Assignee: Brantford Chemicals Inc.

Location: Brantford, CA
No. of patents: 22

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Number	Title	Issue Date
6642384	Preparation of chiral 1,2,3,4-tetrahydro-6,7-dialkoxy-3-isoquinolinecarboxylic acid and derivatives The present invention relates to a process for the production of (S)-1,2,3,4-tetrahydro-6,7-dialkoxy-3-isoquinolinecarboxylic acid compounds (1) and their derivatives from Levodopa (L-Dopa). The ultimately prepared compounds are used as intermediates for,...	11/04/2003
6635753	Process for the preparation of substantially pure stavudine and related intermediates useful in the preparation thereof There are disclosed novel Stavudine solvates as follows: Stavudine NN-dimethyllacetamide solvates; Stavudine NN-dimethylacrylamide solvates and Stavudine NN-dimethylpropionamide solvates and processes for producing Stavudine NN-dimethylacetamide solvates,...	10/21/2003
6600044	Process for recovery of the desired cis-1,3-oxathiolane nucleosides from their undesired trans-isomers A process for the preparation of 1,3-oxathiolane nucleoside analogues in predominantly the cis-form, from mixture of cis-/trans-1,3-oxathiolane nucleosides or their protected derivatives thereof, comprising: (i) treatment of the cis-/trans-1,3-oxathiolane nucl...	07/29/2003
6596866	Process for the preparation of nefazodone hydrochloride A process for the preparation of Nefazodone hydrochloride comprising direct conversion of semicarbazide dihydrochloride 3 into Nefazodone hydrochloride which process involves a reaction of triethyl orthopropionate in the presence of trimethylsilylchloride...	07/22/2003
6593475	Preparation of derivative of 3-sulfonamido-4-phenylaminopyridine This invention relates to the preparation of 3-sulfonamido-4-arylaminopyridines by heating a 3-sulfonamido-4-aminopyridine with an aryl halide in the presence of an alkaline compound, a copper-containing agent and in the presence of a polar protic so...	07/15/2003
6586593	Efficient process for the preparation of lamotrigine and related 3,5-diamino-6-substituted-1,2,4-triazines A process for the manufacture of 3,5-diamino-6-substituted-1,2,4-triazines is disclosed which comprises the steps of: (a) reacting a compound of formula (II): ##STR1## with aminoguanidine salts, (b) dehydrating the compound obtained to form a compound of form...	07/01/2003
6495691	Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives A process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives of general formula I: ##STR1## or their pharmaceutically acceptable salts, wherein the meaning of X is hydrogen, carboxyl, alkoxycarbonyl, aryloxycarbonyl, nitrile, or carbamoyl ...	12/17/2002
6436956	Useful form of anhydrous paroxetine hydrochloride Paroxetine hydrochloride anhydrous designated as Form IV having at least one, some or all of the following characteristics: a) Infrared spectra as shown in FIG. 1 and 2, b) A X-ray powder diffraction pattern as shown in Schedule "C", c) A melting point of between a...	08/20/2002
6407262	Process for the preparation of Ramipril A process for separating diastereomeric mixtures of compounds of formula 1 and formula 2 ##STR1## wherein R1 =H or R1 denotes a carboxyl-esterifying group selected from C1 -C6 alkyl and C7 -C8	06/18/2002
6380388	1,3-oxathiolan-5-ones useful in the production of antiviral nucleoside analogues A compound of the formula A, ##STR1## wherein R* is a chiral auxiliary, and where the configuration at the asymmetric carbon atom between oxygen and sulfur is (R), (S), or combinations of (R) and (S), useful in the preparation of enantiomerically enr...	04/30/2002
6132286	Preparation of 1,2,5,6-tetra-hydro-3-carboalkoxypridines such as arecoline and salts of 1,2,5,6-tetrahydro-3-carboalkoxypridines and arecoline hydrobromide A process is provided for the preparation of 1,2,5,6-tetrahydro-3-carboalkoxypyridines of formula (III) ##STR1## wherein R is a straight or cyclic substituted or unsubstituted alkyl chain having 1 to 6 carbon atoms, phenyl C1-6 alkyl, ment...	10/17/2000
6107490	Process for the manufacture of 4-methyl-5-hydroxymethyl-imidazole A process is provided for the manufacture of 4-lower-alkyl-5-hydroxymethyl-imidazole comprising reacting (4)-lower-alkyl imidazole with formaldehyde in an alkanol solvent having from 2 to 5 carbon atoms in the presence of a solid mild base suspended in ...	08/22/2000
6080860	Methods of making ureas and guanidines including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted Quinazolines), Meobentine and Bethanidine and novel intermediate...	06/27/2000
5919931	Process for the manufacture of intermediates suitable to make doxazosin, terazosin, prazosin, tiodazosin and related antihypertensive medicines A process is provided for the manufacture of: where R is: ##STR1## comprising reacting: ##STR2## wherein R1 may be selected from H, Methyl, Ethyl and suitable lower alkyl groups, Cn H2n+1 (where n is from 3 to 5)...	07/06/1999
5872258	Commercial process for the manufacture of fluconazole and intermediates useful in the manufacture thereof A process for making Fluconazole is provided comprising carrying out the following scheme of reaction: ##STR1##...	02/16/1999
5750714	Process for the manufacture of related intermediates including cistofur A process of manufacture of: R--CH2 --S--CH2 --CH2 --NH2 2HC1 wherein R is selected from the group consisting of ##STR1## is provided, the said process comprising reacting R--CH2 OH.HCL with HSCH...	05/12/1998
5750719	Commercial process for the manufacture of fluconazole and intermediates useful in the manufacture thereof A process for making Fluconazole is provided comprising carrying out the following scheme of reaction: ##STR1##...	05/12/1998
5686612	Methods of making ureas and guanidines, including terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2-substituted quinazoline compounds), and meobentine, and bethanidine and intermediates thereof Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted Quinazolines), Meobentine and Bethanidine and novel intermediate...	11/11/1997
5686627	Sodium enalapril complex and the use thereof to make sodium enalapril A process for making pure sodium enalapril is provided which includes the step of decomplexing essentially pure sodium enalapril-sodium iodide complex to yield essentially pure sodium enalapril....	11/11/1997
5675006	Methods of making ureas and guanidines, including, terazosin, prazosin, doxazosin, tiodazosin, trimazosin, quinazosin, and bunazosin (exemplary of 2- substituted quinazoline compounds), and meobentine, and bethanidine and intermediates therefor Novel methods for the synthesis of substituted ureas and guanidines including Terazosin, Prazosin, Doxazosin, Tiodazosin, Trimazosin, Quinasin and Bunazosin (exemplary of 2-amino substituted Quinazolines), Meobentine and Bethanidine and novel intermediate...	10/07/1997
5670671	Process for the production of an improved form of form 1 ranitidine Process for the production of an improved form of Form 1 Ranitidine Hydrochloride having improved filtration and drying characteristics, said process comprising in a substantially anhydrous hydroxylic solvent, comprising at least one alkanol solvent havin...	09/23/1997
5637730	Sodium enalapril complex and the use thereof to make sodium enalapril A process for making pure sodium enalapril is provided which includes the step of decomplexing essentially pure sodium enalapril-sodium iodide complex to yield essentially pure sodium enalapril....	06/10/1997

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Assignee: Brantford Chemicals Inc.