Did You Know...
...that several people are credited with the invention of the flush toilet? Most people have heard of Thomas Crapper (1837-1910), the sanitary engineer who invented the valve-and-siphon arrangement that made the modern toilet possible. Another claimant to "the throne" was British inventor Alexander Cumming who patented a toilet in 1775. Then there's a nameless Minoan (a native of ancient Crete) who lived 4,000 years ago who supposedly was ahead of his time and created the first flush toilet!
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| Number | Title | Issue Date |
| 7959566 | Methods for delivering a drug to a patient while restricting access to the drug by patients for whom the drug may be contraindicated Methods for delivering a drug to a patients in need of the drug, while restricting access to the drug by patients for whom the drug may be contraindicated are disclosed. The methods are of the type in which prescriptions for the drug are filled by a pharmacy only af... | 06/14/2011 |
| 7874984 | Methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug Novel methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug. Embodiments are provided in which the involved prescribers, pharmacies and patients are registered in one or more computer dat... | 01/25/2011 |
| 7776907 | Methods for the treatment and management of macular degeneration using cyclopropyl-N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-3-oxoisoindoline-4-yl}carboxamide Methods of treating, preventing and/or managing macular degeneration are disclosed. Specific embodiments encompass the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodru... | 08/17/2010 |
| 7459560 | Processes and intermediates for resolving piperidyl acetamide stereoisomers Processes and intermediates for preparing 2-substituted piperidines such as 2-substituted d-threo piperidines are provided, including processes and intermediates for resolution of piperidyl acetamide stereoisomers. ... | 12/02/2008 |
| 7431944 | Delivery of multiple doses of medications Dosage forms for oral administration of a methylphenidate drug are provided. The dosage forms provide a substantially immediate dose of methylphenidate upon ingestion, followed by one or more additional doses at predetermined times. By providing such a drug release ... | 10/07/2008 |
| 7173058 | Fluoroalkoxy-substituted 1,3-dihydro-isoindolyl compounds and their pharmaceutical uses The invention encompasses novel compounds, pharmaceutically acceptable salts, hydrates, solvates, clathrates, enantiomers, diastereomers, racemates, or mixtures of stereoisomers thereof, pharmaceutical compositions of these compounds, and methods of using these comp... | 02/06/2007 |
| 6908432 | Methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug Novel methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug. Embodiments are provided in which the involved prescribers, pharmacies and patients are registered in one or more computer dat... | 06/21/2005 |
| 6869399 | Methods for delivering a drug to a patient while restricting access to the drug by patients for whom the drug may be contraindicated Methods for delivering a drug to a patients in need of the drug, while restricting access to the drug by patients for whom the drug may be contraindicated are disclosed. The methods are of the type in which prescriptions for the drug are filled by a pharmacy only af... | 03/22/2005 |
| 6844359 | Substituted imides Novel imides are inhibitors of tumor necrosis factor alpha and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is (R)-2-Phthalimido-3-(3′,4′-dimethoxyphenyl)propane. ... | 01/18/2005 |
| 6767326 | Methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug Novel methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug. Embodiments are provided in which the involved prescribers, pharmacies and patients are registered in one or more computer dat... | 07/27/2004 |
| 6762195 | Pharmaceutically active isoindoline derivatives Isoindolin-1-one and Isoindoline-1,3-dione substituted in the 2-position with a 2,6-dioxo-3-hydroxypiperidin-5-yl group, which may be further substituted in the 5-position with alkyl or halogeno, and in the 4-position with alkyl or a nitrogen-containing group are in... | 07/13/2004 |
| 6755784 | Methods for delivering a drug to a patient while restricting access to the drug by patients for whom the drug may be contraindicated Methods for delivering a drug to a patients in need of the drug, while restricting access to the drug by patients for whom the drug may be contraindicated are disclosed. The methods are of the type in which prescriptions for the drug are filled by a pharmacy only af... | 06/29/2004 |
| 6699899 | Substituted acylhydroxamic acids and method of reducing TNF levels Imido and amido substituted acylhydroxamic acids which reduce the levels of TNF and inhibit phosphodiesterase in a mammal. A typical embodiment is (3-(1,3-dioxoisoindolin-2-yl)-3-(3-ethoxy-4-methoxyphenyl)propanoylamino)p ropanoate.... | 03/02/2004 |
| 6667316 | Pharmaceutically active isoindoline derivatives A compound of formula I wherein each of R1 and R2, independently of the other, is alkyl, alkoxy, cyano, cycloalkoxy, cycloalkyl or cycloalkylmethoxy; one of X and X' is .dbd.C.dbd.O or .dbd.SO2 and the other of X and X' is... | 12/23/2003 |
| 6656964 | Method of inhibiting phosphodiesterases with substituted alkanohydroxamic acids Imido and amido substituted alkanohydroxamic acids reduce the levels of TNF and inhibit phosphodiesterase in a mammal. A typical embodiment is 3-(3-cyclopentyloxy-4-methoxyphenyl)-N-hydroxy-3-phthalimidopropionamide.... | 12/02/2003 |
| 6561976 | Methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug Novel methods for delivering a drug to a patient while preventing the exposure of a foetus or other contraindicated individual to the drug. Embodiments are provided in which the involved prescribers, pharmacies and patients are registered in one or more c... | 05/13/2003 |
| 6561977 | Methods for delivering a drug to a patient while restricting access to the drug by patients for whom the drug may be contraindicated Methods for delivering a drug to a patients in need of the drug, while restricting access to the drug by patients for whom the drug may be contraindicated are disclosed. The methods are of the type in which prescriptions for the drug are filled by a pharm... | 05/13/2003 |
| 6555554 | Isoindolines, method of use, and pharmaceutical compositions Substituted 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are useful in reducing undesirable levels of TNF in a mammal. Typical embodiments are pharmaceutical compositions containing 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline and 1-o... | 04/29/2003 |
| 6528530 | Phenidate drug formulations having diminished abuse potential Phenidate drug formulations are provided having reduced potential for drug abuse. Dosage forms for treating Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, AIDS Dementia Complex and cognitive decline in HIV-AIDS are provided which mi... | 03/04/2003 |
| 6518281 | Immunotherapeutic agents Novel amides and imides are inhibitors of tumor necrosis factor and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions.... | 02/11/2003 |
| 6486177 | Methods for treatment of cognitive and menopausal disorders with D-threo methylphenidate In one aspect, the present invention is directed to methods for treating fatigue, neurobehavioral slowing and other cognitive disorders and defects due to cancers and treatments associated with cancers, and similar conditions. In a further aspect, the pre... | 11/26/2002 |
| 6479554 | Immunotherapeutic agents Cyano and carboxy derivatives of substituted styrenes are inhibitors of tumor necrosis factor , nuclear factor .kappa.B, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory con... | 11/12/2002 |
| 6476052 | Isoindolines, method of use, and pharmaceutical compositions Substituted 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are useful in treating inflammation, inflammatory disease, autoimmune disease, and oncogenic or cancerous conditions in a mammal. Typical embodiments are 1-oxo-2-(2,6-dioxopiperidin-3yl)4-aminoisoi... | 11/05/2002 |
| 6429221 | Substituted imides Novel imides are inhibitors of tumor necrosis factor and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is 2-Phthalimido-3-(3',4'-dimethoxyphenyl)propane.... | 08/06/2002 |
| 6395754 | Substituted 2-(2,6-dioxopiperidin-3-yl)- phthalimides and 1-oxoisoindolines and method of reducing TNF levels Substituted 2-(2,6-dioxopiperidin-3-yl)-phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNF in a mammal. A typical embodiment is 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline.... | 05/28/2002 |
| 6380239 | Substituted 1-oxo- and 1,3-dioxoisoindoline and method of reducing inflammatory cytokine levels 1-Oxo- and 1,3-dioxoisoindolines substituted in the 4- or 5-position of the indoline ring reduce the levels of inflammatory cytokines such as TNF in a mammal. A typical embodiment is 4-(4-amino-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acid.... | 04/30/2002 |
| 6359139 | Methods for production of piperidyl acetamide stereoisomers Synthetic methods are provided comprising the steps of racemizing l-threo-piperidyl acetamides to form a mixture of d-threo, l-threo, d-erythro, and l-erythro-piperidyl acetamides by reacting said l-threo-piperidyl acetamides with alkanoic acid.... | 03/19/2002 |
| 6355656 | Phenidate drug formulations having diminished abuse potential Phenidate drug formulations are provided having reduced potential for drug abuse. Dosage forms for treating Attention Deficit Disorder, Attention Deficit Hyperactivity Disorder, AIDS Dementia Complex and cognitive decline in HIV-AIDS are provided which mi... | 03/12/2002 |
| 6335349 | Substituted 2(2,6-dioxopiperidin-3-yl)isoindolines Substituted 1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)isoindolines and 1-oxo-2-(2,6-dioxo-piperidin-3-yl)isoindolines reduce the levels of TNF in a mammal and are useful in treating oncogenic conditions, inflammation, and autoimmune diseases. Typical em... | 01/01/2002 |
| 6326388 | Substituted 1,3,4-oxadiazoles and a method of reducing TNF-alpha level Substituted 1,3,4-oxadiazole compounds reduce the levels of TNF in a mammal. Typical embodiments are 2-[1-(3-cyclopentyloxy-4-methoxyphenyl)-2-(1,3,4-oxadiazol-2-yl)ethyl]-5-m ethylisoindoline-1,3-dione and 2-[1-(3-ethoxy-4-methoxyphenyl)-2-(1,... | 12/04/2001 |
| 6316471 | Isoindolines, method of use, and pharmaceutical compositions Substituted 2-(2,6-dioxopiperidin-3-yl)phthalimides and 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines reduce the levels of TNF in a mammal. Typical embodiments are 1-oxo-2-(2,6-dioxo-3-methylpiperidin-3-yl)-4,5,6,7-tetrafluoroisoindoline and 1... | 11/13/2001 |
| 6315720 | Methods for delivering a drug to a patient while avoiding the occurrence of an adverse side effect known or suspected of being caused by the drug Improved methods for delivering to a patient in need of the drug, while avoiding the occurrence of an adverse side effect known or suspected of being caused by the drug are disclosed. The methods are of the type in which prescriptions for the drug are fil... | 11/13/2001 |
| 6284780 | Immunotherapeutic aryl amides Novel aryl amides are inhibitors of tumor necrosis factor and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is N-benzoyl-3-amino-3-(3',4'-dimethoxyphenyl)propanamide.... | 09/04/2001 |
| 6281230 | Isoindolines, method of use, and pharmaceutical compositions Substituted 1-oxo-2-(2,6-dioxopiperidin-3-yl)isoindolines are useful in treating inflammation, inflammatory disease, autoimmune disease, and oncogenic or cancerous conditions in a mammal. Typical embodiments are 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminois... | 08/28/2001 |
| 6262101 | Immunotherapeutic agents Cyano and carboxy derivatives of substituted styrenes are inhibitors of tumor necrosis factor , nuclear factor .kappa.B, and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovis replication, asthma, and inflammatory condi... | 07/17/2001 |
| 6255325 | Chronic, bolus administration of D-threo methylphenidate Chronic bolus administration of D-threo methylphenidate is provided. The administration of the D-threo isomer eliminates adverse side effects associated with the DL racemate, and provides improved effectiveness. The compositions and methods of the inventi... | 07/03/2001 |
| 6214857 | Substituted alkanohydroxamic acids and method of reducing TNF levels Imido and amido substituted alkanohydroxamic acids reduce the levels of TNF and inhibit phosphodiesterase in a mammal. A typical embodiment is 3-(3-cyclopentyloxy-4-methoxyphenyl)-N-hydroxy-3-phthalimidopropionamide.... | 04/10/2001 |
| 6207695 | Chiral imidazole fungicidal compositions and methods for their use Chiral fungicides and compositions containing the same are provided. Also provided are methods for using the compositions of the present invention for inhibiting the growth of fungi, including phytotoxic fungi. The use of a single isomer in treating parti... | 03/27/2001 |
| 6200987 | Cyclic amides Cyclic amides are inhibitors of tumor necrosis factor and can be used to combat cachexia, endotoxic shock, and retrovirus replication. A typical embodiment is 3-phenyl-3-(1-oxoisoindolin-2-yl)propionamide.... | 03/13/2001 |
| 6180644 | Immunotherapeutic agents Novel amides and imides are inhibitors of tumor necrosis factor and phosphodiesterase and can be used to combat cachexia, endotoxic shock, retrovirus replication, asthma, and inflammatory conditions. Typical embodiments include 3-(1,3-dioxoben... | 01/30/2001 |
