Assignee: Center for Blood Research, Inc.

Location: Boston, MA
No. of patents: 19

Number	Title	Issue Date
7569229	Monocyte locomotion inhibitory factor The invention relates to an anti-inflammatory oligopeptide which can be obtained from the microorganism Entamoeba histolytica or synthesized by known methods. The oligopeptides are useful in treating inflammatory diseases when formulated in pharmaceutical com...	08/04/2009
7387777	Methods of treating hemophilia or von willebrand disease with p-selectin The present invention identifies P-selectin as a modulator of hemostasis. Accordingly, the present invention relates to methods for the identification and use of modulators of P-selectin activity as modulators of hemostasis. The invention also relates to methods and...	06/17/2008
7241869	Modified polypeptides stabilized in a desired conformation and methods for producing same The present invention provides a method for stabilizing a protein in a desired conformation by introducing at least one disulfide bond into the polypeptide. Computational design is used to identify positions where cysteine residues can be introduced to form a disulf...	07/10/2007
6797270	Functional derivatives of the intercellular adhesion molecule ICAM-1 in anti-viral therapy The invention concerns the use of functional derivatives of ICAM-1 to treat viral infection. The invention also provides a vaccine to prevent such infection, and a diagnostic assay to determine the existence and extent of such infection. ...	09/28/2004
6777191	Use of functional derivatives of the intercellular adhesion molecule ICAM-1 in diagnosis of viral infection The invention concerns the use of functional derivatives of ICAM-1 to treat viral infection. The invention also provides a vaccine to prevent such infection, and a diagnostic assay to determine the existence and extent of such infection. ...	08/17/2004
6689267	Multi-plate electrophoresis system having non-mechanical buffer circulation An improved electrophoresis device includes first and second end reservoirs of buffer, and a separation tank between the end reservoirs. The separation tank fluidically interconnects the reservoirs and is configured to hold a stack of gel trays in an orie...	02/10/2004
6589526	Enrichment of dendritic cells from blood A method for the enrichment of dendritic cells from the peripheral blood of a mammal is described. Peripheral blood having mononuclear cells from a mammal is provided. The mononuclear cells are separated from the peripheral blood. The mononuclear cells ar...	07/08/2003
6436403	Pharmaceutical composition of the intercellular adhesion molecule ICAM-1 for use in anti-viral prophylactic therapy The invention concerns the use of functional derivatives of ICAM-1 to treat viral infection. The invention also provides a vaccine to prevent such infection, and a diagnostic assay to determine the existence and extent of such infection....	08/20/2002
6274342	Nucleic acid molecules encoding monocyte chemotactic protein 5 (MCP-5) molecules and uses therefor The present invention relates to the discovery of novel genes encoding Monocyte Chemotactic Protein-5 (MCP-5) polypeptides. Therapeutics, diagnostics and screening assays based on these molecules are also disclosed....	08/14/2001
6194204	Enrichment of dendritic cells from blood A method for the enrichment of dendritic cells from the peripheral blood of a mammal is described. Peripheral blood having mononuclear cells from a mammal is provided. The mononuclear cells are separated from the peripheral blood. The mononuclear cells ar...	02/27/2001
6191103	Methods for enhancing thrombolysis in a mammal It has been found that agents which inhibit the interaction between the band 3 protein and its ligand (hereafter sometimes referred to as "interaction inhibitors" or "inhibitors"), CD36/thrombospondin, can also be used to enhance thrombolysis. The inhibit...	02/20/2001
5827672	Human monocyte elastase inhibitor antibodies A new human elastase inhibitor is provided. The human monocyte elastase inhibitor is isolated, purified, characterized at the molecular level and cloned. The human monocyte elastase inhibitor is capable of forming a covalent complex with elastase or Prote...	10/27/1998
5821053	LIL-Stat DNA binding sites and methods for identifying inhibitory binding agents A method for finding an agent which inhibits interaction between LIL-Stat protein and a nucleic acid having a LIL-Stat binding sequence is described. The LIL-Stat protein is contacted with the nucleic acid in the presence of an agent which inhibits or doe...	10/13/1998
5663299	Human monocyte elastase inhibitor A new human elastase inhibitor is provided. The human monocyte elastase inhibitor is isolated, purified, characterized at the molecular level and cloned. The human monocyte elastase inhibitor is capable of forming a covalent complex with elastase or Prote...	09/02/1997
5599676	Method for isolating a novel receptor for 댔 integrins The present invention is directed to a method for isolating a novel receptor for 댔 integrins such as VLA-4, that is distinct from VCAM-1 and from fibronectin. Isolated nucleic acids encoding the receptor and antibodies to the receptor are also prov...	02/04/1997
5514555	Assays and therapeutic methods based on lymphocyte chemoattractants The present invention relates to a novel assay for lymphocyte chemotaxis. The assay is transendothelial assay using endothelial cells cultured on microporous filters. Lymphocyte transmigration through the filter toward a suspected chemoattractant is measu...	05/07/1996
5460945	Device and method for analysis of blood components and identifying inhibitors and promoters of the inflammatory response The present invention provides in vitro models of the in vivo rolling and arrest of leukocytes along the endothelial cell wall, which are important steps in the migration of leukocytes out of the blood stream and into tissue, as part of the inflammatory r...	10/24/1995
4702814	Non-mechanical buffer circulation apparatus for electrophoresis An improvement in electrophoretic apparatus is provided for non-mechanical fluid transfer between the anode and cathode electrode containing chambers of the apparatus. Buffering fluid is transferred from one electrode containing chamber to the other via g...	10/27/1987
4303592	Amidinophenylmethylsulfonylfluoride A new compound amidinophenylmethylsulfonylfluoride is formed and preferably used in the para isomer form as an irreversible inactivator of selected serine proteases....	12/01/1981

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Assignee: Center for Blood Research, Inc.