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| Number | Title | Issue Date |
| 8114461 | Balanced sn-2 myristate-containing edible oil A nutritional fat or oil-based composition for increasing HDL cholesterol, decreasing LDL cholesterol and decreasing the LDL/HDL cholesterol ratio in human plasma is described. The composition typically includes at least 1% by weight myristic acid esterified at the ... | 02/14/2012 |
| 8097750 | Cinchona alkaloid-catalyzed asymmetric mannich reactions The instability of carbamate-protected alkyl imines has greatly hampered the development of catalytic asymmetric Mannich reactions suitable for the synthesis of optically active carbamate-protected chiral alkyl amines. A highly enantioselective Mannich reaction with... | 01/17/2012 |
| 8071734 | Nucleic acid-based detection The invention relates to compositions, systems, and methods for simultaneously detecting the presence and quantity of one or more different compounds in a sample using aptamer beacons. Aptamer beacons are oligonucleotides that have a binding region that can bind to ... | 12/06/2011 |
| 8071143 | Methods for the treatment or prevention of diabetes mellitus and other metabolic imbalances The invention relates to methods for treatment and prevention of a metabolic imbalance, including diabetes mellitus and other related diseases or disorders, using an extract from a fruit of genus Elaeis. ... | 12/06/2011 |
| 7972786 | Detection and analysis of influenza virus An assay comprising more than one primer pair and more than one detection probe, a low copy number synthetic amplicon corresponding to each of the primer pairs. The assay can detect and distinguish between various sub-types and strains of an influenza virus using an... | 07/05/2011 |
| 7936171 | Baluns, a fine balance and impedance adjustment module, a multi-layer transmission line, and transmission line NMR probes using same A pseudo-Marchand balun, compound balun and tunable multi-resonant coaxial balun, and NMR probes employing each such balun, and a fine balance and impedance adjustment module and a multi-layer transmission line for use in such NMR probes. ... | 05/03/2011 |
| 7803531 | Method of inducing apoptosis by reducing the level of thiamin The disclosure describes methods for inducing apoptosis of a selected group of vertebrate cells in vivo by reducing the level of thiamin in the cells. Included are methods for inducing apoptosis of cancer cells. Also described are compounds and compositions for use ... | 09/28/2010 |
| 7767811 | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomer... | 08/03/2010 |
| 7736898 | Thiaminases and thiaminase genes for use in apoptotic therapies This disclosure describes methods for preparing and utilizing thiaminase and thiaminase genes to induce apoptosis in a selected group of vertebrate cells in vivo by reducing the level of thiamin in the cells. Emphasis is on methods for inducing apoptosis in cancer c... | 06/15/2010 |
| 7709038 | Prepared foods containing triglyceride-recrystallized non-esterified phytosterols A dietary supplement is provided which includes at least one triglyceride-based edible fat and between 3% and 50% by weight of triglyceride recrystallized phytosterols. The dietary supplement can be in the form of a capsule, pill or wafer. Additionally, the dietary ... | 05/04/2010 |
| 7632642 | Primers, probes and methods for nucleic acid amplification Homogenous detection during or following PCR amplification, preferably LATE-PCR, utilizing fluorescent DNA dye and indirectly excitable labeled primers and probes, improves reproducibility and quantification. Low-temperature homogeneous detection during or following... | 12/15/2009 |
| 7582764 | Asymmetric carbon-carbon-bond-forming reactions catalyzed by bifunctional cinchona alkaloids One aspect of the present invention relates to quinine-based and quinidine-based catalysts. In certain embodiments, the quinine-based and quinidine-based catalysts contain a hydroxy group at the 6′ position. In certain embodiments, the quinine-based and quinidine-... | 09/01/2009 |
| 7575768 | Dietary supplements and prepared foods containing triglyceride-recrystallized non-esterified phytosterols A nutritional supplement, prepared food product, or direct food additive for ingestion by mammals, and methods for preparing such products, are provided. Products of the invention comprise an oxidation-resistant fat-based composition substantially free of exogenous ... | 08/18/2009 |
| 7556776 | Microfluidic manipulation of fluids and reactions The present invention relates generally to microfluidic structures, and more specifically, to microfluidic structures and methods including microreactors for manipulating fluids and reactions. In some embodiments, structures and methods for manipulating many (e.g., ... | 07/07/2009 |
| 7547436 | Receptor specific transepithelial transport of therapeutics The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to metho... | 06/16/2009 |
| 7531662 | Cinchona-alkaloid-based catalysts, and asymmetric alcoholysis of cyclic anhydrides using them One aspect of the present invention relates to cinchona-alkaloid-based catalysts. A second aspect of the invention relates to a method of preparing a derivatized cinchona alkaloid catalyst by reacting a cinchona-alkaloid with base and a compound that has a suitable ... | 05/12/2009 |
| 7517977 | Reagents and methods for improving reproducibility and reducing mispriming in PCR amplification An additive for preventing mispriming in polymerase chain reaction (PCR) amplifications and assays comprising a hairpin oligonucleotide having a stem duplex greater than six nucleotides in length and a stabilized stem terminus. The additive improves PCR amplificatio... | 04/14/2009 |
| 7465562 | Nucleic acid processing methods, kits and devices Biological samples containing nucleic acids, RNA and DNA, are freed from bound proteins by incubation with a chaotropic agent such as a guanidium salt, and the mixture is readied for further processing by dilution of such agent to a concentration below 0.05 M withou... | 12/16/2008 |
| 7356113 | Tomosynthesis imaging system and method A system for three-dimensional tomosynthesis imaging of a target element includes an image acquisition element and a processor. The image acquisition element obtains a plurality of images of the target element from a plurality of angles and includes a radiation sour... | 04/08/2008 |
| 7312335 | Asymmetric Michael and Aldol additions using bifunctional cinchona-alkaloid-based catalysts One aspect of the present invention relates to quinine-based and quinidine-based catalysts. Another aspect of the invention relates to a method of preparing a derivatized quinine-based or quinidine-based catalyst comprising 1) reacting quinine or quinidine with base... | 12/25/2007 |
| 7229653 | Increasing the HDL level and the HDL/LDL ratio in human serium by balancing saturated and polyunsaturated dietary fatty acids A method of increasing the HDL concentration and the HDL/LDL concentration ratio in human serum by providing a balance between a sufficient and required proportion of cholesterol-free saturated fatty acids in the daily dietary fat of the human and a sufficient and r... | 06/12/2007 |
| 7198897 | Late-PCR A non-symmetric polymerase chain reaction (PCR) amplification method employing a limiting primer in low concentration whose concentration-adjusted melting point at least equals, and preferably exceeds, that of the excess primer, the latter in turn not being more tha... | 04/03/2007 |
| 7144595 | Prepared foods containing triglyceride-recrystallized non-esterified phytosterols A prepared food product for ingestion by mammals is described and methods for preparing such products. The food product includes an oxidation-resistant fat-based composition substantially free of exogenous solubilizing and dispersing agents for phytosterols. The fat... | 12/05/2006 |
| 7078547 | Catalytic asymmetric cyanosilylation of ketones, aldehydes, thioketones, thioaldehydes, imines and hydrazones One aspect of the present invention relates to a method for the catalytic asymmetric cyanosilylation of ketones, aldehydes, thioketones, thioaldehydes, imines and hydrazones. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing cat... | 07/18/2006 |
| 7067129 | Receptor specific transepithelial transport in therapeutics The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to metho... | 06/27/2006 |
| 7060840 | Catalytic asymmetric desymmetrization of prochiral compounds The present invention relates to methods for the synthesis of chiral non-racemic products, e.g., enantiomerically-enriched hemiesters, from prochiral starting materials, e.g., meso anhydrides. The present invention also relates to catalysts for the aforementioned me... | 06/13/2006 |
| 7060274 | Receptor specific transepithelial transport of therapeutics The present invention relates in general to methods and products for initiating an immune response against an antigen, and in particular relates to transepithelial delivery of antigens to provoke tolerance and immunity. The present invention further relates to metho... | 06/13/2006 |
| 7057038 | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomer... | 06/06/2006 |
| 7053236 | Catalytic asymmetric desymmetrization of prochiral and meso compounds The present invention relates to methods for the synthesis of chiral non-racemic products, e.g., enantiomerically-enriched hemiesters, from prochiral and meso starting materials, e.g., prochiral and meso cyclic anhydrides. The present invention also relates to catal... | 05/30/2006 |
| 6878546 | Product and method for swelling a cell nucleus without DNA replication The present invention concerns products and methods particularly useful for activating and analyzing non-dividing cell nuclei. The featured products include activating egg extracts, cytostatic factor (CSF) extracts, kits containing these extracts, and a microchamber... | 04/12/2005 |
| 6755877 | Freestanding plastic container for controlled combustion of alcohol-based lighter fluid A combustible fire-starting or heat-providing assembly is described that includes a suitable quantity of combustible alcohol-based fuel liquid held within a freestanding, combustible, alcohol-resistant and alcohol-impermeable container. The container is configured w... | 06/29/2004 |
| 6744848 | Method and system for low-dose three-dimensional imaging of a scene The present invention provides a system for imaging an object by irradiating it with low doses of radiation, such as x-ray, from a plurality of positions angularly distributed about the object, and analyzing the intensity of the radiation transmitted through the obj... | 06/01/2004 |
| 6743914 | Kinetic resolutions of chiral 2-and 3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or diastereomer... | 06/01/2004 |
| 6680377 | Nucleic acid-based detection The invention relates to compositions, systems, and methods for simultaneously detecting the presence and quantity of one or more different compounds in a sample using aptamer beacons. Aptamer beacons are oligonucleotides that have a binding region that c... | 01/20/2004 |
| 6638547 | Prepared foods containing triglyceride-recrystallized non-esterified phytosterols A prepared food product for ingestion by mammals is described and methods for preparing such products. The food product includes an oxidation-resistant fat-based composition substantially free of exogenous solubilizing and dispersing agents for phytostero... | 10/28/2003 |
| 6630192 | Increasing the HDL level and the HDL/LDL ratio in human serum by balancing saturated and polyunsaturated dietary fatty acids A method of increasing the HDL concentration and the HDL/LDL concentration ratio in human serum by providing a balance between a sufficient and required proportion of cholesterol-free saturated fatty acids in the daily dietary fat of the human and a suffi... | 10/07/2003 |
| 6596870 | Asymmetric synthetic methods based on phase transfer catalysis One aspect of the present invention relates to methods of asymmetric synthesis, e.g., asymmetric hydride reductions of carbonyl groups, using a chiral, non-racemic phase transfer catalyst, a helper nucleophile, and a sterically bulky reagent nucleophile, ... | 07/22/2003 |
| 6580003 | Catalytic asymmetric desymmetrization of meso compounds The present invention relates to methods for the synthesis of chiral non-racemic products, e.g., enantiomerically-enriched hemiesters, from prochiral starting materials, e.g., meso anhydrides. The present invention also relates to catalysts for the aforem... | 06/17/2003 |
| 6562966 | Kinetic resolutions of chiral 2- and 3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or d... | 05/13/2003 |
| 6562967 | Kinetic resolutions of chiral 2-and-3-substituted carboxylic acids One aspect of the present invention relates to a method for the kinetic resolution of racemic and diastereomeric mixtures of chiral compounds. The critical elements of the method are: a non-racemic chiral tertiary-amine-containing catalyst; a racemic or d... | 05/13/2003 |
