Assignee: Centocor, Inc.

Location: Malvern, PA
No. of patents: 129

Number	Title	Issue Date
8114964	Anti-MCP-1 antibodies, compositions, methods and uses The present invention relates to at least one novel anti-MCP-1 antibody, including isolated nucleic acids that encode at least one anti-MCP-1 antibody, MCP-1, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including thera...	02/14/2012
8093068	Methods for use in human-adapting monoclonal antibodies Methods useful for human adapting non-human monoclonal antibodies are disclosed. The methods select candidate human antibody framework sequences from a human germline framework database. ...	01/10/2012
8071729	Anti-integrin antibodies, compositions, methods and uses The present invention relates to at least one novel anti-alpha-V subunit antibodies, including isolated nucleic acids that encode at least one anti-alpha-V subunit antibody, alpha-V subunit, vectors, host cells, transgenic animals or plants, and methods of making an...	12/06/2011
8071333	Anti-integrin antibodies, compositions, methods and uses The present invention relates to at least one novel anti-alpha-V subunit antibodies, including isolated nucleic acids that encode at least one anti-alpha-V subunit antibody, alpha-V subunit, vectors, host cells, transgenic animals or plants, and methods of making an...	12/06/2011
8067191	Method for detecting IL-16 activity and modulation of IL-16 activity based on rantes proxy protein levels Methods for detecting IL-16 biological activity, detecting modulation of IL-16 biological activity, and diagnosing the presence of or susceptibility of a subject to an IL-16-related disorder involve measuring and comparing the levels of RANTES proxy produced by euka...	11/29/2011
8067003	Methods of treating conditions using anti-IL-6 antibodies Anti-IL-6 antibodies are used to treat IL-6 related conditions, such as rheumatoid arthritis, osteoarthritis, osteolysis, aseptic loosening of orthopedic implants, systemic lupus erythematosus, cutaneous lupus erythematosus, lupus nephritis, type 2 diabetes mellitus...	11/29/2011
8043616	sRAGE mimetibody, compositions, methods and uses Mammalian sRAGE mimetibody polypeptides and nucleic acids are disclosed. Methods of utilizing the polypeptides to reduce or inhibit the binding of RAGE and its ligands and to treat RAGE-related diseases are also disclosed. ...	10/25/2011
7982007	Cynomolgus toll-like receptor 3 Isolated polynucleotides encoding Cynomolgus monkey Toll-Like Receptor 3 (cynoTLR3), polypeptides obtainable from expression of these polynucleotides, recombinant cells, methods and uses of these are disclosed. ...	07/19/2011
7955597	Anti-IL-6 antibodies, compositions, methods and uses The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic ani...	06/07/2011
7910101	Melanocortin receptor binding mimetibodies, compositions, methods and uses Melanocortin receptor binding mimetibody polypeptides are disclosed. Polynucleotides encoding these polypeptides, cells comprising these polynucleotides or expressing the mimetibodies, and methods of making and using the forgoing are also disclosed. ...	03/22/2011
7833786	Anti-IL-6 antibodies, compositions, methods and uses The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic ani...	11/16/2010
7820169	Anti-TNF antibodies, compositions, methods and uses The present invention relates to inhibiting TNF in patients having rheumatoid arthritis, psoriatic arthritis or ankylosing spondilitis, by administering anti-TNF antibodies comprising the heavy chain variable region of SEQ ID NO: 7 and the light chain variable regio...	10/26/2010
7815909	Anti-TNF antibodies, compositions, methods and uses The present invention relates to inhibiting TNF in patients having rheumatoid arthritis, psoriatic arthritis or ankylosing spondilitis, by administering anti-TNF antibodies comprising the heavy chain variable region of SEQ ID NO: 7 and the light chain variable regio...	10/19/2010
7790405	Solution phase biopanning method using engineered decoy proteins The invention relates to a method of directing selection of biological therapeutic molecules to specific functional domains of the target biologic molecule. Selection is directed by the use of closely related molecules, where one is a decoy and the other contains th...	09/07/2010
7777018	CDR-grafted anti-tissue factor antibodies and methods of use thereof The present invention provides CDR-grated antibodies against human tissue factor that retain the high binding affinity of rodent monoclonal antibodies against tissue factor but have reduced immunogenicity. The present humanized antibodies are potent anticoagulants a...	08/17/2010
7744885	Methods of treating vascular inflammatory pathology using anti-TNF antibodies and fragments thereof Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and c...	06/29/2010
7736650	Anti-IL-12 antibody based vectors, host cells, and methods of production and uses Antibody expression vectors and plasmids can incorporate various antibody gene portions for transcription of the antibody DNA and expression of the antibody in an appropriate host cell. The expression vectors and plasmids have restriction enzyme sites that facilitat...	06/15/2010
7718778	Antibody reactive with human toll like receptor 3 Toll Like Receptor 3 (TLR3) modulators, such as antibodies, polynucleotides encoding TLR3 antibodies or fragments thereof, and methods of making and using the foregoing are disclosed. ...	05/18/2010
7691378	Anti-TNF antibodies, compositions, methods and uses The present invention relates to methods for treating carcinomas or adenocarcinomas using at least one anti-TNF antibody. ...	04/06/2010
7666993	Cynomolgus prostate specific antigen Isolated polynucleotides encoding Cynomolgus monkey prostate specific antigen and polypeptides obtainable from the polynucleotides and uses are disclosed. ...	02/23/2010
7659250	BMP-7 variant compositions, methods and uses Human Bone Morphogenic Protein 7 (hBMP-7) variant peptide chains, nucleic acids encoding these peptide chains, and methods of making and using the foregoing are disclosed. ...	02/09/2010
7612182	Anti-IL-6 antibodies, compositions, methods and uses The present invention relates to at least one novel chimeric, humanized or CDR-grafted anti-IL-6 antibodies derived from the murine CLB-8 antibody, including isolated nucleic acids that encode at least one such anti-IL-6 antibody, vectors, host cells, transgenic ani...	11/03/2009
7605235	Anti-tissue factor antibodies and compositions Isolated anti-tissue factor antibodies, immunoglobulins, cleavage products and other specified portions and variants thereof having enhanced ADCC activity, as well as anti-tissue factor antibody compositions, encoding or complementary nucleic acids, vectors, host ce...	10/20/2009
7598083	Chemically defined media compositions Chemically defined media compositions for the culture of eukaryotic cells are disclosed. The compositions are useful for eukaryotic cell culture in perfusion bioreactors and other vessels. ...	10/06/2009
7550142	Anti-integrin antibodies, compositions, methods and uses The present invention relates to at least one novel anti-alpha-V subunit antibodies, including isolated nucleic acids that encode at least one anti-alpha-V subunit antibody, alpha-V subunit, vectors, host cells, transgenic animals or plants, and methods of making an...	06/23/2009
7544790	CDR-grafted anti-tissue factor antibodies and methods of uses there of The present invention provides CDR-grated antibodies against human tissue factor that retain the high binding affinity of rodent monoclonal antibodies against tissue factor but have reduced immunogenicity. The present humanized antibodies are potent anticoagulants a...	06/09/2009
7521206	Anti-TNF antibodies, compositions, methods and uses The present invention relates to at least one novel anti-TNF antibodies, including isolated nucleic acids that encode at least one anti-TNF antibody, TNF, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeut...	04/21/2009
7514539	Epitope directed selection of antibodies to murine tissue factor A tissue factor antibody which binds to non-human tissue factor and is useful as a surrogate in preclinical testing where the human therapeutic tissue factor candidate antibody does not interact with the homolog target protein in a manner that would provide meaningf...	04/07/2009
7498150	Materials and methods to increase peptide chain expression DNA sequences that increase peptide chain expression when operably linked to a gene encoding the peptide chain and methods of generating a peptide chain expression host cell using the foregoing are disclosed. Peptide chain expression host cells are also disclosed.	03/03/2009
7491391	Anti-IL-23 antibodies, compositions, methods and uses An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, m...	02/17/2009
7479479	CNGH0010 specific polynucleotides, polypeptides, antibodies, compositions, methods and uses Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucl...	01/20/2009
7479379	Methods for altering protein production rates Methods for altering the cellular secretion rate of a protein, such as an antibody and the altered cells produced by the method are disclosed. The methods and altered cells are useful for producing high levels of proteins for therapeutic, diagnostic or research purp...	01/20/2009
7427471	Modified “S” antibodies The invention relates to the field of antibodies, and particularly to modified antibodies, methods of preparing modified antibodies and uses thereof. More particularly, the invention relates to the preparation of more active IgG antibodies by the addition of an extr...	09/23/2008
7425330	Methods of inhibiting TNFα activity in the blood of a patient Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and c...	09/16/2008
7416729	Methods of treating rheumatoid arthritis with anti-TNF antibodies Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and c...	08/26/2008
7404955	Methods of inhibiting or neutralizing TNFα in patients with tissue injury Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and c...	07/29/2008
7393662	Human EPO mimetic hinge core mimetibodies, compositions, methods and uses The present invention relates to at least one novel human EPO mimetic hinge core mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one EPO mimetic hinge core mimetibody or specified portion or variant, EPO mimetic hing...	07/01/2008
7374761	Recombinant A2-specific TNFα-specific antibodies Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and c...	05/20/2008
7371825	Anti-MCP-1 antibodies, compositions, methods and uses The present invention relates to at least one novel anti-MCP-1 antibodies, including isolated nucleic acids that encode at least one anti-MCP-1 antibody, MCP-1, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including the...	05/13/2008
7365154	Peptides antagonistic to an anti-angiogenic antibody and uses therefor The invention concerns antagonists of alphav-containing integrins which have therapeutic activity in oncology applications and methods for selecting such antagonists using a peptide which competes for alphaV-integrin binding with a known monoclonal antibody having d...	04/29/2008

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Assignee: Centocor, Inc.