Assignee: Boyce Thompson Institute for Plant Research, Inc.

Location: Ithaca, NY
No. of patents: 36

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Number	Title	Issue Date
7572466	Oral immunology using plant product containing a non-enteric pathogen antigen A method for obtaining an immune response to a non-enteric pathogen antigen (NEPA) such as hepatitis B surface antigen (HBsAg) by feeding the antigen in a plant material to an animal that is immunoreceptive to the NEPA. It has now been discovered that the animal may...	08/11/2009
7407802	Vectors and cells for preparing immunoprotective compositions derived from transgenic plants The inventions is drawn towards vectors and methods useful for preparing genetically transformed plant cells that express immunogens from pathogenic organisms which are used to produce immunoprotective particles useful in vaccine preparations. The invention includes...	08/05/2008
7405038	Stable cell lines resistant to apoptosis and nutrient stress and methods of making same Cell lines that are commonly used for protein expression are engineered to include genes that encode suppressors of apoptosis (SA). Insect cell lines expressing these SA genes are resistant to apoptosis or programmed cell death, and express certain recombinant prote...	07/29/2008
7179648	Clonal cell lines derived from BTI-TN-5B1-4 Improved insect cell lines, two of which are designated H5CL-B and H5CL-F (both of which are derived from the parental cell line BTI-TN-5B1-4, ATCC CRL 10859), possess the properties of increased production of baculovirus particles, increased expression of foreign p...	02/20/2007
7169966	Salicylic acid-binding protein encoding nucleic acid, SABP2, and methods of use thereof Novel nucleic acid molecules encoding SA-binding proteins involved in SA-mediated disease resistance responses are disclosed. Methods of use of the nucleic acid molecules and proteins of the invention are also provided. ...	01/30/2007
7138569	Nucleic acids encoding pseudomonas hop proteins and use thereof The present invention relates to isolated nucleic acid molecules encoding a type III—secreted bacterial protein capable of modifying a cell death pathway in a plant cell. One aspect of the present invention involves an isolated nucleic acid molecule having a nucle...	11/21/2006
7132291	Vectors and cells for preparing immunoprotective compositions derived from transgenic plants The inventions is drawn towards vectors and methods useful for preparing genetically transformed plant cells that express immunogens from pathogenic organisms which are used to produce immunoprotective particles useful in vaccine preparations. The invention includes...	11/07/2006
6965059	Method of protecting plants by introducing a gene coded for a protein which enhances virus infection of host insects Recent advances of the research on synergistic effect of a mixed baculovirus infection demonstrated the presence of viral molecules enhancing the early event of infection. The enhancins from the Trichoplusia ni was identified to have such a function, i.e., di...	11/15/2005
6906243	Plant MSH2 sequences and methods of use The invention relates to isolated nucleic acid molecules encoding MutS homologues (MSHs). Such MSH proteins are involved in DNA mismatch-repair processes in organisms. The invention provides isolated nucleic acid molecules comprising MSH2 nucleotide sequences which ...	06/14/2005
6858205	GP64-null baculoviruses pseudotyped with heterologous envelope proteins for gene therapy A pseudotyped baculovirus comprises a deletion, inactivation or reduction from regulation of a baculovirus envelope protein gene, and is engineered to express an envelope protein from another virus or cell, or another protein or molecule that facilitates entry of th...	02/22/2005
6765127	Invertebrate intestinal mucin cDNA and related products and methods The invention represents the disclosure of an insect intestinal mucin (IIM) protein. The IIM protein was been identified and cloned using Trichoplusia ni larva. The cDNA and amino acid sequences have been determined and are disclosed. These sequences are usef...	07/20/2004
6607912	GP64-null baculoviruses pseudotyped with heterologous envelope proteins A pseudotyped baculovirus comprises a deletion, inactivation or reduction from regulation of a baculovirus envelope protein gene, and is engineered to express an envelope protein from another virus or cell, or another protein or molecule that facilitates ...	08/19/2003
6551820	Expression of immunogenic hepatitis B surface antigens in transgenic plants Plant expression vectors comprising at least two expression cassettes are provided which function to reduce transcriptional silencing of polynucleotide expression. Further, novel plant expression vectors for expression of immunogenic polypeptides, includi...	04/22/2003
6403375	Establishment of Trichoplusia ni cell lines in serum-free medium for recombinant protein and baculovirus production This disclosure presents the establishment of new cell lines from Trichoplusia ni eggs, in a commercial serum-free medium. These new cell lines were screened with wild-type Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) and Trichoplus...	06/11/2002
6392121	Gemini virus vectors for gene expression in plants A gene amplification system based on plant viral genetic elements dramatically increases foreign protein production in plants. A safer and more economical production system for vaccines and antibodies in recombinant plants grown using agricultural practic...	05/21/2002
6284946	Banana DNA associated with fruit development The present invention provides isolated and purified genes which are differentially expressed during banana fruit development, and the protein products of these genes. The present invention further provides DNA regulatory elements which are differentially...	09/04/2001
6261805	Sialyiation of N-linked glycoproteins in the baculovirus expression vector system The present disclosure utilizes a novel approach to protein preparation in the baculovirus expression vector system (BEVS). Specifically, the present invention analyzes the effects of microgravity/low shear on complex glycosylation of proteins prepared vi...	07/17/2001
6187558	Invertebrate intestinal mucin cDNA and related products and methods The invention represents the disclosure of a novel insect intestinal mucin comprising two nearly identical isoforms, IIM14 and IIM22 respectively. These isoforms of the IIM protein have been identified and cloned using T. ni larva. The cDNA and amino acid...	02/13/2001
6090379	Stable pre-occluded virus particle for use in recombinant protein production and pesticides A method of infecting insects is disclosed; the method utilizes a form of a baculovirus which is highly efficient at establishing infection and is normally destined to become occluded within the polyhedrin or granulin--Pre-occluded Virus (POV). Specifical...	07/18/2000
5962765	Molecular cloning of a complimentary DNA sequence encoding a cuticle degrading protease produced by entomopathogenic fungi We have studied the regulation of the extracellular chymoelastase protease (Pr1) of Metarhizium anisopliae, an enzyme involved in the penetration of insect cuticle by Metarhizium and other entomopathogenic fungi. We report here the isolation and character...	10/05/1999
5861277	Methods and compositions for enhancing the expression of genes in plants Disclosed are methods of increasing exogenous protein expression in a cell or a transgenic plant. Constructs, i.e., vectors, DNA fusions and polynucleotides, for use in conjunction with the methods to cause increased exogenous protein expression are also ...	01/19/1999
5750383	Baculovirus cloning system Disclosed herein is a novel baculovirus cloning system. The new cloning system is a marker-rescue system, using an essential gene, e.g. gp64. In this system, a gene essential for viral replication, growth, or propagation in cell culture is removed from or...	05/12/1998
5717069	DNA sequence coding for enhancin polypeptide which enhances virus infection of host insects This disclosure relates to an isolated and cloned DNA from a granulovirus virus which comprises an amino acid sequence of the vital gene encoding a polypeptide isolated from occlusion bodies of certain baculoviruses and which polypeptide possesses the bio...	02/10/1998
5686305	Establishment of new cell lines from Pseudaletia unipuncta with differential responses to baculovirus This disclosure presents the establishment of a new cell line from Pseudaletia unipuncta embryos. This cell line demonstrated the ability to produce high numbers of baculoviruses in cell culture. These virus particles are found internally in the cells in ...	11/11/1997
5593669	Stable pre-occluded virus particle A method of infecting insects is disclosed; the method utilizes a form of a baculovirus which is highly efficient at establishing infection and is normally destined to become occluded within the polyhedrin or granulin--Pre-occluded Virus (POV). Specifical...	01/14/1997
5475090	Gene coded for a polypeptide which enhances virus infection of host insects Cloning and sequencing certain baculovirus genes encoding polypeptides termed enhancins. The polypeptides are isolated from the occlusion body of certain baculoviruses such as Trichoplusia ni granulosis virus and Pseudaletia unipuncta granulosis virus, Ha...	12/12/1995
5351643	High density rearing system for larvae Method and apparatus for rearing insects is disclosed. Information concerning the physical and dietary needs of the insect as well as behavioral characteristics are utilized to maximize the number of larvae reared per unit surface area of diet and per uni...	10/04/1994
5348877	Method of adapting anchorage-dependent cell lines to suspension conditions Normally anchorage-dependent insect cell lines are adapted to replicate under suspension conditions by addition of heparin to the culture medium and selection for resulting suspension-tolerant cells....	09/20/1994
5300435	Trichoplusia ni cell line which supports replication of baculoviruses An insect cell line has been established and characterized, derived from embryonic tissue (BTI-TN-5B1-4, ATCC CRL 10859) of Trichoplusia ni (cabbage looper). The line is susceptible to various baculoviruses, including TnSNPV and AcMNPV, and may be used to...	04/05/1994
5298418	Cell line isolated from larval midgut tissue of Trichoplusia ni Two new insect cell lines have been established and characterized; the cell lines were derived from midgut (BTI-TN-MG1, ATC CRL 10860), and embryonic tissue (BTI-TN-5B1-4, ATC CRL 10859) of Trichoplusia ni (cabbage looper). The lines are susceptible to va...	03/29/1994
5290765	Method of protecting biological materials from destructive reactions in the dry state A method is provided for protection of biological materials from the stresses of air-drying and also from destructive reactions, such as oxidation and free-radical attack, which degrade the materials during long-term storage. The method involves drying th...	03/01/1994
5221623	Use of bacterial luciferase structural genes for cloning and monitoring gene expression in microorganisms and for tagging and identification of genetically engineered organisms A host microorganism is genetically and stably modified by the insertion into any of its non-essential chromosomal location of a non-homologous, recombinant foreign DNA fragment, maintaining an insertion of a luxAB gene of a selected bioluminescent bacter...	06/22/1993
5200399	Method of protecting biological materials from destructive reactions in the dry state A method is provided for protection of biological materials from the stresses of air-drying and also from destructive reactions, such as oxidation and free-radical attack, which degrade the materials during long-term storage. The method involves drying th...	04/06/1993
5011685	Baculovirus proteins and viral pesticides containing same Nuclear polyhedrosis viruses, for example, Autographa californica nuclear polyhedrosis virus (AcMNPV), useful in the control of lepidopterous larvae such as the larvae of the cabbage looper Trichoplusia ni, have been found to have enhanced infectivity whe...	04/30/1991
4973667	Baculovirus proteins and viral pesticides containing same Nuclear polyhedrosis viruses, for example, Autographa californica nuclear polyhedrosis virus (AcMNPV), useful in the control of lepidopterous larvae such as the larvae of the cabbage looper Trichoplusia ni, have been found to have enhanced infectivity whe...	11/27/1990
4971793	Subunit canine parvovirus vaccine A recombinant subunit vaccine for protecting dogs against infection caused by canine parvovirus comprising VP-2 protein produced during replication of a recombinant baculovirus in insect tissue culture cells or insects which are a permissive host for the ...	11/20/1990

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Assignee: Boyce Thompson Institute for Plant Research, Inc.