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| Number | Title | Issue Date |
| 7456012 | Method and apparatus for spatially confined electroporation The invention provides hollow-tip-electrodes for spatially localized delivery of substances to one or more biological targets present in a population comprising target and non-target molecules, macromolecules, and/or cells. The invention also provides electrode plat... | 11/25/2008 |
| 7393680 | Combined electroporation and microinjection method for the penetration of lipid bilayer membranes Disclosed is a method for penetration of lipid bilayer membranes in order to insert at the tip of a hollow needle-shaped object, such as a micropipet-, into a container formed of a lipid bilayer membrane, wherein said container is placed between said needle-shaped o... | 07/01/2008 |
| 7390650 | System and method for obtaining and maintaining high-resistance seals in patch clamp recordings The invention provides a system, system components, and a method for rapidly obtaining and stably maintaining a cell in optimal contact with the cell-contacting surface of a sensor in a cell-based biosensor. In one aspect, the system maximizes the seal between a who... | 06/24/2008 |
| 7109034 | Method for electro-permeabilization of individual cellular and organellar structures and use thereof The invention relates to a method for permeabilization of a cell structure consisting of a single cell, an intracellular structure or an organelle comprising the following steps: (a) microelectrodes, preferably two carbon fiber electrodes or hollow fiber electrodes,... | 09/19/2006 |
| 7018819 | Method and apparatus for manipulation of cells and cell-like structures focused electric fields in microfludic systems and use thereof An apparatus and method are disclosed for electromanipulation of at least one cell or cell-like structure having cell-like membranes, the method comprising the steps: (a) at least one cell or cell-like structure is transported from one or more sample containers loca... | 03/28/2006 |
| 6521430 | Method for electro-permeabilization of individual cellular and organellar structures and use thereof The invention relates to a method for permeabilization of a cell structure consisting of a single cell, an intracellular structure or an organelle comprising the following steps: (a) microelectrodes, preferably two carbon fibre electrodes or hollow fibre ... | 02/18/2003 |
| 6455303 | Detection of biologically active molecules by use of pre-activated cell-based biosensors in liquid-based separation systems The invention provides a method for detection of receptor- or ion channel-modulators (e.g., antagonists, blockers, etc.). The method comprises fractionating a sample by using a liquid-based separation means (e.g., such as a capillary electrophoresis devic... | 09/24/2002 |
| 6388746 | Method, apparatus and flow cell for high-sensitivity detection of fluorescent molecules Method and apparatus for high-sensitivity fluorescence detection wherein (I) a sample comprising fluorescent molecules is made to flow through a channel structure (1) comprising a constricted region (2) with a dimension corresponding to the size of a tigh... | 05/14/2002 |
