Assignee: Boston Probes, Inc.

Location: Bedford, MA
No. of patents: 35

Number	Title	Issue Date
8026051	PNA probes, probe sets, methods and kits pertaining to the detection of This invention is related to novel PNA probes, probe sets, methods and kits pertaining to the detection of one or more species of Candida yeast. Non-limiting examples of probing nucleobase sequences that can be used for the probes of this invention can be sel...	09/27/2011
8017758	PNA oligomers, oligomer sets, methods and kits pertaining to the detection of This invention is related to novel PNA probes, probe sets, methods and kits pertaining to the determination of Bacillus anthracis. ...	09/13/2011
7981599	Non-nucleic acid probes, probe sets, methods and kits pertaining to the detection of individual human chromosomes X, Y, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 16, 17, 18 and 20 as 13/21 as a pair This invention is related to novel non-nucleic acid probes, probe sets, methods and kits pertaining to the detection, identification or quantitation of human chromosomes X, Y, 1, 2, 3, 4, 6, 7, 8, 9, 10, 11, 12, 13, 16, 17, 18, 20 and/or 21. The non-nucleic acid pro...	07/19/2011
7892741	Methods, kits and compositions pertaining to linear beacons This invention is directed to methods for determining amplified nucleic acid using Linear Beacons. ...	02/22/2011
7884053	Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions. ...	02/08/2011
7851155	Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions. ...	12/14/2010
7745126	Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions. ...	06/29/2010
7674585	Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions. ...	03/09/2010
7638279	Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions. ...	12/29/2009
7605253	Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions. ...	10/20/2009
7566420	Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions. ...	07/28/2009
7422852	Detection of nucleic acid using linear beacons This invention is directed to methods for determining amplified nucleic acid using Linear Beacons. ...	09/09/2008
7256275	Methods, kits and compositions pertaining to combination oligomers and libraries for their preparation This invention pertains to the field of combination oligomers, including the block synthesis of combination oligomers in the absence of a template, as well as related methods, kits, libraries and other compositions. ...	08/14/2007
7135563	Compositions for detecting target sequences The present invention relates to methods, kits and compositions suitable for the improved detection, quantitation and analysis of nucleic acid target sequences using probe-based hybridization assays. ...	11/14/2006
7125972	Solid carriers with peptide nucleic acid probes and methods for regeneration A method for the detection of point mutation and polymorphisms in nucleic acids or for sequencing of unknown nucleic acids by a simple procedure using arrays uses nucleic acid analoges as sequence discriminators. This procedure simplifies the working mode in complex...	10/24/2006
7108980	Methods for the analysis of microcolonies of bacteria and yeast This invention is related to methods pertaining to the determination of bacteria and yeast wherein the methods comprise: a) filtering a sample containing bacteria and yeast through at least one filter; b) treating the filter or filters with a medium which facilitate...	09/19/2006
6962778	Methods, kits and compositions for suppressing the binding of detectable probes to non-target sequences in hybridization assays This invention relates to methods, kits and compositions suitable for the improved detection, analysis and quantitation of nucleic acid target sequences using probe based hybridization assays. The invention is more specifically directed to methods, kits and composit...	11/08/2005
6949343	Methods, kits and compositions pertaining to PNA Molecular Beacons This invention is directed to methods, kits and compositions pertaining to PNA Molecular Beacons. PNA Molecular Beacons comprise self-complementary arm segments and flexible linkages that promote intramolecular or intermolecular interactions. In the absence of a tar...	09/27/2005
6905824	Methods for determining organisms not requiring the separation of fixative or excess probe This invention is directed to a rapid and simple method for determining organisms and/or cells in a sample. Generally, the method is directed to the use of molecular probes to selectively stain the organisms and/or cells for determination wherein growth medium, fixa...	06/14/2005
6770442	Methods for modulating the solubility of synthetic polymers This invention pertains to solubility enhanced polymers and methods, kits and compositions which enhance the aqueous solubility of said polymers. One set of preferred methods, kits and compositions embody or utilize phosphorous containing synthons and are most usefu...	08/03/2004
6750039	Filtration apparatus and method for the separation of microscopic entities from a fluid This invention relates to a filtration apparatus and method for the separation of microscopic entities from a fluid (liquid or gas) and subsequent visual or imaging microscopic analysis of the entities separated thereon either directly or after treatment of the enti...	06/15/2004
6664045	PNA probes, probe sets, methods and kits pertaining to the detection of microorganisms This invention is related to novel PNA probes, probe sets, methods and kits pertaining to the detection of microorganisms. The probes, probe sets, methods and kits of this invention can be used to detect, identify or quantitate one or more organisms in a ...	12/16/2003
6656687	Multiplex PNA-ISH assay This invention is related to novel PNA probes, probe sets, methods and kits pertaining to the universal detection of bacteria and/or eucarya. Preferred universal probes for the detection of bacteria comprise a probing nucleobase sequence selected from the...	12/02/2003
6649349	In-situ methods for analyzing target sequences using linear beacons This invention is directed to methods, kits and compositions pertaining to Linear Beacons. In the absence of a target sequence, Linear Beacons facilitate efficient energy transfer between the donor and acceptor moieties linked to opposite ends of the prob...	11/18/2003
6607889	Methods, kits and compositions pertaining to detection complexes This invention is directed to methods, kits and compositions which utilize Detection Complexes to detect or identify the presence, absence or quantity of a target molecule in a sample of interest. A Detection Complex comprises at least two component polym...	08/19/2003
6528267	Methods, kits and compositions pertaining to PNA molecular beacons This invention is directed to methods, kits and compositions pertaining to PNA Molecular Beacons. PNA Molecular Beacons comprise self-complementary arm segments and flexible linkages which promote intramolecular or intermolecular interactions. In the abse...	03/04/2003
6485901	Methods, kits and compositions pertaining to linear beacons This invention is directed to methods, kits and compositions pertaining to Linear Beacons. In the absence of a target sequence, Linear Beacons facilitate efficient energy transfer between the donor and acceptor moieties linked to opposite ends of the prob...	11/26/2002
6475721	Sequence specific detection of nucleic acids using a solid carrier bound with nucleic acid analog probes A method for the detection of point mutation and polymorphisms in nucleic acids or for sequencing of unknown nucleic acids by a simple procedure using arrays uses nucleic acid analoges as sequence discriminators. This procedure simplifies the working mode...	11/05/2002
6441152	Methods, kits and compositions for the identification of nucleic acids electrostatically bound to matrices This invention pertains to methods, kits and compositions suitable for the detection, identification and/or quantitation of nucleic acids which are electrostatically immobilized to matrices using non-nucleotide probes which sequence specifically hybridize...	08/27/2002
6361942	Method, kits and compositions pertaining to detection complexes This invention is directed to methods, kits and compositions which utilize Detection Complexes to detect or identify the presence, absence or quantity of a target molecule in a sample of interest. A Detection Complex comprises at least two component polym...	03/26/2002
6355421	Methods, kits and compositions pertaining to PNA molecular beacons This invention is directed to methods, kits and compositions pertaining to PNA Molecular Beacons. PNA Molecular Beacons comprise self-complementary arm segments and flexible linkages which promote intramolecular or intermolecular interactions. In the abse...	03/12/2002
6326479	Synthetic polymers and methods, kits or compositions for modulating the solubility of same This invention pertains to solubility enhanced polymers and methods, kits and compositions which enhance the aqueous solubility of said polymers. One set of preferred methods, kits and compositions embody or utilize phosphorous containing synthons and are...	12/04/2001
6287772	Methods, kits and compositions for detecting and quantitating target sequences The present invention relates to methods, kits and compositions suitable for the improved detection, quantitation and analysis of nucleic acid target sequences using probe-based hybridization assays....	09/11/2001
6280946	PNA probes, probe sets, methods and kits pertaining to the universal detection of bacteria and eucarya This invention is related to novel PNA probes, probe sets, methods and kits pertaining to the universal detection of bacteria and/or eucarya. Preferred universal probes for the detection of bacteria comprise a probing nucleobase sequence selected from the...	08/28/2001
6110676	Methods for suppressing the binding of detectable probes to non-target sequences in hybridization assays This invention relates to methods, kits and compositions suitable for the improved detection, analysis and quantitation of nucleic acid target sequences using probe based hybridization assays. The invention is more specifically directed to methods, kits a...	08/29/2000

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Assignee: Boston Probes, Inc.