Did You Know...
...that the Slinky toy was the result of a failed attempt by engineer Richard James to produce an antivibration device for ship instruments? His goal was to develop a spring that would instantaneously counterbalance the wave motion that rocks a ship at sea. Instead, he developed the Slinky.
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| Number | Title | Issue Date |
| 7459154 | Methods and reagents for the enhancement of virus transduction in the bladder epithelium Agents and methods for enhancing recombinant virus transduction in the bladder epithelium are described. A first method involves contacting the luminal surface of the bladder with a composition comprising a transduction enhancing agent and an oncolytic virus. Altern... | 12/02/2008 |
| 7364727 | Metastatic colon cancer specific promoter and uses thereof Colon cancer specific promoter sequences and adenovirus vehicles are provided. By providing for transcriptional initiating regulation dependent upon transcription factors that are only active in specific, limited cell types, virus replication will be restricted to t... | 04/29/2008 |
| 7319033 | Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof Replication-competent adenovirus vectors specific for cells which allow a probasin transcriptional response element (PB-TRE) to function, such as cells which express the androgen receptor (AR), and methods of use of such viruses are provided. These viruses comprise ... | 01/15/2008 |
| 7276233 | Methods of treating neoplasia with combinations of target cell-specific adenovirus and chemotherapy The invention provides methods of treating neoplasia using combinations of target cell-specific replication competent adenoviral vectors and chemotherapy, radiation therapy or combinations thereof. The adenoviral vectors are target cell-specific for the particular t... | 10/02/2007 |
| 7267815 | Methods and reagents for the enhancement of virus transduction in the bladder epithelium Agents and methods for enhancing recombinant virus transduction in the bladder epithelium are described. A first method involves contacting the luminal surface of the bladder with a composition comprising a transduction enhancing agent and an oncolytic virus. Altern... | 09/11/2007 |
| 7252991 | Method for production of high titer virus and high efficiency retroviral mediated transduction of mammalian cells The invention provides a novel retroviral packaging system, in which retroviral packaging plasmids and packagable vector transcripts are produced from high expression plasmids after stable or transient transfection in mammalian cells. High titers of recombinant retr... | 08/07/2007 |
| 7250299 | Method and means for producing high titer, safe, recombinant lentivirus vectors Lentiviral vectors modified at the 5′ LTR or both the 5′ and 3′ LTR are useful in the production of recombinant lentivirus vectors (See the Figure). Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell ... | 07/31/2007 |
| 7226606 | Cancer-associated antigens and methods of their identification and use The present invention provides novel, isolated, tumor-associated antigens, and methods for identifying such antigens in a biological sample, and of screening for the presence of such an antigen in a biological specimen, wherein the tumor antigen identified reacts wi... | 06/05/2007 |
| 7217421 | Cancer-associated antigens and methods of their identification and use The present invention provides novel, isolated, tumor-associated antigens, and methods for identifying such antigens in a biological sample, and of screening for the presence of such an antigen in a biological specimen, wherein the tumor antigen identified reacts wi... | 05/15/2007 |
| 7186699 | Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes The present invention provides therapeutic compositions and methods for vector-mediated delivery and in vivo expression of polynucleotides encoding anti-cancer compounds that are effective in the treatment of cancer. In particular, the invention relates to the use o... | 03/06/2007 |
| 7179903 | Liver specific transcriptional enhancer Recombinant lentiviruses and transfer vectors for transgene delivery as well as methods for gene therapy using such vectors are disclosed. The invention provides a third generation lentiviral packaging system and a set of vectors for producing recombinant lentivirus... | 02/20/2007 |
| 7176022 | Directly injectable formulations which provide enhanced cryoprotection of cell products This invention provides compositions and methods for cryoprotection of recombinant live cancer cells. Specifically, an improved cryoprotective medium is provided which includes a hydroxyethyl starch and/or derivative thereof alone or in combination with either DMSO ... | 02/13/2007 |
| 7132284 | Adenovirus packaging cell lines Adenovirus packaging cell lines for growth of an E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA) are provided. Methods for producing adenovirus substantially free of RCA are also provided, wherein the adenovirus is g... | 11/07/2006 |
| 7109029 | Vector constructs The present invention provides novel viral vectors and methods useful for the minimization of leaky gene expression, and, in particular, of nonspecific transcriptional read-through of genes. Such constructs may be obtained by the insertion of an insulating sequence ... | 09/19/2006 |
| 7083971 | Hybrid yeast-bacteria cloning system and uses thereof A recombinational approach and system for the cloning, manipulation and delivery of large nucleic acids is disclosed. Vectors relying on homologous recombination to mediate the isolation, manipulation and delivery of large nucleic acid segments are disclosed. ... | 08/01/2006 |
| 7083981 | Method and means for producing high titer, safe, recombinant lentivirus vectors Lentiviral vectors modified at the 5′ LTR or both the 5′ and 3′ LTR's are useful in the production of recombinant lentivirus vectors. Such vectors can be produced in the absence of a functional tat gene. Multiple transformation of the host cell with the vector... | 08/01/2006 |
| 7074618 | Adenoviral E1A/E1B complementing cell line Adenovirus packaging cell lines for growth of E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA), are provided. Methods for producing adenovirus substantially free of RCA are also provided, wherein the adenovirus is gro... | 07/11/2006 |
| 7048920 | Recombinant oncolytic adenovirus for human melanoma The invention provides melanoma cell specific adenovirus vectors, which preferentially replicate in melanoma cells. ... | 05/23/2006 |
| 7026164 | Adenovirus packaging cell lines Adenovirus packaging cell lines for growth of an E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA) are provided. Methods for producing adenovirus substantially free of RCA are also provided, wherein the adenovirus is g... | 04/11/2006 |
| 7001764 | Compositions comprising tissue specific adenoviral vectors Compositions comprising host cell specific adenovirus vehicles are provided for transfecting target host cells. The compositions comprise replication competent adenovirus having an adenovirus gene essential for replication under transcriptional control of a cell typ... | 02/21/2006 |
| 6916918 | Human glandular kallikrein enhancer, vectors comprising the enhancer and methods of use thereof Enhancers which preferentially increase the transcription of cis-linked coding sequences in prostate cells are provided. Methods of using DNA constructs comprising the enhancers to control transcription of heterologous polynucleotides are also provided. Delivery veh... | 07/12/2005 |
| 6863884 | Pseudotyped retroviral vectors The present invention provides pseudotyped retroviral vectors and packaging systems and methods of using such vectors for retroviral-mediated gene transfer. In particular, the present invention provides a retroviral packaging system that comprises at least two vecto... | 03/08/2005 |
| 6797505 | Recombinant AAV vectors for gene therapy of hemophilia A The instant invention provides methods and materials for expressing a polypeptide with factor VIII activity comprising administering an rAAV vector encoding a truncated version of human factor VIII, containing, for example, a 90 kD heavy chain of factor VIII fused t... | 09/28/2004 |
| 6790641 | Lentiviral vector particles resistant to complement inactivation The present invention provides a retroviral gene delivery system that resists complement inactivation through the incorporation of a complement regulatory protein into retroviral particles. In particular, the present invention provides a lentiviral packaging system ... | 09/14/2004 |
