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Assignee: California Institute of Technology


Location: Pasadena, CA
No. of patents: 2210

1                      
NumberTitleIssue Date
8183174IR-doped ruthenium oxide catalyst for oxygen evolution
A method for preparing a metal-doped ruthenium oxide material by heating a mixture of a doping metal and a source of ruthenium under an inert atmosphere. In some embodiments, the doping metal is in the form of iridium black or lead powder, and the source of rutheniu...
05/22/2012
8179135Low field electron paramagnetic resonance imaging with SQUID detection
In one embodiment, a flux transformer with a gradiometer pickup coil is magnetically coupled to a SQUID, and a SQUID array amplifier comprising a plurality of SQUIDs, connected in series, is magnetically coupled to the output of the SQUID. Other embodiments are desc...
05/15/2012
8178347Gene regulatory networks and methods of interdiction for controlling the differentiation state of a cell
The invention provides a method of modulating a regulatory state of a cell. The method consists of: (a) identifying a point of interdiction within a cis regulatory network specifying a genetic regulatory architecture of a cell, and (b) introducing into a progenitor ...
05/15/2012
8175126Arbitrary optical waveform generation utilizing optical phase-locked loops
This invention relates to opto-electronic systems using semiconductor lasers driven by optical phase-locked loops that control the laser's optical phase and frequency. Feedback control provides a means for precise, wideband control of optical frequency and phase, au...
05/08/2012
8174014Apparatus and method of manufacture for depositing a composite anti-reflection layer on a silicon surface
An apparatus and associated method are provided. A first silicon layer having at least one of an associated passivation layer and barrier is included. Also included is a composite anti-reflection layer including a stack of layers each with a different thickness and ...
05/08/2012
8173359Methods and apparatus and assays of bacterial spores
A sample of unknown bacterial spores is added to a test strip. The sample of unknown bacterial spores is drawn to a first sample region on the test strip by capillary action. Species-specific antibodies are bound to the sample when the unknown bacterial spores match...
05/08/2012
8173001Method and apparatus for analysis and sorting of polynucleotides based on size
The invention relates to a microfabricated device and methods of using the device for analyzing and sorting polynucleotide molecules by size. ...
05/08/2012
8170316Tomographic imaging with a stripe-like shaped sensor
Tomographic imaging using an imaging sensor that has a stripe-like shape is disclosed where a stripe sensor is mechanically scanned over a sample at different angles. For a single stripe detector imaging, linear motion and angular rotation are required. Single strip...
05/01/2012
81696213-dimensional imaging by acoustic warping and defocusing
The present invention relates to a system for three-dimensional (3-D) acoustic imaging of a scattering structure using information from a two-dimensional (2-D) image. The system uses a characterized sensor array to emit a signal from the sensor array into an object ...
05/01/2012
8167961Thermochemical synthesis of fuels for storing thermal energy
The present invention provides a method for storing thermal energy, such as solar energy, as a fuel, by heating a reactive oxide substrate to a first temperature, such that the reactive oxide substrate is reduced, wherein the reactive oxide substrate includes a ceri...
05/01/2012
8164816Stabilizing optical resonators
Techniques and devices that stabilize optical resonators. ...
04/24/2012
8164663Analog bus driver and multiplexer
For a source-follower signal chain, the ohmic drop in the selection switch causes unacceptable voltage offset, non-linearity, and reduced small signal gain. For an op amp signal chain, the required bias current and the output noise rises rapidly with increasing the ...
04/24/2012
8158595Modular aptamer-regulated ribozymes
An extensible RNA-based framework for engineering ligand-controlled gene regulatory systems, called ribozyme switches, that exhibit tunable regulation, design modularity, and target specificity is provided. These switch platforms typically contain a sensor domain, c...
04/17/2012
8150356Split analog/digital polynomial nonlinear term generator with reduced number of analog-to-digital converters
A polynomial nonlinear term generator is configured to receive an RF signal. An analog cubic term generator generates an analog cubic term signal and an analog square term generator generates an analog square term signal, both derived from the RF signal. A cubic ter...
04/03/2012
8144052Multi-pixel high-resolution three-dimensional imaging radar
A three-dimensional imaging radar operating at high frequency e.g., 670 GHz radar using low phase-noise synthesizers and a fast chirper to generate a frequency-modulated continuous-wave (FMCW) waveform, is disclosed that operates with a multiplexed beam to obtain ra...
03/27/2012
8143788Compact high current rare-earth emitter hollow cathode for hall effect thrusters
An apparatus and method for achieving an efficient central cathode in a Hall effect thruster is disclosed. A hollow insert disposed inside the end of a hollow conductive cathode comprises a rare-earth element and energized to emit electrons from an inner surface. Th...
03/27/2012
8141573Microfluidic valve having free-floating member and method of fabrication
Micro check valves having a free-floating member for controlling flow of fluid in microfluidic and biomedical applications and methods of fabrication. A micro check valve includes a valve seat, a valve cap that contacts the valve seat and an untethered floating memb...
03/27/2012
8139650Fast noise reduction in digital images and video
Presented are embodiments for nonlocal mean filtering that provide a robust and efficient method for reducing noise in digital images and video frames. These embodiments build on a separable property of neighborhood filtering to offer a fast, parallel and vectorized...
03/20/2012
8137626Fluorescence detector, filter device and related methods
Microfluidic assay detectors and microfluidic assay detection methods are disclosed. A microfluidic chip is coupled to a light emitting device, emission filters and excitation filters. Excited fluorescent light is detected by a camera and a lens. The correspondent r...
03/20/2012
8133727In vitro human B lymphopoiesis culture system
The present disclosure relates to systems, methods and compositions for the generation of antibody-producing B cells in vitro. Some embodiments are related to an in vitro system for generating antibody-producing B cells from hematopoietic stem/progenitor cells (HSPC...
03/13/2012
8133270In-situ formation of a valve
The present invention satisfies the long felt need for a more compact and durable valve which may be formed in situ. The present invention provides a self-deployable valve system, a method of delivery, and a method of manufacturing for the self-deployable valve syst...
03/13/2012
8129176Integrated active flux microfluidic devices and methods
The invention relates to a microfabricated device for the rapid detection of DNA, proteins or other molecules associated with a particular disease. The devices and methods of the invention can be used for the simultaneous diagnosis of multiple diseases by detecting ...
03/06/2012
8128954Biodegradable drug-polymer delivery system
A sustained-release biodegradable polymeric drug-eluting fiber is disclosed. In some embodiments, the therapeutic drug is complexed with cyclodextrin. In certain embodiments, the polymeric component of the fiber comprises cyclodextrin. The fiber may be fabricated to...
03/06/2012
8124927Detecting light in whispering-gallery-mode resonators
An optical device including a whispering gallery mode (WGM) optical resonator configured to support one or more whispering gallery modes; and a photodetector optically coupled to an exterior surface of the optical resonator to receive evanescent light from the optic...
02/28/2012
8124751Hybridization chain reaction amplification for in situ imaging
The present invention relates to the use of fluorescently labeled nucleic acid probes to identify and image analytes in a biological sample. In the preferred embodiments, a probe is provided that comprises a target region able to specifically bind an analyte of inte...
02/28/2012
8124218Microfabricated elastomeric valve and pump systems
A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the fir...
02/28/2012
8123192Control arrangement for microfluidic devices and related methods and systems
Communication between microchannels of a microfluidic circuit is controlled through a combination between a membrane and a pin-actuated valve arrangement. The deformable membrane contributes to the formation of the surface of the microchannels. Alternatively, or in ...
02/28/2012
8121433Ortho-rectification, coregistration, and subpixel correlation of optical satellite and aerial images
Methods for mapping and resampling images such as satellite or aerial images are presented, including methods to measure relative displacements of images, methods to refine look directions of an aircraft or satellite for aerial or satellite imaging and methods to or...
02/21/2012
8120529Method and apparatus for autonomous, in-receiver prediction of GNSS ephemerides
Methods and apparatus for autonomous in-receiver prediction of orbit and clock states of Global Navigation Satellite Systems (GNSS) are described. Only the GNSS broadcast message is used, without need for periodic externally-communicated information. Earth orientati...
02/21/2012
8119772MART-1 T cell receptors
T-cell receptors that recognize MART-1 antigen are provided. The TCRs can be used, for example, to treat patients suffering from melanoma. ...
02/21/2012
8117523Rate-compatible protograph LDPC code families with linear minimum distance
Digital communication coding methods are shown, which generate certain types of low-density parity-check (LDPC) codes built from protographs. A first method creates protographs having the linear minimum distance property and comprising at least one variable node wit...
02/14/2012
8116981Detector using mass spectroscopy for characterization of biological community
Provided are methods and systems for rapidly and effectively characterizing a cell as belonging to a particular genus, species, strain, or having a particular phenotype. The methods and systems utilize mass spectrometry and low-energy negative ionization to detect c...
02/14/2012
8115344Very low voltage, ultrafast nanoelectromechanical switches and resonant switches
The invention provides lateral nanoelectromechanical switches useful for integration into circuitry fabricated using standard semiconductor processing methods, or using techniques compatible with the mainstream semiconductor processing technologies. Methods of fabri...
02/14/2012
8114785Electrical passivation of silicon-containing surfaces using organic layers
Electrical structures and devices may be formed and include an organic passivating layer that is chemically bonded to a silicon-containing semiconductor material to improve the electrical properties of electrical devices. In different embodiments, the organic passiv...
02/14/2012
8114289Method and apparatus for microfiltration to perform cell separation
A microfiltration apparatus and method for separating cells, such as circulating tumor cells, from a sample using a microfiltration device having a top porous membrane and a bottom porous membrane. The porous membranes are formed from parylene and assembled using mi...
02/14/2012
8112157Magnetic material-containing microfabricated devices for wireless data and power transfer
This disclosure relates to the design and fabrication of micro-electromechanical systems (MEMS) for applications in such varied fields as the biomedical, micro-fluidics and chemical analysis fields for wireless data and power transfer. ...
02/07/2012
8111402Optical sensing based on overlapping optical modes in optical resonator sensors and interferometric sensors
Techniques and devices based on transverse magnetic (TM) and transverse electric (TE) modes in an optical resonator or interferometer to provide sensitive optical detection with insensitivity to a change in temperature. A shift in a difference between a first resona...
02/07/2012
8110898Polymer-embedded semiconductor rod arrays
A structure consisting of well-ordered semiconductor structures embedded in a binder material which maintains the ordering and orientation of the semiconductor structures. Methods for forming such a structure include forming the semiconductor structures on a substra...
02/07/2012
8110353Engineered toehold reactions and networks
A catalytic system and method of catalyzing reactions that uses a novel toehold exchange mechanism that allows a specified input to catalyze the release of a specified output, which in turn can serve as a catalyst for other reactions is provided. This toehold exchan...
02/07/2012
8108943Method and system for near-field spectroscopy using targeted deposition of nanoparticles
There is provided in one embodiment of the invention a method for analyzing a sample material using surface enhanced spectroscopy. The method comprises the steps of imaging the sample material with an atomic force microscope (AFM) to select an area of interest for a...
01/31/2012
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