Did You Know...
...that one person who claimed to be the inventor of the television is Russian emigre Vladimir Zworykin? In 1929 David Sarnoff, founder of RCA, asked Zworykin what it would take to develop TV for commercial use. He said: a year and a half and $100,000. In reality, it took 20 years and $50 million! Before his death in 1982 at the age of 92, Zworykin said of his invention: "The technique is wonderful. It is beyond my expectations. But the programs! I would never let my children even come close to this thing."
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| Number | Title | Issue Date |
| 6515021 | Bicyclic aromatic compounds The invention relates to novel bicyclic aromatic compounds which have the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumati... | 02/04/2003 |
| 6506796 | Use of a RAR-γ-specific agonist ligand for increasing the rate of apoptosis Methods of cosmetically or therapeutically treating diseases or disorders in cell populations whose pathology is linked to an inadequate rate of apoptosis by administering a therapeutically effective amount of 6-3-(1-adamantyl)-4-hydroxyphenyl)-2-naphthan... | 01/14/2003 |
| 6326510 | Bi-aromatic compounds, compositions containing them and uses The invention relates to novel biaromatic compounds having general formula I ##STR1## and their use in pharmaceutical compositions for use in human and veterinary medicine, in particular for treating dermatological, rheumatic, respiratory, cardiovasc... | 12/04/2001 |
| 6258775 | Bi-aromatic compounds, pharmaceutical and cosmetic compositions containing same and uses The invention relates to novel biaromatic compounds having general formula I ##STR1## and their use in pharmaceutical compositions for use in human and veterinary medicine, in particular for treating dermatological, rheumatic, respiratory, cardiovasc... | 07/10/2001 |
| 6248749 | Use of inhibitors of the activity of retinoic acid for treating sensit ive skin and/or acute damage induced by UV radiation The invention concerns tye use of a inhibitor of retinoic acid as sole ingredient in a pharmaceutical or cosmetic composition comprising administering effective amount of the composition to treat sensitive skin or skin damage induced by UV radiation.... | 06/19/2001 |
| 6248791 | Stimulating the differentiation of preadipocytic cells and therapies based thereon The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II diabetes and cardiovascular disorders such as hypertension and ... | 06/19/2001 |
| 6225328 | Adamantyl-substituted retinoids and pharmaceutical/cosmetic compositions comprised thereof Pharmaceutically/cosmetically-active adamantyl-substituted retinoid compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(d): ##STR2## and are useful for the treatment of disorders and/or ailments mani... | 05/01/2001 |
| 6211239 | Method for treating or preventing breast cancer or leukemia using 6-[3-[1-adamantyl]-4-hydroxyphenyl]-2-naphthalene carboxylic acid (AHPN) Methods for treating or preventing breast cancer or leukemia in subjects in need of such treatment are provided which involve the administration of 6-[3-[1-adamantyl]-4-hydroxyphenyl]-2-naphthalene carboxylic acid (AHPN), a retinoid which induces G0 | 04/03/2001 |
| 6194450 | Polyaromatic heterocyclic compounds and pharmaceutical compositions comprised thereof Novel pharmaceutically/cosmetically-active polyaromatic heterocyclic compounds have the structural formula (I): ##STR1## in which Z is a divalent radical selected from among --O--, --S-- or --Nr'-- and Ar is either a radical having the following structura... | 02/27/2001 |
| 6171603 | Bioaromatic amido compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active biaromatic amido compounds have the structural formula (I): ##STR1## in which Ar is a radical selected from among those of the following formulae (a)-(e): ##STR2## and are useful for the treatment of a wide ... | 01/09/2001 |
| 6162815 | RXR-agonist polycyclic aromatic compounds, pharmaceutical/cosmetic compositions comprising said compound and uses thereof Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds having the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## which are useful for the treatment of a wide variety of dis... | 12/19/2000 |
| 6162445 | Polyaromatic propynyl compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polyaromatic propynyl compounds have the structural formula (I): in which X is one of the radicals: ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary,... | 12/19/2000 |
| 6156750 | Bioactive bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic,... | 12/05/2000 |
| 6156788 | Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease... | 12/05/2000 |
| 6147255 | Bicyclic-aromatic compounds The invention relates to novel bicyclic aromatic compounds which have the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rhe... | 11/14/2000 |
| 6106848 | Topically applicable O/W emulsions having high glycol content and at least one biologically active agent Stable, topically applicable oil-in-water bioaffecting emulsions having intermediate viscosity, characteristically ranging from 3 to 10 Pa.multidot.s, comprise (a) from 30% to 50% by weight of at least one pro-penetrating glycol, (b) at least one emulsify... | 08/22/2000 |
| 6086580 | Laser treatment/ablation of skin tissue Mammalian skin is treated and advantageously smoothed, for example to remove wrinkles, lines, warts and scars therefrom, by topically applying thereto a composition which comprises at least one laser-absorbing chromophore formulated into a physiologically... | 07/11/2000 |
| 6074653 | Cosmetic/dermatological w/o emulsions highly concentrated in hydroxy acids Topically applicable cosmetic/dermatological compositions well suited for the therapeutic treatment or care of human skin, nails, hair and/or of the scalp, in particular for treating and/or preventing xerosis, ichthyosis, actinic keratosis and/or photoind... | 06/13/2000 |
| 6057341 | Bi-aromatic dibenzofuran derivatives and their use in human and veterinary medicine and in cosmetics The invention concerns novel bi-aromatic dibenzofuran derivatives of formula (I),and their use in pharmaceutical compositions for human or veterinary medicine (skin, rheumatic respiratory, cardiovascular, and ophthalmologic disorders), or in cosmetic comp... | 05/02/2000 |
| 6051243 | Polyaromatic amide compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polyaromatic amides have the structural formula (I): ##STR1## wherein Z is a radical --CO--NH-- or --NH--CO--,and are useful for the treatment of a wide variety of disease states, whether human or veter... | 04/18/2000 |
| 6046220 | Propynyl or dienyl biaromatic compounds The invention relates to novel propynyl or dienyl biaromatic compounds which have the general formula (I) ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatologica... | 04/04/2000 |
| 6030952 | Benzofuran-acrylic acid derivatives and their use as modulators of RXRs or RARs receptors The present invention provides novel heteroaryl compounds having the general formula (I): ##STR1## their pharmaceutical compositions to be used as human and veterinary medicine, particularly in the treatment of dermatological, rheumatic, respira... | 02/29/2000 |
| 6015569 | Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polycyclic aromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(e): ##STR2## and are useful for the treatment of a wide variety of disease... | 01/18/2000 |
| 6004987 | Use of ligands which are specific for RXR receptors The present invention relates to the use of at least one ligand which is specific for RXR receptors, in the preparation of a pharmaceutical composition to be administered systemically and intended to increase the cellular proliferation and/or differentiat... | 12/21/1999 |
| 6001885 | Retinoid inhibition of expression of VEGF The retinoids, in particular the anti-AP-1 retinoids, effectively inhibit the expression of VEGF, and thus are useful for the therapeutic treatment of disease states manifesting an overexpression of VEGF.... | 12/14/1999 |
| 5985928 | Bioactive bicyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active bicyclic aromatic compounds have the structural formula (I): ##STR1## and are useful for the treatment of a wide variety of disease states, whether human or veterinary, for example dermatological, rheumatic,... | 11/16/1999 |
| 5981776 | Heterocyclic biaryl compounds, pharmaceutical and cosmetic compositions containing them and uses thereof The invention relates to novel heterocyclic biaryl compounds which have the general formula (I): ##STR1## as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, r... | 11/09/1999 |
| 5973007 | Use of inhibitors of retinoic acid activity for wound healing A method for promoting healing by administration of an inhibitor of the activity of retinoic acid is provided. Preferred compounds for use in such treatment include antagonists of retinoic acid. The method is particularly applicable for promoting skin hea... | 10/26/1999 |
| 5952382 | Adamantyl-substituted retinoids and pharmaceutical/cosmetic compositions comprised thereof Pharmaceutically/cosmetically-active adamantyl-substituted retinoid compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formula (a) - (d): ##STR2## and are useful for the treatment of disorders and/or ai... | 09/14/1999 |
| 5942531 | Phenolic/naphtholic retinoids for promoting skin/exoskeleton pigmentation Pigmentation of the skin, hair and/or nails of individuals is promoted by administering thereto, advantageously topically and advantageously in combination with enzymes exhibiting tyrosinase activity, effective pigmentation-promoting amounts of at least o... | 08/24/1999 |
| 5939083 | Nongreasy/nonsticky fatty cosmetic/dermatological compositions Nongreasy, nonsticky cosmetic and/or dermatological compositions for topical application to human skin and/or hair, characteristically without imparting a shiny appearance thereto, contain at least one fatty substance and an amount of deformable hollow pa... | 08/17/1999 |
| 5935585 | Biaromatic amido compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active biaromatic amido compounds have the structural formula (I): ##STR1## in which Ar is a radical selected from among those of the following formulae (a)-(e): ##STR2## and are useful for the treatment ... | 08/10/1999 |
| 5910508 | Polycyclic polyenic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polycyclic polyenic compounds have the structural formula (I): ##STR1## and are useful for modulating cellular hormone receptors.... | 06/08/1999 |
| 5905088 | Heterocyclic biaryl compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active heterocyclic biaryl compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(h): ##STR2## and are useful for the treatment of a wide variety of disease... | 05/18/1999 |
| 5877342 | Adamantyl-substituted biaromatic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active adamantyl-substituted biaromatic compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a')-(f'): ##STR2## and are useful for the treatment of a wide var... | 03/02/1999 |
| 5863544 | Cosmetic/dermatological w/o emulsions highly concentrated in hydroxy acids Topically applicable cosmetic/dermatological compositions well suited for the therapeutic treatment or care of human skin, nails, hair and/or of the scalp, in particular for treating and/or preventing xerosis, ichthyosis, actinic keratosis and/or photoind... | 01/26/1999 |
| 5849798 | Polyaromatic heterocyclic compounds and pharmaceutical/cosmetic compositions comprised thereof Novel pharmaceutically/cosmetically-active polyaromatic heterocyclic compounds have the structural formula (I): ##STR1## in which Z is a divalent radical selected from among --O--, --S-- or --Nr'-- and Ar is either a radical having the following stru... | 12/15/1998 |
| 5827500 | Process for identifying RAR-receptor-antagonist compounds The present invention relates to a process for identifying RAR-antagonist molecules, characterized in that it comprises the following steps: (i) a sufficient amount of an RAR-agonist molecule is applied topically to a part of the skin of a mammal, (ii) a ... | 10/27/1998 |
| 5827897 | Stimulating the differentiation of predipocytic cells and therapies based thereon The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II diabetes and cardiovascular disorders such as hypertension and ... | 10/27/1998 |
| 5798354 | Use of adamantyl-substituted polycyclic acetylene compounds in skin and hair treatment Novel pharmaceutically/cosmetically-active adamantyl-substituted polycyclic acetylene compounds have the structural formula (I): ##STR1## wherein Ar is a radical having one of the formulae (a)-(f): ##STR2## and are useful for the treatment of a ... | 08/25/1998 |
