Did You Know...
...that after Parker Brothers executives turned down the game of Monopoly because it had "52 fundamental errors" (including taking too long to play), a copy of the game wound up in the home of the company president who stayed up until 1 a.m. to finish playing it? He was so impressed by the game that the next day he wrote to inventor Charles Darrow and offered to buy it!
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| Number | Title | Issue Date |
| 7565247 | Method for acquisition, storage, and retrieval of cell screening data on a computer system The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involve... | 07/21/2009 |
| 7482167 | Microbead-based test methods for fluorescence imaging systems The present invention provides a test plate and methods for adjusting fluorescence imaging systems involving using a plate with fluorescent microbeads bound to a surface. ... | 01/27/2009 |
| 7476510 | Miniaturized cell array methods and apparatus for cell-based screening Methods and cassettes for cell-based toxin detection and organ localization are disclosed. The cassettes includes an array containing cells and a matrix of openings or depressions, wherein each region of the substrate enclosed by the opening or depression in the mat... | 01/13/2009 |
| 7467153 | Method and system for efficient collection and storage of experimental data Methods and system for efficient collection and storage of experimental data allow experimental data from high-throughput, feature-rich data collection systems, such as high-throughput cell data collection systems to be efficiently collected, stored, managed and dis... | 12/16/2008 |
| 7410769 | Peptide biosensors for anthrax protease The present invention provides a protease biosensor that can be used to detect the presence of the lethal factor protease from Bacillus anthracis, as well as methods for using the protease biosensor. ... | 08/12/2008 |
| 7356416 | Method and system for automated inference creation of physico-chemical interaction knowledge from databases of co-occurrence data Methods and system for automated inference of physico-chemical interaction knowledge from databases of term co-occurrence data. The co-occurrence data includes co-occurrences between chemical or biological molecules or co-occurrences between chemical or biological m... | 04/08/2008 |
| 7244614 | Fusion proteins and assays for molecular binding The present invention provides novel recombinant fusion proteins for detecting binding of a molecule of interest containing a detection domain, a first and optionally a second localization domain, and a binding domain. The invention also provides recombinant nucleic... | 07/17/2007 |
| 7235373 | System for cell-based screening The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involve... | 06/26/2007 |
| 7160687 | Miniaturized cell array methods and apparatus for cell-based screening The present invention describes methods and cassettes for cell-based toxin detection and organ localization. The cassettes includes an array containing cells and a matrix of openings or depressions, wherein each region of the substrate enclosed by the opening or dep... | 01/09/2007 |
| 7117098 | Machine-readable storage medium for analyzing distribution of macromolecules between the cell membrane and the cell cytoplasm The present invention provides systems, methods, and screens for an optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of co... | 10/03/2006 |
| 7085765 | Methods to increase the capacity of high content cell-based screening assays The present invention involves the pooling of multiple high content cell-based screening assays, and carrying out a primary screen in a one or more channels of a fluorescence detection device, which drastically increases the number of simultaneous high content cell-... | 08/01/2006 |
| 7060445 | System for cell-based screening The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invention involve... | 06/13/2006 |
| 6986993 | System for cell-based screening The present invention provides systems, methods, screens, reagents and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large n... | 01/17/2006 |
| 6970789 | Method of determining a best initial focal position estimate The invention provides a method for a method for determining a best initial focal position estimate for a current sample location on a substrate comprising multiple sample locations, comprising determining the best initial focal position estimate by using a result f... | 11/29/2005 |
| 6875578 | System for cell-based screening The present invention provides systems, methods, screens, reagents and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large n... | 04/05/2005 |
| 6813615 | Method and system for interpreting and validating experimental data with automated reasoning A method and system for interpreting experimental data with automated reasoning. Domain specific knowledge is acquired from one or more pharmaceutical information sources. A semantic representation of the domain specific knowledge is created meeting a desired set of... | 11/02/2004 |
| 6780974 | Synthetic DNA encoding an orange seapen-derived green fluorescent protein with codon preference of mammalian expression systems and biosensors Synthetic versions of a full length and termini truncated humanized green fluorescent protein based on Ptilosarcus gurneyi are disclosed which have been modified to the favored or most favored codons for mammalian expression systems. The disclosed encoded pro... | 08/24/2004 |
| 6768982 | Method and system for creating and using knowledge patterns A method and system for creating and using knowledge patterns. One or more patterns derived from one or more pharmaceutical data sources are acquired. A knowledge map is created using the one or more patterns. The knowledge map, such as a self-organizing knowledge m... | 07/27/2004 |
| 6759206 | System for cell-based screening The present invention provides systems, methods, and screens to measure receptor internalization in a single step with appropriate automation and throughput. This approach involves luminescent labeling of the receptor of interest and the automated measurement of rec... | 07/06/2004 |
| 6756207 | System for cell-based screening The present invention provides systems, methods, screens, reagents and kits for optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large n... | 06/29/2004 |
| 6727071 | System for cell-based screening The present invention provides systems, methods, and screens for an optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of co... | 04/27/2004 |
| 6716588 | System for cell-based screening The present invention provides automated systems, methods, screens, and software for the analysis of cell spreading. The invention involves providing cells containing fluorescent reporter molecules in an array of locations, contacting the cells with a test stimulus,... | 04/06/2004 |
| 6671624 | Machine readable storage media for detecting distribution of macromolecules between nucleus and cytoplasm in cells The present invention provides systems, methods, and screens for an optical system analysis of cells to rapidly determine the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large nu... | 12/30/2003 |
| 6620591 | System for cell-based screening The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invent... | 09/16/2003 |
| 6573039 | System for cell-based screening The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invent... | 06/03/2003 |
| 6548263 | Miniaturized cell array methods and apparatus for cell-based screening The present invention describes novel methods for making a substrate for selective cell patterning, and the substrates themselves, wherein the method comprises contacting reactive hydroxyl groups on the surface of a substrate with a hydroxyl-reactive bifu... | 04/15/2003 |
| 6365367 | Environmental chamber for the analysis of live cells This invention provides environmental control devices and methods for live cell analysis. The devices of the invention combine a plate space that can hold specimen plates of a variety of sizes, gas flow control, and temperature control of the entire speci... | 04/02/2002 |
| 6103479 | Miniaturized cell array methods and apparatus for cell-based screening The present invention discloses devices and methods of performing high throughput screening of the physiological response of cells to biologically active compounds and methods of combining high-throughput with high-content spatial information at the cellu... | 08/15/2000 |
| 5989835 | System for cell-based screening The invention relates to an optical system for determining the distribution, environment, or activity of fluorescently labeled reporter molecules in cells for the purpose of screening large numbers of compounds for specific biological activity. The invent... | 11/23/1999 |