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Assignee: Byk Gulden Lomberg Chemische Fabrik GmbH


Location: Constance, DE
No. of patents: 124

1        
NumberTitleIssue Date
6884437Administration form comprising an acid-labile active compound
Novel administration forms for acid-labile active compounds are described. The novel administration forms have no enteric layers and are suitable for oral administration. ...
04/26/2005
6489327Tryptase inhibitors
The invention relates to novel inhibitors of human tryptase which are used in the pharmaceutical industry for the production of medicaments....
12/03/2002
6436952Benzonaphthyridine-N-oxides comprising a PDE3 and PDE4 inhibiting activity
Compounds of the formula I, ##STR1## in which R1, R2, R3 and R4 have the meanings indicated in the description, are novel active bronchial therapeutics....
08/20/2002
6436970Compositions for the treatment of ARDS or IRDS containing 3-(cycloproplymethoxy)-N-(3,5-dichloro-4-pyridinyl)-4-(difluoromethoxy) benzamide and lung surfactant
Compositions for treating IRDS and ARDS contain N-(3,5-dichloropyrid-4-yl)3-cyclopropylmethoxy-4-difluoromethoxybenzamide and/or a pharmacologically tolerable salt thereof and lung surfactant....
08/20/2002
6436953Tetrahydropyridoethers
Compounds of formula (1) in which the substituents have the meanings mentioned in the description, are suitable for the prevention and treatment of gastrointestinal diseases....
08/20/2002
6410551Tetrazole derivatives
Compounds of formula I, ##STR1## in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are efficacious bronchial therapeutics....
06/25/2002
6410569Salt form of pantoprazole
The invention relates to the dihydrate of the magnesium salt of pantoprazole....
06/25/2002
6395732Pyrimidin-aminomethyl-pyridine derivatives, their preparation and their use in the control of helicobacter bacteria
The present invention relates to compounds of formula (I) wherein R1, R2, and R3 are hydrogen, 1-4C-alkyl, or halogen; R4, R5, R6, and R9 are hydrogen or 1-4C-alkyl; R7 and R8 are hydrogen, 1-4C-alkyl, 1-4C-alkoxy, or halogen; A is 1-7C-alkylene, 2-7C-alk...
05/28/2002
6383510Suppository form comprising an acid-labile active compound
Acid-labile active compounds are prepared in suppository form, particularly for rectal administration....
05/07/2002
6384047Benzonaphthyridine
Compounds 8,9-diethoxy-2-methyl-6-[4(p-toluenesulfonamide) phenyl]-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridine and 9-ethoxy-8-methoxy-2-methyl-6-[4-(p-toluenesulfonamido)phenyl]-1,2,3,4,4a, 10b-hexahydrobenzo[c][1,6]naphthyridine and medicament comp...
05/07/2002
6384048Imidazonaphthyridines
Tetrahydropyrido compounds of formula (I) ##STR1## in which the substituents have the meanings mentioned in the description, are suitable for the prevention or treatment of gastrointestinal diseases....
05/07/2002
6380196Dihydrobenzofurans
Compounds of formula I, ##STR1## wherein Het represents a heterocycle having the meaning ##STR2## and R1, R2, R3 and R4 have the meanings as given in the description are novel effective bronchial therapeutics....
04/30/2002
6376485Benzoxazoles with PDE-inhibiting activity
Compounds of formula I ##STR1## in which R1, R2, R3 and A have the meaning set forth in the specification, are selective cyclic nucleotide phosphodiesterase (PDE) inhibitors useful as therapeutics in human and veterinary medicine. They are distinguished ...
04/23/2002
6333354Synergistic combination of PDE inhibitors and adenylate cyclase agonists or guanyl cyclyse agonists
A diseased state based on acute or chronic obstruction of vessels and/or bronchi, acute or chronic inflammation and/or edema formation is advantageously treated by the combined administration of a PDE inhibitor with either an adenylate cyclase agonist or ...
12/25/2001
6328993Oral administration form for an acid liable active proton pump inhibitor
Novel administration form for acid-labile active compounds are described. The novel administration forms have no enteric layers and are suitable for oral administration....
12/11/2001
6315983Process for the production of powdered pulmonary surfactant preparations
A powdered pulmonary surfactant preparation containing a hydrophobic protein serving as a pulmonary surfactant is obtained by spray drying an organic solution or suspension containing a hydrophobic protein serving as a pulmonary surfactant and possibly ot...
11/13/2001
6306867Imidazo- and oxazolopyridines
##STR1## are useful for preventing or treating airway disorders, dermatoses, disorders based on excessive release of TNF and leukotrienes, disorders of the immune system and generalized inflammation in the gastrointestinal area....
10/23/2001
6306869N-oxides
N-oxides of formula 1 ##STR1## wherein R1, R2, R3 and R4 have the meanings given in the description, are selective inhibitors of types 3 and 4 of cyclic nucleotide phosphodiesterase (PDE3, PDE4); they are useful on the one hand as bronchial therapeut...
10/23/2001
6303644Proton pump inhibitor in therapeutic combination with antibacterial substances
The invention relates to the use of proton pump inhibitors as combination therapeutics in the treatment of bacterial diseases which do not affect the gastrointestinal track using antibacterially active compounds....
10/16/2001
6303789Benzamides with tetrahydrofuranyloxy substitutents as phosphodiesterase 4 inhibitors
Compounds of the formula I ##STR1## in which R1, R2, R3, R4, R5, m and n have the meanings cited in the description, are novel effective PDE-inhibitors....
10/16/2001
6274173Oral pharmaceutical composition with delayed release of active ingredient for pantoprazole
An oral pharmaceutical composition comprises an acid-labile irreversible proton pump inhibitor in pellet or tablet form, wherein the irreversible proton pump inhibitor is at least partly in slow-release form. On combined administration with an anti-microb...
08/14/2001
6255303Phthalazinone PDE III/IV inhibitors
The compounds of formula (I) in which R1, R2, R3, R4, R5, X and Y have the meanings as given in the description are novel effective bronchial therapeutica....
07/03/2001
6214839Substituted 6-alkylphenanthridines
Compounds of formula I ##STR1## pharmaceutically acceptable salts thereof and compositions of either are useful for treating conditions amenable to treatment with a phosphodiesterase inhibitor type 4....
04/10/2001
6211203Benzofuran-4-carboxamides
Compounds of formula I ##STR1## wherein R1 is 1-2C-alkoxy optionally substituted by flourine, R2 is methyl, 1-methylethyl, 3-7C-cycloalkyl or 3-7Ccycloalkylmethyl and Ar is a pyridyl which is optionally di-halo substituted....
04/03/2001
6197783Tetrahydropyrido compounds
Tetrahydropyrido compounds of formula (I) ##STR1## in which the substituents have the meanings mentioned in the description, are suitable for the prevention or treatment of gastrointestinal diseases....
03/06/2001
6191138Phenanthridines
Compounds of formula (I), where R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings given in the description, are new active bronchial therapeutic agents. ##STR1##...
02/20/2001
6172074Imidazopyridines and oxazolopyridines
Compounds of formula (I), ##STR1## wherein A, B, D, E, R1, R2, R3 and Y have the meanings cited in the description, are effective bronchial therapeutic agents....
01/09/2001
6162809Pyridylthio compounds for controlling helicobacter bacteria
Pyridinylthiomethyl- and pyrimidinylthiomethyl-pyridines and their pharmacologically-acceptable compositions are useful for controlling Helicobacter bacteria and for treating those afflicted with diseases based on Helicobacter bacteria....
12/19/2000
6160119Fused dihydropyrans
Compounds of formula (I) in which the substituents have the meanings mentioned in the specification, are suitable for the prevention and treatment of gastrointestinal diseases. ##STR1##...
12/12/2000
6143759Tetrazoles
Compounds of formula (I) in which R4 is a phenyl radical substituted by R5, where R5 is a tetrazole-5-yl-radical optionally substituted by a radical R6, are novel efficacious PDE3/4 inhibitiors....
11/07/2000
6132768Oral pharmaceutical composition with delayed release of active ingredient for reversible proton pump inhibitors
An oral pharmaceutical composition of a reversible proton pump inhibitor in pellet or tablet form, wherein the reversible proton pump inhibitor is at least partly in slow-release form, is distinguished, on combined administration with an antimicrobially-a...
10/17/2000
6127378Phenanthridines substituted in the 6 position
Compounds of the formula I in which R1, R2, R3, R31, R4, R5, R51 and R6 have the meanings indicated in the description, are novel efficacious bronchial therapeutics....
10/03/2000
6124313Imidazopyridine azolidinones
Imidazopyridine-azolidinones are useful for treating or preventing amenable gastro-intestinal ailments....
09/26/2000
6121274Dihydrobenzofurane
The invention concerns componuds of formula (I), in which R1, R2, R3 and R4 have the meanings given in the description. The compounds are novel, effective PDE-inhibitors....
09/19/2000
6120752Medicinal aerosol products containing formulations of ciclesonide and related steroids
A pharmaceutical aerosol formulation suitable for oral and/or nasal inhalation including an anti-inflammatory steroid of the formula ##STR1## in which: R1 is 1-butyl, 2-butyl, cyclohexyl or phenyl and R2 is acetyl or isobutanoyl, in ...
09/19/2000
6121279Substituted 6-phenylphenanthridines
The invention relates to compounds of formula (I): wherein R1, R2, R3, R31, R4, R5, R51 and R6 are as defined in the specification. The compounds are phosphodiesterase inhibitors. Also disclosed are pharmaceutical compositions and methods of use of the co...
09/19/2000
6107312Thiopyridines for use in the control of helicobacter bacteria
Thiopyridines of formula (I) ##STR1## in which the substituents and symbols are as defined in the specification are suitable for use in controlling Helicobacter bacteria. They are compounded into medicament compositions and administered to subjects ...
08/22/2000
6103718Phthalazinones
Compounds of formula I wherein R1, R2, R3, R4 and R5 have the means set forth in the description are selective cyclic nucleotide phosphodiesterase (PDE) inhibitors (specifically of type 4), which are effective bronchial therapeutics....
08/15/2000
60967583-methylimidazopyridines
The invention relates to certain substituted imidazo[1,2-a]pyridines useful in the treatment of gastro-intestinal disorders....
08/01/2000
6080782Cyclohexyl dihydrobenzofuranes
Compounds of formula I are selective cyclic nucleotide phosphodiesterase (PDE) inhibitors (namely of type IV). They and pharmaceutical compositions in which they are active ingredients are useful as bronchial therapeutics, for elimination of erectile dysf...
06/27/2000
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