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Assignee: Brown University Research Foundation


Location: Providence, RI
No. of patents: 177

1          
NumberTitleIssue Date
8311377Method and apparatus for detecting multiple optical wave lengths
Optical gratings that perform a number of functions at various wavelengths are formed by various methods that preserve spectral information within a wavelength band, the functions including: coupling radiation from one waveguide (7a3) to another...
11/13/2012
8138154Biglycan and related therapeutics and methods of use
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophi...
03/20/2012
8072005Apparatus, method and computer program product providing radial addressing of nanowires
Disclosed is a method to construct a device that includes a plurality of nanowires (NWs) each having a core and at least one shell. The method includes providing a plurality of radially encoded NWs where each shell contains one of a plurality of different shell mate...
12/06/2011
8041163Method and apparatus for detecting multiple optical wavelengths
Optical gratings that perform a number of functions at various wavelengths are formed by various methods that preserve spectral information within a wavelength band, the functions including: coupling radiation from one waveguide to another, controllable gratings tha...
10/18/2011
7816322Biglycan and related therapeutics and methods of use
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophi...
10/19/2010
7693370Method and apparatus for processing optical signals with supergratings
An optical component including at least one optical supergrating is provided. The optical supergrating includes a quantized refractive index profile adapted to exhibit a finite plurality of refractive indexes; which in turn are adapted to generate a reflectance spec...
04/06/2010
7496257Method and apparatus for detecting multiple optical wavelengths
Optical gratings that perform a number of functions at various wavelengths are formed by various methods that preserve spectral information within a wavelength band, the functions including: coupling radiation from one waveguide to another, controllable gratings tha...
02/24/2009
7471859Programmable optical grating device and method
An optical waveguide has a surface. An array of separately actuated bodies is disposed proximal to the exposed surface, and an actuator separately actuates at least some of the bodies to change a spectral characteristic of a wave propagating through the waveguide. P...
12/30/2008
7392079Neurological signal decoding
A system using neurological control signals to control a device is disclosed. The system may include a sensor sensing electrical activity of a plurality of neurons over time and a vector generator generating a neural control vector from the sensed electrical activit...
06/24/2008
7373045Method and apparatus for processing optical signals with supergratings
An optical component including at least one optical supergrating is provided. The optical supergrating includes a quantized refractive index profile adapted to exhibit a finite plurality of refractive indexes; which in turn are adapted to generate a reflectance spec...
05/13/2008
7356224Method and apparatus for detecting multiple optical wave lengths
Optical gratings that perform a number of functions at various wavelengths are formed by various methods that preserve spectral information within a wavelength band, the functions including: coupling radiation from one waveguide to another, controllable gratings tha...
04/08/2008
7355597Method, apparatus and computer program product for the interactive rendering of multivalued volume data with layered complementary values
Described is a system, method and computer program product for rendering volumetric multivalued primary data. The system includes a rendering engine having an input coupled to a source of multivalued primary data and an output coupled to a display. The rendering eng...
04/08/2008
7335637Biglycan and related therapeutics and methods of use
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophi...
02/26/2008
7280870Optically-connected implants and related systems and methods of use
According to embodiments of the invention, one or more implants in a body may be connected with optical fibers for transmitting data and/or power to or from the implants. Aspects of the invention related to various embodiments of the actual implant as well as to var...
10/09/2007
7265158Non-metal aerogel materials and detectors, liquid and gas absorbing objects, and optical devices comprising same
New aerogels are disclosed which comprise silica and at least one organic polymer having polar functional groups. Also disclosed are methods for making such aerogels and for making them as substantially transparent objects. In addition, gas detectors, liquid and gas...
09/04/2007
7263258Programmable optical grating device and method
An optical waveguide has a surface. An array of separately actuated bodies is disposed proximal to the exposed surface, and an actuator separately actuates at least some of the bodies to change a spectral characteristic of a wave propagating through the waveguide. P...
08/28/2007
7212851Microstructured arrays for cortex interaction and related methods of manufacture and use
A brain implant system consistent with embodiments of the present invention includes an electrode array having a plurality of electrodes for sensing neuron signals. A method for manufacturing the electrode array includes machining a piece of an electrically conducti...
05/01/2007
7147701Printing medium comprising aerogel materials
New aerogels are disclosed which comprise silica, at least one organic polymer having polar functional groups, and at least one metal ion. Also disclosed are methods for making such aerogels. The present invention further concerns printable objects comprising these ...
12/12/2006
7145330Scanning magnetic microscope having improved magnetic sensor
A scanning magnetic microscope SMM (20) includes a sensor (10) for sensing a magnetic field generated by a specimen (78), the sensor including one of a MTJ, a GMR, or an EHE sensor; translation apparatus (22A–C, 52) for translati...
12/05/2006
7101684Modified modular polyketide synthase
Modular polyketide synthases modified so as not to incorporate natural starter units can be used for clean synthesis of novel polyketides. ...
09/05/2006
7071324Systems and methods for sequencing by hybridization
The systems and methods described herein relate to nucleic acid probes comprising a pattern of universal and designate nucleotides (or analogs thereof), or ‘gapped’ probes, and the use of sets of gapped probes in sequencing by hybridization to determine the sequ...
07/04/2006
7064827Optical tracking and detection of particles by solid state energy sources
A particle detector has a chamber defining a pathway that a target particle follows between an entry and an exit point, a solid-state energy source such as an LED, and a re-emission sensor. The energy source imparts energy to the particle between the two points, and...
06/20/2006
7037366Printing medium comprising aerogel materials
New aerogels are disclosed which comprise silica, at least one organic polymer having polar functional groups, and at least one metal ion. Also disclosed are methods for making such aerogels. The present invention further concerns printable objects comprising these ...
05/02/2006
7034143Systems and methods for sequencing by hybridization
The systems and methods described herein relate to nucleic acid probes comprising a a pattern of universal and designate nucleotides, or ‘gapped’ probes, and the use of sets of gapped probes in sequencing by hybridization to determine the sequence of nucleic aci...
04/25/2006
7029700Micronized freeze-dried particles
A process is provided for making dry, micronized particles of an agent, such as a drug. The method includes (a) dissolving a macromolecular material, preferably a polymer, in an effective amount of a solvent, to form a solution; (b) dissolving or dispersing the agen...
04/18/2006
7018832Human N-type calcium channel isoform and uses thereof
The invention pertains to a human N-type calcium channel isoform, hα1B+SFVG, which is involved in central nervous system signaling, and nucleic acids relating thereto. The present invention also includes fragments and biologically functional variants of ...
03/28/2006
6961742Signal adaptive filter bank optimization
A method for finding optimal filter coefficients for a filter given an input data sequence and an objective function is disclosed. The method includes selecting a wavelet basis having k parameters and minimizes the k parameters according to the predetermined objecti...
11/01/2005
6960351Implantable biocompatible immunoisolatory vehicle for delivery of selected therapeutic products
An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and...
11/01/2005
6930479High resolution scanning magnetic microscope operable at high temperature
A scanning magnetic microscope (SMM) (20) includes a current source (27) for imposing an excitation current to a conductor-under-test (CUT) (70) and, if applicable, a reference current to a proximally located reference conductor (72). Dur...
08/16/2005
6924908Color management systems and methods with improved color matching techniques
Improved color management techniques use sample identifiers that define sample color areas having core areas and buffer areas adjacent the core areas. The core area defined by each sample identifier includes a unique set of colors. However, the buffer area defined b...
08/02/2005
6913889Methods to screen for antibiotic agents and their use in treatment of opportunistic infections
The present invention provides novel targets in eukaryotic cells for antibiotic agents and methods for identification of antibiotic agents affecting such targets and the use of the identified antibiotic agents in treatment of opportunistic infections in eukaryotic h...
07/05/2005
6890507Ozone treatment of fly ash
Carbon-containing fly ash has been treated with optimum amounts of ozone. There is homogenous treatment of the fly ash with ozone and over saturation with ozone is avoided. In a further embodiment of the invention carbon, from various sources is oxygenated to be inc...
05/10/2005
6864224Kinase inhibitors and methods of use in screening assays and modulation of cell proliferation and growth
The invention relates to the discovery of a novel amino acid sequence motif, herein termed the RKIP motif, and to the family of proteins defined by the presence of that motif. Proteins comprising the RKIP motif modulate kinases involved in signal transduction pathwa...
03/08/2005
6864236Biglycan and related therapeutics and methods of use
The invention provides compositions and methods for treating, preventing, and diagnosing diseases or conditions associated with an abnormal level or activity of biglycan; disorders associated with an unstable cytoplasmic membrane, due, e.g., to an unstable dystrophi...
03/08/2005
6824791Methods for micronization of hydrophobic drugs
The invention involves methods and products related to the micronization of hydrophobic drugs. A method of micronizing hydrophobic drugs using a set of solutions including an aqueous solution is provided. The invention also relates to products of micronized hydropho...
11/30/2004
6778236Reflective liquid crystal strain gauge with aspected particles and polarization-sensitive devices
A reflective strain gauge includes an holographically-formed polymer dispersed liquid crystal (H-PDLC) film comprising layers of liquid crystal (LC) droplets in a matrix polymer, the H-PDLC film having a reflection or transmission grating capable of reflecting or tr...
08/17/2004
6756237Reduction of noise, and optimization of magnetic field sensitivity and electrical properties in magnetic tunnel junction devices
Magnetic tunneling junction devices (MTJ) useful for sensing and memory applications and characterized by reduced resistance, magnetic noise, increased sensitivity, and increased magnetoresistance are disclosed herein. A method for fabrication of said MTJ is also di...
06/29/2004
6753315α-bungarotoxin molecules and uses thereof
This invention relates to compositions and methods for the specific inhibition of neurotransmission. More specifically, the invention relates to isolated modified α-bungarotoxin molecules that show high specificity for nicotinic acetylcholine receptors. Such modifi...
06/22/2004
6750040Cell-free synthesis of polyketides
Cell-free systems which effect the production of polyketides employing modular polyketide synthases are described. Libraries of new and/or known polyketides may also be produced in cell-free systems employing aromatic PKS, modular PKS or both. ...
06/15/2004
6746654Dry and semi-dry methods for removal of ammonia from fly ash
A method for removing ammonia from fly ash employs water mist (a water fog) or a flowing warm humid air stream to rid the fly ash of ammonia. Ozone alone or with other co-oxidants such as hydrogen peroxide are also used to rid fly ash of ammonia. ...
06/08/2004
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