Assignee: Brigham and Women's Hospital

Location: Boston, MA
No. of patents: 284

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Number	Title	Issue Date
8080394	Method for determining predisposition to pulmonary infection Provided herein are methods and materials for diagnosing a subject's predisposition for pulmonary infection in a CF subject by detecting a pulmonary infection genetic marker. Pulmonary infection markers have been identified in the IL-1 gene cluster and may be useful...	12/20/2011
7993627	Methods for determining whether a compound alters the amount of at least one αβ (X-41) peptide and the amount of either total αβ or at least one αβ (X-40) peptide produced by a non-human mammal This invention provides methods of screening compounds for their ability to alter the production of Aβ(x≧41) alone or in combination with Aβ(x≦40). The methods involve administering compounds to cells, specifically measuring the amounts of Aβ(x≦40) and Aβ(...	08/09/2011
7875710	Nucleic acids encoding platelet derived growth factor receptor alpha (PDGFRA) activating mutations This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly PDGFRA variants, which are activating forms of these molecules and are linked to neoplasms and/or the development or progression of cancer. The disclosure further provides metho...	01/25/2011
7722868	Agents that modulate the interaction of B7-1 polypeptide with PD-L1 and methods of use thereof Disclosed are methods for modulating an immune response including a method for inhibiting the interaction between a B7 polypeptide and a PD-1 ligand, the method comprising contacting an immune cell bearing a PD-1 ligand, or an immune cell bearing a B7 polypeptide, w...	05/25/2010
7595154	Method of detecting a neoplasia associated with an activating platelet derived growth factor receptor alpha (PDGFRA) mutation This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly PDGFRA variants, which are activating forms of these molecules and are linked to neoplasms and/or the development or progression of cancer. The disclosure further provides metho...	09/29/2009
7432059	Methods of identifying compounds that upmodulate T cell activation in the presence of a PD-1 mediated signal The invention provides isolated nucleic acids molecules, designated PD-L2 nucleic acid molecules, which encode novel B7-related molecules which are ligands for PD-1. The invention also provides antisense nucleic acid molecules, recombinant expression vectors contain...	10/07/2008
7427591	Suppression of immune response via inhibition of cathepsin S Methods and products for suppressing a class II MHC-restricted immune response in a mammal, or in mammalian cells, are described. The methods depend upon inhibiting invariant chain proteolysis by cathepsin S from class II MHC/invariant chain complexes, thereby reduc...	09/23/2008
7175599	Shear mode diagnostic ultrasound A method of diagnosing a subject by delivering ultrasound signals using shear waves includes applying a portion of an ultrasound mainbeam to a bone surface at an incident angle relative to the surface of the bone to induce shear waves in the bone, energy in the shea...	02/13/2007
7157500	Nitrosylation of protein SH groups and amino acid residues as a therapeutic modality Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to novel compounds...	01/02/2007
7153934	T cell costimulatory polypeptides containing alternative domains Structural forms of T cell costimulatory polypeptides are described. These forms comprise an alternative structural domain (i.e., a structural domain having an amino acid sequence which differs from a known amino acid sequence) or have a structural domain deleted or...	12/26/2006
7098311	Fusion of jAZF1 and jjAZ1 genes in endometrial stromal tumors The invention provides isolated nucleic acids molecules, designated jAZF1, jjAZ1 or jAZF1/jjAZ1 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing jAZF1, jjAZ1 or jAZF1/jjAZ1 nucleic acid m...	08/29/2006
7038014	Polycation-sensing receptor in aquatic species and methods of use thereof Polycation-sensing receptors present in aquatic species and methods of regulating polycation-sensing receptor-mediated functions in aquatic species are described. ...	05/02/2006
7033999	Nitrosated and nitrosylated heme proteins Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to novel compounds...	04/25/2006
7012133	Antibodies to C-C chemokine Receptor 3 Protein The present invention relates to isolated and/or recombinant nucleic acids which encode a mammalian (e.g., human) receptor protein designated C—C Chemokine Receptor 3 (CKR-3) or Eos L2, and to proteins or polypeptides, referred to herein as isolated, recombinant m...	03/14/2006
6994977	Method of identifying inhibitors of C—C chemokine receptor 3 The present invention relates to a method of identifying an inhibitor of a mammalian (e.g., human) C—C chemokine receptor 3 (CCR3), comprising combining (a) a compound to be tested, (b) a host cell expressing a recombinant protein comprising a mammalian CCR3, and ...	02/07/2006
6949637	Methods for diagnosis, prediction and treatment of asthma and other inflammatory conditions based on eotaxin coding sequence polymorphism Methods and compositions for diagnosing and treating asthma are provided. The methods involve the discovery of a correlation between an eotaxin gene polymorphism and the ocurrence of asthma. ...	09/27/2005
6929608	Apparatus for deposition of ultrasound energy in body tissue An apparatus for providing ultrasonic energy for deposition in body tissue including an array of elements having at least two different sizes and at least one element being aperiodically spaced with the respect to other elements in the array. Excitation of the eleme...	08/16/2005
6907881	Variable peak pressure ventilation method and system A system and method for ventilating a lung in a living being by varying the peak inspiratory pressure. The peak inspiratory pressure may deviate about a mean that is chosen to correspond with a knee in a pressure-volume curve of the lung. ...	06/21/2005
6909284	High efficiency planar open magnet MRI system structured and arranged to provide orthogonal ferrorefractory effect A planar MRI system is disclosed. The system has an open magnet configuration that produces a magnetic field having a remote region of substantial magnetic field homogeneity. Spatial encoding gradient coils and a rf coil provide MRI data for image reconstruction. Th...	06/21/2005
6878129	Atraumatic temporary arterial branch perfusion device A perfusion catheter system that allows selective temporary perfusion of small vascular or other anatomic structures arising from a host structure atraumatically. The perfusion device has an elongate body having an afferent end portion for receiving perfusion fluid,...	04/12/2005
6831463	Ferrorefraction MRI system having two orthogonal remote field polarization axes A planar MRI system is disclosed. The system has an open magnet configuration that produces a magnetic field having a remote region of substantial magnetic field homogeneity. Spatial encoding gradient coils and a rf coil provide MRI data for image reconstruction. A ...	12/14/2004
6806061	G protein-coupled receptor gene and methods of use therefor The present invention relates to isolated and/or recombinant nucleic acids which encode a mammalian (e.g., human) receptor protein designated C-C Chemokine Receptor 3 (CKR-3) or Eos L2, and to proteins or polypeptides, referred to herein as isolated, recombinant mam...	10/19/2004
6797511	Alarm related peptides and nucleic acids and diagnosis using them We have identified a novel protein, named ALARM or δ-catenin, on the basis of its ability to bind to presenilin 1. ALARM contains 4 copies of the arm repeat and is expressed almost exclusively in brain tissue. ...	09/28/2004
6794358	Peptide ligands of the urokinase receptor Novel peptides that are capable of binding to uPAR and inhibiting the binding of an integrin and vitronectin are described. Also provided are nucleic acid sequences encoding the novel peptides. Methods for screening for small molecules, other peptides, or peptoids t...	09/21/2004
6770031	Ultrasound therapy A method of delivering ultrasound signals includes providing an image of at least a portion of a subject intended to receive ultrasound signals between sources of the ultrasound signals and a desired region of the subject for receiving focused ultrasound signals, id...	08/03/2004
6750360	Lipoxin compounds and their use in treating cell proliferative disorders Compounds having the active site of natural lipoxins, but a longer tissue half-life are disclosed. In particular, 15-epi-lipoxins and their use in ameliorating undesired cell proliferation, which characterizes diseases such as cancer, are also disclosed. ...	06/15/2004
6730475	Methods of diagnosis and treatment of meniere disease The invention features methods of diagnosing and treating Meniere disease. The invention also features kits and probes for diagnosing Meniere disease. ...	05/04/2004
6723506	Method of identifying PAX8-PPAR gamma-nucleic acid molecules An oncogene designated PAX8-PPARγ1 contains a PAX8 coding region fused to PPARγ coding region. Molecular characterization of PAX8-PPARγ1 molecules provides nucleotide and amino acid sequences useful for detection and treatment of certain tumors, particularly thyr...	04/20/2004
6714010	Combining unfold with parallel magnetic resonance imaging A method for combining UNFOLD with a parallel magnetic resonance imaging (MRI) technique, such as SMASH, SENSE, or SPACE-RIP is provided. When acquiring only one nth of the usual amount of k-space data, data is acquired n times faster, but n signals will ...	03/30/2004
6710084	Inhibition of TNFα-initiated neutrophil response The impact of lipoxin A4 (LXA4) and aspirin-triggered-lipoxins (ATL) was investigated in tumor necrosis factor (TNFα)-initiated neutrophil (PMN) responses in vitro and in vivo using metabolically stable LX analogs. At concentrations as low as ...	03/23/2004
6703423	Inhibition of TNF଱-initiated neutrophil response The impact of lipoxin A4 (LXA4) and aspirin-triggered-lipoxins (ATL) was investigated in tumor necrosis factor (TNF଱)-initiated neutrophil (PMN) responses in vitro and in vivo using metabolically stable LX analogs. At concentra...	03/09/2004
6699905	Modulation of inflammation related to columnar epithelia This invention provides pharmaceutical compositions containing lipoxin compounds and therapeutic uses for the compounds in treating or preventing a disease or condition associated with columnar epithelial inflammation. The invention also discloses methods...	03/02/2004
6696480	Upregulation of type III endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization A use for agents that disrupt actin cytoskeletal organization is provided. In the instant invention, agents that disrupt actin cytoskeletal organization are found to upregulate endothelial cell Nitric Oxide Synthase activity. As a result, agents that disr...	02/24/2004
6684098	Versatile stereotactic device and methods of use A stereotactic device for use with an imager such as a magnetic resonance imager is disclosed, which permits an imaging scan to be taken with reference to a personal coordinate system (or PCS) that is independent of a machine coordinate system (or MCS). M...	01/27/2004
6670396	Aspirin-triggered lipid mediators Aspirin triggered lipid mediators (ATLMs) are disclosed which are useful for the treatment of prevention of inflammation associated with various diseases, including ischemia....	12/30/2003
6659282	Prevention of neutrophil recruitment Aspirin (ASA) triggers a switch in the biosynthesis of lipid mediators, inhibiting prostanoid production and initiating 15-epi-lipoxin generation, through the acetylation of cyclooxygenase II....	12/09/2003
6640134	Health monitoring system A health monitoring system which tracks the state of health of a patient and compiles a chronological health history of the patient uses a multiparametric monitor which periodically and automatically measures and records a plurality of physiological data ...	10/28/2003
6612988	Ultrasound therapy The invention provides a method of delivering ultrasound signals. The method includes providing an image of at least a portion of a subject intended to receive ultrasound signals between sources of the ultrasound signals and a desired region of the subjec...	09/02/2003
6610493	Screening compounds for the ability to alter the production of amyloid-ଲ peptide This invention provides methods of screening compounds for their ability to alter the production of Aଲ(xࣙ41) alone or in combination with Aଲ(xࣘ40). The methods involve administering compounds to cells, specifically measuring the amounts of...	08/26/2003
6583113	Nitrosated and nitrosylated heme proteins Nitrosylation of proteins and amino acid groups enables selective regulation of protein function, and also endows the proteins and amino acids with additional smooth muscle relaxant and platelet inhibitory capabilities. Thus, the invention relates to nove...	06/24/2003

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Assignee: Brigham and Women's Hospital