565802	Apparatus, systems and methods for processing and treating a biological fluid with light Apparatus, systems and methods are disclosed for treating a biological fluid with light. A container of biological fluid is introduced into a fluid treatment chamber where it is contacted with light provided by one or more light sources in proximity to th...	05/20/2003
6566046	Synthetic media for blood components Synthetic media formulations are disclosed for use with blood preparations intended for in vivo use, including synthetic media formulations to be employed in conjunction with the photodecontamination of platelets....	05/20/2003
6544727	Methods and devices for the removal of psoralens from blood products Methods and devices for the removal of psoralens and psoralen photoproducts from blood products are described. The methods include contacting a psoralen- and irradiation-treated blood product with a resin capable of adsorbing psoralens and psoralen photop...	04/08/2003
6514987	Frangible compounds for pathogen inactivation Compounds and methods for inactivating pathogens in materials are described, including compositions and methods for inactivating pathogens in biological materials such as red blood cell preparations and plasma. The compounds and methods may be used to tre...	02/04/2003
6503699	Method for photodecontamination of pathogens in blood using 5'-primary aminopsoralens Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in ...	01/07/2003
6469052	Compounds for the photodecontamination of pathogens in blood The present invention includes compositions comprising new psoralens with either a 4 ', or 5 'primary amino substituent and a blood product that is suitable for in vivo use. The compositions are useful for the inactivation of pathogens in blood products s...	10/22/2002
6461567	Device and method for photoactivation A device comprising a light source, a sample holder and a temperature control chamber. The sample holder supports the vessels in a fixed relationship relative to the light source. The temperature control chamber surrounds the sample holder and vessels, so...	10/08/2002
6455286	Psoralens for pathogen inactivation Psoralen compound compositions are synthesized which have primaryamino substitutions on the 3-, 4-, 5-, and 8-positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these psoralens re...	09/24/2002
6433343	Device and method for photoactivation Methods and compositions are described for treating contaminants in material intended for in vivo use, and in particular blood and blood products for human use. Contaminants in blood cell preparations are inactivated prior to long term storage and transfu...	08/13/2002
6420570	Psoralen compounds Psoralen compound compositions are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these bound psoralens result in ...	07/16/2002
6410219	Treating blood or blood products with compounds which have a mustard, azirdinium or aziridine group and a nucleic acid binding group Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques...	06/25/2002
6281225	Inhibiting proliferation of arterial smooth muscle cells The present invention provides methods for inhibiting restenosis at a site of vascular recanalization. The methods include intravascular administration of a reactive acridine compound to the site of injury, without the requirement for activation or sustai...	08/28/2001
6270952	Methods for quenching pathogen inactivators in biological materials Methods are provided for quenching undesired side reactions of pathogen inactivating compounds in biological materials. In a particular embodiment, methods are provided for quenching undesired side reactions of a pathogen inactivating compound that includ...	08/07/2001
6258319	Device and method for photoactivation A device comprising a light source, a sample holder and a temperature control chamber. The sample holder supports the vessels in a fixed relationship relative to the light source. The temperature control chamber surrounds the sample holder and vessels, so...	07/10/2001
6218100	5'-primary aminoalkyl psoralen compositions with platelets Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in sa...	04/17/2001
6194139	Methods for photodecontamination of pathogens in blood Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in sa...	02/27/2001
6177441	Treating red blood cell solutions with anti-viral agents Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques...	01/23/2001
6171777	Treating blood or blood product with a compound having a mustard and a nucleic acid binding moiety Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques...	01/09/2001
6143490	Treating blood or blood product with a compound having a mustard and a nucleic acid binding moiety Methods and compositions for treating pathogens in material are described, including methods of decontaminating human fluids prior to processing in the clinical laboratory and methods for decontaminating blood products prior to in vivo use. The techniques...	11/07/2000
6133460	Psoralens for pathogen inactivation Psoralen compound compositions are synthesized which have primaryamino substitutions on the 3-, 4-, 5-, and 8- positions of the psoralen, which yet permit their binding to nucleic acid of pathogens. Reaction conditions that photoactivate these psoralens r...	10/17/2000
6093725	Frangible compounds for pathogen inactivation Compounds and methods for inactivating pathogens in materials are described, including compositions and methods for inactivating pathogens in biological materials such as red blood cell preparations and plasma. The compounds and methods may be used to tre...	07/25/2000
6017691	4'-primary aminopsoralen and platelet compositions Psoralen compounds are synthesized which have substitutions on the 4, 4', 5', and 8 positions of the psoralen, which permit enhanced binding to nucleic acid of pathogens. Higher psoralen binding levels and lower mutagenicity are described, resulting in sa...	01/25/2000

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Assignee: Cerus Corporation