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| Number | Title | Issue Date |
| 7344705 | Composition comprising low density microspheres Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void which contains a gas or the vapor of a volatile liquid selected from the group consisting of aliphatic hydrocarbons, chlorofluorocarb... | 03/18/2008 |
| 7083572 | Therapeutic delivery systems Targeted therapeutic delivery systems comprising gas- or gaseous precursor-filled lipid microspheres comprising a therapeutic are described. Methods for employing such microspheres in therapeutic delivery applications are also provided. Targeted therapeutic d... | 08/01/2006 |
| 6773696 | Contrast agent comprising low density microspheres Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void having a volume that comprises at least about 75% of the total volume of the microspheres, and which contains a gas or the vapor of a... | 08/10/2004 |
| 6551576 | Container with multi-phase composition for use in diagnostic and therapeutic applications A container comprising an aqueous lipid suspension and a gaseous phase substantially separate from the aqueous stabilizing phase, useful in diagnostic imaging such as ultrasound and magnetic resonance imaging and in therapeutic applications, is disclosed.... | 04/22/2003 |
| 6548047 | Thermal preactivation of gaseous precursor filled compositions The present invention describes, among other things, the surprising discovery that gaseous precursor filled compositions are profoundly more effective as acoustically active contrast agents when they are thermally preactivated to temperatures at or above ... | 04/15/2003 |
| 6528039 | Low density microspheres and their use as contrast agents for computed tomography and in other applications Substantially homogeneous aqueous suspensions of low density microspheres are presented as contrast media for imaging the gastrointestinal tract and other body cavities using computed tomography. In one embodiment, the low density microspheres are gas-fil... | 03/04/2003 |
| 6521211 | Methods of imaging and treatment with targeted compositions Novel ultrasound methods comprising administering to a patient a targeted vesicle composition which comprises vesicles comprising a lipid, protein or polymer, encapsulating a gas, in combination with a targeting ligand, and scanning the patient using ultr... | 02/18/2003 |
| 6479034 | Method of preparing gas and gaseous precursor-filled microspheres Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly useful, for example, in ultrasonic imaging applications and in the... | 11/12/2002 |
| 6416740 | Acoustically active drug delivery systems The present invention is directed to targeted therapeutic delivery systems comprising a gas or gaseous precursor filled microsphere wherein said gas or gaseous precursor filled microsphere comprises an oil, a surfactant, and a therapeutic compound. Method... | 07/09/2002 |
