Assignee: Cambridge NeuroScience, Inc.

Location: Cambridge, MA
No. of patents: 40

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Number	Title	Issue Date
6787569	Therapeutic guanidines The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines. ...	09/07/2004
6774263	Pharmaceutically active compound and methods of use This invention relates to racemic and optically active N-(2-chloro-5-methylthiophenyl)-N′-(3-methylsulfinylphenyl)-N′-methylguanidine, N-(2-chloro-5-methylsulfinylphenyl)-1-(7-trifluoromethyl- 1,2,3,4-tetrahydroquinolinyl)carboximidamide, and N-(3-methylsulfinyl...	08/10/2004
6756389	Pharmaceutically active compounds and methods of use The present invention relates to certain imine-substituted heterocyclic compounds, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more such compounds. Compounds of the invention are particularly useful for the treatment or p...	06/29/2004
6242198	Methods of treatment of eye trauma and disorders Methods are provided for treatment of eye disorders and injury, including methods for treatment of reduced flow of blood or other nutrients to retinal tissue and/or optic nerve, methods for treatment of retinal ischemia and trauma and methods for treatmen...	06/05/2001
6232286	Methods of stimulating mitogenesis in glial cells using glial mitogenic factors The invention features methods for stimulating glial cell mitogenesis by contacting the glial cells with p185erbB2 ligand polypeptides, including glial growth factor (GGF), a GGF splice variant comprised of segments E, B, A, C, and C/D or C/D',...	05/15/2001
6204241	Method for treating nervous system pathophysiologies using glial growth factors Disclosed are methods for treating pathophysiological conditions of the mammalian nervous system. The methods involve administering an effective amount of a polypeptide comprising amino acids 51 to 422 of human GGF2....	03/20/2001
6194377	Methods for treating nervous system pathophysiologies using glial growth factors Disclosed are methods for treating pathophysiological conditions of the mammalian nervous system. The methods involve administering pharmaceutically effective amounts of recombinant polypeptides comprising epidermal growth factor-like domains encoded by t...	02/27/2001
6174924	Therapeutic guanidines The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines....	01/16/2001
6147190	Glial mitogenic factors, their preparation and use Disclosed is the characterization and purification of DNA encoding a numerous polypeptides useful for the stimulation of glial cell (particularly, Schwann cell) mitogenesis and treating glial cell tumors. Also disclosed are DNA sequences encoding novel po...	11/14/2000
6143791	Therapeutic guanidines The present invention provides therapeutically useful substituted guanidines, and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines....	11/07/2000
6087346	Sigma receptor ligands and the use thereof The invention relates to methods for the treatment of central nervous system disorders, neurological disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising ...	07/11/2000
6087323	Use of neuregulins as modulators of cellular communication The present invention relates to methods of affecting cellular communication in a vertebrate. The communication is affected by the administration of a neuregulin to a vertebrate, where the neuregulin interacts with a first cell type which results in the p...	07/11/2000
6071969	Substituted aminoguanidines and methods of use thereof Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use o...	06/06/2000
6025355	Pharmaceutically active compounds and methods of use The present invention relates to pharmaceutically acceptable compounds, including certain substituted indolinyl and derivatives thereof, 1,2,3,4-tetrahydroquinolinyl and derivatives thereof, 1,2,3,4-tetrahydroisoquinolinyl, benz[cd]indolinyl and 5,6-...	02/15/2000
6013675	Therapeutic substituted guanidines The present invention provides therapeutically useful substituted guanidines and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines....	01/11/2000
5955507	Therapeutic substituted guanidines The present invention provides therapeutically useful substituted guanidines and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines....	09/21/1999
5922772	Therapeutic substituted guanidines The present invention provides therapeutically useful substituted guanidines and methods of treatment and pharmaceutical compositions that utilize or comprise one or more of such guanidines....	07/13/1999
5876973	Method for making antibodies which specifically bind to glial growth factors Disclosed is the characterization and purification of DNA encoding numerous polypeptides factors useful for the inhibition of cell (particularly, Schwann cell) proliferation. These factors are useful for the treatment of neural tumors. Also disclosed are ...	03/02/1999
5854220	Glial mitogenic factors, their preparation and use Disclosed is the characterization and purification of DNA encoding a numerous polypeptides useful for the stimulation of glial cell (particularly, Schwann cell) mitogenesis and treating glial cell tumors. Also disclosed are DNA sequences encoding novel po...	12/29/1998
5847006	Therapeutic guanidines The present invention provides N,N'-diaryl substituted guanidines having therapeutic utility. The compounds of the present invention are represented by the formula: ##STR1## wherein R and R1 represent hydrogen or other group and Ar and ...	12/08/1998
5837737	Hydrazinedicarboximidamide compounds and pharmaceutical composition comprising same Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use o...	11/17/1998
5741661	Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use o...	04/21/1998
5716930	Glial growth factors The invention involves secretable glial growth factors....	02/10/1998
5686495	Substituted hydrazinedicarboximidamides and methods of use thereof Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use o...	11/11/1997
5681568	Device for delivery of substances and methods of use thereof This invention comprises devices and methods for producing a composite microporous membrane specifically tailored to be useful for optimizing the delivery of macromolecules to a therapeutic target....	10/28/1997
5681861	Aminoguanidines and methods of use of same Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N'"-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use o...	10/28/1997
5677348	Substituted aminoguanidines and methods of use thereof Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use o...	10/14/1997
5672608	Acenaphthyl substituted guanidines and methods of use thereof Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N'"-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use o...	09/30/1997
5670519	Acenaphthyl-substituted guanidines and methods of use thereof Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use o...	09/23/1997
5652269	Substituted hydrazinecarboximidamides and methods of use thereof Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use o...	07/29/1997
5637623	Substituted adamantyl guanidines and methods of use there of Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use o...	06/10/1997
5622968	Acenaphthyl substituted guanidines and methods of use thereof Modulators of neurotransmitter release including substituted guanidines, and N"-aminoguanidines, and N,N'N", N'"-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the ...	04/22/1997
5621081	Glial mitogenic factors The invention is concerned with new glial growth factors, such as the molecule referred to as GGF2. These factors are mitogenic factors for, e.g., Schwann cells....	04/15/1997
5614630	Acenaphthyl substituted guanidines and methods of use thereof Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N'"-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use o...	03/25/1997
5606032	Process for preparing glial mitogenic factors The invention involves the purification of various glial mitogenic factors. In one aspect of the invention, vertebrate brain material is extracted, and the extract is then subjected to chromatographic separation. The glial mitogenic factors which can be o...	02/25/1997
5530109	DNA encoding glial mitogenic factors The invention relates to isolated nucleic acid molecules which encode for part or all of glial growth factor molecules, as well as recombinant vectors and transfected cell lines....	06/25/1996
5438130	Fucosylated guanosine disulfates as excitatory amino acid antagonists A compound consisting of a base, a ribose and a fucose, in which the base is a purine or a pyrimidine, the ribose has R1 and R2 attached respectively to any two of 2'-O, 3'-O and 5'-O, and the fucose has R3, R4 ...	08/01/1995
5403861	Substituted guanidines and derivatives thereof as modulators of neurotransmitter release and novel methodology for identifying neurotransmitter release blockers Modulators of neurotransmitter release including substituted guanidines, N"-aminoguanidines, and N,N'N",N"'-tetrasubstituted hydrazinedicarboximidamides, and pharmaceutical compositions thereof are disclosed. Also disclosed are methods involving the use o...	04/04/1995
5312928	Calcium channel antagonists and methodology for their identification A substantially pure compound of the formula: ##STR1## wherein each of R1 and R2, independently, is H, CH3, CF3, F, Cl, Br, I, OH, OCH3, OCF3, SH, SCH3, NH2, N	05/17/1994
5298657	Preparation of substituted guanidines A process for the preparation of a substituted guanidine by reacting a substituted cyanamide with ammonia or a substituted amine in the presence of a Lewis acid catalyst. Also disclosed is a process for the preparation of a tri-substituted guanidine by re...	03/29/1994

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Assignee: Cambridge NeuroScience, Inc.