Assignee: Celltech Limited

Location: Berkshire, GB
No. of patents: 27

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Number	Title	Issue Date
7176215	Bicyclic oxopyridine and oxopyrimidine derivatives Compounds of formulae (1a) and (1b) are described: in which the dashed line represents an optional bond; A is a —N═ atom or a —N(Rb)—, —C(Rb)═ or —C(Rb)(RC)— group; Ra, Rb and Rc ...	02/13/2007
7015234	Hydroxamic acid derivatives Compounds of the general formula (I) are described wherein R1 and R2, which may be the same or different, is each a hydrogen atom or a CF3, CF2H or CFH2 group, pro...	03/21/2006
7012076	Bicyclic amine derivatives as inhibitors of class 1 receptor tyrosine kinases Fused bicyclic amines of formula (1) are described wherein Ar is an aryl or heteroaryl group; Y is a —S(O2)— or —C(O)— group; R1 is a hydrogen or halogen atom or an alkyl, haloalkyl, alkoxy, haloalkoxy or cyano group; X is a nitrogen at...	03/14/2006
6774228	Tetra-aza macrocycles and metal complexes thereof 1,4,7,10-Tetrazacyclododecanes carrying a side chain terminating in a group capable of reacting with an antibody, and their complexes with a di- or tripositive metal having a coordination number of 6 or more can be used to prepare imaging agents. Typical metals are ...	08/10/2004
6740654	Squaric acid derivatives Squaric acid derivatives of formula (1) are described: wherein Het is an optionally substituted bicyclic fused ring heteroaromatic group; L2 is a covalent bond or an atom or group —O—, —S�...	05/25/2004
6583301	Lipids Bipolar lipids are described which are able to form complexes with polyanions. The lipids comprise a cationic head linked to a hydrophobic backbone and a hydrophilic tail and are capable of self assembly to form stable complexes in aqueous solutions. The ...	06/24/2003
6307026	Humanized antibodies directed against A33 antigen A33 antigen binding proteins are described for use in the diagnosis or treatment of colorectal tumors and metastases arising therefrom. The binding protein may be a humanized A33 antibody, including complete antibody molecules, fragments thereof, and part...	10/23/2001
5965405	Method for producing Fv fragments in eukaryotic cells Methods for preparing Fv fragments which lack linking polypeptides in eukaryotic cells are provided....	10/12/1999
5958413	Use of antibodies to TNF or fragments derived thereof and xanthine derivatives for combination therapy and compositions therefor A combined preparation for simultaneous combined, simultaneous separate, or sequential use in the therapy of prophylaxis of disorders associated with undesirable high levels of TNF, e.g. septic or endotoxic shock and immunoregulatory and inflammatory diso...	09/28/1999
5864019	Multivalent antigen-binding proteins A multivalent antigen-binding protein comprises a first Fv fragment bound to at least one further Fv fragment by a connecting structure which links the Fv fragments to each other but which maintains them spaced apart such that the proteins are capable of ...	01/26/1999
5858755	Lipase from human gastric mucosal tissue A human gastric lipase protein for use in the treatment of lipase deficiency. A process is described for producing gastric lipase using recombinant DNA technology to produce a host organism (for example E. coli) capable of producing a methionine-gastric l...	01/12/1999
5859205	Humanised antibodies CDR-grafted antibody heavy and light chains comprise acceptor framework and donor antigen binding regions, the heavy chains comprising donor residues at at least one of positions (6, 23) and/or (24, 48) and/or (49, 71) and/or (73, 75) and/or (76) and/or (...	01/12/1999
5691181	DNA encoding lipase from human gastric mucosal tissue A human gastric lipase protein for use in the treatment of lipase deficiency. A process is described for producing gastric lipase using recombinant DNA technology to produce a host organism (for example E. coli) capable of producing a methionine-gastric l...	11/25/1997
5681718	Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof Methods for enhancing the production of tissue plasminogen activator (TPA) in cell culture are disclosed. The methods involve culturing TPA-producing cells in growth media supplemented with an alkanoic acid or salt thereof at a concentration which enhance...	10/28/1997
5658759	Recombinant DNA expression vectors The invention provides expression vectors containing the promoter, enhancer and substantially complete 5'-untranslated region including the first intron of the major immediate early gene of human cytomegalovirus. Further vectors including the hCMV-MIE DNA...	08/19/1997
5591639	Recombinant DNA expression vectors The invention provides expression vectors containing the promoter, enhancer and substantially complete 5'-untranslated region including the first intron of the major immediate early gene of human cytomegalovirus. Further vectors including the hCMV-MIE DNA...	01/07/1997
5569665	Peptidyl derivatives and their use as metalloproteinases inhibitors Metalloproteinase inhibitors are provided which are selective inhibitors of the action of gelatinase, and may be of use in the treatment of cancer to control the development of tumour metastases....	10/29/1996
5484893	Tri-aza macrocycles and metal complexes thereof Ti-aza macrocycles of formula (1), wherein m and n, which may be the same or different, is each zero or an integer 1, 2, or 3; p is zero or an integer 1 or 2; q is zero or an integer from 1 to 6 inclusive; R1, R2 and R3, w...	01/16/1996
5332664	Human calcitonin precursor polyprotein structural gene Production of human calcitonin precursor structural gene, the insertion of this gene in a vector system, the cloning thereof and a process for the production of authentic human calcitonin using recombinant DNA biotechnology....	07/26/1994
5332805	Process for the recovery of recombinantly produced chymosin from insoluble aggregate The production of recombinant chymosin is disclosed in which an insoluble form of chymosin precursor is produced by a bacterial host cell transformed by a vector including a coding sequence for said precursor. Solubilization of said insoluble form of chym...	07/26/1994
5300501	Peptidyl derivatives A compound of formula (I): ##STR1## wherein R represents a --CONHOH, carboxyl (--CO2 H) or esterified carboxyl group; X represents an amino (--NH2), or substituted amino, hydroxyl or substituted hydroxyl group; and their use as ...	04/05/1994
5271927	Antibody conjugates with macrocyclic ligands The conjugation of antibodies to a macrocyclic conjugate compound wherein the conjugate compound has the structure (I), wherein R1 is --(CH2)p --R6 --CH2)q -- where p and q are the same or ...	12/21/1993
5219996	Recombinant antibodies and methods for their production in which surface residues are altered to cysteine residues for attachment of effector or receptor molecules The present invention provides an altered antibody molecule wherein a residue in a surface pocket on the molecule has been changed to a cysteine residue to introduce a thiol group in the surface pocket and a process for its production by recombinant DNA t...	06/15/1993
5183657	Antibodies for use in antilymphocyte antibody therapy The use of antibodies against human alpha tumor necrosis factor in antilymphocyte antibody therapy is described. The anti-human alpha tumor necrosis factor antibodies may be used to prevent or treat shock-related conditions arising from antilymphocyte ant...	02/02/1993
5093241	C-terminal CAT fusion protein and process of preparation by recombinant DNA A process for the production of a fusion protein comprising an active portion of a chloramphenicol acetyltransferase (CAT) protein and a polypeptide. The fusion protein may be purified using CAT substrate affinity chromatography. The eucaryotic polypeptid...	03/03/1992
4760026	Monoclonal antibody A monoclonal antibody having specificity for an antigenic determinant of a B-type blood cell. The monoclonal anti-B, produced by a hybridoma cell (the preparation of which is described), affords a defined, specific and cheap blood grouping reagent. The mo...	07/26/1988
4615974	Yeast expression vectors There are described a number of plasmid vectors suitable for the expression of genetic material, at various levels in yeasts. The plasmids each comprise a yeast selective marker, a yeast replication origin and a yeast promoter positioned relative to a uni...	10/07/1986

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Assignee: Celltech Limited