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| Number | Title | Issue Date |
| 7611854 | Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of α-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that th... | 11/03/2009 |
| 7416881 | Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of α-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that th... | 08/26/2008 |
| 7361498 | Yeast cells expressing modified G proteins and methods of use therefor The present invention pertains to novel yeast cells which are useful for the expression of heterologous G protein coupled receptors. The yeast cells of the present invention can be used in screening assays which can be used to screen for modulators of G protein coup... | 04/22/2008 |
| 7319009 | Methods and compositions for identifying receptor effectors The present invention makes available rapid, effective assays for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assays enable rapid screenin... | 01/15/2008 |
| 7273747 | Cell having amplified signal transduction pathway responses and uses therefor The invention provides recombinant cells that have been engineered such that ligand stimulation of a receptor expressed by the cells leads to amplified signal transduction responses. In one embodiment, the receptor-expressing cells have been engineered to carry a he... | 09/25/2007 |
| 7250263 | Methods and compositions for identifying receptor effectors The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assay enables rapid screeni... | 07/31/2007 |
| 7235648 | Yeast cells engineered to produce pheromone system protein surrogates, and uses therefor Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of α-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that th... | 06/26/2007 |
| 7223533 | Cell surface proteins and use thereof as indicators of activation of cellular signal transduction pathways The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e.g., a receptor or ion channel. The ... | 05/29/2007 |
| 7122305 | Methods and compositions for identifying receptor effectors The present invention makes available a rapid, effective assay for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular receptor or ion channel. The subject assay enables rapid screeni... | 10/17/2006 |
| 7105309 | Yeast cells engineered to produce pheromone system protein surrogates and uses therefor Yeast cells are engineered to express both a surrogate of a pheromone system protein (e.g., enzymes involved in maturation of α-factor, transporters of a-factor, pheromone receptors, etc.) and a potential peptide modulator of the surrogate, in such a manner that th... | 09/12/2006 |
| 7090991 | System for detection of a functional interaction between a compound and a cellular signal transduction component The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e.g., a receptor. or ion channel. The... | 08/15/2006 |
| 7081360 | Expression of G protein-coupled receptors with altered ligand binding and/or coupling properties Modified forms of G protein-coupled receptors which display altered ligand binding and/or coupling properties are provided as well as cells expressing such receptors and assays utilizing these cells for screening and identifying pharmaceutically effective compounds ... | 07/25/2006 |
| 7022513 | Cell based signal generation The present invention makes available a rapid, reproducible, robust assay system for screening and identifying pharmaceutically effective compounds that specifically interact with and modulate the activity of a cellular protein, e.g., a receptor or ion channel. The ... | 04/04/2006 |
| 6864060 | Yeast cells expressing modified G proteins and methods of use therefor The present invention pertains to novel yeast cells which are useful for the expression of heterologous G protein coupled receptors. The yeast cells of the present invention can be used in screening assays which can be used to screen for modulators of G protein coup... | 03/08/2005 |
