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| Number | Title | Issue Date |
| 6610854 | Substituted condensation products of N-benzyl-3-indenylacentamides with heterocyclic aldehydes for neoplasia Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes are useful for inducing or promoting apotosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and trea... | 08/26/2003 |
| 6562830 | Method of treating a patient having precancerous lesions with phenyl quinazolinone derivatives Derivatives of 2-phenyl quinazolinones are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.... | 05/13/2003 |
| 6555547 | Method for treating a patient with neoplasia by treatment with a vinca alkaloid derivative This invention provides a method for treating a patient with neoplasia by an adjuvant therapy that includes treatment with an antineoplastic vinca alkaloid derivative.... | 04/29/2003 |
| 6538029 | Methods for treatment of renal cell carcinoma A method of treating renal cell carcinoma in a mammal with that disease comprising administering to the mammal a physiologically effective amount of an inhibitor of PDE10.... | 03/25/2003 |
| 6500610 | Methods for identifying compounds for inhibiting of neoplastic lesions, and pharmaceutical compositions containing such compounds This invention provides pharmaceutical compositions containing compounds for the treatment of neoplasia in mammals. The phosphodiesterase inhibitory activity of a compound is determined along with COX inhibitory activity. Growth inhibitory and apoptosis i... | 12/31/2002 |
| 6486155 | Method of inhibiting neoplastic cells with isoquinoline derivatives A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to isoquinoline derivatives.... | 11/26/2002 |
| 6486158 | [4,5]-fused-3,6-disubstituted-pyridazines with sulfur-containing substituents in position three for the treatment of neoplasia [4,5]-Fused-3,6 disubstituted-pydidazines of Formula I are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasia: ##STR1## wher... | 11/26/2002 |
| 6479520 | Method of treating a patient having precancerous lesions with phenyl pyridinone derivatives Derivatives of phenyl pyridinone are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit the growth of neoplastic cells.... | 11/12/2002 |
| 6479493 | Methods for treatment of type I diabetes Substituted condensation products of -benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of type I diabetes.... | 11/12/2002 |
| 6472420 | Method for treating a patient with neoplasia by treatment with a paclitaxel derivative This invention provides a method for treating a patient with neoplasia by an adjuvant therapy that includes treatment with a paclitaxel derivative.... | 10/29/2002 |
| 6465494 | Methods for treatment of cystic fibrosis Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes and other such inhibitors are useful for the treatment of cystic fibrosis.... | 10/15/2002 |
| 6455703 | 1,3,6,-Trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia 1,3,6-Trihydro-6-Aza-3-Oxapentalen-2-One Derivatives which have the following formula: ##STR1## wherein R1, R2, R3, R4, R5, Y, X, m, and n are as defined in the specification.... | 09/24/2002 |
| 6440981 | Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones A method for inhibiting the growth of neoplastic cells by exposure to 2,9-disubstituted purin-6-ones.... | 08/27/2002 |
| 6432950 | Method for inhibiting neoplastic cells and related conditions by exposure to benzothienopyrimidine derivatives Benzothienopyrimidine derivatives for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and specifically for arresting and treating neoplasia, including precancerous and cancerous lesions.... | 08/13/2002 |
| 6420410 | Method for treating neoplasia by exposure to N,N'-substituted benzimidazol-2-ones A method for inhibiting neoplastic cells and related conditions by exposing them to N,N'-substituted benzimidazol-2-ones.... | 07/16/2002 |
| 6410584 | Method for inhibiting neoplastic cells with indole derivatives A method for inhibiting neoplastic cells and related conditions by exposing them to substituted indole derivatives.... | 06/25/2002 |
| 6403831 | Substituted benzylidene indenyl formamides, acetamides and propionamides Substituted benzylidene indenyl formamides, acetamides and propionamides are useful in the treatment of precancerous lesions and neoplasms.... | 06/11/2002 |
| 6391885 | Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives Derivatives of Phenyl Cycloamino Pyrimidinone are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.... | 05/21/2002 |
| 6380206 | Method of inhibiting neoplastic cells with 4,5-diaminopyrimidine derivatives A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to 4,5-diaminopyrimidine derivatives.... | 04/30/2002 |
| 6369092 | Method for treating neoplasia by exposure to substituted benzimidazole derivatives A method for inhibiting neoplastic cells and related conditions by exposing them to substituted benzimidalole derivatives.... | 04/09/2002 |
| 6365627 | Method for treating a patient with neoplasia by treatment with a paclitaxel derivative This invention provides a method for treating a patient with neoplasia by an adjuvant therapy that includes treatment with a paclitaxel derivative.... | 04/02/2002 |
| 6359002 | Method for treating a patient with neoplasia by treatment with a platinum coordination complex This invention provides a method for treating a patient with neoplasia by an adjuvant therapy that includes treatment with an antineoplastic platinum coordination complex.... | 03/19/2002 |
| 6358992 | Method of inhibiting neoplastic cells with indole derivatives A method for inhibiting neoplasia, particularly cancerous and precancerous lesions, by exposing the affected cells to indole derivatives.... | 03/19/2002 |
| 6348032 | Method of inhibiting neoplastic cells with benzimidazole derivatives A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to benzimidazole derivatives.... | 02/19/2002 |
| 6300346 | Indenyl hydroxamic acids, (hydroxy) ureas and urethanes for treating patients with precancerous lesions Indenyl hydroxamic acids, (hydroxy) ureas and urethanes are useful in the treatment of precancerous lesions and neoplasms.... | 10/09/2001 |
| 6268372 | Method for inhibiting neoplastic cells and related conditions by exposure to 2,9-disubstituted purin-6-ones A method for inhibiting the growth of neoplastic cells by exposure to 2,9-disubstituted purin-6-ones.... | 07/31/2001 |
| 6262059 | Method of treating a patient having precancerous lesions with quinazoline derivatives Derivatives of Quinazoline are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.... | 07/17/2001 |
| 6239136 | Method of treating a patient having precancerous lesions with phenyl pyrimidinone derivatives Derivatives of Phenyl Pyrimidinone are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.... | 05/29/2001 |
| 6235776 | Method for treating a patient with neoplasia by treatment with a paclitaxel derivative This invention provides a method for treating a patient with neoplasia by an adjuvant therapy that includes treatment with a paclitaxel derivative.... | 05/22/2001 |
| 6232312 | Method for treating patient having precancerous lesions with a combination of pyrimidopyrimidine derivatives and esters and amides of substituted indenyl acetic acides Combinations of substituted indenyl acetic acids and pyrimido-pyrimidine derivatives are useful in the treatment of colonic polyps and inhibiting the growth of neoplastic cells.... | 05/15/2001 |
| 6211177 | Method for treating neoplasia by exposure to substituted 2-aryl-benzimidazole derivatives A method for inhibiting neoplasia, particularly cancerous and precancerous lesions, by exposing the affected cells to substituted 2-aryl-benzimidazoles.... | 04/03/2001 |
| 6211220 | Method for treating neoplasia with amino or pyridylamino cyclobutene derivatives A method for inhibiting neoplasia, particularly cancerous and precancerous lesions by exposing the affected cells to amino or pyridylamino cyclobutane derivatives.... | 04/03/2001 |
| 6207666 | Method for treating a patient having precancerous lesion with 4-phenylphthalazine derivatives Derivatives of 4-phenylphthalazine are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit the growth of neoplastic cells.... | 03/27/2001 |
| 6200980 | Method of treating a patient having precancerous lesions with phenyl purinone derivatives Derivatives of Phenyl Purinone are useful for the treatment of patients having precancerous lesions. These compounds are also useful to inhibit growth of neoplastic cells.... | 03/13/2001 |
| 6200771 | Method of using a novel phosphodiesterase in pharmaceutical screeing to identify compounds for treatment of neoplasia A method for identifying compounds useful for the treatment of neoplasia involves acertaining whether such compounds exhibit an ability to inhibit a PDE that is characterized by cGMP specificity, cooperative kinetic behavior and insensitivity to phosphory... | 03/13/2001 |
| 6187779 | Method for inhibiting neoplastic cells and related conditions by exposure to 2,8-disubstituted quinazoline derivatives A method for inhibiting neoplastic cells and related conditions by exposing them to 2,8 disubstituted quinazolinone compounds.... | 02/13/2001 |
| 6180629 | [4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen containing substitutents in position one for the treatment of neoplasia [4,5]-Fused-1,3-disubstituted-1,2-diazine-6-one derivatives with nitrogen-containing substituents in position one are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in t... | 01/30/2001 |
| 6177471 | Method for treating patients with acne by administering a CGMP-specific PDE inhibitor Inhibitors of cGMP-specific PDE are useful in the treatment of acne.... | 01/23/2001 |
| 6166053 | Substituted condensation products of N-benzyl-3-idenylacetamides with heterocyclic aldehydes for neoplasia Substituted condensation products of N-benzyl-3-indenylacetamides with heterocyclic aldehydes are useful for inducing or promoting apotosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and trea... | 12/26/2000 |
| 6160003 | 1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the treatment of neoplasia 1,3,6-Trihydro-6-Aza-3-Oxapentalen-2-One Derivatives of Formula I are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasia: ##... | 12/12/2000 |
