Assignee: Caliper Life Sciences, Inc.

Location: Mountain View, CA
No. of patents: 88

Number	Title	Issue Date
8021531	Method for modifying the concentration of reactants in a microfluidic device A method of carrying out a chemical reaction on a microfluidic device in which a first reactant at a first concentration is delivered into a reaction channel; within the reaction channel the concentration of the first reactant is changed from the first concentration...	09/20/2011
8017384	Modular membrane supported bioreactor for conversion of syngas components to liquid products A modular membrane supported bioreactor for anaerobic conversion of gas into liquid products including membrane module(s) having a plurality of hollow fibers packed across a cross sectional area of the membrane module in a direction transverse to the axis of the mem...	09/13/2011
8007738	Western blot by incorporating an affinity purification zone An upstream affinity purification region is used to bind one or more component of interest in a mixture of components prior to separating the mixture of components. Detection of the separated components and a released component of interest provide identification of ...	08/30/2011
8006554	Filter and SPE plate clogged well detection The invention provides a method, a system, and a computer readable medium for determining the fill-ready status of one or more wells of a plurality of wells formed in a filter or solid-phase extraction (SPE) plate. In the method, a signal is directed toward a well o...	08/30/2011
7925451	Software for the display of chromatographic separation data Techniques for displaying chromatographic data using a graphical user interface are provided. Chromatographic separation data that represent a series of measurements for multiple samples at a detection location over time can be displayed on a display device as a ser...	04/12/2011
7901621	Methods for removing biological residue from capillary walls in microchannels Methods for removing a residue of one or more biological materials deposited on the walls of a microfluidic conduit in microscale devices are provided. In an example of the methods, one or more colloidal-size particles, such as colloidal silica particles, are flowed...	03/08/2011
7846392	Prevention of precipitate blockage in microfluidic channels The present invention provides novel microfluidic devices and methods for preventing/ameliorating formation of precipitate blockages in microfluidic devices. In particular, the devices and methods of the invention utilize microchannels of specific cross-sectional co...	12/07/2010
7867776	Priming module for microfluidic chips Methods and apparatuses for priming sample substrates such as DNA sipper chips are disclosed. According to one aspect of the present invention, a priming system that is suitable for priming a substrate which has a plurality of wells and at least one channel includes...	01/11/2011
7816148	Open-field serial to parallel converter Microfluidic devices and systems for affecting the serial to parallel conversion of materials introduced into the device or system. Material or materials to be converted from a serial orientation, e.g., a single channel, into a parallel orientation, e.g., multiple c...	10/19/2010
7790116	Microfluidic device with controlled substrate conductivity A method to achieve controlled conductivity in microfluidic devices, and a device formed thereby. The method comprises forming a microchannel or a well in an insulating material, and ion implanting at least one region of the insulating material at or adjacent the mi...	09/07/2010
7758737	Total analyte quantitation Methods for determining total analyte concentrations and amounts, especially in combination with analyte separations are provided. Microfluidic devices are used to separate analyte mixtures and detect the individual analytes. Signal areas are summed for each individ...	07/20/2010
7754150	Microfluidic analytic detection assays, devices, and integrated systems Methods of detecting a component of interest, such as a protein, in a microfluidic system are provided. The methods include the use of a component-binding moiety specific to the component of interest, such as an antibody, to detect the component of interest. Also in...	07/13/2010
7727371	Electrode apparatus for use with a microfluidic device An electrode alignment apparatus may be used with a microfluidic device for accurate and repeatable alignment of electrode pins with reservoirs on the microfluidic device. The apparatus includes a base unit and an electrode block assembly that are moveable with resp...	06/01/2010
7723123	Western blot by incorporating an affinity purification zone An upstream affinity purification region is used to bind one or more component of interest in a mixture of components prior to separating the mixture of components. Detection of the separated components and a released component of interest provide identification of ...	05/25/2010
7702470	Software for the display of chromatographic separation data Techniques for displaying chromatographic data using a graphical user interface are provided. Chromatographic separation data that represent a series of measurements for multiple samples at a detection location over time can be displayed on a display device as a ser...	04/20/2010
7645581	Determining nucleic acid fragmentation status by coincident detection of two labeled probes Methods for determining nucleic acid fragmentation status are provided. A nucleic acid of interest in a reaction mixture is contacted with two or more different probes complementary to sites separated by a point of potential fragmentation. The probes each comprise a...	01/12/2010
7595197	Automated sample analysis Samples of materials used in industrial processes are analyzed to determine the concentration of certain materials of interest. The quantitative analysis of samples for these materials is provided without the need for manual methods such as titration. Indicators suc...	09/29/2009
7527769	Microtitre plate with a relieved perimeter A microtitre plate having a relieved perimeter includes a plate defining a plurality of wells and the perimeter of the plate is horizontally relieved. Alternatively, a microtitre plate may include a base and a holding section extending from the base. The holding sec...	05/05/2009
7514046	Methods and systems for processing microscale devices for reuse This invention provides methods and systems for flushing, washing, and priming microscale devices for reuse. Washing and priming methods include flowing solutions from a manifold to flush wells and microchannels of a microfluidic chip. Systems include manifolds adap...	04/07/2009
7351377	Methods and devices for enhancing bonded substrate yields and regulating temperature Methods and devices that include the use of venting elements for enhancing bonded substrate yields and regulating temperature. Venting elements are generally fabricated proximal to functionalized regions in substrate surfaces to prevent bond voids that form during b...	04/01/2008
7344865	Sequencing by incorporation Nucleotides and nucleotide analogs are used in various sequencing by incorporation/sequencing by synthesis methods. Nucleotide analogs comprising 3′-blocking groups are used to provide reversible chain-termination for sequencing by synthesis. Typical blocking grou...	03/18/2008
7316801	High throughput microfluidic systems and methods The invention provides improved systems, devices, and methods for analyzing a large number of sample compounds contained in standard multi-well microtiter plates or other array structures. The multi-well plates travel along a conveyor system to a test station having...	01/08/2008
7303862	Microfabrication methods and devices Microfabrication methods and devices in which microscale structural elements are provided in an intermediate polymer layer between two planar substrates. Preferred aspects utilize photoimagable or ablatable polymer layers as the intermediate polymer layer. ...	12/04/2007
7303727	Microfluidic sample delivery devices, systems, and methods Methods and apparatus for delivering fluidic materials to sample destinations, including mass spectrometers for analysis are provided. In preferred embodiments, sample aliquots are electrosprayed from tapered spray tips of capillary elements into the orifices of mas...	12/04/2007
7285411	High throughput screening assay systems in microscale fluidic devices The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effe...	10/23/2007
7264702	Total analyte quantitation Methods for determining total analyte concentrations and amounts, especially in combination with analyte separations are provided. Microfluidic devices are used to separate analyte mixtures and detect the individual analytes. Signal areas are summed for each individ...	09/04/2007
7252928	Methods for prevention of surface adsorption of biological materials to capillary walls in microchannels Methods for reducing surface adsorption of biological materials to the walls of microfluidic conduits in microscale devices are provided. In an example of the methods, one or more colloidal-size particles, such as colloidal silica particles, are flowed in a fluid wi...	08/07/2007
7238323	Microfluidic sequencing systems Integrated systems, apparatus, software, and methods for performing biochemical analysis, including DNA sequencing, genomic screening, purification of nucleic acids and other biological components and drug screening are provided. Microfluidic devices, systems and me...	07/03/2007
7233865	Method for determining diffusivity and molecular weight in a microfluidic device The present invention is directed to a method for determining the molecular weight and diffusivity of a sample solute by providing a plus shaped microchannel network on a microfluidic chip, having at least four microchannels intersecting at a cross point; flowing a ...	06/19/2007
7208320	Open-field serial to parallel converter Microfluidic devices and systems for affecting the serial to parallel conversion of materials introduced into the device or system. Material or materials to be converted from a serial orientation, e.g., a single channel, into a parallel orientation, e.g., multiple c...	04/24/2007
7208125	Methods and apparatus for minimizing evaporation of sample materials from multiwell plates Methods and devices for reducing evaporation of sample materials from the wells of multiwell plates are disclosed which find particular utility when the plates are placed in a stacked configuration. An example of the methods includes providing at least a first multi...	04/24/2007
7195986	Microfluidic device with controlled substrate conductivity A method to achieve controlled conductivity in microfluidic devices, and a device formed thereby. The method comprises forming a microchannel or a well in an insulating material, and ion implanting at least one region of the insulating material at or adjacent the mi...	03/27/2007
7192559	Methods and devices for high throughput fluid delivery Methods and devices for delivering fluids into microfluidic device body structures are described. The methods and devices include the use of fluid manifolds which are integrated or interchangeable with device body structures. Methods of fabricating manifolds are als...	03/20/2007
7171983	Multi-reservoir pressure control system Improved microfluidic devices, systems, and methods allow selective transportation of fluids within microfluidic channels of a microfluidic network by applying, controlling, and varying pressures at a plurality of reservoirs. Modeling the microfluidic network as a s...	02/06/2007
7169277	High throughput separations based analysis systems Devices, systems and methods for use in separating sample materials into different fractions that employ bulk fluid flow for loading of samples followed by electrophoretic separation of the sample material. Devices employ configurations that optionally allow bulk sa...	01/30/2007
7161356	Voltage/current testing equipment for microfluidic devices The present invention provides novel methods and devices for testing/verifying the configuration of one or more microfluidic elements in a microfluidic device. In particular the methods and devices of the invention are useful in testing for blockages or the presence...	01/09/2007
7160423	Mixed mode microfluidic systems Methods and systems that employ hybrid fluid flow profiles for optimized movement of materials through channel networks. These systems employ hybrid pressure-based and electrokinetic based flow systems for moving materials through interconnected channel networks whi...	01/09/2007
7156969	Microfluidic matrix localization apparatus and methods Multiphasic microfluidic apparatus for performing product fluid manipulation and separation in a single continuous unit are provided. Related methods, kits, and compositions are also provided. ...	01/02/2007
7153673	Microfluidic devices and methods for performing temperature mediated reactions In a method for performing a hot start polymerase chain reaction, a reaction mixture including a primer, a template molecule, and a buffer—but no polymerase enzyme—is loaded in a reaction channel of a microfluidic device. An electrical current is applied to heat...	12/26/2006
7155344	Distributed database for analytical instruments Techniques for controlling analytical instruments are provided. A sequence of steps can be utilized to specify wells of a microfluidic device, mobility to be applied to fluid in the wells, and the duration to apply the mobility. For example, fluids can be sequential...	12/26/2006

«First «Previous1 2 3 Next»Last»

PatentStorm

Bizarre Patents

PatentStorm News

Assignee: Caliper Life Sciences, Inc.