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| Number | Title | Issue Date |
| 6884437 | Administration form comprising an acid-labile active compound Novel administration forms for acid-labile active compounds are described. The novel administration forms have no enteric layers and are suitable for oral administration. ... | 04/26/2005 |
| 6489327 | Tryptase inhibitors The invention relates to novel inhibitors of human tryptase which are used in the pharmaceutical industry for the production of medicaments.... | 12/03/2002 |
| 6436952 | Benzonaphthyridine-N-oxides comprising a PDE3 and PDE4 inhibiting activity Compounds of the formula I, ##STR1## in which R1, R2, R3 and R4 have the meanings indicated in the description, are novel active bronchial therapeutics.... | 08/20/2002 |
| 6436970 | Compositions for the treatment of ARDS or IRDS containing 3-(cycloproplymethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy) benzamide and lung surfactant Compositions for treating IRDS and ARDS contain N-(3,5-dichloropyrid-4-yl)3-cyclopropylmethoxy-4-difluoromethoxybenzamide and/or a pharmacologically tolerable salt thereof and lung surfactant.... | 08/20/2002 |
| 6436953 | Tetrahydropyridoethers Compounds of formula (1) in which the substituents have the meanings mentioned in the description, are suitable for the prevention and treatment of gastrointestinal diseases.... | 08/20/2002 |
| 6410551 | Tetrazole derivatives Compounds of formula I, ##STR1## in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are efficacious bronchial therapeutics.... | 06/25/2002 |
| 6410569 | Salt form of pantoprazole The invention relates to the dihydrate of the magnesium salt of pantoprazole.... | 06/25/2002 |
| 6395732 | Pyrimidin-aminomethyl-pyridine derivatives, their preparation and their use in the control of helicobacter bacteria The present invention relates to compounds of formula (I) wherein R1, R2, and R3 are hydrogen, 1-4C-alkyl, or halogen; R4, R5, R6, and R9 are hydrogen or 1-4C-alkyl; R7 and R8 are hydrogen, 1-4C-alkyl, 1-4C-alkoxy, or halogen; A is 1-7C-alkylene, 2-7C-alk... | 05/28/2002 |
| 6383510 | Suppository form comprising an acid-labile active compound Acid-labile active compounds are prepared in suppository form, particularly for rectal administration.... | 05/07/2002 |
| 6384047 | Benzonaphthyridine Compounds 8,9-diethoxy-2-methyl-6-[4(p-toluenesulfonamide) phenyl]-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridine and 9-ethoxy-8-methoxy-2-methyl-6-[4-(p-toluenesulfonamido)phenyl]-1,2,3,4,4a, 10b-hexahydrobenzo[c][1,6]naphthyridine and medicament comp... | 05/07/2002 |
| 6384048 | Imidazonaphthyridines Tetrahydropyrido compounds of formula (I) ##STR1## in which the substituents have the meanings mentioned in the description, are suitable for the prevention or treatment of gastrointestinal diseases.... | 05/07/2002 |
| 6380196 | Dihydrobenzofurans Compounds of formula I, ##STR1## wherein Het represents a heterocycle having the meaning ##STR2## and R1, R2, R3 and R4 have the meanings as given in the description are novel effective bronchial therapeutics.... | 04/30/2002 |
| 6376485 | Benzoxazoles with PDE-inhibiting activity Compounds of formula I ##STR1## in which R1, R2, R3 and A have the meaning set forth in the specification, are selective cyclic nucleotide phosphodiesterase (PDE) inhibitors useful as therapeutics in human and veterinary medicine. They are distinguished ... | 04/23/2002 |
| 6333354 | Synergistic combination of PDE inhibitors and adenylate cyclase agonists or guanyl cyclyse agonists A diseased state based on acute or chronic obstruction of vessels and/or bronchi, acute or chronic inflammation and/or edema formation is advantageously treated by the combined administration of a PDE inhibitor with either an adenylate cyclase agonist or ... | 12/25/2001 |
| 6328993 | Oral administration form for an acid liable active proton pump inhibitor Novel administration form for acid-labile active compounds are described. The novel administration forms have no enteric layers and are suitable for oral administration.... | 12/11/2001 |
| 6315983 | Process for the production of powdered pulmonary surfactant preparations A powdered pulmonary surfactant preparation containing a hydrophobic protein serving as a pulmonary surfactant is obtained by spray drying an organic solution or suspension containing a hydrophobic protein serving as a pulmonary surfactant and possibly ot... | 11/13/2001 |
| 6306867 | Imidazo- and oxazolopyridines ##STR1## are useful for preventing or treating airway disorders, dermatoses, disorders based on excessive release of TNF and leukotrienes, disorders of the immune system and generalized inflammation in the gastrointestinal area.... | 10/23/2001 |
| 6306869 | N-oxides N-oxides of formula 1 ##STR1## wherein R1, R2, R3 and R4 have the meanings given in the description, are selective inhibitors of types 3 and 4 of cyclic nucleotide phosphodiesterase (PDE3, PDE4); they are useful on the one hand as bronchial therapeut... | 10/23/2001 |
| 6303644 | Proton pump inhibitor in therapeutic combination with antibacterial substances The invention relates to the use of proton pump inhibitors as combination therapeutics in the treatment of bacterial diseases which do not affect the gastrointestinal track using antibacterially active compounds.... | 10/16/2001 |
| 6303789 | Benzamides with tetrahydrofuranyloxy substitutents as phosphodiesterase 4 inhibitors Compounds of the formula I ##STR1## in which R1, R2, R3, R4, R5, m and n have the meanings cited in the description, are novel effective PDE-inhibitors.... | 10/16/2001 |
| 6274173 | Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole An oral pharmaceutical composition comprises an acid-labile irreversible proton pump inhibitor in pellet or tablet form, wherein the irreversible proton pump inhibitor is at least partly in slow-release form. On combined administration with an anti-microb... | 08/14/2001 |
| 6255303 | Phthalazinone PDE III/IV inhibitors The compounds of formula (I) in which R1, R2, R3, R4, R5, X and Y have the meanings as given in the description are novel effective bronchial therapeutica.... | 07/03/2001 |
| 6214839 | Substituted 6-alkylphenanthridines Compounds of formula I ##STR1## pharmaceutically acceptable salts thereof and compositions of either are useful for treating conditions amenable to treatment with a phosphodiesterase inhibitor type 4.... | 04/10/2001 |
| 6211203 | Benzofuran-4-carboxamides Compounds of formula I ##STR1## wherein R1 is 1-2C-alkoxy optionally substituted by flourine, R2 is methyl, 1-methylethyl, 3-7C-cycloalkyl or 3-7Ccycloalkylmethyl and Ar is a pyridyl which is optionally di-halo substituted.... | 04/03/2001 |
| 6197783 | Tetrahydropyrido compounds Tetrahydropyrido compounds of formula (I) ##STR1## in which the substituents have the meanings mentioned in the description, are suitable for the prevention or treatment of gastrointestinal diseases.... | 03/06/2001 |
| 6191138 | Phenanthridines Compounds of formula (I), where R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings given in the description, are new active bronchial therapeutic agents. ##STR1##... | 02/20/2001 |
| 6172074 | Imidazopyridines and oxazolopyridines Compounds of formula (I), ##STR1## wherein A, B, D, E, R1, R2, R3 and Y have the meanings cited in the description, are effective bronchial therapeutic agents.... | 01/09/2001 |
| 6162809 | Pyridylthio compounds for controlling helicobacter bacteria Pyridinylthiomethyl- and pyrimidinylthiomethyl-pyridines and their pharmacologically-acceptable compositions are useful for controlling Helicobacter bacteria and for treating those afflicted with diseases based on Helicobacter bacteria.... | 12/19/2000 |
| 6160119 | Fused dihydropyrans Compounds of formula (I) in which the substituents have the meanings mentioned in the specification, are suitable for the prevention and treatment of gastrointestinal diseases. ##STR1##... | 12/12/2000 |
| 6143759 | Tetrazoles Compounds of formula (I) in which R4 is a phenyl radical substituted by R5, where R5 is a tetrazole-5-yl-radical optionally substituted by a radical R6, are novel efficacious PDE3/4 inhibitiors.... | 11/07/2000 |
| 6132768 | Oral pharmaceutical composition with delayed release of active ingredient for reversible proton pump inhibitors An oral pharmaceutical composition of a reversible proton pump inhibitor in pellet or tablet form, wherein the reversible proton pump inhibitor is at least partly in slow-release form, is distinguished, on combined administration with an antimicrobially-a... | 10/17/2000 |
| 6127378 | Phenanthridines substituted in the 6 position Compounds of the formula I in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel efficacious bronchial therapeutics.... | 10/03/2000 |
| 6124313 | Imidazopyridine azolidinones Imidazopyridine-azolidinones are useful for treating or preventing amenable gastro-intestinal ailments.... | 09/26/2000 |
| 6121274 | Dihydrobenzofurane The invention concerns componuds of formula (I), in which R1, R2, R3 and R4 have the meanings given in the description. The compounds are novel, effective PDE-inhibitors.... | 09/19/2000 |
| 6120752 | Medicinal aerosol products containing formulations of ciclesonide and related steroids A pharmaceutical aerosol formulation suitable for oral and/or nasal inhalation including an anti-inflammatory steroid of the formula ##STR1## in which: R1 is 1-butyl, 2-butyl, cyclohexyl or phenyl and R2 is acetyl or isobutanoyl, in ... | 09/19/2000 |
| 6121279 | Substituted 6-phenylphenanthridines The invention relates to compounds of formula (I): wherein R1, R2, R3, R31, R4, R5, R51 and R6 are as defined in the specification. The compounds are phosphodiesterase inhibitors. Also disclosed are pharmaceutical compositions and methods of use of the co... | 09/19/2000 |
| 6107312 | Thiopyridines for use in the control of helicobacter bacteria Thiopyridines of formula (I) ##STR1## in which the substituents and symbols are as defined in the specification are suitable for use in controlling Helicobacter bacteria. They are compounded into medicament compositions and administered to subjects ... | 08/22/2000 |
| 6103718 | Phthalazinones Compounds of formula I wherein R1, R2, R3, R4 and R5 have the means set forth in the description are selective cyclic nucleotide phosphodiesterase (PDE) inhibitors (specifically of type 4), which are effective bronchial therapeutics.... | 08/15/2000 |
| 6096758 | 3-methylimidazopyridines The invention relates to certain substituted imidazo[1,2-a]pyridines useful in the treatment of gastro-intestinal disorders.... | 08/01/2000 |
| 6080782 | Cyclohexyl dihydrobenzofuranes Compounds of formula I are selective cyclic nucleotide phosphodiesterase (PDE) inhibitors (namely of type IV). They and pharmaceutical compositions in which they are active ingredients are useful as bronchial therapeutics, for elimination of erectile dysf... | 06/27/2000 |