Did You Know...
...Chester Carlson was a patent agent who tired of having to make multiple copies of patent applications using the only duplication method available at the time: carbon paper. In 1959 he came up with a new copying system and took it to IBM for evaluation. The "experts" at IBM determined potential sales to be only 5,000 units because people wouldn't want to use a bulky machine when they had carbon paper. Carlson's invention was the xerography process, the company founded on the system is Xerox.
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| Number | Title | Issue Date |
| 5218106 | 2',3'-dideoxy-2'-fluoronucleosides There are disclosed novel 2',3'-dideoxy-2'-fluoronucleosides and 2'-3'-dideoxy-2',3'-didehydro-2'-fluoronucleosides and processes for their preparation. The compounds so produced exhibit therapeutically useful antiviral and, more particularly, anti-HIV ef... | 06/08/1993 |
| 5164379 | Sucralfate/cyclodextrin complexes Complexes of sucralfate with alpha cyclodextrin, beta cyclodextrin, gamma cyclodextrin or 2-hydroxypropyl beta cyclodextrin are disclosed. Also disclosed are a process for producing complexes and compositions and a method for reducing gastric injury, empl... | 11/17/1992 |
| 5130421 | Production of 2',3'-dideoxy-2',3'-didehydronucleosides There are disclosed novel processes for producing 2',3'-dideoxy-2'3'-didehydronucleosides, for example, 2',3'-dideoxy-2',3'-didehydrothymidine in high yields and on a large scale. The compounds so-produced are useful as antiviral agents, especially a... | 07/14/1992 |
| 5126506 | 2',3'-Dideoxy-2'-fluoronucleosides There are disclosed novel 2',3'-dideoxy-2'-fluoronucleosides and 2'-3'-dideoxy-2',3'-didehydro-2'-fluoronucleosides and processes for their preparation. The compounds so produced exhibit therapeutically useful antiviral and, more particularly, anti-HIV ef... | 06/30/1992 |
| 5120862 | Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof There is provided a novel and efficient stereoselective total synthesis of epipodophyllotoxin and related epipodophyllotoxin compounds of the and present invention ##STR1## wherein R1 and R2 each are independently hydrogen or ... | 06/09/1992 |
| 5114857 | Actinomadura hibisca microorganism useful for preparing serine analogs of BU-3608 antibiotics Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof. These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.... | 05/19/1992 |
| 5110960 | Antifungal antibiotics Novel antibiotic herein designated as BU-3608, BU-3608 B, and BU-3608 C are produced by fermentation of Actinomadura hibisca Strain No. P157-2, ATCC 53557, and Strain No. Q278-4, ATCC 53646. The antibiotics possess antifungal and antiviral activities.... | 05/05/1992 |
| 5110940 | Antihypercholesterolemic tetrazole compounds Compounds of the formula ##STR1## wherein R1 and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, or trifluoromethyl; R2,R3,R5 and R6 each are ind... | 05/05/1992 |
| 5106996 | Process for the preparation of podophyllotoxin There are disclosed intermediates which can be converted into podophyllotoxin and related compounds, which are known antineoplastic agents. There are also disclosed processes for the preparation of such intermediates, and processes for the conversion of t... | 04/21/1992 |
| 5099016 | Substituted 7-oxomitosanes The present invention provides novel mitomycin analogs containing a disulfide group and processes for the preparation thereof. These compounds are mitomycin A analogs in which the 7-alkoxy group bears an organic substituent incorporating a disulfide group... | 03/24/1992 |
| 5097036 | Substituted 7-oxomitosanes The present invention provides novel mitomycin analogs containing a disulfide group and processes for the preparation thereof. These compounds are mitomycin A analogs in which the 7-alkoxy group bears an organic substituent incorporating a disulfide group... | 03/17/1992 |
| 5096817 | Process for producing antibiotics BU-3608 D and BU-3608 E Disclosed herein are antibiotic BU-3608 D and E isolated from Actinomadura hibisca. These compounds are active antifungal agents.... | 03/17/1992 |
| 5095011 | Lyophilized cefepime dihydrochloride for parenteral use A stable, amorphous, lyophilized dihydrochloride salt of 7-[-(2-aminothiazol-4-yl)--(z)-methoxyiminoacetamido]-3-[(1- methyl-1-pyrrolidinium) methyl]-3-cephem-4-carboxylate is described. This lyophilized salt is more easily prepared than the ... | 03/10/1992 |
| 5089526 | Antiarrhythmic class III process A process is provided for preventing or ameliorating arrhythmia by administering to mammals, including man, an effective dose of d-sotalol to lengthen the action potential duration of cardiac cell without blockade of beta-adrenergic receptor sites.... | 02/18/1992 |
| 5086182 | Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof There is provided a novel and efficient stereoselective total synthesis of epiodophyllotoxin and related epipodophyllotoxin compounds of the general formula ##STR1## wherein R1 and R2 are independently hydrogen or (lower)-alkoxy... | 02/04/1992 |
| 5073633 | BMY-41950 antitumor antibiotic An antitumor antibiotic designated BMY-41950 is produced by fermentation of Streptomyces staurosporeus ATCC 55006 or Streptomyces hygroscopicus ATCC 53730. The BMY-41950 antibiotic exhibits both antimicrobial and antitumor activities.... | 12/17/1991 |
| 5071957 | Antibiotic BU-4061T The antibiotic designated BU-4061T is produced by fermentation of actinomycete strain Q996-17 (ATCC-53904). The BU-4061T antibiotic exhibits both in vitro and in vivo antitumor activity.... | 12/10/1991 |
| 5070206 | Tetrazol-1-yl containing intermediates Compounds of the formula ##STR1## wherein R1, R2, R3 and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy or trifluoromethyl; R is hydrogen, C1-4 alkyl or phe... | 12/03/1991 |
| 5068346 | Tetrazole compounds Compounds of the formula ##STR1## wherein R1 and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy, or trifluoromethyl; R2, R3,R5 and R6 each are in... | 11/26/1991 |
| 5066645 | Epipodophyllotoxin altroside derivatives The present invention provides antitumor 4'-Demethylepipodophyllotoxin glycosides characterized by the fact that the glycoside moiety is altrose.... | 11/19/1991 |
| 5061624 | Serine analogs of BU-3608 antibiotics Disclosed are antibiotics BU-3608 FA-1 and FA-2 and alkyl derivatives thereof. These compounds are useful as antifungal agents. BU-3608 FA-1 and FA-2 are produced from Actinomadura hibisca in a medium containing a source of D-serine.... | 10/29/1991 |
| 5053395 | Pradimicin amide derivatives Disclosed herein are pradimicin amides which are active as antifungel agents.... | 10/01/1991 |
| 5047246 | Direct compression cyclophosphamide tablet A directly compressible pharmaceutical composition comprising cyclophosphamide and a partially or fully pregelatinized starch is disclosed. The pharmaceutical composition, when directly compressed into a tablet, exhibits unexpected stability when compared... | 09/10/1991 |
| 5041424 | Epipodophyllotoxin glucoside 4'-phosphate derivatives Phosphate derivatives of 4'-demethylepipodophyllotoxin glucosides are novel antitumor agents and the salts thereof offer the pharmaceutical advantage of high water solubility.... | 08/20/1991 |
| 5036008 | Antitumor antibiotic BU-3285T The present invention relates to the antitumor antibiotic compound BU-3285T and its preparation. The compound is obtained by culturing a new strain of Chainia rosea and demonstrates both antitumor and antifungal activity. It also relates to the desulfated... | 07/30/1991 |
| 5036010 | BMY-40800 antitumor antibiotics A new antitumor antibiotic designated BMY-40800 is produced by fermentation of Streptomyces hygroscopicus ATCC 53653. The new compound inhibits the growth of tumors in experimental animals.... | 07/30/1991 |
| 5036055 | Acylated derivatives of etoposide The epipodophyllotoxin glucosides disclosed are acylated at herein one or both sugar hydroxyl groups. These compounds exhibit significant activity against P388 murine leukemia.... | 07/30/1991 |
| 5028730 | Antihypercholesterolemic nitrile compounds Compounds of the formula ##STR1## wherein R1, R2, R3 and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy or trifluoromethyl; A is ##STR2## and R5 ... | 07/02/1991 |
| 5025023 | Peptide antibiotics Novel peptides of the formula ##STR1## wherein R is CH3 --(CH2)6, CH3 --(CH2)4 --CH.dbd.CH--(CH2)2 and CH3 (CH2)8 having antibiot... | 06/18/1991 |
| 5013851 | Intermediates for the production of podophyllotoxin and related compounds There are disclosed intermediates which can be converted into podophyllotoxin and related compounds, which are known antineoplastic agents. There are also disclosed processes for the preparation of such intermediates, and processes for the conversion of t... | 05/07/1991 |
| 5011948 | Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof There is provided a novel and efficient stereoselective total synthesis of epipodophyllotoxin and related epipodophyllotoxin compounds of the general formula ##STR1## wherein R1 and R2 each are independently hydrogen or (lo... | 04/30/1991 |
| 5010205 | Antihypercholesterolemic tetrazol-1-yl intermediates Compounds of the formula ##STR1## wherein R1, R2, R3 and R4 each are independently hydrogen, halogen, C1-4 alkyl, C1-4 alkoxy or trifluoromethyl; R is hydrogen, C1-4 alkyl or phe... | 04/23/1991 |
| 5001130 | Psychotropic heterobicycloalkylpiperazine derivatives A series of psychotropic heterobicycloalkylpiperazine derivatives having the structure ##STR1## wherein V is a 3- or 4-membered unsaturated chain, containing all carbon atoms when 4-membered, or when a 3-membered chain, V contains an oxygen or s... | 03/19/1991 |
| 5001112 | Antitumor antibiotic kedarcidin Kedarcidin is a protein antitumor antibiotic produced by Streptoalloteichus sp. nov. strain L585-6, ATCC 53650. The antibiotic comprises a non-protein chromophore and a single chain polypeptide having 114 amino acid residues.... | 03/19/1991 |
| 5001058 | BU-3839T antibiotic A new antibiotic having the chromophore structure of the plurmycin family of antibiotics is produced by fermentation of Streptomyces violaceus ATCC 53807. The new antibiotic designated BU-3839T, exhibits potent antibacterial activity and also inhibits the... | 03/19/1991 |
| 5000314 | Unit dose package A unit dose package, which is usable with a bottle to reconstruct the contents of the package, has a plastic fitment which defines a mouth opening for the package. The plastic fitment is bonded to a wall of the package and has a channel which receives the... | 03/19/1991 |
| 4994476 | Dihydropyridin-3,5-dicarboxylates incorporating aryloxypropanolamine moieties A series of compounds useful in treating cardiovascular disorders due to the combined expression of both ଲ-block and calcium-block activity by these agents. This useful combination of actions is effected by a novel combination of structural subunits... | 02/19/1991 |
| 4994271 | BMY-40800 antitumor antibiotics A new antitumor antibiotic designated BMY-40800 is produced by fermentation of Streptomyces hygroscopicus ATCC 53653. The new compound inhibits the growth of tumors in experimental animals.... | 02/19/1991 |
| 4994451 | Cephalosporin salts and injectable compositions Crystalline sulfuric, di-nitric, mono-hydrochloric, di-hydrochloric, and di- and sesqui-orthosphosphoric acid addition salts of 7-[-(2-aminothiazol-4-yl)--(Z)-methoxyiminoacetamido]-3-[(1- methyl-1-pyrrolidinio)methyl]-3-cephem-4-carboxylate ... | 02/19/1991 |
| 4992376 | Biological pure culture of Streptomyces violaceus ATCC 53807 An new antibiotic having the chromophore structure of the pluramycin family of antibiotics is produced by fermentation of Streptomyces violaceus ATCC 53807. The new antibiotic designated BU-3839T, exhibits potent antibacterial activity and also inhibits t... | 02/12/1991 |
