Assignee: Burnham Institute for Medical Research

Location: La Jolla, CA
No. of patents: 34

Number	Title	Issue Date
8178349	Homogeneous neural precursor cells This invention provides pure populations of neural precursor cells, capable of differentiation into neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations (such as embryonic stem cells) in a cocktail of growth condition...	05/15/2012
8168391	Method for modulating insulin production The present invention provides screening methods for the detection of agents that affect various aspects of β-cell biology, particularly insulin gene expression. Screening methods are also provided for detection of agents that affect β-cell differentiation from pr...	05/01/2012
8039668	Naphthalene-based inhibitors of anti-apoptotic proteins Methods of using apogossypol and its derivatives for treating inflammation is disclosed. Also, there is described a group of compounds having structure A, or a pharmaceutically acceptable salt, hydrate, N-oxide, or solvate thereof are provided:	10/18/2011
8008354	Death receptor sensitizing compounds and methods of use therefor Methods of identifying death receptor sensitizing compounds and methods of using death receptor sensitizing compounds are provided. ...	08/30/2011
7982002	Nucleic acid encoding proteins involved in protein degradation, products and methods related thereto In accordance with the present invention, there are provided novel Siah-Mediated-Degradation-Proteins (SMDPS) and/or SCF-Complex Proteins (SCPs). Nucleic acid sequences encoding such proteins and assays employing same are also disclosed. The invention SMDPs and/or S...	07/19/2011
7951832	Pyrazole derivatives as kinase inhibitors The present invention provides compounds having the general structure I, or a pharmaceutically acceptable salt thereof: wherein X is a six-member ring selected from phenyl, pyridine, or pyrimidine; Y is H, an alkenyl, a sub...	05/31/2011
7947717	Inhibitors of lethal factor protease The invention provides compounds that can efficiently and specifically inhibit bacterial toxins, such as inhibit the lethal factor (LF) protease activity of anthrax toxin and/or botulinum neurotoxin type A. The invention also provides methods for inhibiting protease...	05/24/2011
7888355	Compositions and methods for inhibiting growth and metastasis of melanoma There are provided methods of inhibiting growth and metastasis of melanoma, methods of sensitizing melanoma cells to apoptosis, and methods of treating a subject having melanoma using acetyl isogambogic acid, celastrol, or a derivative thereof. There are further pro...	02/15/2011
7871793	Antimicrobial carbohydrates and methods of using same Compositions useful for inhibiting the growth of bacteria, including bacteria that can cause gastric ulcers, are provided. In addition, transgenic organism that can produce such compositions are provided. Methods of using the compositions to treat or prevent gastric...	01/18/2011
7799826	Inhibition of fatty acid synthase by beta-lactones and other compounds for inhibition of cellular proliferation The present invention features methods of treating a cancer in a subject by administering an effective amount of a beta-lactone to the subject. The invention also features methods of inhibiting angiogenesis in a subject by administering an effective amount of an inh...	09/21/2010
7786347	Inhibitor of apoptosis proteins and nucleic acids and methods for making and using them The invention provides polypeptides comprising inhibitor of apoptosis protein (IAP) family members, such as BmIAP initially derived from Bombyx mori BmN cells, and nucleic acids encoding them, and methods for making and using these compositions, including the...	08/31/2010
7776894	Compositions and methods for inhibiting growth and metastasis of melanoma There are provided methods of inhibiting growth and metastasis of melanoma, methods of sensitizing melanoma cells to apoptosis, and methods of treating a subject having melanoma using acetyl isogambogic acid, celastrol, or a derivative thereof. There are further pro...	08/17/2010
7745410	Bladder tumor-targeting peptide and use thereof The present invention relates to a bladder tumor-targeting peptide and use thereof. More particularly, the present invention relates to a bladder tumor-targeting peptide having an amino acid sequence represented by SEQ ID NO: 7 and use thereof. The peptide according...	06/29/2010
7723474	Molecules that selectively home to vasculature of pre-malignant dysplastic lesions or malignancies The present invention provides a conjugate that contains a therapeutic moiety linked to a homing peptide or peptidomimetic which selectively homes to vasculature of pre-malignant dysplastic skin and which includes the amino acid sequence SRPRR (SEQ ID NO: 1) or a co...	05/25/2010
7718680	Inhibition of lethal factor protease activity from anthrax toxin The present invention provides compounds that efficiently and specifically inhibit lethal factor (LF) protease activity of anthrax toxin. ...	05/18/2010
7704700	Methods for determining the prognosis for patients with a prostate neoplastic condition using inhibitor of apoptosis polypeptides The invention provides a method of determining a prognosis for survival for a patient with a prostate neoplastic condition. The method consists of (a) measuring the level of XIAP in a neoplastic prostate cell-containing sample from the patient, and (b) comparing the...	04/27/2010
7671183	PAAD domain-containing polypeptides, encoding nucleic acids, and methods of use The invention provides isolated nucleic acid molecules encoding PAAD-domain containing polypeptides and functional fragments thereof, including fragments containing PAAD domains, NACHT domains and ARED domains, encoded polypeptides, and antibodies. Also provided are...	03/02/2010
7671021	Peptides that home to tumor lymphatic vasculature and methods of using same The present invention provides a conjugate containing a moiety linked to a homing molecule that selectively homes to tumor lymphatic vasculature. The invention also provides a method of directing a moiety to tumor lymphatic vasculature in a subject by administering ...	03/02/2010
7666607	TRAF family proteins In accordance with the present invention, there are provided novel TRAF-Protein-Binding-Domain polypeptides (TPBDs). The invention also provides nucleic acid molecules encoding TPBDs, vectors containing these nucleic acid molecules and host cells containing the vect...	02/23/2010
7666391	Breast homing peptides and methods of identifying same using aminopeptidase P The present invention provides a method of directing a moiety to breast vasculature in a subject by administering to the subject a conjugate which contains a moiety linked to a homing molecule that selectively homes to breast vasculature, whereby the moiety is direc...	02/23/2010
7638324	Bcl-G polypeptides, encoding nucleic acids and methods of use The invention provides Bcl-G polypeptides and encoding nucleic acids. Bcl-G polypeptides include Bcl-GL and Bcl-GS. The invention also provides mouse Bcl-G. The invention also provides vectors containing Bcl-G nucleic acids, host cells containi...	12/29/2009
7626001	Card domain containing polypeptides, encoding nucleic acids, and methods of use The invention provides caspase recruitment domain (CARD)-containing polypeptides, CARD, NB-ARC, ANGIO-R, LRR and SAM domains therefrom, as well as encoding nucleic acid molecules and specific antibodies. The invention also provides related screening, diagnostic and ...	12/01/2009
7615623	BAG proteins and nucleic acid molecules encoding them The present invention provides a family of BAG-1 related proteins from humans (BAG-1L, BAG-1, BAG-2, BAG-3, BAG-4 and BAG-5), the invertebrate C. elegans (BAG-1, BAG-2) and the fission yeast S. pombe (BAG-1A, BAG-1B) and the nucleic acid molecules that...	11/10/2009
7588914	Bacterial Bcl-2 domain-containing polypeptides, encoding nucleic acid molecules, and related methods The invention provides isolated Bcl-2 domain-containing polypeptides from Mycobacterial species, including M. tuberculosis, M. avium, M. bovis, M. leprae and M. smegmatis, and from Streptomyces species, including S. coelicolor, as well as modifi...	09/15/2009
7582438	EphB receptor-binding peptides The application is related to the identification of peptides that selectively bind to Eph receptors of the B class. Also disclosed are uses of such peptides in the treatment of a variety of diseases. Additionally, imaging tumors in patients is described by administr...	09/01/2009
7544767	HMGN2 peptides and related molecules that selectively home to tumor blood vessels and tumor cells The present invention provides a conjugate which contains a therapeutic moiety linked to a homing molecule that selectively homes to tumor blood vessels and tumor cells and that specifically binds the receptor bound by peptide KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK (SEQ ID...	06/09/2009
7537911	ATM related kinase, ATX, nucleic acids encoding same and methods of use The invention provides an isolated nucleic acid molecule having substantially the same nucleotide sequence as SEQ ID NO:1. Also provided is an isolated oligonucleotide having at least 15 contiguous nucleotides of a nucleotide sequence referenced as SEQ ID NO:11. An ...	05/26/2009
7521548	Apoptosis modulator Bcl-B and methods for making and using same A novel human member of the Bcl-2 family Bcl-B has been identified, which is closest in amino-acid sequence homology to the Boo (Diva) protein. The Bcl-B protein is widely expressed in adult human tissues. The Bcl-B protein modulates apoptosis. Bcl-B also binds Bcl-...	04/21/2009
7501486	Peptides that selectively home to heart vasculature and related conjugates and methods The present invention provides a variety of isolated peptides and peptidomimetics, which can be useful, for example, in constructing the conjugates of the invention or, where the peptide itself has biological activity, in unconjugated form as a therapeutic for treat...	03/10/2009
7488792	Collagen-binding molecules that selectively home to tumor vasculature and methods of using same The present invention provides a conjugate containing a therapeutic agent linked to a homing molecule that selectively homes to tumor vasculature and selectively binds collagen such as non-helical collagen or collagen IV. In one embodiment, the conjugate contains a ...	02/10/2009
7470658	Methods for inhibiting tumor metastasis, and peptides useful therefor In accordance with the present invention, there are provided peptides that bind to a member of the mammalian selectin family and inhibit the binding of a carbohydrate to the selectin. Invention peptides are useful to inhibit of the adhesion of cells containing parti...	12/30/2008
7439319	Selective substrates for matrix metalloproteinases The invention provides isolated MMP-2, MMP-9 and MT1-MMP selective substrate polypeptides or functional peptidomimetics. The selective substrate polypeptides contain the following sequences: MMP-2 selective substrate polypeptides contain SEQ ID NOS:1-27, MMP-9 selec...	10/21/2008
7439063	Neuroprotective synergy of erythropoietin and insulin-like growth factors The present invention provides a method of providing acute neuroprotection by inducing the erythropoietin (EPO) signaling pathway in neuronal cells close to or subsequent to the time of excitatory insult; and inducing an insulin-like growth factor (IGF) signaling pa...	10/21/2008
7393666	Use of hepatitis B X-interacting protein (HBXIP) in modulation of apoptosis Novel methods of regulating cellular apoptosis by affecting the interaction of hepatitis B X-interacting protein (HBXIP) with Survivin are described. More specifically, these novel methods of enhancing apoptosis of neoplastic cells comprises inhibiting interaction o...	07/01/2008

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Assignee: Burnham Institute for Medical Research